FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\kibra
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General Information
Symbol
Dmel\kibra
Species
D. melanogaster
Name
kibra
Annotation Symbol
CG33967
Feature Type
protein_coding_gene
FlyBase ID
FBgn0262127
Gene Model Status
Current
Stock Availability
45 publicly available
Gene Summary
Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Kibra acts synergistically along with Ex and Mer to regulate the Hippo signaling pathway. (UniProt, Q9VFG8)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

kib, Kbr, l(3)02404

Key Links
Genomic Location
Cytogenetic map
88D1-88D1
Sequence location
Recombination map
3-56
RefSeq locus
NT_033777 REGION:14697689..14724261
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (20 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables protein binding
inferred from physical interaction with UniProtKB:Q07436
(Yu et al., 2010)
inferred from physical interaction with UniProtKB:Q24564
(Yu et al., 2010)
inferred from physical interaction with UniProtKB:Q8T0S6
(Yu et al., 2010)
inferred from physical interaction with UniProtKB:Q9VCR6
(Yu et al., 2010)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables kinase binding
inferred from biological aspect of ancestor with PANTHER:PTN002308339
(GO Reference Genome Project, 2011-)
enables molecular adaptor activity
inferred from biological aspect of ancestor with PANTHER:PTN002308339
(GO Reference Genome Project, 2011-)
Biological Process (11 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
involved_in border follicle cell migration
inferred from mutant phenotype
(Lucas et al., 2013)
involved_in compound eye morphogenesis
inferred from genetic interaction with FLYBASE:crb; FB:FBgn0259685
(Ling et al., 2010)
involved_in negative regulation of glial cell proliferation
inferred from mutant phenotype
(Reddy and Irvine, 2011)
involved_in negative regulation of organ growth
inferred from mutant phenotype
(Baumgartner et al., 2010)
involved_in positive regulation of apoptotic process
inferred from mutant phenotype
(Baumgartner et al., 2010)
involved_in positive regulation of hippo signaling
inferred from mutant phenotype
(Tokamov et al., 2023, Fletcher et al., 2018, Su et al., 2017, Fletcher et al., 2015, Baumgartner et al., 2010, Genevet et al., 2010)
inferred from genetic interaction with FLYBASE:yki; FB:FBgn0034970
(Baumgartner et al., 2010)
inferred from genetic interaction with FLYBASE:hpo; FB:FBgn0261456
(Baumgartner et al., 2010, Genevet et al., 2010, Yu et al., 2010)
inferred from genetic interaction with FLYBASE:l(2)gl; FB:FBgn0002121
(Parsons et al., 2014)
inferred from genetic interaction with FLYBASE:ex; FB:FBgn0004583
(Genevet et al., 2010, Yu et al., 2010)
inferred from genetic interaction with FLYBASE:Mer; FB:FBgn0086384
(Genevet et al., 2010, Yu et al., 2010)
inferred from genetic interaction with FLYBASE:slmb; FB:FBgn0283468
(Tokamov et al., 2021)
inferred from direct assay
(Yu et al., 2010)
inferred from genetic interaction with FLYBASE:sav; FB:FBgn0053193
(Yu et al., 2010)
involved_in R8 cell development
(Sang et al., 2021)
involved_in R8 cell fate specification
inferred from mutant phenotype
(Jukam and Desplan, 2011)
involved_in regulation of DNA-templated transcription
inferred from direct assay
(Baumgartner et al., 2010)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in cell migration
inferred from biological aspect of ancestor with PANTHER:PTN002308339
(GO Reference Genome Project, 2011-)
involved_in negative regulation of organ growth
inferred from biological aspect of ancestor with PANTHER:PTN002308339
(GO Reference Genome Project, 2011-)
involved_in regulation of DNA-templated transcription
inferred from biological aspect of ancestor with PANTHER:PTN002308339
(GO Reference Genome Project, 2011-)
involved_in regulation of hippo signaling
inferred from biological aspect of ancestor with PANTHER:PTN002308339
(GO Reference Genome Project, 2011-)
Cellular Component (6 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
is_active_in apical cortex
inferred from direct assay
(Tokamov et al., 2023)
located_in apicomedial cortex
inferred from direct assay
(Su et al., 2017)
colocalizes_with cell-cell junction
inferred from direct assay
(Su et al., 2017)
located_in cytoplasmic side of apical plasma membrane
inferred from direct assay
(Genevet et al., 2010, Yu et al., 2010)
located_in cytoplasm
inferred from direct assay
(Yu et al., 2010)
part_of Kibra-Ex-Mer complex
inferred from physical interaction with FLYBASE:ex; FB:FBgn0004583,FLYBASE:Mer; FB:FBgn0086384
(Genevet et al., 2010)
inferred from direct assay
(Yu et al., 2010)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN002308339
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the WWC family. KIBRA subfamily. (Q9VFG8)
Protein Signatures (InterPro)
Summaries
Pathway (FlyBase)
POSITIVE REGULATORS OF HIPPO SIGNALING PATHWAY -
The Hippo signaling pathway is an intracellular kinase cascade in which hpo kinase in complex with sav, phosphorylates wts kinase which, in turn, phosphorylates yki transcriptional co-activator leading to its cytosolic retention. Positive regulators of the pathway, enhance the cytosolic retention of yki, negatively regulating tissue growth (Adapted from FBrf0224870).
Gene Group (FlyBase)
KIBRA-EX-MER COMPLEX -
The KEM complex is an apical protein complex that contains the proteins Kibra, Expanded and Merlin. It positively regulates the Hippo pathway, acting as a scaffolding complex. (Adapted from FBrf0210017).
Protein Function (UniProtKB)
Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Kibra acts synergistically along with Ex and Mer to regulate the Hippo signaling pathway.
(UniProt, Q9VFG8)
Summary (Interactive Fly)

