From the official docs. Simplest deployment via Flask.

A more in-depth Django deployment is at cs50w.

Rename variables in kubernetes.yml, edit docker files, update dependencies in requirements.txt, and fill out Tiltfile per official KB articles.

Then run

# start minikube
minikube start --memory=2048 --cpus=3 -p minikube

# start tilt
tilt up

Any changes made to source files (cf. Dockerfile, app.py) will be immediately built and deployed in k8s.