FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\TER94
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General Information
Symbol
Dmel\TER94
Species
D. melanogaster
Name
Transitional endoplasmic reticulum 94
Annotation Symbol
CG2331
Feature Type
protein_coding_gene
FlyBase ID
FBgn0286784
Gene Model Status
Current
Stock Availability
35 publicly available
Gene Summary
Transitional endoplasmic reticulum 94 (TER94) encodes a protein that operates as a hexamere, functioning as a ubiquitin-dependent molecular chaperone. The hexamere associates with different co-factors to process nuclear and cytoplasmic substrates marked by ubiquitin. [Date last reviewed: 2019-09-26] (FlyBase Gene Snapshot)
All Summaries
Also Known As

VCP, dVCP, p97, l(2)03775, dmTERA

Key Links
Genomic Location
Cytogenetic map
46D1-46D1
Sequence location
Recombination map
2-61
RefSeq locus
NT_033778 REGION:9989159..9993559
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (42 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables protein binding
inferred from physical interaction with UniProtKB:Q9VBP9
(Hao et al., 2015)
inferred from physical interaction with FLYBASE:papi; FB:FBgn0031401
(Liu et al., 2011)
enables protein sequestering activity
inferred from physical interaction with FLYBASE:Mer; FB:FBgn0086384
(Li et al., 2024)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
enables ATP binding
inferred from electronic annotation with InterPro:IPR003959, InterPro:IPR003960
(InterPro Project Members, 2004-)
enables ATP hydrolysis activity
inferred from biological aspect of ancestor with PANTHER:PTN004603074
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR003959, InterPro:IPR003960
(InterPro Project Members, 2004-)
enables hydrolase activity
inferred from electronic annotation with InterPro:IPR005938
(InterPro Project Members, 2004-)
enables polyubiquitin modification-dependent protein binding
inferred from biological aspect of ancestor with PANTHER:PTN000554506
(GO Reference Genome Project, 2011-)
Biological Process (26 terms)
Terms Based on Experimental Evidence (23 terms)
CV Term
Evidence
References
involved_in autophagosome maturation
inferred from mutant phenotype
(Johnson et al., 2015)
involved_in autophagosome-lysosome fusion
inferred from mutant phenotype
(Johnson et al., 2021)
involved_in cellular response to virus
inferred from mutant phenotype
(Panda et al., 2013)
involved_in dendrite morphogenesis
inferred from mutant phenotype
(Rumpf et al., 2011)
involved_in endoplasmic reticulum organization
inferred from mutant phenotype
(Ruden et al., 2000)
involved_in Golgi organization
inferred from mutant phenotype
(Ruden et al., 2000)
involved_in larval midgut cell programmed cell death
inferred from mutant phenotype
(Santhanam et al., 2014)
involved_in lysosomal membrane organization
inferred from mutant phenotype
(Johnson et al., 2021)
involved_in lysosome organization
inferred from mutant phenotype
(Johnson et al., 2015)
involved_in microtubule cytoskeleton organization
inferred from mutant phenotype
(Ruden et al., 2000)
involved_in muscle cell cellular homeostasis
inferred from mutant phenotype
(Johnson et al., 2015)
involved_in negative regulation of canonical Wnt signaling pathway
inferred from mutant phenotype
(Reim et al., 2014)
involved_in negative regulation of hippo signaling
inferred from mutant phenotype
(Li et al., 2024)
involved_in negative regulation of smoothened signaling pathway
inferred from mutant phenotype
(Zhang et al., 2013)
involved_in pole cell formation
inferred from genetic interaction with FLYBASE:tud; FB:FBgn0003891
(Thomson et al., 2008)
inferred from genetic interaction with FLYBASE:vas; FB:FBgn0283442
(Thomson et al., 2008)
involved_in positive regulation of neuron apoptotic process
inferred from mutant phenotype
(Higashiyama et al., 2002)
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process
inferred from direct assay
(Santhanam et al., 2014)
inferred from mutant phenotype
(Lundgren et al., 2005)
involved_in positive regulation of viral entry into host cell
inferred from mutant phenotype
(Panda et al., 2013)
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process
inferred from genetic interaction with FLYBASE:sordd1; FB:FBgn0030693
(Xu et al., 2020)
involved_in proteolysis
inferred from mutant phenotype
(Lundgren et al., 2005)
involved_in regulation of neuron apoptotic process
inferred from mutant phenotype
(Rumpf et al., 2011)
involved_in regulation of pole plasm oskar mRNA localization
inferred from mutant phenotype
(Ruden et al., 2000)
involved_in ubiquitin-dependent protein catabolic process
inferred from mutant phenotype
(Beskow et al., 2009)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
involved_in autophagosome maturation
inferred from biological aspect of ancestor with PANTHER:PTN000554506
(GO Reference Genome Project, 2011-)
involved_in endoplasmic reticulum membrane fusion
inferred from sequence or structural similarity with SGD:S000002284
(Ruden et al., 2000)
involved_in mitotic spindle disassembly
inferred from biological aspect of ancestor with PANTHER:PTN000554506
(GO Reference Genome Project, 2011-)
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process
inferred from biological aspect of ancestor with PANTHER:PTN000554506
(GO Reference Genome Project, 2011-)
involved_in retrograde protein transport, ER to cytosol
inferred from biological aspect of ancestor with PANTHER:PTN000554506
(GO Reference Genome Project, 2011-)
Cellular Component (10 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
located_in autolysosome
inferred from direct assay
(Johnson et al., 2015)
located_in cytoplasm
inferred from high throughput direct assay
(Lee et al., 2014)
inferred from direct assay
(Leon and McKearin, 1999)
is_active_in cytosol
inferred from mutant phenotype
(Li et al., 2024)
located_in fusome
inferred from direct assay
(Lighthouse et al., 2008, Leon and McKearin, 1999)
located_in lysosomal membrane
inferred from direct assay
(Johnson et al., 2021)
located_in nuclear membrane
inferred from high throughput direct assay
(Lee et al., 2014)
located_in nucleus
inferred from high throughput direct assay
(Lee et al., 2014)
located_in P granule
inferred from direct assay
(Thomson et al., 2008)
located_in plasma membrane
inferred from high throughput direct assay
(Tan et al., 2009)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
is_active_in cytosol
inferred from biological aspect of ancestor with PANTHER:PTN000554506
(GO Reference Genome Project, 2011-)
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000554506
(GO Reference Genome Project, 2011-)
part_of VCP-NPL4-UFD1 AAA ATPase complex
inferred from biological aspect of ancestor with PANTHER:PTN000554506
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the AAA ATPase family. (Q7KN62)
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
ATP hydrolysis activity
RHEA 13065:
Summaries
Gene Snapshot
Transitional endoplasmic reticulum 94 (TER94) encodes a protein that operates as a hexamere, functioning as a ubiquitin-dependent molecular chaperone. The hexamere associates with different co-factors to process nuclear and cytoplasmic substrates marked by ubiquitin. [Date last reviewed: 2019-09-26]
Pathway (FlyBase)
NEGATIVE REGULATORS OF WNT-TCF SIGNALING PATHWAY -
Negative regulators of Wnt-TCF (canonical Wnt) signaling down-regulate the pathway, resulting in the attenuation of transcriptional regulation mediated by β-catenin (arm).
NEGATIVE REGULATORS OF HIPPO SIGNALING PATHWAY -
The Hippo signaling pathway is an intracellular kinase cascade in which hpo kinase in complex with sav, phosphorylates wts kinase which, in turn, phosphorylates yki transcriptional co-activator leading to its cytosolic retention. Negative regulators of the pathway promote the nuclear accumulation of yki, enhancing yki-mediated transcriptional regulation and the expression of genes that positively regulate tissue growth (Adapted from FBrf0224870).
NEGATIVE REGULATORS OF HEDGEHOG SIGNALING PATHWAY -
Negative regulators of hedgehog signaling down-regulate the pathway, resulting in the repression of transcription of hh-responsive genes.
Gene Group (FlyBase)
UNCLASSIFIED ATPASES -
This group comprises ATPases that do not classify under other groups in FlyBase.
Protein Function (UniProtKB)
Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Involved in the ubiquitin-proteasome system. Important for oskar mRNA localization and/or anchoring during oogenesis. Involved in germ cell formation.
(UniProt, Q7KN62)
Summary (Interactive Fly)

AAA family ATPase, CDC48 subfamily - modulation of proteolytic degradation - Hedgehog pathway -Wingless pathway - dendritic pruning - motor neuron degeneration - ER stress response - maintenance of paternal chromosome integrity in the Drosophila zygote

Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
4

Please see the JBrowse view of Dmel\TER94 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q7KN62)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
PDB - An information portal to biological macromolecular structures
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Gene model reviewed during 5.52

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
TER94-RA
FBtr0088391
NM_058021
3016
801
TER94-RC
FBtr0112905
NM_001103779
3058
826
TER94-RD
FBtr0112906
NM_001103780
3125
759
TER94-RE
FBtr0343852
NM_001299332
3055
825
Additional Transcript Data and Comments
Reported size (kB)

3.2 (northern blot)

(Leon and McKearin, 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
TER94-PA
FBpp0087479
88.9
801
4.98
Q7KN62
NP_477369
AAF58863
TER94-PC
FBpp0111818
92.1
826
5.00
NP_001097249
ABV53745
TER94-PD
FBpp0111819
84.2
759
4.99
NP_001097250
ABV53746
TER94-PE
FBpp0310395
91.9
825
5.00
A0A0B4LFZ4
NP_001286261
AHN56059
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)

799 (aa); 94 (kD predicted)

(Ruden et al., 2000)

94 (kD observed); 89 (kD predicted)

(Leon and McKearin, 1999)

801 (aa); 94 (kD observed)

(Pinter et al., 1998)
Comments
External Data
Subunit Structure (UniProtKB)

Homohexamer (PubMed:10564274). Interacts with tud, vas, papi and AGO3 (PubMed:18590813, PubMed:21447556). Interacts with Npl4 (PubMed:26471729).

