Papers by Prof.Dr. Sedef Yenice
Indian Journal of Clinical Biochemistry, 2019
Journal of neurosciences in rural practice
Neuromyelitis optica (NMO) has evolved from devic's classical description to a broader diseas... more Neuromyelitis optica (NMO) has evolved from devic's classical description to a broader disease spectrum, from monophasic illness to a polyphasic illness with multiple recurrences, disease confined to optic nerve and spinal cord to now brain stem, cerebrum and even endocrinopathy due to hypothalamic involvement. To report, the epidemiological characteristics, clinical presentations, recurrence rate, treatment and response to therapy in 26 patients with NMO and NMO spectrum disorder among the Indian population. We performed observational, retrospective analysis of our prospectively maintained data base of patients with NMO, longitudinally extensive transverse myelitis during the period of January 2003-December 2012 who satisfied the national multiple sclerosis society (NMSS) task force criteria for diagnosis of NMO and NMO spectrum disorder. There were 26 patients (female: male, 21:5), the mean age of onset of symptom was 27 years (range 9-58, standard deviation = 12). Twenty-one ...
Detection of Epithelial Cell Transfer in Spinal Areas by Light Microscopy and Determining Any Tissue Coring via Cell Culture During Combined Spinal-Epidural Interventions
Regional Anesthesia and Pain Medicine, 2006
Pharmacology Biochemistry and Behavior, 1994
The ability to regulate body temperature diminishes with age. Exercise training is known to incre... more The ability to regulate body temperature diminishes with age. Exercise training is known to increase cardiovascular performance, and there is some evidence of a cross-adaptation between exercise and cold tolerance in young rats. The present study was designed to examine the effects of physical training by treadmill running on the capacity for brown adipose tissue (BAT) thermogenesis in young and old rats. To this end, we assessed BAT uncoupling protein (UCP) mRNA expression in sedentary and exercise-trained 5and 25-mo-old F-344 rats. The amount of UCP mRNA, whether expressed as per unit RNA or per BAT, did not change with either age or training. These data indicate that there is no cross-adaptation by exercise on adaptive thermogenesis in BAT in either young or old rats.
Urinary Nitrite Excretion in Low Birth Weight Neonates with Systemic Inflammatory Response Syndrome
Neonatology, 1997
Increased nitric oxide (NO) levels are thought to play an important role in the pathophysiology o... more Increased nitric oxide (NO) levels are thought to play an important role in the pathophysiology of the systemic inflammatory response syndrome (SIRS) which is caused by disseminated vascular endothelial damage. Clinical studies have shown that urinary nitrite (NO2 and nitrate (NO3) excretions can be utilized as indexes of NO formation. The SIRS and NO relationship was investigated in 15 neonates with SIRS, gestational age 32.5 ± 4.4 weeks and weight 1,737 ± 753 g. The control group comprised 18 neonates with a gestational age of 32.8 ± 3.5 weeks and a weight of 1,778 ± 538 g. There was no significant difference in birth weights and gestational ages between the two groups (p > 0.05 and p > 0.05). The urinary nitrite levels obtained in the subjects were normalized for urinary creatinine concentrations. The mean urinary nitrite levels in the control group neonates were found to be 4.22 ± 1.8 μmol/mmol creatinine on the 1st day, 4.09 ± 2.28 on the 2nd, 3.62 ± 1.6 on the 3rd, and 4...
Farklı Doku Örneklerinin Kollagen Ve Elastin Oranları
... Üniversitesi Açık Erişim Sistemi; Mitos Demo; Mitos Ulusal Açık Erişim Sistemi; Muğla Ünivers... more ... Üniversitesi Açık Erişim Sistemi; Mitos Demo; Mitos Ulusal Açık Erişim Sistemi; Muğla Üniversitesi Açık Erişim Sistemi; TOBB Ekonomi ve Teknoloji Enstitüsü Açık Arşiv Sistemi; Yaşar Üniversitesi Açık Erişim Sistemi. Türkçe Türkçe.
