FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Tsc1
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General Information
Symbol
Dmel\Tsc1
Species
D. melanogaster
Name
TSC complex subunit 1
Annotation Symbol
CG6147
Feature Type
protein_coding_gene
FlyBase ID
FBgn0290397
Gene Model Status
Current
Stock Availability
33 publicly available
Gene Summary
Tsc1 (Tsc1) encodes a tumour suppressor protein that forms a complex with the product of gig. They control cellular growth via antagonizing insulin and TOR signalling pathways. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

dTsc1, TSC, tuberous sclerosis complex 1, rocky

Key Links
Genomic Location
Cytogenetic map
95E1-95E1
Sequence location
Recombination map
3-83
RefSeq locus
NT_033777 REGION:24130307..24134654
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (32 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables GTPase activator activity
inferred from direct assay
(Zhang et al., 2003)
enables kinase binding
inferred from physical interaction with FLYBASE:mTor; FB:FBgn0021796
(Gao et al., 2002)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables protein folding chaperone
inferred from biological aspect of ancestor with PANTHER:PTN000389117
(GO Reference Genome Project, 2011-)
Biological Process (27 terms)
Terms Based on Experimental Evidence (27 terms)
CV Term
Evidence
References
involved_in cellular response to hypoxia
inferred from mutant phenotype
(Lee et al., 2008)
involved_in cholesterol homeostasis
inferred from genetic interaction with FLYBASE:gig; FB:FBgn0005198
(Danielsen et al., 2016)
involved_in determination of adult lifespan
inferred from mutant phenotype
(Kapahi et al., 2004)
involved_in enteroendocrine cell differentiation
inferred from mutant phenotype
(Quan et al., 2013)
involved_in intestinal stem cell homeostasis
inferred from mutant phenotype
(Quan et al., 2013)
involved_in larval midgut histolysis
inferred from genetic interaction with FLYBASE:gig; FB:FBgn0005198,FLYBASE:Atg18a; FB:FBgn0035850
(Denton et al., 2012)
inferred from genetic interaction with FLYBASE:gig; FB:FBgn0005198,FLYBASE:Atg1; FB:FBgn0260945
(Denton et al., 2012)
involved_in lipid homeostasis
inferred from genetic interaction with FLYBASE:gig; FB:FBgn0005198
(Gutierrez et al., 2007)
involved_in lymph gland development
inferred from mutant phenotype
(Benmimoun et al., 2012)
involved_in negative regulation of cell growth
inferred from mutant phenotype
(Tapon et al., 2001)
inferred from genetic interaction with FLYBASE:gig; FB:FBgn0005198
(Tapon et al., 2001)
inferred from mutant phenotype
(Gao et al., 2002)
inferred from genetic interaction with UniProtKB:Q8INB9
(Potter et al., 2002)
involved_in negative regulation of cell population proliferation
inferred from mutant phenotype
(Potter et al., 2002)
inferred from genetic interaction with FLYBASE:gig; FB:FBgn0005198
(Tapon et al., 2001)
involved_in negative regulation of cell size
inferred from mutant phenotype
(Cully et al., 2010, Sims et al., 2009, Saucedo et al., 2003, Gao and Pan, 2001)
inferred from genetic interaction with FLYBASE:gig; FB:FBgn0005198
(Gao and Pan, 2001, Potter et al., 2001)
involved_in negative regulation of developmental growth
inferred from mutant phenotype
(Teleman et al., 2008)
involved_in negative regulation of imaginal disc growth
inferred from mutant phenotype
(Gerlach et al., 2018)
involved_in negative regulation of insulin receptor signaling pathway
inferred from genetic interaction with FLYBASE:InR; FB:FBgn0283499
(Gao and Pan, 2001)
inferred from mutant phenotype
(Kockel et al., 2010, Miron et al., 2003)
inferred from genetic interaction with FLYBASE:gig; FB:FBgn0005198,FLYBASE:InR; FB:FBgn0283499
(Potter et al., 2001)
involved_in negative regulation of organ growth
inferred from mutant phenotype
(Gao and Pan, 2001, Tapon et al., 2001)
inferred from genetic interaction with FLYBASE:gig; FB:FBgn0005198
(Gao and Pan, 2001, Potter et al., 2001)
involved_in negative regulation of TOR signaling
inferred from genetic interaction with UniProtKB:Q8T9I6
(Gao et al., 2002)
involved_in negative regulation of TORC1 signaling
inferred from mutant phenotype
(Tran et al., 2013, Yang et al., 2006)
inferred from genetic interaction with UniProtKB:Q9VW83
(Wang et al., 2012)
inferred from genetic interaction with FLYBASE:gig; FB:FBgn0005198
(Kim et al., 2017)
involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway
inferred from mutant phenotype
(Tran et al., 2013)
involved_in oogenesis
inferred from genetic interaction with FLYBASE:Akt; FB:FBgn0010379
(Wei and Lilly, 2014)
involved_in open tracheal system development
inferred from high throughput mutant phenotype
(Ghabrial et al., 2011)
involved_in positive regulation of hippo signaling
inferred from mutant phenotype
(Parker and Struhl, 2015)
involved_in positive regulation of macroautophagy
inferred from mutant phenotype
(Juhász et al., 2008)
involved_in positive regulation of TORC2 signaling
inferred from mutant phenotype
(Yang et al., 2006)
inferred from genetic interaction with UniProtKB:Q9VW83
(Wang et al., 2012)
involved_in regulation of cell cycle
inferred from mutant phenotype
(Tapon et al., 2001)
involved_in regulation of cell population proliferation
inferred from mutant phenotype
(Hsieh et al., 2010)
involved_in response to nutrient
inferred from mutant phenotype
(Gao et al., 2002)
involved_in signal transduction
inferred from genetic interaction with FLYBASE:mTor; FB:FBgn0021796
(Gao et al., 2002)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in negative regulation of cell population proliferation
inferred from biological aspect of ancestor with PANTHER:PTN001032121
(GO Reference Genome Project, 2011-)
involved_in negative regulation of TOR signaling
inferred from biological aspect of ancestor with PANTHER:PTN000389117
(GO Reference Genome Project, 2011-)
involved_in regulation of cell cycle
inferred from biological aspect of ancestor with PANTHER:PTN000389117
(GO Reference Genome Project, 2011-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
is_active_in cytosol
inferred from direct assay
(Potter et al., 2002)
part_of TSC1-TSC2 complex
inferred from physical interaction with FLYBASE:gig; FB:FBgn0005198
(Zhang et al., 2003, Potter et al., 2001)
inferred from direct assay
(Potter et al., 2002, Gao and Pan, 2001)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
part_of TSC1-TSC2 complex
inferred from biological aspect of ancestor with PANTHER:PTN000389117
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Tsc1 (Tsc1) encodes a tumour suppressor protein that forms a complex with the product of gig. They control cellular growth via antagonizing insulin and TOR signalling pathways. [Date last reviewed: 2019-03-14]
Pathway (FlyBase)
NEGATIVE REGULATORS OF INSULIN-LIKE RECEPTOR SIGNALING PATHWAY -
Negative regulators of the Insulin-like Receptor signaling pathway suppress Insulin-like receptor (InR) activation or the activity of intracellular effectors. (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989).
NEGATIVE REGULATORS OF PVR SIGNALING PATHWAY -
Negative regulators of Platelet-derived Growth Factor-Vascular Endothelial Growth Factor Receptor-related (Pvr) signaling down-regulate the pathway.
POSITIVE REGULATORS OF HIPPO SIGNALING PATHWAY -
The Hippo signaling pathway is an intracellular kinase cascade in which hpo kinase in complex with sav, phosphorylates wts kinase which, in turn, phosphorylates yki transcriptional co-activator leading to its cytosolic retention. Positive regulators of the pathway, enhance the cytosolic retention of yki, negatively regulating tissue growth (Adapted from FBrf0224870).
Gene Group (FlyBase)
TSC1-TSC2 COMPLEX -
The Tsc1-Tsc2 complex is a heterodimeric GTPase Activating Protein (GAP) complex that negatively regulates mTOR (TORC1 complex) signaling. The Tsc1-Tsc2 complex stimulates the small GTPase, Rheb, to hydrolyze bound GTP to GDP. GTP-bound Rheb activates TORC1. (Adapted from FBrf0214848 and FBrf0136941).
Summary (Interactive Fly)