signaling protein that functions together with Merlin and Expanded in a protein complex that regulates the Hippo kinase cascade via direct binding to Hippo and Salvador

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\kibra for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VFG8)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.53

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
kibra-RA
FBtr0100008
NM_001038966
4909
1288
kibra-RB
FBtr0344383
NM_001300400
5750
1288
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
kibra-PA
FBpp0099467
144.3
1288
5.79
Q9VFG8
NP_001034055
AAF55090
kibra-PB
FBpp0310756
144.3
1288
5.79
Q9VFG8
NP_001287329
AHN57328
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1288 aa isoforms: kibra-PA, kibra-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Forms a complex with Mer and Ex. Interacts (via domain WW 1) with Ex (via RXPPXY motif). Interacts with Mer, Sav, Hpo and Wts.

(UniProt, Q9VFG8)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\kibra using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.52

Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
wing disc
(Genevet et al., 2010)
oogenesis stage S9 & adult stage | female
border follicle cell
(Lucas et al., 2013)
oogenesis stage S8 -- S10
follicle cell
(Genevet et al., 2010)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
is_active_in apical cortex
inferred from direct assay
(Tokamov et al., 2023)
located_in apicomedial cortex
inferred from direct assay
(Su et al., 2017)
colocalizes_with cell-cell junction
inferred from direct assay
(Su et al., 2017)
located_in cytoplasmic side of apical plasma membrane
inferred from direct assay
(Genevet et al., 2010, Yu et al., 2010)
located_in cytoplasm
inferred from direct assay
(Yu et al., 2010)
part_of Kibra-Ex-Mer complex
inferred from physical interaction with FLYBASE:ex; FB:FBgn0004583,FLYBASE:Mer; FB:FBgn0086384
(Genevet et al., 2010)
inferred from direct assay
(Yu et al., 2010)
Expression Deduced from Reporters
Reporter: P{GawB}kibraNP0056
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage -- pupal stage
epidermal cell
(Ninov et al., 2007)
embryonic/larval epidermis
(Ninov et al., 2007)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\kibra in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 47 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 34 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of kibra
Transgenic constructs containing regulatory region of kibra
Aberrations (Deficiencies and Duplications) ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal (with Df(3R)BSC841)
lethal | pupal stage, with Scer\GAL4pnr-MD237
lethal | recessive
lethal - all die before end of first instar larval stage | recessive
lethal - all die before end of pupal stage (with kibra1)
lethal - all die before end of pupal stage (with kibra02404)
partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
Sterility
Allele
fertile
sterile
Other Phenotypes
Allele
abnormal body color, with Scer\GAL4pnr-MD237
abnormal cell migration
abnormal size | adult stage, with Scer\GAL4en-e16E
abnormal size | adult stage, with Scer\GAL4nub-AC-62