(UniProt, Q7KN62)
Crossreferences
InterPro - A database of protein families, domains and functional sites
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\TER94 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

3.50

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
anterior endoderm anlage
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
anterior endoderm
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
inclusive hindgut primordium
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
central brain primordium
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
Malpighian tubule primordium
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
larval nervous system
(Fisher et al., 2012)
gonad
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage & oogenesis
cyst cell of ovary
(Leon and McKearin, 1999)
nurse cell
(Leon and McKearin, 1999)
ovary
(Leon and McKearin, 1999)
germarium region 1
(Leon and McKearin, 1999)
cystoblast
(Leon and McKearin, 1999)
follicle cell
(Leon and McKearin, 1999)
oocyte
(Leon and McKearin, 1999)
Additional Descriptive Data

TER94 transcripts are strongly expressed in nurse cells starting in stage 9-10 of oogenesis. Strong expression is also observed in developing ommatidia in the eye imaginal disc.

(Ruden et al., 2000)

TER94 transcripts are present in germarium region 1 and are present in all germ line cells and follicle cells.

(Leon and McKearin, 1999)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage & oogenesis
germarium
(Leon and McKearin, 1999)
fusome
(Leon and McKearin, 1999)
cyst cell of ovary
(Leon and McKearin, 1999)
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult mushroom body alpha-lobe
(Pinter et al., 1998)
adult mushroom body beta-lobe
(Pinter et al., 1998)
adult stage & oogenesis
germarium region 2b
(Ruden et al., 2000)
oogenesis stage S1 & adult stage | female
egg chamber
(Ruden et al., 2000)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | female
ovary
(Pisa et al., 2009)
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage & pupal stage & adult stage
(Pinter et al., 1998)
adult stage | female
nurse cell
(Pinter et al., 1998)
oocyte
(Pinter et al., 1998)
adult stage
mushroom body calyx
(Pinter et al., 1998)
ellipsoid body
(Pinter et al., 1998)
adult mushroom body
(Pinter et al., 1998)
adult antennal lobe glomerulus
(Pinter et al., 1998)
adult stage | male
spermatozoon
(Pinter et al., 1998)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in autolysosome
inferred from direct assay
(Johnson et al., 2015)
located_in cytoplasm
inferred from high throughput direct assay
(Lee et al., 2014)
inferred from direct assay
(Leon and McKearin, 1999)
is_active_in cytosol
inferred from mutant phenotype
(Li et al., 2024)
located_in fusome
inferred from direct assay
(Lighthouse et al., 2008, Leon and McKearin, 1999)
located_in lysosomal membrane
inferred from direct assay
(Johnson et al., 2021)
located_in nuclear membrane
inferred from high throughput direct assay
(Lee et al., 2014)
located_in nucleus
inferred from high throughput direct assay
(Lee et al., 2014)
located_in P granule
inferred from direct assay
(Thomson et al., 2008)
located_in plasma membrane
inferred from high throughput direct assay
(Tan et al., 2009)
Expression Deduced from Reporters
Reporter: P{PTT-GB}TER94CB04973
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | female
germarium
• fusome
(Lighthouse et al., 2008)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\TER94 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 26 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 42 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of TER94
Transgenic constructs containing regulatory region of TER94
Aberrations (Deficiencies and Duplications) ( 19 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL4bam.PU
lethal, with Scer\GAL4Mef2.PR
lethal, with Scer\GAL4pnr-MD237
lethal, with Scer\GAL4sd.PU
lethal (with Df(2R)BSC152)
lethal (with Df(2R)BSC158)
lethal (with Df(2R)X1)
lethal | larval stage
lethal | P-stage
lethal | recessive
lethal - all die before end of P-stage, with Scer\GAL4Mef2.PR
lethal - all die before end of P-stage, with Scer\GAL4tin.CΔ4
lethal - all die during embryonic stage
lethal - all die during embryonic stage | recessive
partially lethal, with Scer\GAL4tin.CΔ4
partially lethal - majority die, with Scer\GAL4VGlut1-OK371
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4VGlut1-OK371
Sterility
Allele
male sterile
male sterile, with Scer\GAL4bam.PU
Other Phenotypes
Allele
abnormal developmental rate | maternal effect, with Scer\GAL4VP16.mat.αTub67C
abnormal developmental rate | prepupal stage, with Scer\GAL4Tub.PU
abnormal learning, with Scer\GAL4elav-C155
abnormal locomotor behavior | adult stage
abnormal locomotor behavior | adult stage | male limited | progressive
abnormal locomotor behavior | adult stage | progressive
abnormal locomotor behavior | third instar larval stage
abnormal locomotor behavior | third instar larval stage, with Scer\GAL4Mef2.PR
abnormal neuroanatomy, with Scer\GAL419-12
abnormal neuroanatomy, with Scer\GAL4elav-C155
abnormal neuroanatomy, with Scer\GAL4ninaE.PT
abnormal neuroanatomy, with Scer\GAL4Or22a.8197
abnormal neuroanatomy, with Scer\GAL4ppk.PG
abnormal neuroanatomy | larval stage, with Scer\GAL4ppk.PG
abnormal neuroanatomy | pupal stage, with Scer\GAL4ppk.PG
abnormal neuroanatomy | RU486 conditional, with Scer\GAL4ppk.Switch.PR
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4VGlut1-OK371
abnormal neurophysiology | adult stage | progressive
abnormal short-term memory | adult stage
abnormal size | adult stage | male, with Scer\GAL4bam.PU
abnormal size | prepupal stage, with Scer\GAL4Tub.PU
abnormal stress response, with Scer\GAL4elav-C155
abnormal stress response, with Scer\GAL4hs.PU
chemical sensitive | adult stage
decreased cell death | pupal stage, with Scer\GAL419-12