acts in conjunction with TSC2 to suppress cell growth by inhibiting Tor, a central controller of cell growth - TSC1/TSC2 has GAP activity toward the Rheb small GTPase which acts upstream of and stimulates TOR - TSC2 is the catalytic GAP subunit, while TSC1 enhances TSC2 function by stabilizing TSC2

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Tsc1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VCC9)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.49

Low-frequency RNA-Seq exon junction(s) not annotated.

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Tsc1-RA
FBtr0084546
NM_058067
3896
1100
Additional Transcript Data and Comments
Reported size (kB)

3.8 (longest cDNA)

(Ito and Rubin, 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Tsc1-PA
FBpp0083931
124.8
1100
6.40
Q9VCC9
NP_477415
AAF56240
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

1100 (aa)

(Ito and Rubin, 1999)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tsc1 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.28

Transcript Expression
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
is_active_in cytosol
inferred from direct assay
(Potter et al., 2002)
part_of TSC1-TSC2 complex
inferred from physical interaction with FLYBASE:gig; FB:FBgn0005198
(Zhang et al., 2003, Potter et al., 2001)
inferred from direct assay
(Potter et al., 2002, Gao and Pan, 2001)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Tsc1 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 18 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 30 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Tsc1
Transgenic constructs containing regulatory region of Tsc1
Aberrations (Deficiencies and Duplications) ( 7 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal (with Df(3R)crb87-4)
lethal | conditional | pupal stage
lethal | larval stage
lethal | recessive
lethal - all die before end of larval stage
lethal - all die before end of larval stage (with Df(3R)crb-F89-4)
lethal - all die before end of larval stage (with Tsc11A2)
lethal - all die before end of larval stage (with Tsc12G3)
lethal - all die before end of larval stage (with Tsc12X1)
lethal - all die before end of larval stage (with Tsc1Q87X)
lethal - all die before end of larval stage | recessive
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal cell cycle | oogenesis, with Scer\GAL4nanos.PG
abnormal cell number | P-stage, with Scer\GAL4Mef2.247
abnormal cell number | P-stage, with Scer\GAL4phtm.PO, Scer\GAL80spok.1.45
abnormal developmental rate
abnormal learning | adult stage
abnormal learning | adult stage | adult stage | RU486 conditional, with Scer\GAL4elav.Switch.PO
abnormal learning | adult stage | adult stage | RU486 conditional, with Scer\GAL4Mef2.247.Switch
abnormal memory | adult stage
abnormal memory | adult stage | RU486 conditional, with Scer\GAL4elav.Switch.PO
abnormal memory | adult stage | RU486 conditional, with Scer\GAL4Mef2.247.Switch
abnormal mitotic cell cycle | adult stage | somatic clone
abnormal mitotic cell cycle | somatic clone
abnormal neuroanatomy | adult stage | somatic clone
abnormal planar polarity | recessive | somatic clone
abnormal size | adult stage, with Scer\GAL4eya.enh1+E+2
abnormal size | adult stage | somatic clone
abnormal size | somatic clone
abnormal stress response | oogenesis, with Scer\GAL4nanos.PG
decreased cell death | somatic clone
decreased cell number | adult stage | somatic clone
decreased cell number | oogenesis, with Scer\GAL4VP16.nanos.UTR
decreased cell number | somatic clone
decreased cell number | somatic clone | spermatogenesis
hyperplasia | somatic clone
increased cell death | adult stage | somatic clone
increased cell death | female limited | nutrition conditional, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG
increased cell death | somatic clone
increased cell number | adult stage | somatic clone
increased cell number | cell autonomous | somatic clone
increased cell number | pupal stage | somatic clone
increased cell number | somatic clone
increased cell size | cell autonomous | somatic clone
increased cell size | recessive | somatic clone
increased cell size | somatic clone
increased cell size | third instar larval stage, with Scer\GAL4AB1
increased occurrence of cell division | larval stage | somatic clone
increased size | adult stage, with Scer\GAL4GMR.PU
increased size | larval stage, with Hsap\RELAp65(AD)::pMag.Ubi, Scer\GAL4rn-G4DBD::nMagHigh1
increased size | P-stage, with Scer\GAL4Mef2.247
increased size | spermatogenesis, with Scer\GAL4VP16.bam
increased size | third instar larval stage, with Scer\GAL4en.PU
long lived, with Scer\GAL4da.G32
melanotic mass phenotype | adult stage | somatic clone
some die during larval stage
some die during larval stage (with Df(3R)crb-F89-4)
some die during larval stage (with Tsc11A2)
some die during larval stage (with Tsc12G3)
some die during larval stage (with Tsc12X1)
some die during larval stage (with Tsc1Q87X)
some die during larval stage | recessive
visible, with Scer\GAL4pnr-MD237
visible | adult stage, with Scer\GAL4eya.enh1+E+2
visible | adult stage, with Scer\GAL4GMR.PU
visible | adult stage | somatic clone
visible | recessive | somatic clone
visible | somatic clone
wild-type
wild-type, with Scer\GAL4Bx-MS1096
Phenotype manifest in
Allele
adult head | somatic clone
adult head capsule | somatic clone
autophagosome |  :chemical conditional | nutrition conditional, with Scer\GAL4Mef2.PR
chaeta | increased number, with Scer\GAL4pnr-MD237
cone cell | somatic clone
cyst cell of testis | somatic clone
cyst progenitor cell | somatic clone
dendrite | adult stage | somatic clone
distal medullary amacrine neuron Dm8a | adult stage | somatic clone
egg chamber | nutrition conditional, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG
embryo
enteroendocrine cell | P-stage | increased number, with Scer\GAL4Mef2.247