abnormal size | larval stage | somatic clone
abnormal size | somatic clone | third instar larval stage, with Scer\GAL4Tub.PU
abnormal size | third instar larval stage, with Scer\GAL4hh-Gal4
decreased cell death | pupal stage | somatic clone
decreased cell number | somatic clone, with Scer\GAL4Act5C.PP
decreased size | adult stage
decreased size | adult stage, with Scer\GAL4nub.PU
increased cell death, with Scer\GAL4GMR.PF
increased cell death, with Scer\GAL4GMR.PU
increased cell death | somatic clone | RU486 conditional, with Scer\GAL4Act5C.Switch.PR
increased cell number | somatic clone
increased cell number | third instar larval stage, with Scer\GAL4repo.PU
increased occurrence of cell division | larval stage | somatic clone
increased size | adult stage, with Scer\GAL4ptc.PU
increased size | adult stage | somatic clone - tissue specific
some die during first instar larval stage | recessive
some die during pupal stage (with kibra1)
some die during pupal stage (with kibra02404)
visible, with Scer\GAL4ey.PH
visible, with Scer\GAL4GMR.PF
visible, with Scer\GAL4GMR.PFa, Scer\GAL4ey.200.Exel
visible, with Scer\GAL4GMR.PU
visible, with Scer\GAL4hh.PU
visible | adult stage
visible | adult stage, with Scer\GAL4en-e16E
visible | adult stage, with Scer\GAL4nub.PU
visible | adult stage, with Scer\GAL4nub-AC-62
visible | adult stage, with Scer\GAL4ptc.PU
visible | somatic clone
Phenotype manifest in
Allele
border follicle cell
eye, with Scer\GAL4ey.PH
eye, with Scer\GAL4GMR.PF
eye, with Scer\GAL4GMR.PFa, Scer\GAL4ey.200.Exel
eye, with Scer\GAL4GMR.PU
eye | somatic clone
eye | somatic clone - tissue specific
eye disc, with Scer\GAL4GMR.PF
eye disc, with Scer\GAL4GMR.PU
eye disc | third instar larval stage, with Scer\GAL4repo.PU
follicle cell | somatic clone
imaginal disc | somatic clone
interommatidial bristle | somatic clone
larval glial cell | third instar larval stage, with Scer\GAL4repo.PU
mesonotum, with Scer\GAL4pnr-MD237
ommatidium | somatic clone
oocyte nucleus | somatic clone
retina | pupal stage | somatic clone
rhabdomere | somatic clone - tissue specific
wing
wing, with Scer\GAL4en-e16E
wing, with Scer\GAL4nub.PU
wing, with Scer\GAL4nub-AC-62
wing, with Scer\GAL4ptc.PU
wing | somatic clone
wing blade, with Scer\GAL4nub-AC-62
wing blade posterior compartment, with Scer\GAL4hh.PU
wing disc | somatic clone
wing disc | somatic clone, with Scer\GAL4Act5C.PP
wing disc | somatic clone | RU486 conditional, with Scer\GAL4Act5C.Switch.PR
wing disc | somatic clone | third instar larval stage, with Scer\GAL4Tub.PU
wing disc | third instar larval stage, with Scer\GAL4hh-Gal4
wing vein | ectopic, with Scer\GAL4nub-AC-62
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (36)
Hsap\WWC1
13 of 14
Yes
Yes
1  
Hsap\WWC2
13 of 14
Yes
Yes
1  
Hsap\WWC3
12 of 14
No
Yes
3  
Hsap\AREL1
1 of 14
No
No
Hsap\ASCC1
1 of 14
No
No
1  
Hsap\BAG3
1 of 14
No
No
Hsap\GAS7
1 of 14
No
No
Hsap\HACE1
1 of 14
No
No
Hsap\HECTD1
1 of 14
No
No
Hsap\HECTD2
1 of 14
No
No
Hsap\HECTD3
1 of 14
No
No
Hsap\HECW1
1 of 14
No
No
Hsap\HECW2
1 of 14
No
No
Hsap\HERC3
1 of 14
No
No
1  
Hsap\HERC4
1 of 14
No
No
1  
Hsap\HERC5
1 of 14
No
No
Hsap\HERC6
