FlyBase Gene Report: Dmel\Gfr

General Information

Symbol

Dmel\Gfr

Species

D. melanogaster

Name

Golgi GDP-fucose transporter

Annotation Symbol

CG9620

Feature Type

protein_coding_gene

FlyBase ID

FBgn0265351

Gene Model Status

Current

Stock Availability

8 publicly available

Gene Summary

Golgi GDP-fucose transporter (Gfr) encodes a Golgi transmembrane transporter that specifically imports GDP-L-fucose from the cytosol into the Golgi lumen where it is used for the fucosylation of N- and O-glycans. [Date last reviewed: 2024-09-26] (FlyBase Gene Snapshot)

All Summaries

Also Known As

nac

Key Links

Genomic Location

Cytogenetic map

84F10-84F10

Sequence location

3R:8,302,686..8,304,023 [-]

Recombination map

3-48

RefSeq locus

NT_033777 REGION:8302686..8304023

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (21 terms)

Molecular Function (9 terms)

Terms Based on Experimental Evidence (8 terms)

CV Term

Evidence

References

enables GDP-fucose transmembrane transporter activity

inferred from direct assay

(Ishikawa et al., 2005, Luehn et al., 2004)

inferred from mutant phenotype

(Geisler et al., 2012)

NOT enables CMP-N-acetylneuraminate transmembrane transporter activity

inferred from direct assay

(Ishikawa et al., 2005)

NOT enables GDP-mannose transmembrane transporter activity

inferred from direct assay

(Ishikawa et al., 2005)

NOT enables UDP-galactose transmembrane transporter activity

inferred from direct assay

(Ishikawa et al., 2005)

NOT enables UDP-glucose transmembrane transporter activity

inferred from direct assay

(Ishikawa et al., 2005)

NOT enables UDP-glucuronate transmembrane transporter activity

inferred from direct assay

(Ishikawa et al., 2005)

NOT enables UDP-N-acetylgalactosamine transmembrane transporter activity

inferred from direct assay

(Ishikawa et al., 2005)

NOT enables UDP-N-acetylglucosamine transmembrane transporter activity

inferred from direct assay

(Ishikawa et al., 2005)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables antiporter activity

inferred from biological aspect of ancestor with PANTHER:PTN002540544

(GO Reference Genome Project, 2011-)

enables GDP-fucose transmembrane transporter activity

inferred from biological aspect of ancestor with PANTHER:PTN000123147

(GO Reference Genome Project, 2011-)

Biological Process (9 terms)

Terms Based on Experimental Evidence (9 terms)

CV Term

Evidence

References

involved_in GDP-fucose import into Golgi lumen

inferred from direct assay

(Geisler et al., 2012)

inferred from mutant phenotype

(Geisler et al., 2012)

involved_in GDP-fucose transmembrane transport

inferred from direct assay

(Ishikawa et al., 2005, Luehn et al., 2004)

NOT involved_in CMP-N-acetylneuraminate transmembrane transport

inferred from direct assay

(Ishikawa et al., 2005)

NOT involved_in GDP-mannose transmembrane transport

inferred from direct assay

(Ishikawa et al., 2005)

NOT involved_in UDP-galactose transmembrane transport

inferred from direct assay

(Ishikawa et al., 2005)

NOT involved_in UDP-glucose transmembrane transport

inferred from direct assay

(Ishikawa et al., 2005)

NOT involved_in UDP-glucuronate transmembrane transport

inferred from direct assay

(Ishikawa et al., 2005)

NOT involved_in UDP-N-acetylgalactosamine transmembrane transport

inferred from direct assay

(Ishikawa et al., 2005)

NOT involved_in UDP-N-acetylglucosamine transmembrane transport

inferred from direct assay

(Ishikawa et al., 2005)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in GDP-fucose import into Golgi lumen

inferred from biological aspect of ancestor with PANTHER:PTN000123147

(GO Reference Genome Project, 2011-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

located_in Golgi apparatus

inferred from direct assay

(Ishikawa et al., 2010, Ishikawa et al., 2005)

located_in Golgi membrane

inferred from direct assay

(Geisler et al., 2012)

located_in Golgi-associated vesicle

inferred from direct assay

(Luehn et al., 2004)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in Golgi membrane

inferred from biological aspect of ancestor with PANTHER:PTN002540544

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

SLC35 FAMILY OF NUCLEOTIDE SUGAR TRANSPORTERS

Pathway (FlyBase)

DE NOVO GDP-FUCOSE BIOSYNTHESIS

Protein Family (UniProt)

Belongs to the TPT transporter family. SLC35C subfamily. (Q9VHT4)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

SLC35 FAMILY OF NUCLEOTIDE SUGAR TRANSPORTERS -: Solute carrier family 35 (SLC35) members transport nucleotide sugars and adenosine 3'-phospho 5'-phosphosulfate from the cytosol to the endoplasmic reticulum and the Golgi apparatus. These sugars serve as substrates for the glycosylation and sulfation of proteins, lipids and proteoglycans. (Adapted from FBrf0221674, FBrf0193270 and PMID:23506892).