enteroendocrine cell | P-stage | increased number, with Scer\GAL4phtm.PO, Scer\GAL80spok.1.45
enteroendocrine cell | somatic clone
eye, with Scer\GAL4eya.enh1+E+2
eye, with Scer\GAL4GMR.PU
eye | somatic clone
eye-antennal disc | somatic clone
eye disc & mitotic cell cycle | ectopic | somatic clone
eye disc & mitotic cell cycle | somatic clone
eye disc & S phase | ectopic | somatic clone
eye disc & S phase | somatic clone
eye disc | somatic clone
eye disc morphogenetic furrow | somatic clone
eye photoreceptor cell | cell autonomous | somatic clone
eye photoreceptor cell | somatic clone
eye photoreceptor cell | somatic clone | increased number
fat body, with Scer\GAL4Act5C.PP
fat cell | third instar larval stage, with Scer\GAL4AB1
female germline stem cell, with Scer\GAL4nanos.PG
female germline stem cell | decreased number, with Scer\GAL4VP16.nanos.UTR
imaginal disc | somatic clone
interommatidial bristle | somatic clone
interommatidial bristle | somatic clone | increased number
intestinal stem cell | somatic clone
larval tracheal system
macrochaeta | ectopic (with Df(3R)crb87-5)
macrochaeta | somatic clone
mechanosensory neuron | adult stage | somatic clone
melanotic mass | somatic clone
mesonotum, with Scer\GAL4pnr-MD237
mesonotum | adult stage | somatic clone
mesothoracic bristle | adult stage | somatic clone
mesothoracic bristle | adult stage | somatic clone | increased number
mitochondrion | oogenesis, with Scer\GAL4nanos.PG
muscle system | P-stage, with Scer\GAL4Mef2.247
nucleus | larval stage | somatic clone
ommatidial precursor cluster | somatic clone
ommatidium | cell autonomous | somatic clone
ommatidium | somatic clone
photoreceptor cell R1 | somatic clone
photoreceptor cell R6 | somatic clone
photoreceptor cell R7 | somatic clone
retina | pupal stage | somatic clone
rhabdomere
rhabdomere | cell autonomous | somatic clone
rhabdomere | somatic clone
spermatocyte, with Scer\GAL4VP16.bam
terminal tracheal cell
terminal tracheal cell | larval stage
tormogen cell | adult stage | somatic clone
wing (with Df(3R)crb87-5)
wing | somatic clone
wing disc | larval stage, with Hsap\RELAp65(AD)::pMag.Ubi, Scer\GAL4rn-G4DBD::nMagHigh1
wing disc | somatic clone
wing disc posterior compartment | third instar larval stage, with Scer\GAL4en.PU
wing margin | somatic clone
wing margin bristle | somatic clone
wing vein | somatic clone
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (1)
Hsap\TSC1
12 of 14
Yes
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (1)
Rnor\Tsc1
12 of 14
Yes
Yes
Mus musculus (laboratory mouse) (1)
Mmus\Tsc1
12 of 14
Yes
Yes
Xenopus tropicalis (Western clawed frog) (2)
Xtro\tsc1
6 of 13
Yes
Yes
Xtro\fam177b
1 of 13
No
No
Danio rerio (Zebrafish) (2)
Drer\tsc1a
12 of 14
Yes
Yes
Drer\tsc1b
12 of 14
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (0)
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP003445
11 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\tsc1
3 of 12
Yes
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Tsc1. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 6 )
Potential Models Based on Orthology ( 2 )
Human Ortholog
Disease
Evidence
References
TSC1; TSC complex subunit 1
model of  lymphangioleiomyomatosis
IEA
(FlyBase, 2019-)
model of  tuberous sclerosis 1
IEA
(FlyBase, 2019-)
Modifiers Based on Experimental Evidence ( 3 )
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
TSC1; TSC complex subunit 1
12 of 14
605284
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
Interaction Browsers
View in FlyBase Interactions Browser   View in MIST tool (external link)
Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
Tsc1 - 14-3-3ε
anti tag coimmunoprecipitation, Identification by mass spectrometry, peptide massfingerprinting
(Vinayagam et al., 2016, Glatter et al., 2011)
Tsc1 - 14-3-3ζ
anti tag coimmunoprecipitation, peptide massfingerprinting, Identification by mass spectrometry
(Vinayagam et al., 2016, Glatter et al., 2011)
Tsc1 - AGO2
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - Aldh
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - Arc1
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - Bap55
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - Brr2
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - CCT1
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - CG11180
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - CG11417
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - CG11583
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - CG11920
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - CG13096
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - CG15019
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - CG1513
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - CG15784
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - CG1620
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - CG2691
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - CG2972
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - CG30122
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - CG31550
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - CG32344
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - CG32409
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - CG3817
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - CG5033
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - CG5645
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - CG5787
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - CG6418
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - CG6693
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - CG7518
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - CG8939
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - Caf1-55
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - Caper
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - Capr
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - Cdc5
