Multimodal analysis of macaque motor and premotor cortex reveals novel parcellation 3D atlas ... more Multimodal analysis of macaque motor and premotor cortex reveals novel parcellation 3D atlas with cyto-and multireceptor architectonic features of 16 (pre)motor areas Primary motor area 4 is cyto-and receptor architectonically heterogeneous (Pre)motor areas differ in their functional connectivity fingerprints
The intraparietal sulcus (IPS) is structurally and functionally heterogeneous. We performed a qua... more The intraparietal sulcus (IPS) is structurally and functionally heterogeneous. We performed a quantitative cyto-/myelo- and receptor architectonical analysis to provide a multimodal map of the macaque IPS. We identified 17 cortical areas, including novel areas PEipe, PEipi (external and internal subdivisions of PEip), and MIPd. Multivariate analyses of receptor densities resulted in a grouping of areas based on the degree of (dis)similarity of their receptor architecture: a cluster encompassing areas located in the posterior portion of the IPS and associated mainly with the processing of visual information, a cluster including areas found in the anterior portion of the IPS and involved in sensorimotor processing, and an ‘intermediate’ cluster of multimodal association areas. Thus, differences in cyto-/myelo- and receptor architecture segregate the cortical ribbon within the IPS, and receptor fingerprints provide novel insights into the relationship between the structural and functio...
The macaque monkey superior parietal lobule (SPL) is part of a neuronal network involved in the i... more The macaque monkey superior parietal lobule (SPL) is part of a neuronal network involved in the integration of information from visual and somatosensory cortices for execution of reaching and grasping movements. The cytoarchitecture of areas V6, V6Ad, V6Av, PE, PEc, PEci and PGm of the SPL has been described, but little is known about their receptor architectonic organization, although receptor analyses not only provide information concerning brain structure, but also crucial insights into its functional organization. Quantitative in vitro receptor autoradiography was applied to analyze the distribution patterns of 15 different receptors for glutamate, GABA, acetylcholine, serotonin, dopamine and adenosine in the SPL of three adult male Macaca fascicularis monkeys. For each area, mean (averaged over all cortical layers) receptor densities were visualized as a receptor fingerprint of each area. Multivariate analyses were conducted to detect clusters of areas according to the degree o...
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