decreased size | adult stage, with Scer\GAL4nub.PU
decreased size | adult stage, with Scer\GAL4ptc.PU
decreased size | adult stage, with Scer\GAL4sd.PU
decreased size | larval stage | somatic clone
flightless, with Scer\GAL4Mhc.PW
flightless | temperature conditional, with Scer\GAL4Mhc.PW, Scer\GAL80ts.αTub84B
increased cell death, with Scer\GAL4GMR.PF
increased cell death, with Scer\GAL4GMR.PS
increased cell death | larval stage, with Scer\GAL4nub.PU
increased cell death | larval stage, with Scer\GAL4sd.PU
increased cell death | pupal stage, with Scer\GAL419-12
increased cell number | adult stage, with Scer\GAL4Delta-05151-G
increased cell number | adult stage, with Scer\GAL4NP5130
increased cell number | adult stage, with Scer\GAL4Su(H).GBE.cLa
increased cell number | adult stage | somatic clone
increased occurrence of cell division | adult stage, with Scer\GAL4NP5130
majority die during embryonic stage | maternal effect, with Scer\GAL4VP16.mat.αTub67C
short lived
short lived, with Scer\GAL4Hand.PU
short lived, with Scer\GAL4tin.CΔ4
short lived | dominant
short lived | heat sensitive, with Scer\GAL4tin.CΔ4
short lived | RU486 conditional, with Scer\GAL4GS.Hand.PU
some die during embryonic stage | recessive
some die during pupal stage, with Scer\GAL4VGlut1-OK371
visible, with Scer\GAL4GMR.PS
visible, with Scer\GAL4Mhc.PU
visible | adult stage, with Scer\GAL4GMR.PF
visible | adult stage, with Scer\GAL4nub.PU
visible | adult stage, with Scer\GAL4sd.PU
visible | recessive | somatic clone
Phenotype manifest in
Allele
A band, with Scer\GAL4Mhc.PW
adult head bristle | somatic clone
adult heart, with Scer\GAL4GS.Hand.PU
adult heart, with Scer\GAL4Hand.PU
adult midgut epithelium | somatic clone
adult midgut progenitor cell | increased number, with Scer\GAL4NP5130
adult mushroom body, with Scer\GAL4elav-C155
adult neuromuscular junction | decreased number
centrosome | embryonic stage | maternal effect, with Scer\GAL4VP16.mat.αTub67C
dendrite, with Scer\GAL419-12
dendrite, with Scer\GAL4ppk.PG
dendrite | larval stage, with Scer\GAL4ppk.PG
dendrite | RU486 conditional, with Scer\GAL4ppk.Switch.PR
DLM motor neuron | adult stage
egg | germline clone
egg chamber | germline clone
elongation stage spermatid | absent, with Scer\GAL4bam.PU
embryo | germline clone
embryonic/first instar larval cuticle | germline clone
embryonic/larval hypodermal muscle cell | larval stage
embryonic dorsal vessel | embryonic stage 16, with Scer\GAL4how-24B
embryonic heart cardioblast | embryonic stage 16, with Scer\GAL4how-24B
embryonic somatic muscle cell | embryonic stage 16, with Scer\GAL4how-24B
endoplasmic reticulum & egg chamber
enteroblast | adult stage | increased number, with Scer\GAL4Delta-05151-G
enteroblast | adult stage | increased number, with Scer\GAL4NP5130
enteroblast | adult stage | increased number, with Scer\GAL4Su(H).GBE.cLa
eye, with Scer\GAL4GMR.PF
eye, with Scer\GAL4GMR.PS
eye photoreceptor cell, with Scer\GAL4GMR.PF, TER94A229E.UAS
eye photoreceptor cell, with Scer\GAL4GMR.PF, TER94R152H.UAS
eye photoreceptor cell, with Scer\GAL4GMR.PF, TER94R188Q.UAS
eye photoreceptor cell, with Scer\GAL4GMR.PF, TER94UAS.cCa
filamentous actin | embryonic stage, with Scer\GAL4VP16.mat.αTub67C
flight muscle cell, with Scer\GAL4Mhc.PU
germarium | germline clone
interommatidial bristle, with Scer\GAL4GMR.PS
intestinal stem cell | adult stage | increased number, with Scer\GAL4Delta-05151-G
intestinal stem cell | adult stage | increased number, with Scer\GAL4NP5130
larval multidendritic class III neuron, with Scer\GAL419-12
larval multidendritic class III neuron, with Scer\GAL4ppk.PG
larval multidendritic class IV neuron, with Scer\GAL4ppk.PG
larval multidendritic class IV neuron | pupal stage, with Scer\GAL4ppk.PG
larval multidendritic class IV neuron | RU486 conditional, with Scer\GAL4ppk.Switch.PR
larval somatic muscle cell | third instar larval stage, with Scer\GAL4C57
lysosome
lysosome | larval stage
lysosome | third instar larval stage, with Scer\GAL4C57
male germ cell nucleus, with Scer\GAL4bam.PU
midgut | prepupal stage, with Scer\GAL4Tub.PU
mitochondrion, with Scer\GAL4Mhc.PU
mitochondrion | adult stage, with Scer\GAL4Mef2.PR
mitochondrion | third instar larval stage, with Scer\GAL4C57
mitochondrion | third instar larval stage, with Scer\GAL4Mef2.PR
muscle cell | embryonic stage, with Scer\GAL4how-24B
myofibril | adult stage | progressive | RU486 conditional, with Scer\GAL4GS.Hand.PU
NMJ bouton, with Scer\GAL4VGlut1-OK371
NMJ bouton | adult stage | decreased number
nuclear lamina | larval stage
nucleus | embryonic stage, with Scer\GAL4VP16.mat.αTub67C
nucleus | larval stage
olfactory receptor neuron, with Scer\GAL4Or22a.8197
ommatidium, with Scer\GAL4GMR.PF
ommatidium, with Scer\GAL4GMR.PS
onion stage spermatid | absent, with Scer\GAL4bam.PU
oocyte | germline clone
outer photoreceptor cell, with Scer\GAL4ninaE.PT
pigment cell, with Scer\GAL4GMR.PS
pole bud | embryonic stage | maternal effect, with Scer\GAL4VP16.mat.αTub67C
presynaptic active zone, with Scer\GAL4VGlut1-OK371
presynaptic active zone | adult stage | decreased number
rhabdomere, with Scer\GAL4GMR.PF
rhabdomere, with Scer\GAL4ninaE.PT
sarcomere | adult stage | progressive | RU486 conditional, with Scer\GAL4GS.Hand.PU
scutellar bristle | somatic clone
seminal vesicle, with Scer\GAL4bam.PU
somatic muscle cell
spermatid
spermatid, with Scer\GAL4bam.PU
spermatid | absent | germline clone, with Scer\GAL4vas.PU
spermatocyte cyst, with Scer\GAL4bam.PU
spermatozoon | absent, with Scer\GAL4bam.PU
sternopleural bristle | somatic clone
testis, with Scer\GAL4bam.PU
wing, with Scer\GAL4Mhc.PU
wing, with Scer\GAL4nub.PU
wing, with Scer\GAL4ptc.PU
wing, with Scer\GAL4sd.PU
wing disc | larval stage, with Scer\GAL4nub.PU
wing disc | larval stage, with Scer\GAL4sd.PU
wing disc | larval stage | somatic clone
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (35)
Hsap\VCP
14 of 14
Yes
Yes
 