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - Chro
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - Claspin
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - Ctf4
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - Dcr-2
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - E(bx)
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - HDAC1
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - Hsc70-3
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - Imp
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - Ipo9
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - Iswi
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - Lst8
anti tag coimmunoprecipitation, peptide massfingerprinting
(Glatter et al., 2011)
Tsc1 - MBD-R2
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - MEP-1
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - Mi-2
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - Mink
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - NAT1
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - Nap1
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - Nnp-1
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - Noc3
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - Non3
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - Nopp140
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - Ns1
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - Nsun2
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - Nup358
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - Patronin
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - Polr1A
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - Prp19
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - Psi
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - Ptcd3
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - RanGAP
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - Rbcn-3A
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - Rheb
anti tag coimmunoprecipitation, peptide massfingerprinting
(Glatter et al., 2011)
Tsc1 - RhoGEF2
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - Rm62
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - RpL13A
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - RpL18A
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - RpL23
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - RpL8
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - RpL9
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - RpLP1
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - RpLP2
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - RpS11
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - RpS13
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - RpS14a
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - RpS15
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - RpS17
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - RpS23
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - RpS6
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - RpS7
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - RpS9
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - Rtf1
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - S6kII
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - Sf3b2
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - Smr
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - Srp54
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - TBC1d7
anti tag coimmunoprecipitation, peptide massfingerprinting, anti tag western blot
(Ren et al., 2018, Glatter et al., 2011)
Tsc1 - Tango4
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - TfIIFβ
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - ZAP3
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - Zn72D
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - alt
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - brm
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - bsf
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - cindr
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - cora
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - ctp
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - dom
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - eIF3a
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - eIF3b
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - eIF3c
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - eIF3d1
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - eIF3g1
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - eIF3h
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - eIF3i
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - eIF3k
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - eIF4G1
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - gig
anti tag coimmunoprecipitation, peptide massfingerprinting, pull down, autoradiography, anti tag western blot, anti bait coimmunoprecipitation, western blot, Identification by mass spectrometry
(Vinayagam et al., 2016, Glatter et al., 2011, Dong and Pan, 2004, Zhang et al., 2003, Gao and Pan, 2001, Potter et al., 2001)
Tsc1 - hfp
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - kis
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - kst
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - l(2)09851
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - larp
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - lds
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - lqfR
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - mRpL3
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - mRpL44
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - mRpS23
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - mRpS31
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - mTor
anti tag coimmunoprecipitation, anti tag western blot
(Gao et al., 2002)
Tsc1 - mahj
