FlyBase Gene Report: Dmel\Dhc16F

General Information

Symbol

Dmel\Dhc16F

Species

D. melanogaster

Name

Dynein heavy chain at 16F

Annotation Symbol

CG7092

Feature Type

protein_coding_gene

FlyBase ID

FBgn0283476

Gene Model Status

Current

Stock Availability

4 publicly available

Enzyme Name (EC)

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Also Known As

Dhc

Key Links

Genomic Location

Cytogenetic map

16F6-16F6

Sequence location

X:18,064,483..18,078,472 [+]

Recombination map

1-59

RefSeq locus

NC_004354 REGION:18064483..18078472

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR035699

(InterPro Project Members, 2004-)

enables dynein intermediate chain binding

inferred from electronic annotation with InterPro:IPR026983

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000743491

(GO Reference Genome Project, 2011-)

enables dynein light intermediate chain binding

inferred from biological aspect of ancestor with PANTHER:PTN000743491

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR026983

(InterPro Project Members, 2004-)

enables minus-end-directed microtubule motor activity

inferred from sequence or structural similarity with UniProtKB:P45444

(Gene Ontology Curators, 2002-)

inferred from biological aspect of ancestor with PANTHER:PTN000743491

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR004273

(InterPro Project Members, 2004-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in flagellated sperm motility

inferred from expression pattern

(Zur Lage et al., 2021)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in cilium movement involved in cell motility

inferred from biological aspect of ancestor with PANTHER:PTN000743491

(GO Reference Genome Project, 2011-)

involved_in microtubule-based movement

inferred from electronic annotation with InterPro:IPR004273, InterPro:IPR026983

(InterPro Project Members, 2004-)

inferred from electronic annotation with InterPro:IPR026983

(InterPro Project Members, 2004-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

is_active_in sperm flagellum

inferred from direct assay

(Zur Lage et al., 2021)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in 9+2 motile cilium

inferred from biological aspect of ancestor with PANTHER:PTN000743491

(GO Reference Genome Project, 2011-)

part_of dynein complex

inferred from biological aspect of ancestor with PANTHER:PTN000743491

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR004273, InterPro:IPR026983

(InterPro Project Members, 2004-)

inferred from electronic annotation with InterPro:IPR026983

(InterPro Project Members, 2004-)

Gene Group (FlyBase)

AXONEMAL INNER ARM DYNEIN HEAVY CHAINS

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

minus-end-directed microtubule motor activity

Summaries

Gene Group (FlyBase)

AXONEMAL INNER ARM DYNEIN HEAVY CHAINS -: Dynein heavy chains are minus end-directed microtubule motor proteins. Axonemal dynein complexes interact with adjacent microtubules in the axoneme. Coordinated binding and release of the axonemal dyneins slide the microtubules relative to each other causing the axoneme to bend driving ciliary and flagellar motion. Axonemal inner arm dynein heavy chains are the microtubule-binding motor protein of the dynein inner arm. (Adapted from FBrf0230280).

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

cvl-6: crossveinless like 6

Removes crossveins. Developmental sequence differs from that of cv and cvl-5; longitudinal veins form in time and manner expected of wild type; cvl-6 differs in that the wings begin vein development with a joining of the wing surfaces through the crossvein region; partial repair is accomplished by a secondary developmental sequence, including withdrawal of cell processes joining the wing surfaces at this position and subsequent reorganization of a crossvein around this gap (Mohler and Swedberg, 1964, Genetics 50: 1403-19).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Dhc16F for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VWZ3)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.53

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Dhc16F-RA

FBtr0074509

NM_078670

12442

4081

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Dhc16F-PA

FBpp0074283

469.1

4081

6.29

Q9VWZ3

NP_523394

AAF48792

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dhc16F using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Dhc16F_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

4.71

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 14 -- 16

chordotonal neuron

(Zur Lage et al., 2019)

mutational analysis

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | male

spermatogonium

Comment: data from FlyAtlas

(Zur Lage et al., 2019)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

(Rasmusson et al., 1994)

adult stage

testis

(Rasmusson et al., 1994)

adult stage | male

(Rasmusson et al., 1994)

Additional Descriptive Data

As part of a survey of ciliary motility gene homologs in Drosophila, expression of Dhc16F was assayed in motile ciliated cell types. Expression was observed in both chordotonal neurons and testis (sperm).

(Zur Lage et al., 2019)

Dhc16F transcripts are expressed in male testis and at lower levels in and embryos.