10  
Hsap\NVL
4 of 14
No
No
1  
Hsap\SPATA5
4 of 14
No
No
Hsap\SPATA5L1
4 of 14
No
No
Hsap\PEX1
3 of 14
No
No
2  
Hsap\ATAD1
2 of 14
No
No
Hsap\ATAD2B
2 of 14
No
Yes
Hsap\FIGN
2 of 14
No
No
Hsap\NSF
2 of 14
No
No
8  
Hsap\PEX6
2 of 14
No
No
Hsap\TRIP13
2 of 14
No
No
Hsap\AFG3L2
1 of 14
No
No
1  
Hsap\ATAD2
1 of 14
No
No
Hsap\ATAD3A
1 of 14
No
No
Hsap\ATAD3B
1 of 14
No
No
Hsap\ATAD3C
1 of 14
No
No
Hsap\BCS1L
1 of 14
No
No
1  
Hsap\FIGNL1
1 of 14
No
No
Hsap\FIGNL2
1 of 14
No
No
Hsap\IQCA1
1 of 14
No
No
Hsap\IQCA1L
1 of 14
No
No
Hsap\KATNA1
1 of 14
No
No
1  
Hsap\KATNAL1
1 of 14
No
No
Hsap\KATNAL2
1 of 14
No
No
Hsap\PSMC1
1 of 14
No
No
2  
Hsap\PSMC2
1 of 14
No
No
Hsap\PSMC3
1 of 14
No
No
Hsap\PSMC4
1 of 14
No
No
Hsap\PSMC5
1 of 14
No
No
1  
Hsap\PSMC6
1 of 14
No
No
Hsap\SPAST
1 of 14
No
No
7  
Hsap\SPG7
1 of 14
No
No
Hsap\VPS4A
1 of 14
No
No
Hsap\VPS4B
1 of 14
No
No
Hsap\YME1L1
1 of 14
No
No
1  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (22)
Rnor\Vcp
14 of 14
Yes
Yes
Rnor\Nvl
4 of 14
No
No
Rnor\Spata5l1
4 of 14
No
No
Rnor\Spata5
4 of 14
No
No
Rnor\Pex1
3 of 14
No
No
Rnor\Atad1
2 of 14
No
No
Rnor\Fign
2 of 14
No
No
Rnor\Pex6
2 of 14
No
No
Rnor\Spast
2 of 14
No
No
Rnor\Trip13
2 of 14
No
No
Rnor\Atad2b
1 of 14
No
Yes
Rnor\Atad2
1 of 14
No
Yes
Rnor\Atad3a
1 of 14
No
No
Rnor\Fignl1
1 of 14
No
No
Rnor\Iqca1l
1 of 14
No
No
Rnor\Katna1
1 of 14
No
No
Rnor\Katnal1
1 of 14
No
No
Rnor\Katnal2
1 of 14
No
No
Rnor\Nsf
1 of 14
No
No
Rnor\Psmc2
1 of 14
No
No
Rnor\Vps4a
1 of 14
No
No
Rnor\Vps4b
1 of 14
No
No
Mus musculus (laboratory mouse) (25)
Mmus\Vcp
14 of 14
Yes
Yes
Mmus\Spata5
4 of 14
No
No
Mmus\Nvl
3 of 14
No
No
Mmus\Pex1
3 of 14
No
No
Mmus\Atad1
2 of 14
No
No
Mmus\Fignl2
2 of 14
No
No
Mmus\Fign
2 of 14
No
No
Mmus\Nsf
2 of 14
No
No
Mmus\Pex6
2 of 14
No
No
Mmus\Spast
2 of 14
No
No
Mmus\Spata5l1
2 of 14
No
No
Mmus\Trip13
2 of 14
No
No
Mmus\Atad2b
1 of 14
No
Yes
Mmus\Atad2
1 of 14
No
Yes
Mmus\Atad3a
1 of 14
No
No
Mmus\Fignl1
1 of 14
No
No
Mmus\Iqca1l
1 of 14
No
No
Mmus\Iqca
1 of 14
No
No
Mmus\Katna1
1 of 14
No
No
Mmus\Katnal1
1 of 14
No
No
Mmus\Katnal2
1 of 14
No
No
Mmus\Psmc2
1 of 14
No
No
Mmus\Vps4a
1 of 14
No
No
Mmus\Vps4b
1 of 14
No
No
Mmus\Yme1l1
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (27)
Xtro\vcp
11 of 13
Yes
Yes
Xtro\spata5l1
3 of 13
No
No
Xtro\spata5
3 of 13
No
No
Xtro\nvl
2 of 13
No
No
Xtro\pex1
2 of 13
No
No
Xtro\atad1
1 of 13
No
No
Xtro\atad2b
1 of 13
No
Yes
Xtro\atad2
1 of 13
No
Yes
Xtro\atad3a
1 of 13
No
No
Xtro\bcs1l
1 of 13
No
No
Xtro\cyp4f22
1 of 13
No
No
Xtro\fignl1
1 of 13
No
No
Xtro\fign
1 of 13
No
No
Xtro\katna1
1 of 13
No
No
Xtro\katnal1
1 of 13
No
No
Xtro\katnal2
1 of 13
No
No
Xtro\LOC733566
1 of 13
No
Yes
Xtro\pex6
1 of 13
No
No
Xtro\prxl2a
1 of 13
No
Yes
Xtro\psmc3
1 of 13
No
No
Xtro\psmc4
1 of 13
No
No
Xtro\psmc6
1 of 13
No
No
Xtro\rab3gap2
1 of 13
No
No
Xtro\rfx6
1 of 13
No
No
Xtro\spast
1 of 13
No
No
Xtro\spg7
1 of 13
No
No
Xtro\trip13
1 of 13
No
No
Danio rerio (Zebrafish) (30)
Drer\vcp
14 of 14
Yes
Yes
Drer\zgc:136908
12 of 14
No
Yes
Drer\nvl
4 of 14
No
No
Drer\spata5l1
4 of 14
No
No
Drer\atad1a
2 of 14
No
No
Drer\atad1b
2 of 14
No
No
Drer\fignl1
2 of 14
No
No
Drer\nsfa
2 of 14
No
No
Drer\nsfb
2 of 14
No
No
Drer\pex1
2 of 14
No
No
Drer\pex6
2 of 14
No
No
Drer\trip13
2 of 14
No
No
Drer\atad2b
1 of 14
No
Yes
Drer\atad2
1 of 14
No
Yes
Drer\atad3
1 of 14
No
No
Drer\fign
1 of 14
No
No
Drer\fignl2
1 of 14
No
No
Drer\iqca1
1 of 14
No
No
Drer\katna1
1 of 14
No
No
Drer\katnal1
1 of 14
No
No
Drer\katnal2
1 of 14
No
No
Drer\psmc2
1 of 14
No
No
Drer\si:dkey-195m11.8
1 of 14
No
No
Drer\spast
1 of 14
No
No
Drer\spata5
1 of 14
No
No
Drer\vps4a
1 of 14
No
No
Drer\vps4b
1 of 14
No
No
Drer\yme1l1a
1 of 14
No
No
Drer\yme1l1b
1 of 14
No
No
Drer\zgc:153738
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (27)
Cele\cdc-48.1
14 of 14
Yes
Yes
Cele\cdc-48.2
14 of 14
Yes
Yes
Cele\cdc-48.3
4 of 14
No
No
Cele\mac-1
4 of 14
No
No
Cele\figl-1
2 of 14
No
No
Cele\pch-2
2 of 14
No
No
Cele\prx-1
2 of 14
No
No
Cele\prx-6
2 of 14
No
No
Cele\atad-3
1 of 14
No
No
Cele\bcs-1
1 of 14
No
No
Cele\F56F11.4
1 of 14
No
No
Cele\lex-1
1 of 14
No
Yes
Cele\mei-1
1 of 14
No
No
Cele\mspn-1
1 of 14
No
No
Cele\nsf-1
1 of 14
No
No
Cele\ppgn-1
1 of 14
No
No
Cele\rpt-1
1 of 14
No
No
Cele\rpt-3
1 of 14
No
No
Cele\rpt-4
1 of 14
No
No
Cele\rpt-5
1 of 14
No
No
Cele\rpt-6
1 of 14
No
No
Cele\spas-1
1 of 14
No
No
Cele\spg-7
1 of 14
No
No
Cele\vps-4
1 of 14
No
No
Cele\Y47C4A.1
1 of 14
No
No
Cele\ymel-1
1 of 14
No
No
Cele\ZK938.3
1 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (31)
Agam\AgaP_AGAP005630
12 of 12
Yes
Yes
Agam\AgaP_AGAP006205
4 of 12
No
No
Agam\AgaP_AGAP011652
4 of 12
No
No
Agam\AgaP_AGAP009548
3 of 12
No
No
Agam\AgaP_AGAP010924
3 of 12
No
No
Agam\AgaP_AGAP012655
3 of 12
No
No
Agam\AgaP_AGAP001522
2 of 12
No
No
Agam\AgaP_AGAP001612
2 of 12
No
No
Agam\AgaP_AGAP007769
2 of 12
No
No
Agam\AgaP_AGAP009625
2 of 12
No
No
Agam\AgaP_AGAP012684
2 of 12
No
No
Agam\SPAST_ANOGA
2 of 12
No
No
Agam\AgaP_AGAP000560
1 of 12
No
No
Agam\AgaP_AGAP000616
1 of 12
No
No
Agam\AgaP_AGAP000625
1 of 12
No
No
Agam\AgaP_AGAP001407
1 of 12
No
No
Agam\AgaP_AGAP001783
1 of 12
No
No
Agam\AgaP_AGAP001792
1 of 12
No
No
Agam\AgaP_AGAP003008
1 of 12
No
No
Agam\AgaP_AGAP003215
1 of 12
No
No
Agam\AgaP_AGAP003216
1 of 12
No
No
Agam\AgaP_AGAP004012
1 of 12
No
No
Agam\AgaP_AGAP004266
1 of 12
No
No
Agam\AgaP_AGAP006949
1 of 12
No
No
Agam\AgaP_AGAP007243
1 of 12
No
No
Agam\AgaP_AGAP009973
1 of 12
No
No
Agam\AgaP_AGAP011174
1 of 12
No
No
Agam\AgaP_AGAP011557
1 of 12
No
No
Agam\AgaP_AGAP011743
1 of 12
No
No
Agam\AgaP_AGAP011967
1 of 12
No
No
Agam\AgaP_AGAP012537
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (82)
Atha\AtCDC48B
13 of 13
Yes
Yes
Atha\AtCDC48C
13 of 13
Yes
Yes
Atha\CDC48
13 of 13
Yes
Yes
Atha\CDC48B
4 of 13
No
No
Atha\CDC48C
4 of 13
No
No
Atha\CIP111
4 of 13
No
No
Atha\PEX1
3 of 13
No
No
Atha\AT1G02890
2 of 13
No
No
Atha\AT1G50140
2 of 13
No
No
Atha\AT1G62130
2 of 13
No
No
Atha\AT2G45500
2 of 13
No
No
Atha\AT3G19740
2 of 13
No
No
Atha\AT3G24530
2 of 13
No
Yes
Atha\AT3G27120
2 of 13
No
No
Atha\AT4G02480
2 of 13
No
No
Atha\AT4G04180
2 of 13
No
Yes
Atha\AT4G24710
2 of 13
No
No
Atha\AT4G24860
2 of 13
No
No
Atha\AT4G27680
2 of 13
No
No
Atha\AT4G28000
2 of 13
No
No
Atha\AT5G52882
2 of 13
No
No
Atha\AT5G53540
2 of 13
No
No
Atha\DAA1
2 of 13
No
No
Atha\NSF
2 of 13
No
No
Atha\PEX6
2 of 13
No
No
Atha\AT1G05910
1 of 13
No
No
Atha\AT1G08270
1 of 13
No
No
Atha\AT1G43910
1 of 13
No
No
Atha\AT1G45000
1 of 13
No
No
Atha\AT1G53780
1 of 13