Pathway (FlyBase)

DE NOVO GDP-FUCOSE BIOSYNTHESIS -: In the 'de novo' GDP-L-fucose biosynthetic pathway, GDP-L-fucose is produced from GDP-D-mannose via a 2-step process in the cytosol and then imported in the Golgi apparatus where fucosyltransferases use it as a fucose donor for the N- and O-fucosylation of proteins and lipids.This is the only pathway for GDP-L-fucose biosynthesis in D. melanogaster as the enzymes involved in the salvage pathway - which uses L-fucose as a substrate - are not present in the Dmel genome. (Adapted from FBrf0144936.)

Protein Function (UniProtKB)

Involved in GDP-fucose import from the cytoplasm into the Golgi lumen (PubMed:15530860, PubMed:22745127). Plays a major role in the fucosylation of N-glycans (PubMed:15530860, PubMed:22745127). Functions redundantly with Efr in the O-fucosylation of Notch, positively regulating Notch signaling (PubMed:19948734).

(UniProt, Q9VHT4)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

nac: neuronally-altered-carbohydrate (F. Katz)

Mutants show alteration or loss of a normally neuron-specific glycoconjugate; staining by anti-HRP antibodies in imaginal and adult neural tissue is eliminated. At 25 the mutant flies are viable and fertile; nac/nac females, however are sterile at 18. Under heat stress (37 for five minutes) they show abnormal jittery behavior. Developmental abnormalities, including defects in the assembly of the ommatidia and in the formation of the wing, appear at 18 in the homozygous offspring of heterozygous parents. Maternal effect embryos show loss of the anti-HRP glycan determinant and are lethal.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Gfr for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VHT4)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.45

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Gfr-RA

FBtr0081863

NM_141525

1225

337

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Gfr-PA

FBpp0081352

38.1

337

9.24

Q9VHT4

NP_649782

AAF54215

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Gfr using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

nac_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.53

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in Golgi apparatus

inferred from direct assay

(Ishikawa et al., 2010, Ishikawa et al., 2005)

located_in Golgi membrane

inferred from direct assay

(Geisler et al., 2012)

located_in Golgi-associated vesicle

inferred from direct assay

(Luehn et al., 2004)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Gfr in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Gfr

View exonic expression by tissue for Dmel\Gfr

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40981/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0265351

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0037567

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0265351

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9620

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 7 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 11 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Gfr

Transgenic constructs containing regulatory region of Gfr

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3R)Exel6147

(Ryder, 2004.4.26)

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die during embryonic stage, with Scer\GAL4^elav.PU

Gfr^UAS.cGa

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Gfr^GD2857

viable, with Scer\GAL4^Mef2.PR

Gfr^GD2857

viable, with Scer\GAL4^pnr-MD237

Gfr^GD2857

viable, with Scer\GAL4^tin.CΔ4

Gfr^GD2857

Sterility

Allele

female sterile

Gfr¹

female sterile | recessive | cold sensitive

Gfr¹

Other Phenotypes

Allele

abnormal behavior | heat sensitive

Gfr¹

abnormal behavior | recessive

Gfr¹

abnormal body color, with Scer\GAL4^69B

Gfr^RNAi.UAS.cYa

abnormal grooming behavior

Gfr¹

bang sensitive | heat sensitive

Gfr¹

some die during embryonic stage, with Scer\GAL4^elav.PU

Gfr^UAS.cGa

visible | dominant | maternal effect

Gfr¹

visible | dominant | paternal effect

Gfr¹

visible | recessive | cold sensitive

Gfr¹

Phenotype manifest in

Allele

adult abdomen, with Scer\GAL4^69B

Gfr^RNAi.UAS.cYa

ommatidium | maternal effect

Gfr¹

ommatidium | paternal effect

Gfr¹

sensory neuron & wing

Gfr¹

wing & sensory organ cell | ectopic

wing | cold sensitive

Gfr¹

wing | heat sensitive

wing | heat sensitive (with Df(3R)Exel6147)

wing | heat sensitive (with Gfr^Gfr-1)

Gfr^Gfr-2

wing | heat sensitive (with Gfr^Gfr-2)

Gfr^Gfr-1

wing | maternal effect

Gfr¹

wing | paternal effect

Gfr¹

wing vein L3

Gfr^Gfr-2

wing vein L3 | heat sensitive

Gfr^Gfr-1

wing vein L4

Gfr^Gfr-2

wing vein L4 | heat sensitive

Gfr^Gfr-1

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (10)

Hsap\SLC35C1

14 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (9)

Rnor\Slc35c1

14 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (9)

Mmus\Slc35c1

13 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (7)

Xtro\slc35c1

11 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Danio rerio (Zebrafish) (10)