(Rasmusson et al., 1994)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood | male -- day 7 of adulthood | male

spermatozoon

(Wasbrough et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

is_active_in sperm flagellum

inferred from direct assay

(Zur Lage et al., 2021)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Dhc16F in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Dhc16F

View exonic expression by tissue for Dmel\Dhc16F

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0013809

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32785/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0283476

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0013809

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0283476

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7092

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 4 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 1 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Dhc16F

Transgenic constructs containing regulatory region of Dhc16F

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 9 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal | recessive

partially lethal - majority die, with Scer\GAL4^pnr-MD237

Dhc16F^GD12125

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Dhc16F^GD12125

viable, with Scer\GAL4^Mef2.PR

Dhc16F^GD12125

viable, with Scer\GAL4^tin.CΔ4

Dhc16F^GD12125

Sterility

Allele

male sterile, with Scer\GAL4^VP16.bam

Dhc16F^GD12125

Other Phenotypes

Allele

abnormal locomotor behavior | adult stage, with Scer\GAL4^sca.PU

Dhc16F^GD12125

some die during pupal stage, with Scer\GAL4^pnr-MD237

Dhc16F^GD12125

visible, with Scer\GAL4^pnr-MD237

Dhc16F^GD12125

visible | recessive

Dhc16F¹

Phenotype manifest in

Allele

crossvein

mesonotum, with Scer\GAL4^pnr-MD237

Dhc16F^GD12125

trichogen cell, with Scer\GAL4^pnr-MD237

Dhc16F^GD12125

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (16)

Hsap\DNAH6

13 of 14

Yes

Hsap\DNAH1

6 of 14

Yes

5 of 14

5 of 14

5 of 14

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

Yes

Hsap\DYNC2H1

2 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (15)

Rnor\Dnah6

12 of 14

Yes

Rnor\Dnah1

6 of 14

Yes

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

Yes

Rnor\Dnah10

1 of 14

Rnor\Dnah14

1 of 14

Yes

Mus musculus (laboratory mouse) (19)

Mmus\Dnah6

13 of 14

Yes

Mmus\Dnah1

6 of 14

Yes

5 of 14

5 of 14

5 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

Yes

Mmus\Map1lc3b

1 of 14

Xenopus tropicalis (Western clawed frog) (23)

Xtro\dnah6

10 of 13

Yes

Xtro\dnah12

3 of 13

Xtro\dnah1

2 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (15)

Drer\dnah6

11 of 14

Yes

Drer\dnah1

5 of 14

Yes

5 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

Yes

Drer\dnah3

1 of 14

Drer\dync1h1

1 of 14

Drer\LOC110439139

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (4)

Cele\dhc-1

4 of 14

Yes

Cele\che-3

3 of 14

Cele\dhc-3

2 of 14

Cele\dhc-4

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (12)

Agam\AgaP_AGAP003226

12 of 12

Yes

Agam\AgaP_AGAP002009

4 of 12

Agam\AgaP_AGAP009550

4 of 12

Yes

4 of 12

4 of 12

3 of 12

3 of 12

3 of 12

2 of 12

2 of 12

2 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\DYN1

4 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\dhc1

4 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Dhc16F. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (14)

8 of 13

8 of 13

8 of 13

8 of 13

7 of 13

7 of 13

7 of 13

7 of 13

btv

6 of 13

6 of 13

6 of 13

6 of 13

3 of 13

sac

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

DNAH1; dynein axonemal heavy chain 1

model of spermatogenic failure 18

IEA

(FlyBase, 2019-)