No
No
Atha\AT2G18190
1 of 13
No
No
Atha\AT2G18193
1 of 13
No
No
Atha\AT2G18330
1 of 13
No
No
Atha\AT2G46620
1 of 13
No
No
Atha\AT3G02450
1 of 13
No
No
Atha\AT3G03060
1 of 13
No
No
Atha\AT3G28510
1 of 13
No
No
Atha\AT3G28520
1 of 13
No
No
Atha\AT3G28540
1 of 13
No
No
Atha\AT3G28560
1 of 13
No
No
Atha\AT3G28570
1 of 13
No
No
Atha\AT3G28580
1 of 13
No
No
Atha\AT3G28600
1 of 13
No
No
Atha\AT3G28610
1 of 13
No
No
Atha\AT3G29800
1 of 13
No
No
Atha\AT3G50940
1 of 13
No
No
Atha\AT4G05380
1 of 13
No
No
Atha\AT4G25835
1 of 13
No
No
Atha\AT4G30250
1 of 13
No
No
Atha\AT4G36580
1 of 13
No
No
Atha\AT5G16930
1 of 13
No
No
Atha\AT5G17730
1 of 13
No
No
Atha\AT5G17740
1 of 13
No
No
Atha\AT5G17750
1 of 13
No
No
Atha\AT5G17760
1 of 13
No
No
Atha\AT5G20000
1 of 13
No
No
Atha\AT5G40000
1 of 13
No
No
Atha\AT5G57480
1 of 13
No
No
Atha\BCS1
1 of 13
No
No
Atha\CCP1
1 of 13
No
No
Atha\EMB2083
1 of 13
No
No
Atha\EMB3144
1 of 13
No
No
Atha\ERH3
1 of 13
No
No
Atha\FTSH1
1 of 13
No
No
Atha\ftsh3
1 of 13
No
No
Atha\ftsh4
1 of 13
No
No
Atha\FTSH6
1 of 13
No
No
Atha\ftsh7
1 of 13
No
No
Atha\FTSH8
1 of 13
No
No
Atha\ftsh9
1 of 13
No
No
Atha\ftsh10
1 of 13
No
No
Atha\FTSH11
1 of 13
No
No
Atha\FTSH12
1 of 13
No
No
Atha\FtsHi1
1 of 13
No
No
Atha\RPT1A
1 of 13
No
No
Atha\RPT4A
1 of 13
No
No
Atha\RPT5A
1 of 13
No
No
Atha\RPT5B
1 of 13
No
No
Atha\RPT6A
1 of 13
No
No
Atha\SKD1
1 of 13
No
No
Atha\VAR1
1 of 13
No
No
Atha\VAR2
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (22)
Scer\CDC48
12 of 13
Yes
Yes
Scer\AFG2
3 of 13
No
No
Scer\PEX1
3 of 13
No
No
Scer\RIX7
3 of 13
No
No
Scer\MSP1
2 of 13
No
No
Scer\PCH2
2 of 13
No
No
Scer\PEX6
2 of 13
No
No
Scer\SAP1
2 of 13
No
No
Scer\SEC18
2 of 13
No
No
Scer\YTA6
2 of 13
No
No
Scer\AFG3
1 of 13
No
No
Scer\BCS1
1 of 13
No
No
Scer\RPT1
1 of 13
No
No
Scer\RPT2
1 of 13
No
No
Scer\RPT3
1 of 13
No
No
Scer\RPT4
1 of 13
No
No
Scer\RPT5
1 of 13
No
No
Scer\RPT6
1 of 13
No
No
Scer\VPS4
1 of 13
No
No
Scer\YME1
1 of 13
No
No
Scer\YTA7
1 of 13
No
No
Scer\YTA12
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (15)
Spom\cdc48
12 of 12
Yes
Yes
Spom\pex1
3 of 12
No
No
Spom\SPBC16E9.10c
3 of 12
No
No
Spom\SPBC56F2.07c
3 of 12
No
No
Spom\pex6
2 of 12
No
No
Spom\sec18
2 of 12
No
No
Spom\SPAC328.04
2 of 12
No
No
Spom\SPBC947.01
2 of 12
No
No
Spom\SPCC24B10.10c
2 of 12
No
No
Spom\rpt1
1 of 12
No
No
Spom\rpt6
1 of 12
No
No
Spom\SPAC31G5.19
1 of 12
No
Yes
Spom\SPBP22H7.05c
1 of 12
No
Yes
Spom\SPCC965.04c
1 of 12
No
No
Spom\vps4
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:TER94. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (32)
CG5776
6 of 13
CG12010
6 of 13
smid
6 of 13
Pex1
5 of 13
Pex6
3 of 13
CG4701
2 of 13
CG31495
2 of 13
comt
2 of 13
Fign
2 of 13
nmd
2 of 13
Nsf2
2 of 13
pch2
2 of 13
spas
2 of 13
Afg3l2
1 of 13
Bcs1
1 of 13
bor
1 of 13
CG10793
1 of 13
CG14183
1 of 13
CG16789
1 of 13
Kat60
1 of 13
kat-60L1
1 of 13
Rpt1
1 of 13
Rpt2
1 of 13
Rpt3
1 of 13
Rpt3R
1 of 13
Rpt4
1 of 13
Rpt4R
1 of 13
Rpt6
1 of 13
Rpt6R
1 of 13
Spg7
1 of 13
Vps4
1 of 13
YME1L
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 22 )
Allele
Disease
Evidence
References
TER9426-8
model of  frontotemporal dementia
CEA
(Rumpf et al., 2014)
model of  frontotemporal dementia and/or amyotrophic lateral sclerosis 6
CEA
(Rumpf et al., 2014)
TER94k15502
model of  inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1
CEA
(Zhang et al., 2017)
TER94GD9777
model of  inclusion body myopathy with Paget disease of bone and frontotemporal dementia
CEA
(Johnson et al., 2015)
model of  frontotemporal dementia and/or amyotrophic lateral sclerosis 6
CEA
(Tsumaki et al., 2024, Gonzalez and Wang, 2020)
TER94HMS00656
model of  frontotemporal dementia and/or amyotrophic lateral sclerosis 6
CEA
(Tendulkar et al., 2022)
TER94R152H.UAS
model of  inclusion body myopathy with Paget disease of bone and frontotemporal dementia
CEA
(Viswanathan et al., 2016, Johnson et al., 2015, Chang et al., 2011)
CEC
(Liang et al., 2014)
model of  inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1
CEA
(Zhang et al., 2017)
TER94R188Q.UAS
model of  inclusion body myopathy with Paget disease of bone and frontotemporal dementia
CEA
(Viswanathan et al., 2016, Johnson et al., 2015, Chang et al., 2011)
CEC
(Liang et al., 2014)
TER94A229E.UAS
model of  inclusion body myopathy with Paget disease of bone and frontotemporal dementia
CEA
(Viswanathan et al., 2016, Johnson et al., 2015, Chang et al., 2011)
CEC
(Liang et al., 2014)
model of  inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1
CEA
(Zhang et al., 2017)
model of  amyotrophic lateral sclerosis
CEA with TBPHUAS.Tag:HA
(Rumpf et al., 2014)
TER94UAS.cRa
model of  frontotemporal dementia and/or amyotrophic lateral sclerosis 6
CEA
(Tsumaki et al., 2024, Tendulkar et al., 2022)
TER94R152H.UAS.R
model of  neurodegenerative disease
CEA
(Ritson et al., 2010)
model of  frontotemporal dementia and/or amyotrophic lateral sclerosis 6
CEA
(Thulasidharan et al., 2024, Chalmers et al., 2023, Tendulkar et al., 2022, Gonzalez and Wang, 2020)
TER94A229E.UAS.R
model of  neurodegenerative disease
CEA
(Ritson et al., 2010)
model of  frontotemporal dementia and/or amyotrophic lateral sclerosis 6
CEA
(Tsumaki et al., 2024, Tendulkar et al., 2022, Gonzalez and Wang, 2020)
TER94GL00448
model of  primary ovarian insufficiency
CEA
(Gorsi et al., 2022)
TER94E375Q.E575Q.UAS
model of  frontotemporal dementia
CEA
(Rumpf et al., 2014)
model of  frontotemporal dementia and/or amyotrophic lateral sclerosis 6
CEC
(Rumpf et al., 2014)
TER94RNAi.CDS.UAS
model of  frontotemporal dementia and/or amyotrophic lateral sclerosis 6
CEA
(Gonzalez and Wang, 2020)
TER94P134L.sfGFP
model of  inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1
CEA
(Johnson et al., 2021, Wall et al., 2021)
TER94R152C.sfGFP
model of  inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1
CEA
(Wall et al., 2021)
TER94R152H.sfGFP
model of  inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1
CEA
(Wall et al., 2021)
TER94A154R.sfGFP
model of  inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1
CEA
(Wall et al., 2021)
TER94R156C.sfGFP
model of  inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1
CEA
(Wall et al., 2021)
TER94R188Q.sfGFP
model of  inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1
CEA
(Wall et al., 2021)
TER94L195W.sfGFP
model of  inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1
CEA
(Wall et al., 2021)
TER94T259A.sfGFP
model of  inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1
CEA
(Wall et al., 2021)
TER94A436S.sfGFP
