Hello, I recently ran into the issue of my Telegram Bot not responding to updates. I set up debug logging and noticed that after getting updates, the bot does not process them. This usually occurs after the bot has been running for awhile (30 minutes or so).

Logs:
2016-12-31 19:19:10,915 - telegram.bot - DEBUG - Exiting: getUpdates
2016-12-31 19:19:10,915 - telegram.bot - DEBUG - Entering: getUpdates
2016-12-31 19:19:10,953 - telegram.ext.dispatcher - DEBUG - Processing Update: ...
2016-12-31 19:19:10,962 - telegram.bot - DEBUG - Entering: sendMessage
2016-12-31 19:19:13,520 - telegram.bot - DEBUG - Getting updates: [678494921]
2016-12-31 19:19:13,521 - telegram.bot - DEBUG - [<telegram.update.Update object at 0x7591fff0>]
2016-12-31 19:19:13,522 - telegram.bot - DEBUG - Exiting: getUpdates
2016-12-31 19:19:13,522 - telegram.bot - DEBUG - Entering: getUpdates
2016-12-31 19:19:17,573 - telegram.bot - DEBUG - Getting updates: [678494922]
2016-12-31 19:19:17,575 - telegram.bot - DEBUG - [<telegram.update.Update object at 0x75940330>]

At this point I attempted to end the script by hitting CTRL-C

2016-12-31 19:32:13,272 - JobQueue - DEBUG - JobQueue thread stopped
2016-12-31 19:32:13,273 - telegram.ext.updater - DEBUG - Stopping Updater and Dispatcher...
2016-12-31 19:32:13,274 - telegram.ext.updater - DEBUG - Requesting Dispatcher to stop...
2016-12-31 19:32:16,752 - telegram.bot - DEBUG - No new updates found.
2016-12-31 19:32:16,752 - telegram.bot - DEBUG - []
2016-12-31 19:32:16,753 - telegram.bot - DEBUG - Exiting: getUpdates
2016-12-31 19:32:16,753 - telegram.ext.updater - DEBUG - updater - ended

At this point the logging stopped.