Drer\slc35c1

13 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (5)

Cele\nstp-10

13 of 14

Yes

Cele\nstp-9

10 of 14

Yes

Cele\bus-12

1 of 14

Yes

Cele\sqv-7

1 of 14

Cele\Y47G6A.7

1 of 14

Anopheles gambiae (African malaria mosquito) (4)

Agam\AgaP_AGAP002393

12 of 12

Yes

Agam\AgaP_AGAP000544

1 of 12

Agam\AgaP_AGAP005200

1 of 12

Agam\AgaP_AGAP005537

1 of 12

Arabidopsis thaliana (thale-cress) (41)

Atha\AT1G12500

2 of 13

Yes

Atha\AT1G77610

2 of 13

Yes

Atha\AT3G10290

2 of 13

Yes

Atha\AT3G11320

2 of 13

Yes

Atha\AT5G04160

2 of 13

Yes

Atha\AT5G05820

2 of 13

Yes

Atha\GONST3

2 of 13

Yes

Atha\GONST5

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (5)

Scer\HVG1

1 of 13

Yes

Scer\SLY41

1 of 13

Yes

Scer\VRG4

1 of 13

Yes

Scer\YJL193W

1 of 13

Yes

Scer\YMD8

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (4)

Spom\SPAC22F8.04

9 of 12

Yes

Spom\SPAC22E12.01

1 of 12

Spom\SPBC83.11

1 of 12

Spom\vrg4

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Gfr. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (3)

CG14621

3 of 13

CG14971

3 of 13

frc

3 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

congenital disorder of glycosylation, type IIc

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

Gfr^Gfr-1

model of congenital disorder of glycosylation type II

CEA

(Ishikawa et al., 2005)

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

SLC35C1; solute carrier family 35 member C1

model of congenital disorder of glycosylation type IIc

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SLC35C1; solute carrier family 35 member C1

14 of 14

SOLUTE CARRIER FAMILY 35, MEMBER C1; SLC35C1

CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIc; CDG2C

congenital disorder of glycosylation type IIc

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Dmel gene

Ortholog showing functional complementation

Supporting References

Gfr

Hsap\SLC35C1

(Ishikawa et al., 2005)

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0265351

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

DE NOVO GDP-FUCOSE BIOSYNTHESIS

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-48

Cytogenetic map

84F10-84F10

Sequence location

3R:8,302,686..8,304,023 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

84F10-84F10

Limits computationally determined from genome sequence between P{PZ}Mcm2^rL074 and P{EP}EP833

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-48

(FlyBase, 2016)

3-44.9

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (8)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

6369

st¹ Gfr¹

6387

st¹ Gfr⁴ e^s/TM6

15517

y¹ w^67c23; P{EPgy2}Gfr^EY01553

78208

y¹ sc^* v¹ sev²¹; P{TOE.GS01386}attP40

83441

y¹ sc^* v¹ sev²¹; P{TKO.GS03468}attP40/CyO

VDRC

v105410

P{KK101122}VIE-260B

v42623

w¹¹¹⁸; P{GD2857}v42623

v318805

PBac{fTRG01221.sfGFP-TVPTBF}VK00002

Genomic Clones (10)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (35)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE40567

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0265351

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RE52321

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Gfr may transport GDP-fucose from the cytosol into the golgi.

(Ishikawa et al., 2005)

N signaling deteriorates in Gfr mutants.

(Ishikawa et al., 2005)

The phenotypes of Fas1, Fas2, Fas3 and nac mutants were analysed in the developing wing: the axon tracts in the CNS for the most part remain unaltered, and none of the phenotypes are 100% penetrant, indicating a fine-tuning role for these molecules in both the PNS and CNS.

(Whitlock, 1993)

A mutation in nac affects anti-horse radish peroxidase (anti-HRP) epitope expression in imaginal nervous tissue causing behavioural defects.

(Katz et al., 1988)

Relationship to Other Genes

Source for database merge of

Source for merge of: nac Gfr

(Geisler et al., 2012)

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Gfr nac

(Ishikawa et al., 2010)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (9)

Reported As

Name Synonyms

Gfr

Golgi GDP-fucose transporter

(Walski et al., 2017, Ishikawa et al., 2010, Ishikawa et al., 2005)

neurally altered carbohydrate

(Walski et al., 2017)

neuronally altered carbohydrate

neuronally-altered-carbohydrate

(Lindsley and Zimm, 1992)

Secondary FlyBase IDs

FBgn0002918
FBgn0037567

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 28 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40981

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VHT4

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VHT4

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VHT4

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40981/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0265351

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0265351

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG9620

MARRVEL_MODEL - MARRVEL (model organism gene)

40981

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0265351

DroID - A comprehensive database of gene and protein interactions.

FBgn0265351

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

nac_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0037567

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0265351

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9620

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0265351

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC012326

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (51)

The following external sites may use different assemblies or annotations than FlyBase.

-0.53

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