model of  inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1
CEA
(Wall et al., 2021)
Potential Models Based on Orthology ( 3 )
Modifiers Based on Experimental Evidence ( 18 )
Allele
Disease
Interaction
References
TER9403775
exacerbates  amyotrophic lateral sclerosis
modeled by cazRNAi.UAS.cUa
(Azuma et al., 2014)
exacerbates  amyotrophic lateral sclerosis type 6
modeled by cazRNAi.UAS.cUa
(Azuma et al., 2014)
exacerbates  amyotrophic lateral sclerosis type 10
modeled by TBPHKK108354
(Kushimura et al., 2018)
TER9426-8
ameliorates  retinitis pigmentosa
modeled by ninaED1
(Griciuc et al., 2010)
modeled by ninaEP37H
(Griciuc et al., 2010)
ameliorates  neurodegenerative disease
modeled by Zzzz\CAGQ92.GMR.Tag:FLAG
(Higashiyama et al., 2002)
TER94k15502
exacerbates  amyotrophic lateral sclerosis
modeled by cazRNAi.UAS.cUa
(Azuma et al., 2014)
ameliorates  retinitis pigmentosa
modeled by ninaEP37H
(Griciuc et al., 2010)
exacerbates  amyotrophic lateral sclerosis type 6
modeled by cazRNAi.UAS.cUa
(Azuma et al., 2014)
ameliorates  Parkinson's disease 2
modeled by Mul1A6, park25
(Zhang et al., 2017)
exacerbates  frontotemporal dementia and/or amyotrophic lateral sclerosis 7
modeled by Hsap\CHMP2BIntron5.UAS
(Lu et al., 2020)
exacerbates  amyotrophic lateral sclerosis type 10
modeled by TBPHKK108354
(Kushimura et al., 2018)
TER94GD9777
model of  frontotemporal dementia and/or amyotrophic lateral sclerosis 6
is ameliorated by Mcm2UAS.ORF
(Tsumaki et al., 2024)
exacerbates  frontotemporal dementia and/or amyotrophic lateral sclerosis 2
modeled by Chchd2S81L.UAS
(Baek et al., 2021)
TER94UAS.cHa
ameliorates  amyotrophic lateral sclerosis
modeled by cazRNAi.UAS.cUa
(Azuma et al., 2014)
exacerbates  neurodegenerative disease
modeled by Zzzz\CAGQ92.GMR.Tag:FLAG
(Higashiyama et al., 2002)
ameliorates  amyotrophic lateral sclerosis type 6
modeled by cazRNAi.UAS.cUa
(Azuma et al., 2014)
ameliorates  amyotrophic lateral sclerosis type 10
modeled by TBPHKK108354
(Kushimura et al., 2018)
TER94JF03402
exacerbates  C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis
modeled by Zzzz\poly-GRPO-36.UAS
(Park et al., 2021)
modeled by Zzzz\poly-PRPO-36.UAS
(Park et al., 2021)
ameliorates  cancer
modeled by NUAS.Tag:V5,Tag:polyHis
(Khaket et al., 2024)
TER94HMS00656
ameliorates  Machado-Joseph disease
modeled by Hsap\ATXN3fl.SCA3.UAS
(Ristic et al., 2018)
ameliorates  amyotrophic lateral sclerosis type 8
modeled by Vap33Δ166, Vap33ALS8
(Thulasidharan et al., 2024)
modeled by Vap33Δ166, Vap33P58S.cRa.UAS
(Tendulkar et al., 2022)
exacerbates  amyotrophic lateral sclerosis type 8
modeled by Vap33Δ166, Vap33P58S.cRa.UAS
(Tendulkar et al., 2022)
ameliorates  C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis
modeled by Zzzz\poly-GR80.UAS.Tag:FLAG
(Li et al., 2023)
TER94UAS.cCa
ameliorates  Parkinson's disease 2
modeled by park25
(Zhang et al., 2017)
ameliorates  Parkinson's disease 6
modeled by Pink15
(Zhang et al., 2017)
TER94R152H.UAS
model of  inclusion body myopathy with Paget disease of bone and frontotemporal dementia
is ameliorated by Der-1UAS.cLa
(Liang et al., 2014)
TER94R188Q.UAS
model of  inclusion body myopathy with Paget disease of bone and frontotemporal dementia
is ameliorated by PTPMT1KK108325
(Chang et al., 2011)
is ameliorated by PTPMT1GD4965
(Chang et al., 2011)
is ameliorated by Der-1UAS.cLa
(Liang et al., 2014)
TER94A229E.UAS
model of  inclusion body myopathy with Paget disease of bone and frontotemporal dementia
is ameliorated by PTPMT1KK108325
(Chang et al., 2011)
is ameliorated by PTPMT1GD4965
(Chang et al., 2011)
is ameliorated by Der-1UAS.cLa
(Liang et al., 2014)
is ameliorated by Der-1Δα.UAS
(Liang et al., 2014)
is exacerbated by sip3GD3145
(Liang et al., 2014)
is exacerbated by Der-1GD818
(Liang et al., 2014)
is ameliorated by Der-1UAS.Tag:FLAG
(Liang et al., 2014)
is ameliorated by Der-1UAS.Tag:MYC.cLa
(Liang et al., 2014)
is ameliorated by Der-1L204G.UAS
(Liang et al., 2014)
TER94UAS.cRa
ameliorates  Parkinson's disease
modeled by Pink1B9
(Kim et al., 2013)
DOES NOT ameliorate  Parkinson's disease
modeled by park25
(Kim et al., 2013)
exacerbates  amyotrophic lateral sclerosis type 8
modeled by Vap33Δ166, Vap33ALS8
(Thulasidharan et al., 2024)
modeled by Vap33Δ166, Vap33P58S.cRa.UAS
(Tendulkar et al., 2022)
ameliorates  C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis
modeled by Zzzz\poly-PR80.UAS.Tag:FLAG
(Li et al., 2020)
modeled by Zzzz\poly-GR80.UAS.Tag:FLAG
(Li et al., 2020)
ameliorates  Alzheimer's disease 1
modeled by Hsap\APPC99.UAS.Exel.Tag:MYC
(Rimal et al., 2021)
TER94R152H.UAS.R
model of  neurodegenerative disease
is ameliorated by TBPHGD6943
(Ritson et al., 2010)
is ameliorated by Hrb27CGD6964
(Ritson et al., 2010)
is exacerbated by TBPHUAS.cRa
(Ritson et al., 2010)
is exacerbated by Hsap\TARDBPNESmut.UAS.Tag:MYC
(Ritson et al., 2010)
is exacerbated by Hsap\TARDBPUAS.Tag:MYC
(Ritson et al., 2010)
is ameliorated by x16GD6898
(Ritson et al., 2010)
is exacerbated by Hsap\TARDBPNLSmut.UAS.Tag:MYC
(Ritson et al., 2010)
model of  frontotemporal dementia and/or amyotrophic lateral sclerosis 6
is exacerbated by mir-34UAS.pLUC
(Chalmers et al., 2023)
is exacerbated by mir-34sponge.V2.UAS.mCherry
(Chalmers et al., 2023)
is ameliorated by Eip74EFJF02515
(Chalmers et al., 2023)
is exacerbated by mir-34UAS.DsRed(Unk)
(Chalmers et al., 2023)
exacerbates  amyotrophic lateral sclerosis type 8
modeled by Vap33Δ166, Vap33ALS8
(Thulasidharan et al., 2024)
ameliorates  amyotrophic lateral sclerosis type 8
modeled by Vap33Δ166, Vap33P58S.cRa.UAS
(Tendulkar et al., 2022)
TER94GL00448
ameliorates  Machado-Joseph disease
modeled by Hsap\ATXN3fl.SCA3.UAS
(Ristic et al., 2018)
TER94E375Q.E575Q.UAS
model of  frontotemporal dementia
is ameliorated by Sox14UAS.cRa
(Rumpf et al., 2014)
model of  frontotemporal dementia and/or amyotrophic lateral sclerosis 6
is ameliorated by Sox14UAS.cRa
(Rumpf et al., 2014)
TER94GS10258
ameliorates  neurodegenerative disease
modeled by Hsap\HTT103Q.Ex1.UAS
(Fujita et al., 2013)
modeled by Hsap\ATXN185Q.UAS.Tag:MYC
(Fujita et al., 2013)
TER94UAS.cHb
ameliorates  neurodegenerative disease
modeled by trpP365
(Huang et al., 2016)
TER94RNAi.CDS.UAS
model of  frontotemporal dementia and/or amyotrophic lateral sclerosis 6
is ameliorated by Dhc64C6-10
(Gonzalez and Wang, 2020)
is ameliorated by MiroUAS.Tag:T7
(Gonzalez and Wang, 2020)
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
VCP; valosin containing protein
14 of 14
VALOSIN-CONTAINING PROTEIN; VCP
 