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - mask
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - mle
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - msn
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - nclb
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - nonA
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - peng
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - pins
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - pzg
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - qkr58E-3
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - rin
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - rump
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - sip2
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - sle
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - smid
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - spoon
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - sqd
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - tyf
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - vig
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - vig2
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - wal
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - yps
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - α-Spec
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Tsc1 - β'COP
anti tag coimmunoprecipitation, Identification by mass spectrometry
(Vinayagam et al., 2016)
Summary of Genetic Interactions
Interaction Browsers
View in FlyBase Interactions Browser   View in MIST tool (external link)
Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Tsc1|gig
suppressible
Atg1
(Denton et al., 2012)
Tsc1|gig
suppressible
Atg18a
(Denton et al., 2012)
Tsc1
suppressible
bam
(Yuen et al., 2021)
Tsc1|gig
enhanceable
Cdk4
(Tapon et al., 2001)
Tsc1|gig
suppressible
Cdk8
(Tang et al., 2018)
Tsc1|gig
suppressible
Cpsf6
(Tang et al., 2018)
Tsc1|gig
suppressible
Cpsf160
(Tang et al., 2018)
Tsc1|gig
suppressible
CstF64
(Tang et al., 2018)
Tsc1|gig
suppressible
CycC
(Tang et al., 2018)
Tsc1|gig
suppressible
CycD
(Tapon et al., 2001)
Tsc1|gig
suppressible
CycD|Cdk4
(Tapon et al., 2001)
Tsc1|gig
enhanceable
CycE
(Tapon et al., 2001)
Tsc1|gig
suppressible
CycE
(Tapon et al., 2001)
Tsc1|gig
suppressible
Doa
(Tang et al., 2018)
Tsc1
enhanceable
E2f1
(Hsieh et al., 2010)
Rbf|Tsc1
suppressible
E2f1
(Hsieh et al., 2010)
Tsc1
enhanceable
E2f1|Rbf
(Hsieh et al., 2010)
Tsc1
enhanceable
foxo
(Junger et al., 2003)
Tsc1
suppressible
heca|unk
(Avet-Rochex et al., 2014)
Tsc1|gig
suppressible
Hr3
(Montagne et al., 2010)
Tsc1
enhanceable
Hsc70-4
(Hennig et al., 2006)
Tsc1
suppressible
mTor
(Gao et al., 2002, Radimerski et al., 2002)
S6k|Tsc1
suppressible
mTor
(Radimerski et al., 2002)
Tsc1|gig
suppressible
Myc
(Tapon et al., 2001)
Tsc1
suppressible
nero
(Patel et al., 2009)
Tsc1|gig
suppressible
Pi3K59F
(Juhász et al., 2008)
Tsc1|gig
enhanceable
Pten
(Tapon et al., 2001)
Tsc1|gig
enhanceable
Ras85D
(Tapon et al., 2001)
Tsc1
enhanceable
Rbf
(Hsieh et al., 2010)
Tsc1|gig
suppressible
Rheb
(Saucedo et al., 2003)
Tsc1
suppressible
Rheb
(Stocker et al., 2003, Zhang et al., 2003)
Rbf|Tsc1
suppressible
Rheb
(Hsieh et al., 2010)
Tsc1
suppressible
RpL8
(Xu et al., 2008)
mTor|Tsc1
suppressible
S6k
(Radimerski et al., 2002)
Tsc1|gig
suppressible
S6k
(Montagne et al., 2010, Tapon et al., 2001)
Tsc1
suppressible
S6k
(Radimerski et al., 2002)
Tsc1
suppressible
Tctp
(Hsu et al., 2007)
Tsc1
enhanceable
Uba5|Ufl1
(Li et al., 2023)
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Akt
suppressible
gig|Tsc1
(Potter et al., 2002)
Akt
suppressible
Tsc1
(Wei and Lilly, 2014, Gao and Pan, 2001)
Atg1
suppressible
Tsc1|gig
(Denton et al., 2012)
Atg9
suppressible
Tsc1|gig
(Wen et al., 2017)
Atg18a
suppressible
Tsc1|gig
(Denton et al., 2012)
atos
suppressible
Tsc1
(Emtenani et al., 2022)
btl::Egfr|Pi3K92E
enhanceable
Tsc1
(Read et al., 2009)
Cul1
suppressible
Tsc1|gig
(Wong et al., 2013)
gig
enhanceable
Tsc1
(Potter et al., 2002)
hpo
suppressible
Tsc1
(Udan et al., 2003)
hppy
suppressible
Tsc1|gig
(Lam et al., 2010)
Hr51
suppressible
Tsc1
(Yaniv et al., 2012)
Hsc70-4
enhanceable
Tsc1
(Hennig et al., 2006)
InR
suppressible
Tsc1
(Gao and Pan, 2001)
InR
suppressible
Tsc1|gig
(Potter et al., 2001)
mio
suppressible
Tsc1
(Wei et al., 2014)
Mitf
suppressible
Tsc1
(Zhang et al., 2015)
mTor
enhanceable
Tsc1
(Hennig et al., 2006)
norpA
suppressible
Tsc1|gig
(Wang et al., 2009)
norpA
suppressible
Tsc1
(Wang et al., 2009)
Npc1a
suppressible
Tsc1|gig
(Danielsen et al., 2016)
Nup44A
suppressible
Tsc1
(Wei et al., 2014)
path
suppressible
gig|Tsc1
(Goberdhan et al., 2005)
Pten
suppressible
Tsc1|gig
(Nowak et al., 2013, Vereshchagina et al., 2008)
Pten
suppressible
Tsc1
(Nowak et al., 2013)
pths
suppressible
Tsc1
(Emtenani et al., 2022)
Ras85D|Apc|p53|Pten
enhanceable
Tsc1
(Bangi et al., 2016)
Rbf
enhanceable
Tsc1
(Hsieh et al., 2010)
Rheb
suppressible
Tsc1|gig
(Stocker et al., 2003)
trp
suppressible
Tsc1|gig
(Huang et al., 2016)
Vap33
suppressible
Tsc1
(Deivasigamani et al., 2014)
Vap33
suppressible
Tsc1|gig
(Deivasigamani et al., 2014)
Wdr24
suppressible
Tsc1
(Cai et al., 2016)
zfh2
suppressible
Tsc1|gig
(Rojas Villa et al., 2019)
External Data
Linkouts
Pathways
Class of Gene
Genomic Location and Detailed Mapping Data
Chromosome (arm)
3R
Recombination map
3-83
Cytogenetic map
95E1-95E1
Sequence location
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
95E1-95E1
Limits computationally determined from genome sequence between P{PZ}Syx1A06737&P{PZ}Syx1A10660 and P{PZ}crb07207&P{PZ}BRWD305842
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Location based on deficiency mapping with Df(3R)crb-F89-4 and Df(3R)3450.
(Ghabrial et al., 2011)
99A-98E
(Ghabrial et al., 2011)
95E4-95E5
(Ito, 1999.7.29)
95E4-95E5
(determined by in situ hybridisation)
(Ito and Rubin, 1999)
Experimentally Determined Recombination Data
Location