EJIFCC, 2021
The increased availability and use of POCT are being influenced by many factors, such as; industr... more The increased availability and use of POCT are being influenced by many factors, such as; industry trends to move towards patient-centered care and healthcare decentralization, the increasing prevalence of infectious diseases also including the current use of Rapid SARS-CoV-2 Testing, a growing incidence of lifestyle diseases such as diabetes, heart disease, and hypertension, as well as advances in in-vitro diagnostic medical technologies. The use of POCT can increase the efficiency of services and improve outcomes for patients. However, the variability of the testing environment and conditions as well as the competency of staff performing the tests may have a significant impact on the quality and accuracy of POCT results. A majority of the staff who perform POCT are not trained laboratory staff and may not be as knowledgeable about the processes involved in testing, such as patient preparation, sample collection, management of equipment and supplies, instrument calibration and main...
Son Dönem Böbrek Hastalarında Hemoglobin-A1 Düzeyleri
Son Dönem Böbrek Hastalarında Hemoglobin-A1 Düzeyleri
Clinical Biochemistry, 2009
This article appeared in a journal published by Elsevier. The attached copy is furnished to the a... more This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and education use, including for instruction at the authors institution and sharing with colleagues. Other uses, including reproduction and distribution, or selling or licensing copies, or posting to personal, institutional or third party websites are prohibited. In most cases authors are permitted to post their version of the article (e.g. in Word or Tex form) to their personal website or institutional repository. Authors requiring further information regarding Elsevier's archiving and manuscript policies are encouraged to visit: http://www.elsevier.com/copyright
Quantitation of MCA, CA 19.9, CA 125 and TSA levels in lung cancer
Biochemical Society Transactions, Nov 1, 1995
... 1995 Nov;23(4):530S. Quantitation of MCA, CA 19.9, CA 125 and TSA levels in lung cancer.Yenis... more ... 1995 Nov;23(4):530S. Quantitation of MCA, CA 19.9, CA 125 and TSA levels in lung cancer.Yenisey C, Yenice S, Güner G, Güner S. Department of Biochemistry, Adnan Menderes University, Faculty of Medicine, Turkey. PMID: 8654715 [PubMed - indexed for MEDLINE]. ...
Evaluation of tumor-associated antigens and total sialic acid levels in effusions of malignant and benign origin
Biochemical Society Transactions, May 1, 1996
... 1996 May;24(2):301S. Evaluation of tumor-associated antigens and total sialic acid levels in ... more ... 1996 May;24(2):301S. Evaluation of tumor-associated antigens and total sialic acid levels in effusions of malignant and benign origin. Yenisey C, Yenice S, Güner G, Güner S. Department of Biochemistry, Adnan Menderes University, Faculty of Medicine, Aydin, Turkey. ...
DergiPark (Istanbul University), Apr 1, 1991
Lactate is known to be formed from pyruvate in glycolysis in hypoxic conditions. This study was c... more Lactate is known to be formed from pyruvate in glycolysis in hypoxic conditions. This study was carried out to investigate the possible change in lactate concentrations of cerebrospinal flu id and plasma in different types of brain tumours. Ce rebrospinal fluid and plasma samples were obtained from patients admitted to Dokuz Eyliil University Neurosurgery Department and diagnosed to have brain tumours of various types. Twenty eight cases were divided into iwo distinct categories, as malig nant (n=14) and benign (n=14) tumour groups. The control group consisted of fifteen neurologically normal subjects. Cerebrospinal fluid and plasma lac tate levels were determined using the enzymatic UV method o f Bergmeyer, employing lactate dehydro genase. The mean cerebrospinal fluid and plasma lactate concentrations were found to be statistically elevated in two distinct type of brain tumour groups, when com pared with the controls (p<0.05 and p<0.01, respectively). These findings may reflect a generalized, or localized hypoxy in the tumoural state.