NVL; nuclear VCP like
4 of 14
602426
       
      AFG2A; AAA ATPase AFG2A
      4 of 14
      613940
        AFG2B; AAA ATPase AFG2B
        4 of 14
        619578
          PEX1; peroxisomal biogenesis factor 1
          3 of 14
          PEROXISOME BIOGENESIS FACTOR 1; PEX1
           
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Dmel gene
          Ortholog showing functional complementation
          Supporting References
          TER94
          Hsap\VCP
          (Li et al., 2024, Johnson et al., 2015)
          Interactions
          Summary of Physical Interactions
          Interaction Browsers
          View in FlyBase Interactions Browser   View in MIST tool (external link)
          Please see the Physical Interaction reports below for full details
          protein-protein
          Physical Interaction
          Assay
          References
          TER94
          anti tag coimmunoprecipitation, western blot
          (Johnson et al., 2021, Kim et al., 2013)
          TER94 - AGO1
          anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, anti tag western blot
          (Gao et al., 2022, Kobayashi et al., 2019)
          TER94 - AGO3
          anti bait coimmunoprecipitation, western blot
          (Liu et al., 2011)
          TER94 - Akap200
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - Akt
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          TER94 - Aldo
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - AnxB10
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - Ar2
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - CCT3
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - CCT8
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - CG17124
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - CG3008
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - CG43755
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - CG8892
          two hybrid
          (Hu et al., 2017.6.13)
          TER94 - CG9467
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - CaBP1
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - Calr
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - Chc
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - Chd64
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - Cndp2
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - Cnx99A
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - Cul1
          anti tag coimmunoprecipitation, anti tag western blot
          (Zhang et al., 2013)
          TER94 - Der-1
          anti bait coimmunoprecipitation, western blot, pull down
          (Liang et al., 2014)
          TER94 - Df31
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - Diap1
          anti tag coimmunoprecipitation, western blot
          (Rumpf et al., 2011)
          TER94 - Echs1
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - Fim
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - FipoQ
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - Glt
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - GluProRS
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - Golgin97
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - Gp93
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - Gsc
          two hybrid
          (Hu et al., 2017.6.13)
          TER94 - GstO3
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - Gtpx
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - Hsap\ATXN3
          pull down, western blot, anti tag coimmunoprecipitation
          (Johnson et al., 2021, Ristic et al., 2018)
          TER94 - Hsp110
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - Idh3a
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - Inos
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - MRP
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - Marf
          anti tag coimmunoprecipitation, anti tag western blot
          (Zhang et al., 2017, Kim et al., 2013)
          TER94 - Mdh2
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - Mer
          anti tag coimmunoprecipitation, peptide massfingerprinting, anti tag western blot
          (Li et al., 2024, Kwon et al., 2013)
          TER94 - Mfap1
          anti tag coimmunoprecipitation, anti tag western blot
          (Rode et al., 2017)
          TER94 - Moe
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - Nacα
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - Nlp
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - Npl4
          anti tag coimmunoprecipitation, anti tag western blot
          (Zhang et al., 2013)
          TER94 - OstΔ
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - Pdi
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - Pgk
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - Pi3K68D
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - Pih1D1
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - Prosα6
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - Prosα7
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - Prosβ1
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - Prx6c
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - Ptp52F
          anti tag coimmunoprecipitation, western blot, anti tag western blot, Identification by mass spectrometry
          (Santhanam et al., 2014)
          TER94 - Ptpmeg
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Li et al., 2015)
          TER94 - Rab11
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - Rdh1
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - Rheb
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          TER94 - Roc1a
          anti tag coimmunoprecipitation, anti tag western blot
          (Zhang et al., 2013)
          TER94 - RpL22
          anti bait coimmunoprecipitation, western blot
          (Gao et al., 2022)
          TER94 - RpLP0
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - RpS10b
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - SerRS
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - Sh3β
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - Stip1
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - Svip
          pull down, anti tag western blot, molecular weight estimation by staining
          (Johnson et al., 2021)
          TER94 - Tdp1
          experimental knowledge based, inferred by curator
          (Guruharsha et al., 2011)
          TER94 - Tkt
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - Trf4
          anti bait coimmunoprecipitation, western blot
          (Kurshakova et al., 2019)
          TER94 - Uch
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - Ufd1
          anti tag coimmunoprecipitation, anti tag western blot
          (Zhang et al., 2013)
          TER94 - amls
          anti tag coimmunoprecipitation, Identification by mass spectrometry, anti tag western blot, experimental knowledge based, western blot, bimolecular fluorescence complementation, fluorescence microscopy
          (Reim et al., 2014, Guruharsha et al., 2011)
          TER94 - atl
          anti tag coimmunoprecipitation, peptide massfingerprinting, western blot
          (O'Sullivan et al., 2013)
          TER94 - awd
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - boca
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - bor
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - cPges
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - capt
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - casp
          anti bait coimmunoprecipitation, western blot, Identification by mass spectrometry
          (Tendulkar et al., 2022)
          TER94 - cbc
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Wu et al., 2021)
          TER94 - cib
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - clu
          anti tag coimmunoprecipitation, anti tag western blot, western blot, Identification by mass spectrometry
          (Wang et al., 2016)
          TER94 - drl
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - eEF1δ
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - fabp
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - fax
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - ft
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Kwon et al., 2013)
          TER94 - lwr
          two hybrid
          (Hu et al., 2017.6.13)
          TER94 - mu2
          proximity ligation assay, fluorescence microscopy
          (Chang et al., 2021)
          TER94 - p47
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - papi
          anti bait coimmunoprecipitation, western blot
          (Liu et al., 2011)
          TER94 - regucalcin
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - rictor
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          TER94 - scf
          experimental knowledge based
          (Guruharsha et al., 2011)
          TER94 - slmb
          anti tag coimmunoprecipitation, anti tag western blot
          (Zhang et al., 2013)
          TER94 - tud
          anti bait coimmunoprecipitation, cross-linking study, Identification by mass spectrometry
          (Thomson et al., 2008)
          TER94 - α-Spec
          experimental knowledge based
          (Guruharsha et al., 2011)
          Summary of Genetic Interactions
          Interaction Browsers
          View in FlyBase Interactions Browser   View in MIST tool (external link)
          Please look at the allele data for full details of the genetic interactions
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          TER94
          suppressible
          bsk
          (Liu et al., 2022)
          TER94
          suppressible
          Cat
          (Liu et al., 2022)
          TER94
          suppressible
          clu
          (Wang et al., 2016)
          TER94
          suppressible
          cnc
          (Liu et al., 2022)
          TER94
          suppressible
          Der-1
          (Liang et al., 2014)
          TER94
          enhanceable
          Der-1
          (Liang et al., 2014)
          TER94
          suppressible
          Diap1
          (Rumpf et al., 2011)
          TER94
          suppressible
          ex
          (Li et al., 2024)
          TER94
          suppressible
          hpo
          (Li et al., 2024)
          TER94
          suppressible
          Hrb27C
          (Ritson et al., 2010)
          TER94
          suppressible
          kibra
          (Li et al., 2024)
          TER94
          suppressible
          mats
          (Li et al., 2024)
          TER94
          suppressible
          Mer
          (Li et al., 2024)
          TER94
          suppressible
          PTPMT1
          (Chang et al., 2011)
          TER94
          suppressible
          Sce
          (Butsch et al., 2023)
          TER94
          enhanceable
          sip3
          (Liang et al., 2014)
          TER94
          suppressible
          TBPH
          (Ritson et al., 2010)
          TER94
          suppressible
          x16
          (Ritson et al., 2010)
          TER94
          suppressible
          yki
          (Li et al., 2024)
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          amls
          suppressible
          TER94
          (Reim et al., 2014)
          atl
          suppressible
          TER94
          (O'Sullivan et al., 2013)
          atl
          enhanceable
          TER94
          (O'Sullivan et al., 2013)
          caz
          enhanceable
          TER94
          (Azuma et al., 2014)
          caz
          suppressible
          TER94
          (Azuma et al., 2014)
          Chchd2
          enhanceable
          TER94
          (Baek et al., 2021)
          clu
          suppressible
          TER94
          (Wang et al., 2016)
          Der-1
          suppressible
          TER94
          (Liang et al., 2014)
          Mer
          suppressible
          TER94
          (Li et al., 2024)
          ninaE
          suppressible
          TER94
          (Griciuc et al., 2010)
          park
          enhanceable
          TER94
          (Kim et al., 2013)
          Pink1
          suppressible
          TER94
          (Kim et al., 2013)
          Ptp52F
          suppressible
          TER94
          (Santhanam et al., 2014)
          Svip
          suppressible
          TER94|spin
          (Johnson et al., 2021)
          trp
          suppressible
          TER94
          (Huang et al., 2016)
          Ubqn
          suppressible
          TER94
          (Jantrapirom et al., 2018)
          External Data
          Subunit Structure (UniProtKB)
          Homohexamer (PubMed:10564274). Interacts with tud, vas, papi and AGO3 (PubMed:18590813, PubMed:21447556). Interacts with Npl4 (PubMed:26471729).
          (UniProt, Q7KN62 )
          Linkouts
          Pathways
          Class of Gene
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          2R
          Recombination map
          2-61
          Cytogenetic map
          46D1-46D1
          Sequence location
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          46D1-46D1
          Limits computationally determined from genome sequence between P{lacW}Adamk13906&P{EP}Pka-R2EP2162 and P{PZ}14-3-3ζ07103
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          The l(2)46Db complementation group maps to the genomic interval 2R:9959818..10025288 , release 6 genome (left limit from complementation mapping against Df(2R)01D09Y-M073, right limit from complementation mapping against Df(2R)BSC158).
          (Kahsai and Cook, 2018)
          46D1-46D2
          (Ruden, 1999.11.4, BDGP Project Members, 1994-1999)
          Complementation data from unspecified deficiency chromosomes.
          (Goldstein et al., 1993)
          46C-46D
          (Pinter, 1998.2.8)
          46D-46D
          (determined by in situ hybridisation)
          (Leon and McKearin, 1999, McKearin, 1998.3.18)
          46D1-46D2
          (determined by in situ hybridisation)
          (Spradling et al., 1999)
          46C-46D
          (determined by in situ hybridisation)
          (Pinter et al., 1998)
          46C8-46F6
          (Goldstein et al., 1993)
          Experimentally Determined Recombination Data
          Location

          2-61

          (FlyBase, 2016)

          2-60.1

          (Comeron et al., 2012)

          2-

          (O'Brien et al., 1994)
          Left of (cM)
          Right of (cM)
          Notes
          Stocks and Reagents
          Stocks (35)
          Genomic Clones (17)
           

          Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

          cDNA Clones (196)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
          Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            Antibody Information
            Laboratory Generated Antibodies
             

            polyclonal

            (Krämer et al., 2023, Gao et al., 2022, Chang et al., 2021, Kurshakova et al., 2019, Beskow et al., 2009, Leon and McKearin, 1999)
            Commercially Available Antibodies
             
            Cell Line Information
            Publicly Available Cell Lines
             
              Other Stable Cell Lines
               
                Other Comments

                TER94-dependent th degradation is required for proper neuronal remodelling and apoptosis.

                (Rumpf et al., 2011)

                TER94 inhibition interferes with class IV neuron dendrite pruning and class III neuron apoptosis during the pupal stage.

                (Rumpf et al., 2011)

                dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                (Kiger et al., 2003)

                TER94 is involved in osk localisation during oogenesis.

                (Ruden et al., 2000)

                Identification: approximately 3.3kb transcript identified during molecular analysis of the eve genomic region.

                (Sackerson et al., 1999)

                Identification: Physical interaction with bam protein in a yeast two hybrid assay.

                (Chandrasekaran et al., 1998, Leon and McKearin, 1998)

                TER94 has been cloned using an antibody to Canp, a Ca2+-activated protease (FBrf0055463), but TER94 protein expressed in E.coli does not show Ca2+-activated protease activity.

                (Pinter et al., 1998)

                A Drosophila homolog of CDC48, a protein that has been linked to vesicle fusion in yeast and vertebrate cells, isolated in a protein interaction screen showing interaction with bam.

                (McKearin, 1997)

                Complementation group identified in an EMS and DEB screen to isolate deficiencies that uncover Jra.

                (Goldstein et al., 1993)
                Relationship to Other Genes
                Source for database merge of

                Source for merge of: TER94 l(2)03775

                (Spradling et al., 1999)

                Source for merge of: TER94 Apple

                (Sackerson, 2001.1.17)

                Source for merge of: TER94 l(2)46Ch

                (Goldstein et al., 2001)

                Source for merge of: TER94 l(2)46CFf l(2)46CFs

                (Goldstein, 2004.3.15)

                Source for merge of: Tera TER94

                (Leon and McKearin, 1999)

                Source for merge of: TER94 l(2)46Db

                (Kahsai and Cook, 2018)
                Additional comments

                The l(2)46Db complementation group corresponds to TER94, even though l(2)46Db[2] shows a complex complementation pattern with other TER94 alleles.