3-83

(FlyBase, 2016)

3-82.7

(Comeron et al., 2012)
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (33)
Genomic Clones (14)
 

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (51)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Other clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Cell Line Information
    Publicly Available Cell Lines
     
      Other Stable Cell Lines
       
        Other Comments

        Tsc1 negatively regulates bantam activity.

        (Nolo et al., 2006)

        dsRNA made from templates generated with primers directed against this gene significantly increases the level of S6k phosphorylation and decreases the level of Akt1 phosphorylation, especially in response to insulin stimulation, in S2 cells.

        (Yang et al., 2006)

        Tsc1 controls the timing of differentiation in the developing eye.

        (Bateman and McNeill, 2004)

        Tsc1 acts as part of a complex with gig to antagonise Tor.

        (Gao et al., 2002)

        Loss of Tsc1 and gig results in a Tor-dependent increase in S6k activity. Tsc1 mutant cells fail to respond to amino acid starvation by decreasing S6k activity.

        (Gao et al., 2002)

        Evidence from dsRNAi in Drosophila cell culture suggests that Tsc1 and gig are necessary for wild-type levels of S6k and Akt1 activity.

        (Radimerski et al., 2002)

        Tsc1 is a negative regulator of insulin signalling.

        (Gao and Pan, 2001)

        Cells mutant for Tsc1 are dramatically increased in size yet differentiate normally.

        (Potter et al., 2001)

        Mutations in Tsc1 result in enhanced growth and cell size with no change in ploidy. Overall, mutant cells spend less time in G1.

        (Tapon et al., 2001)

        Cells in mutant clones are significantly larger than their wild-type neighbours and contain larger nuclei.

        (Tapon and Hariharan, 2000)
        Relationship to Other Genes
        Source for database merge of

        Source for merge of: Tsc1 rocky

        (Hariharan, 2000.3.17)

        Source for merge of: Tsc1 l(3)95Ec

        (Popodi et al., 2025.8.28)
        Additional comments
        Nomenclature History
        Source for database identify of

