const _ = require('lodash');

// Sample JSON object
const json = {
  level1: {
    level2: {
      key1: 'value1',
      key2: 'value2'
    }
  }
};

// Remove the nested key
_.unset(json, 'level1.level2.key1');

// Set a new value with the desired key at the same position
_.set(json, 'level1.level2.newKey', 'newValue');

console.log(json);

{
  level1: {
    level2: {
      key2: 'value2',
      newKey: 'newValue'
    }
  }
}