                (Kahsai and Cook, 2018)
                Nomenclature History
                Source for database identify of
                Nomenclature comments
                Etymology
                Synonyms and Secondary IDs (51)
                Reported As
                Symbol Synonym
                (VCP)/p97
                (Yamaguchi et al., 2021)
                22.26
                (Currie and Sullivan, 1994)
                7.12
                (Currie and Sullivan, 1994)
                Apple
                (Sackerson et al., 1999)
                BcDNA.GM02885
                (Tsang, 1999.3.2)
                BcDNA:GM02885
                CDC48
                (Dorer et al., 2006)
                CG2331
                (Yamaguchi and Takashima, 2018, Kolkhof et al., 2017, Hosono et al., 2015, Rosa-Ferreira et al., 2015, Schertel et al., 2013, Christis and Munro, 2012, Cammarato et al., 2011, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Perkins et al., 2009, Pisa et al., 2009, Hughes et al., 2008, Pflieger et al., 2008, Dorer et al., 2006, Lundgren et al., 2005, Dunne et al., 2002)
                DmTER94
                (Frohlich, 2001)
                I
                (Bour et al., 1995)
                Q7KN62
                (Sap et al., 2017)
                TER94
                (Szlanka et al., 2024, Wang et al., 2024, Zappia et al., 2024, Aromolaran et al., 2023, Kyrchanova et al., 2023, Ecovoiu et al., 2022, Gorsi et al., 2022, Pun et al., 2022, Tendulkar et al., 2022, Baek et al., 2021, Chang et al., 2021, Johnson et al., 2021, Park et al., 2021, Sureka and Mishra, 2021, Watanabe and Riddle, 2021, Zhang et al., 2021, Gupta and Stocker, 2020, Kitani-Morii and Noto, 2020, Srinivasan and Mishra, 2020, Hall et al., 2019, Kurshakova et al., 2019, Meltzer, 2019-, Meltzer et al., 2019, Tsakiri et al., 2019, Azuma et al., 2018, Kahsai and Cook, 2018, Yamaguchi and Takashima, 2018, Zhang et al., 2018, Zhang et al., 2018, Bussmann and Storkebaum, 2017, Galluzzi et al., 2017, Hsu and Drummond-Barbosa, 2017, Hu et al., 2017.6.13, Ji et al., 2017, Miller, 2017.3.9, Paiardi et al., 2017, Sekiya et al., 2017, Transgenic RNAi Project members, 2017-, Ye et al., 2017, Viswanathan et al., 2016, Dent et al., 2015, Li et al., 2015, Bischof, 2014.10.20, Chen et al., 2014, Delabaere et al., 2014, Lee et al., 2014, Liang et al., 2014, Mukherjee et al., 2014, Piccirillo et al., 2014, Santhanam et al., 2014, Bonke et al., 2013, Fujioka et al., 2013, Kwon et al., 2013, Kwon et al., 2013, O'Sullivan et al., 2013, Schertel et al., 2013, Chan et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Van Bortle et al., 2012, Chang et al., 2011, Franco et al., 2011, Friedman et al., 2011, Grimberg et al., 2011, Liu et al., 2011, Dekanty et al., 2010, Kallappagoudar et al., 2010, Ritson et al., 2010, Avery et al., 2009, Carpenter et al., 2009, Fujioka et al., 2009, Nahvi et al., 2009, Pisa et al., 2009, Tan et al., 2009, Fisher et al., 2008, Lighthouse et al., 2008, Thomson et al., 2008, Buszczak et al., 2007, Stuart et al., 2007, Beller et al., 2006, Dorer et al., 2006, Lundgren et al., 2005, Leon and McKearin, 1999)
                Ter 94
                (Sankaranarayanan and Weil, 2020)
                Ter94
                (Deshpande et al., 2025, Ramesh et al., 2023, Evans et al., 2021, Rai et al., 2021, Lu et al., 2020, Wang et al., 2016, Hao et al., 2015, Johnson et al., 2015, Reim et al., 2014, Li et al., 2013, Zhang et al., 2013, Zhang et al., 2013, Hare et al., 2008, Dunne and Rabouille, 2001, Sackerson, 2001.1.17)
                Tera
                VCP
                (Prifti et al., 2025, Geng et al., 2024, Li et al., 2024, Rui, 2024, Thulasidharan et al., 2024, Butsch et al., 2023, Butsch et al., 2023, Li et al., 2023, Johnson et al., 2021, Johnson et al., 2021, Rimal et al., 2021, Wall et al., 2021, Gonzalez and Wang, 2020, Li et al., 2020, Xu et al., 2020, Casci et al., 2019, Portela et al., 2019, Blount et al., 2018, Ristic et al., 2018, Zülbahar et al., 2018, Rode et al., 2017, Wang et al., 2016, Yaniv and Schuldiner, 2016, Casci and Pandey, 2015, Johnson et al., 2015, Kuang et al., 2014, Rumpf et al., 2014, O'Sullivan et al., 2013, Nezis, 2012, Rumpf et al., 2011, Griciuc et al., 2010, Avery et al., 2009, Lundgren et al., 2005)
                VCP ATPase
                (Lundgren et al., 2005)
                VCP/p97
                (Olarte et al., 2020, Wojcik et al., 2004)
                VCP1
                (Lieber et al., 2019)
                VIII
                (O'Brien et al., 1994)
                Vcp
                (Spradling et al., 1999)
                anon-WO2004063362.65
                anon-WO2004063362.67
                cdc48
                (Péan and Dionne, 2014, Lundgren et al., 2005)
                dTERA
                (McKearin, 1998.3.18)
                dVCP
                (Chalmers et al., 2023, Johnson et al., 2021, Wu et al., 2019, Fujita et al., 2013, Fujita et al., 2013, Kim et al., 2013, Panda et al., 2013, Romano et al., 2012, Ritson et al., 2010)
                dmTERA
                (Chandrasekaran et al., 1998, Leon and McKearin, 1998, Patel and Latterich, 1998)
                dvcp
                (Rumpf et al., 2011)
                l(2)03775
                (Beaton, 2000.1.31, Meister and Braun, 1995.10, BDGP Project Members, 1994-1999)
                l(2)46CFf
                l(2)46CFs
                l(2)46Ch
                l(2)46Db
                (Kahsai and Cook, 2018)
                p97
                (Loboda et al., 2016, Péan and Dionne, 2014, Piccirillo et al., 2014, Grimberg et al., 2011, Beskow et al., 2009, Dorer et al., 2006, Lundgren et al., 2005)
                pTER94
                (Wojcik et al., 2004)
                ter94
                (Braems et al., 2021, Layalle et al., 2021, Liguori et al., 2021, Liguori et al., 2021, Yamaguchi et al., 2021, Kushimura et al., 2018, Vandal et al., 2018, Azuma et al., 2014, Griciuc et al., 2010, Koike et al., 2010, Xiao and Ruden, 2003, Dunne et al., 2002, Higashiyama et al., 2002, Xiao et al., 2002, Goldstein et al., 2001, Ruden et al., 2000, Ruden et al., 1999)
                vcp
                (Xie et al., 2021, Zhang et al., 2017, Huang et al., 2016, Rumpf et al., 2014)
                Name Synonyms
                Complementation group I
                (Goldstein et al., 2001, Bour et al., 1995)
                Group VIII
                (O'Brien et al., 1994)
                TER94
                (Cammarato et al., 2011)
                TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE TER94
                (Hull et al., 2015)
                Ter94
                (Hare et al., 2008)
                Transitional Endoplasmic Reticulum 94
                (Thomson et al., 2008)
                Transitional endoplasmic reticulum 94
                (Liu et al., 2011)
                Transitional endoplasmic reticulum ATPase
                (McKearin, 1998.3.18)
                VCP
                (Lu and Guo, 2020)
                Valosin containing protein
                (Kuang et al., 2014)
                Valosin-Containing Protein
                (Rumpf et al., 2014)
                Valosin-containing protein
                (Nezis, 2012, Rumpf et al., 2011, Spradling et al., 1999)
                lethal (2) 46Db
                (O'Brien et al., 1994)
                p97
                (Gonzalez and Wang, 2020)
                p97 ATPase
                (Grimberg et al., 2011)
                ter94
                (Higashiyama et al., 2002)
                transitional endoplasmic reticulum ATPase
                (Ye et al., 2017, Pinter, 1998.2.8)
                valosin containing protein
                (Xu et al., 2020)
                valosin-containing protein
                (Avery et al., 2009)
                Secondary FlyBase IDs
                • FBgn0014986
                • FBgn0261014
                • FBgn0024923
                • FBgn0010554
                • FBgn0015484
                • FBgn0019709
                • FBgn0019722
                • FBgn0025353
                • FBgn0027618
                • FBgn0064213
                • FBgn0082213
                • FBgn0082214
                • FBgn0024280
                Datasets (0)
                Study focus (0)
                Experimental Role
                Project
                Project Type
                Title
                Study result (0)
                Result
                Result Type
                Title
                External Crossreferences and Linkouts ( 79 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                Other crossreferences
                AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                FlyBase CV Report -
                InterPro - A database of protein families, domains and functional sites
                KEGG Genes - Molecular building blocks of life in the genomic space.
                MARRVEL_MODEL - MARRVEL (model organism gene)
                PDB - An information portal to biological macromolecular structures
                Linkouts
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                References (270)