        Source for identity of: Tsc1 CG6147

        (Kodira, 1999.11)
        Nomenclature comments
        Etymology
        Synonyms and Secondary IDs (26)
        Reported As
        Symbol Synonym
        CG6147
        (National Institute of Genetics Fly Stocks, 2023-, Fukuoh et al., 2014, Meadows, 2014.12.12, Schertel et al., 2013, Glatter et al., 2011, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Perkins et al., 2009, Lee et al., 2008, Ni et al., 2008, Derré et al., 2007, Dorer et al., 2006)
        TSC
        (Bonfini et al., 2016, Wang et al., 2014, Kapuria et al., 2012, Wessells et al., 2007)
        TSC1
        (Fischer et al., 2025, Serebrovska et al., 2025, Toshniwal et al., 2025, Zhai et al., 2023, Emtenani et al., 2022, Francis et al., 2022, Gu et al., 2022, Kakanj et al., 2022, Yang et al., 2021, Khan et al., 2020, Luo et al., 2020, Ramond et al., 2020, Sheard et al., 2020, Yang et al., 2020, Zugasti et al., 2020, Galenza and Foley, 2019, Sênos Demarco et al., 2019, Ahmad et al., 2018, Inoue et al., 2018, Staats et al., 2018, Tang et al., 2018, Haller et al., 2017, Liu and Jin, 2017, Stefana et al., 2017, Sun et al., 2017, Wen et al., 2017, Agrawal et al., 2016, Danielsen et al., 2016, Koyama and Mirth, 2016, Aradhya et al., 2015, Burn et al., 2015, Fischer et al., 2015, Housden et al., 2015, Mitchell et al., 2015, Nässel et al., 2015, Sano et al., 2015, Zhang and Baehrecke, 2015, Zhang et al., 2015, Mulakkal et al., 2014, Varma et al., 2014, Koyama et al., 2013, Quan et al., 2013, Shim et al., 2013, Sim and Denlinger, 2013, Tang et al., 2013, Wong et al., 2013, Yamanaka et al., 2013, Denton et al., 2012, Kapuria et al., 2012, Lv et al., 2012, Mirth and Shingleton, 2012, Pallares-Cartes et al., 2012, Papatheodorou et al., 2012, Tokusumi et al., 2012, Wang et al., 2012, Zitserman et al., 2012, Ghabrial et al., 2011, Oldham, 2011, Serfontein et al., 2011, Storelli et al., 2011, Yang and Xu, 2011, Birse et al., 2010, Bland et al., 2010, Chang and Neufeld, 2010, Cully et al., 2010, Hsieh et al., 2010, Karbowniczek et al., 2010, Lam et al., 2010, Ribeiro and Dickson, 2010, Géminard et al., 2009, Read et al., 2009, Slaidina et al., 2009, Layalle et al., 2008, Teleman et al., 2008, Bourouis et al., 2007, Hietakangas and Cohen, 2007, Hoshizaki and Gibbs, 2007, Hsu and Choi, 2007, Knox et al., 2007, Lasko and Sonenberg, 2007, Martin et al., 2007, Tyler et al., 2007, Dorer et al., 2006, Edgar, 2006, Lee et al., 2006, Min et al., 2006, Nolo et al., 2006, Wu and Brown, 2006, Yang et al., 2006, Mikeladze-Dvali et al., 2005, Hay and Sonenberg, 2004, Colombani et al., 2003, Lee and Orr-Weaver, 2003, Neufeld, 2003, Nijhout, 2003, Stocker et al., 2003, Hengstschlaeger et al., 2001, Tapon and Hariharan, 2001, Ito, 1999.7.29)
        TsC1
        (Texada et al., 2020)
        Tsc
        (Melani et al., 2017)
        Tsc1
        (Amartuvshin et al., 2025, Proshkina et al., 2025, Simmons et al., 2025, Collins et al., 2024, Rigato et al., 2024, Tang et al., 2024, Zhang et al., 2024, Heigwer et al., 2023, Koehler and Huber, 2023, Li et al., 2023, Saavedra et al., 2023, Zhou et al., 2023, Beaver et al., 2022, Chang et al., 2022, Kubrak et al., 2022, Palozzi et al., 2022, Thangadurai et al., 2022, Azuma et al., 2021, Bilder et al., 2021, Dong et al., 2021, Heier et al., 2021, Ishibashi et al., 2021, Kim and O'Connor, 2021, Liguori et al., 2021, Sood et al., 2021, Yuen et al., 2021, Zhou et al., 2021, Gupta and Stocker, 2020, Gupta and Stocker, 2020, Koyama et al., 2020, Lee et al., 2020, Lin and Hsu, 2020, Luo et al., 2020, Mariano et al., 2020, Murakawa et al., 2020, Parniewska and Stocker, 2020, Perez-Gomez et al., 2020, Robles-Murguia et al., 2020, Drummond-Barbosa, 2019, Li et al., 2019, Luhur et al., 2019, Sharma et al., 2019, Texada et al., 2019, Ueoka et al., 2019, Alfred and Vaccari, 2018, Calap-Quintana et al., 2018, Jia et al., 2018, Kang et al., 2018, Lehmann, 2018, Nowak et al., 2018, Manent et al., 2017, Mensah et al., 2017, Murillo-Maldonado and Riesgo-Escovar, 2017, Song et al., 2017, Transgenic RNAi Project members, 2017-, Allen et al., 2016, Cai et al., 2016, Dong et al., 2016, Kuleesha et al., 2016, Mukherjee et al., 2016, Sarov et al., 2016, Vinayagam et al., 2016, Yadav et al., 2016, Androschuk et al., 2015, Calap-Quintana et al., 2015, Das and Dobens, 2015, Hatfield et al., 2015, Sopko et al., 2015, Wang et al., 2015, Avet-Rochex et al., 2014, Deivasigamani et al., 