Determination of creatine kinase levels in pleural effusions
Biochemical Society Transactions, 1989
Clinical Biochemistry, 2019
Verification of laboratory test results represents the last opportunity to identify errors before... more Verification of laboratory test results represents the last opportunity to identify errors before they become part of the electronic medical record. Manual verification of test results places significant reliance on the experience and attentiveness of individual observers to identify errors and is vulnerable to errors through omission and neglect. Peer-reviewed publications have documented gains in process efficiency and quality improvement by use of middleware or laboratory information systems to autoverify test results based on pre-defined acceptability criteria. This review evaluates the acceptability of autoverification (AV) as a safe and reliable alternative to total manual review of laboratory test results. AV schemes developed in accordance with international guidelines and standards are applied throughout the laboratory. Careful design of AV systems involves using multidisciplinary teams to develop test-specific decision algorithms, to assist with programming, to verify programming, and validate programmed algorithms prior to use in evaluation of patient test result profiles. Development of test specific decision algorithms makes use of criteria based on instrument messages and flags, quality control status, result limit checks, delta checks, critical values, consistency checks, and patient-related clinical information. Monitoring of the performance of AV parameters, and regular audits of the AV system integrity is recommended in both the literature and guidelines. The potential for gains to process efficiency, error detection and patient safety, through adoption of AV as part of a laboratories quality assurance tool-case, is well supported in published literature.
Critical Reviews in Clinical Laboratory Sciences, 2019
International standards and practice guidelines recommend the use of delta check alerts for labor... more International standards and practice guidelines recommend the use of delta check alerts for laboratory test result interpretation and quality control. The value of contemporary applications of simple univariate delta checks determined as an absolute change, percentage change, or rate of change to recognize specimen misidentification or other laboratory errors has not received much study. This review addresses these three modes of calculation, but in line with the majority of published work, most attention is focused on the identification of specimen misidentification errors. Investigation of delta check alerts are time-consuming and the yield of identified errors is usually small compared to the number of delta check alerts; however, measured analytes with low indices of individuality frequently perform better. While multivariate approaches to delta checks suggest improved usefulness over simple univariate delta check strategies, some of these are complex and not easily applied in contemporary laboratory information systems and middleware. Nevertheless, a simple application of delta checks may hold value in identifying clinically significant changes in several clinical situations: for acute kidney injury using changes in serum creatinine, for risk of osmotic demyelination syndrome using rapid acute changes in serum sodium levels, or for early triage of chest pain patients using high sensitivity troponin assays. A careful and highly selective approach to identifying delta check analytes, calculation modes, and thresholds before putting them into practice is warranted; then follow-up with careful monitoring of performance and balancing true positives, false negatives, and false positives among delta check alerts is needed.
Turkish Journal of Biochemistry
The increasing availability and use of POCT are influenced by many factors, including the industr... more The increasing availability and use of POCT are influenced by many factors, including the industry trend toward patient-centered care and decentralization of health care; the increasing prevalence of infectious diseases, which includes the current use of rapid SARS-CoV-2 testing; the increasing incidence of lifestyle diseases such as diabetes, heart disease, and hypertension; and advances in in-vitro medical diagnostics. The use of POCT can increase the efficiency of services and improve patient outcomes. However, the variability of the testing environment and conditions, as well as the competency of the staff performing the tests, can have a significant impact on the quality and accuracy of POCT results. Most personnel performing POCT are not trained laboratory staff and may not be as familiar with the processes associated with testing, such as patient preparation, specimen collection, management of equipment and supplies, calibration and maintenance of equipment, the performance o...
Interstitialcollagens isolated from lung of rabbits with alloxan-induced diabetes mellitus
Biochemical Society Transactions, 1993
Immunospecificity of soluble elastin peptides: Determination by ELISA assay
Biochemical Society Transactions, 1993
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Papers by Prof.Dr. Sedef Yenice