model of primary ciliary dyskinesia 37

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

DNAH6; dynein axonemal heavy chain 6

13 of 14

603336

DNAH1; dynein axonemal heavy chain 1

6 of 14

603332

DNAH3; dynein axonemal heavy chain 3

5 of 14

603334

DNAH7; dynein axonemal heavy chain 7

5 of 14

610061

CILIARY DYSKINESIA, PRIMARY, 50; CILD50

DNAH12; dynein axonemal heavy chain 12

5 of 14

603340

SPERMATOGENIC FAILURE 100; SPGF100

DNAH2; dynein axonemal heavy chain 2

4 of 14

603333

SPERMATOGENIC FAILURE 45; SPGF45

spermatogenic failure 45

DNAH9; dynein axonemal heavy chain 9

4 of 14

603330

CILIARY DYSKINESIA, PRIMARY, 40; CILD40

primary ciliary dyskinesia 40

DNAH11; dynein axonemal heavy chain 11

4 of 14

603339

CILIARY DYSKINESIA, PRIMARY, 7; CILD7

primary ciliary dyskinesia 7

DNAH17; dynein axonemal heavy chain 17

4 of 14

610063

SPERMATOGENIC FAILURE 39; SPGF39

spermatogenic failure 39

DNAH5; dynein axonemal heavy chain 5

3 of 14

603335

CILIARY DYSKINESIA, PRIMARY, 3; CILD3

primary ciliary dyskinesia 3

DNAH8; dynein axonemal heavy chain 8

3 of 14

603337

SPERMATOGENIC FAILURE 46; SPGF46

spermatogenic failure 46

DNAH10; dynein axonemal heavy chain 10

3 of 14

605884

SPERMATOGENIC FAILURE 56; SPGF56

spermatogenic failure 56

DYNC1H1; dynein cytoplasmic 1 heavy chain 1

3 of 14

600112

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Dhc16F - Mis12

anti tag coimmunoprecipitation, peptide massfingerprinting

(Przewloka et al., 2007)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

MIST (protein-protein) - An integrated Molecular Interaction Database

32785

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Motor proteins

Class of Gene

gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-59

Cytogenetic map

16F6-16F6

Sequence location

X:18,064,483..18,078,472 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

16F6-16F6

Limits computationally determined from genome sequence between P{EP}EP970 and P{EP}ari-1^EP317

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

16F-16F

(Li, 1993)

16F-16F

(determined by in situ hybridisation)

(Rasmusson et al., 1994)

Experimentally Determined Recombination Data

Location

1-59

(FlyBase, 2016)

1-58.9

(Comeron et al., 2012)

(Li, 1993)

1-59.1

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (4)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

63069

w¹¹¹⁸ Dhc16F^M33

63070

w¹¹¹⁸ Dhc16F^M146/FM7c

98547

w^* TI{KozakGAL4}Dhc16F^{CR70559-KO-kG4}

VDRC

v27837

w¹¹¹⁸; P{GD12125}v27837

Genomic Clones (20)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (5)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LP05023

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0283476

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Spindle pole movements in embryos are directed by a temporally coordinated balance of forces generated by three mitotic motors; cytoplasmic dynein, Klp61F and ncd. Dynein acts to move the poles apart throughout mitosis, and this activity is augmented by Klp61F after the fenestration of the nuclear envelope, which occurs at the onset of prometaphase. ncd generates forces that pull the poles together between interphase and metaphase, antagonising the activity of both cytoplasmic dynein and Klp61F and serving as a brake for spindle assembly.

(Sharp et al., 2000)

Identification: PCR screen for Dynein heavy chain genes.

(Kurek et al., 1998)

Dhc16F has been cloned and characterised.

(Rasmusson et al., 1994)

Relationship to Other Genes

Source for database merge of

Source for merge of: Dhc16F cvl-6

(Ray, 2015.6.29)

Additional comments

Based on the map position and crossveinless phenotype, Dhc16F likely corresponds to the 'cvl-6' locus of Mohler.

(Ray, 2015.6.29)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

CG7092

(Hosono et al., 2015, Begun et al., 2007, Przewloka et al., 2007, Wickstead and Gull, 2007, Goldstein and Gunawardena, 2000)

DHC

(Cytrynbaum et al., 2003, Sharp et al., 2000)

DHC9

(Kollmar, 2015.9.15)

Dhc

(Johnstone and Lasko, 2001, Starr et al., 1998)

Dhc16F

(Adashev et al., 2022, Banho et al., 2021, Zur Lage et al., 2019, Gene Disruption Project members, 2018-, Ray, 2015.6.29, Newton et al., 2012, Senthilan et al., 2012, Rees et al., 2011, Wasbrough et al., 2010, Begun et al., 2007, Robida et al., 2007)

atoll

(Ray, 2015.6.29)

cvl-6

dhc

(Basto et al., 2004)

Name Synonyms

Dynein heavy chain at 16F

crossveinless-like 6

dynein-related heavy chain polypeptide

(Li, 1993)

Secondary FlyBase IDs

FBgn0013809
FBgn0004671

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 47 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32785

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VWZ3

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VWZ3

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0013809

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32785/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0283476

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0283476

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG7092

MARRVEL_MODEL - MARRVEL (model organism gene)

32785

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0283476

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Dhc16F_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0013809

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0283476

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7092

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC000119

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Motor proteins

MIST (protein-protein) - An integrated Molecular Interaction Database

32785

References (50)

The following external sites may use different assemblies or annotations than FlyBase.

4.71

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