2014, Ghosh et al., 2014, Kim and Choe, 2014, Wei and Lilly, 2014, Wei et al., 2014, Natarajan et al., 2013, Nowak et al., 2013, Schertel et al., 2013, Sopko and Perrimon, 2013, Tran et al., 2013, Zirin et al., 2013, Alvarez-Ponce et al., 2012, Avet-Rochex et al., 2012, Hafezi et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Kapuria et al., 2012, Marinari et al., 2012, Papatheodorou et al., 2012, Yaniv et al., 2012, Glatter et al., 2011, Lindquist et al., 2011, Sousa-Nunes et al., 2011, Zhang et al., 2011, Kockel et al., 2010, LaFever et al., 2010, Lee et al., 2010, Montagne et al., 2010, Nisoli et al., 2010, Pospisilik et al., 2010, Potter et al., 2010, Potter et al., 2010, Potter et al., 2010, Sun et al., 2010, Zheng and Sehgal, 2010, Chang and Neufeld, 2009, Chang and Neufeld, 2009, Demontis and Perrimon, 2009, Nuzhdin et al., 2009, Patel et al., 2009, Ravi et al., 2009, Schleich and Teleman, 2009, Sims et al., 2009, Wang et al., 2009, Harvey et al., 2008, Hou et al., 2008, Juhász et al., 2008, Lee et al., 2008, Vereshchagina et al., 2008, Xu et al., 2008, Gutierrez et al., 2007, Hsu et al., 2007, Tseng et al., 2007, Hamaratoglu et al., 2006, Hennig et al., 2006, Igaki et al., 2006, Igaki et al., 2006, Patel and Tamanoi, 2006, Silva, 2006, Goberdhan et al., 2005, Jordan et al., 2005, Teleman et al., 2005, Terashima and Bownes, 2005, Aspuria and Tamanoi, 2004, Udan et al., 2003)
        dTSC
        (Junger et al., 2003)
        dTSC-1
        (Pospisilik et al., 2010)
        dTSC1
        (Nishimura et al., 2011, Read et al., 2009, Oldham et al., 2004, Manning and Cantley, 2003, Oldham and Hafen, 2003, Ito and Gusella, 2002, Kozma and Thomas, 2002, Potter et al., 2001)
        dTsc1
        (Frappaolo and Giansanti, 2023, Chattopadhyay and Thirumurugan, 2020, Parkhitko et al., 2020, Álvarez-Rendón et al., 2018, Eleftherianos and Castillo, 2012, Katewa and Kapahi, 2011, Partridge et al., 2011, Montagne et al., 2010, Ravi et al., 2009, Schleich and Teleman, 2009, Findlay et al., 2007, Findlay et al., 2005, Kapahi et al., 2004, Kapahi et al., 2004, Jacinto and Hall, 2003, Miron et al., 2003, Marygold and Leevers, 2002, Radimerski et al., 2002)
        dtsc1
        (Gordon et al., 2013)
        l(3)95Ec
        rocky
        (Tapon and Hariharan, 2000)
        tSC1
        (Canales Coutiño et al., 2020)
        tsc1
        (Xue et al., 2025, Galenza et al., 2023, Gui et al., 2023, Jouandin et al., 2022, Øvrebø et al., 2022, Ghosh et al., 2020, Morata and Calleja, 2020, Lee et al., 2019, Bangi et al., 2016, Huang et al., 2016, Parker and Struhl, 2015, Zhang et al., 2014, Marshall et al., 2012, Wang et al., 2012, Zitserman et al., 2012, Wang et al., 2009, McNeill et al., 2008, Goraksha and Neufeld, 2006, Silva et al., 2006, Bier, 2005, Goraksha and Neufeld, 2005, McNeill and Bateman, 2005, Bateman and McNeill, 2004)
        Name Synonyms
        TSC complex subunit 1
        TSC1
        (Martin et al., 2007)
        TTuberous Sclerosis Complex 1
        (Terashima and Bownes, 2005)
        Tsc1
        (Ribeiro and Dickson, 2010)
        Tuberous Sclerosis 1
        (Potter et al., 2010)
        Tuberous Sclerosis Complex 1
        (Koyama et al., 2013, Hsieh et al., 2010)
        Tuberous sclerosis complex 1
        (Dong et al., 2016, LaFever et al., 2010, Sun et al., 2010)
        hamartin
        (Lamb et al., 2000)
        jolly green giant
        (Ghabrial et al., 2011)
        lethal (3) 95Ec
        rocky
        (Hengstschlaeger et al., 2001)
        tuberous sclerosis 1
        (Patel et al., 2009)
        tuberous sclerosis complex 1
        (Lee et al., 2010, Harvey et al., 2008, Yang et al., 2006)
        tuberous sclerosis complex protein 1
        (Calap-Quintana et al., 2015)
        Secondary FlyBase IDs
        • FBgn0026317
        • FBgn0067349
        Datasets (1)
        Study focus (1)
        Experimental Role
        Project
        Project Type
        Title
        • bait_protein
        PPI_InR-Tor_interaction_map
        Interaction map generated by purification of insulin pathway factors, with identification of copurifying proteins by mass spectrometry.
        Study result (0)
        Result
        Result Type
        Title
        External Crossreferences and Linkouts ( 26 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL - MARRVEL (model organism gene)
        Linkouts
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
        References (425)