1 of 14
No
No
Hsap\HUWE1
1 of 14
No
No
1  
Hsap\MAGI1
1 of 14
No
No
Hsap\MAGI2
1 of 14
No
No
Hsap\MAGI3
1 of 14
No
No
Hsap\MAGIX
1 of 14
No
No
Hsap\NEDD4
1 of 14
No
No
Hsap\NEDD4L
1 of 14
No
No
Hsap\PLEKHA5
1 of 14
No
No
Hsap\PLEKHA7
1 of 14
No
No
Hsap\SMURF1
1 of 14
No
No
Hsap\SMURF2
1 of 14
No
No
Hsap\TRIP12
1 of 14
No
No
2  
Hsap\UBE3B
1 of 14
No
No
Hsap\UBE3C
1 of 14
No
No
Hsap\UBR5
1 of 14
No
No
Hsap\WWP1
1 of 14
No
No
2  
Hsap\WWP2
1 of 14
No
No
Hsap\WWTR1
1 of 14
No
No
1  
Hsap\YAP1
1 of 14
No
No
16  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (25)
Rnor\Wwc1
13 of 14
Yes
Yes
Rnor\Wwc2
13 of 14
Yes
Yes
Rnor\Wwc3
11 of 14
No
Yes
Rnor\Magi1
2 of 14
No
No
Rnor\Magi3
2 of 14
No
No
Rnor\Arel1
1 of 14
No
No
Rnor\Bag3
1 of 14
No
No
Rnor\Hace1
1 of 14
No
No
Rnor\Hectd1
1 of 14
No
No
Rnor\Hectd3
1 of 14
No
No
Rnor\Hecw1
1 of 14
No
No
Rnor\Hecw2
1 of 14
No
No
Rnor\Herc3
1 of 14
No
No
Rnor\Herc6
1 of 14
No
No
Rnor\Magi2
1 of 14
No
No
Rnor\Magix
1 of 14
No
No
Rnor\Nedd4l
1 of 14
No
No
Rnor\Plekha5
1 of 14
No
No
Rnor\Smurf1
1 of 14
No
No
Rnor\Trip12
1 of 14
No
No
Rnor\Ube3a
1 of 14
No
No
Rnor\Ube3b
1 of 14
No
No
Rnor\Wwp1
1 of 14
No
No
Rnor\Wwp2
1 of 14
No
No
Rnor\Wwtr1
1 of 14
No
No
Mus musculus (laboratory mouse) (34)
Mmus\Wwc1
13 of 14
Yes
Yes
Mmus\Wwc2
12 of 14
No
Yes
Mmus\Magi1
2 of 14
No
No
Mmus\Magi3
2 of 14
No
No
Mmus\Arel1
1 of 14
No
No
Mmus\Bag3
1 of 14
No
No
Mmus\Gas7
1 of 14
No
No
Mmus\Hace1
1 of 14
No
No
Mmus\Hectd2
1 of 14
No
No
Mmus\Hectd3
1 of 14
No
No
Mmus\Hecw1
1 of 14
No
No
Mmus\Hecw2
1 of 14
No
No
Mmus\Herc3
1 of 14
No
No
Mmus\Herc4
1 of 14
No
No
Mmus\Herc6
1 of 14
No
No
Mmus\Huwe1
1 of 14
No
No
Mmus\Itch
1 of 14
No
No
Mmus\Magi2
1 of 14
No
No
Mmus\Magix
1 of 14
No
No
Mmus\Nedd4l
1 of 14
No
No
Mmus\Nedd4
1 of 14
No
No
Mmus\Plekha5
1 of 14
No
No
Mmus\Plekha7
1 of 14
No
No
Mmus\Smurf1
1 of 14
No
No
Mmus\Smurf2
1 of 14
No
No
Mmus\Trip12
1 of 14
No
No
Mmus\Ube3a
1 of 14
No
No
Mmus\Ube3b
1 of 14
No
No
Mmus\Ube3c
1 of 14
No
No
Mmus\Ubr5
1 of 14
No
No
Mmus\Wwp1
1 of 14
No
No
Mmus\Wwp2
1 of 14
No
No
Mmus\Wwtr1
1 of 14
No
No
Mmus\Yap1
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (12)
Xtro\wwc1
10 of 13
Yes
Yes
Xtro\wwc2
10 of 13
Yes
Yes
Xtro\wwc3
9 of 13
No
Yes
Xtro\atp5f1c
1 of 13
No
No
Xtro\gatad2a
1 of 13
No
No
Xtro\nrcam
1 of 13
No
No
Xtro\nsmf
1 of 13
No
Yes
Xtro\osr2
1 of 13
No
No
Xtro\pabpn1
1 of 13
No
No
Xtro\slc23a2
1 of 13
No
No
Xtro\tmem164
1 of 13
No
No
Xtro\tuba5
1 of 13
No
No
Danio rerio (Zebrafish) (23)
Drer\wwc1
13 of 14
Yes
Yes
Drer\wwc3
12 of 14
No
Yes
Drer\bag3
1 of 14
No
No
Drer\hectd2
1 of 14
No
No
Drer\hecw1b
1 of 14
No
No
Drer\hecw2a
1 of 14
No
No
Drer\herc3
1 of 14
No
No
Drer\herc4
1 of 14
No
No
Drer\herc5.1
1 of 14
No
No
Drer\herc5.2
1 of 14
No
No
Drer\herc5.4
1 of 14
No
No
Drer\LOC556872
1 of 14
No
No
Drer\magi2a
1 of 14
No
No
Drer\plekha5
1 of 14
No
No
Drer\plekha7a
1 of 14
No
No
Drer\smurf1
1 of 14
No
No
Drer\smurf2
1 of 14
No
No
Drer\trip12
1 of 14
No
No
Drer\ube3a
1 of 14
No
No
Drer\ube3b
1 of 14
No
No
Drer\wwp2
1 of 14
No
No
Drer\wwtr1
1 of 14
No
No
Drer\yap1
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (9)
Cele\etc-1
1 of 14
Yes
No
Cele\frm-8
1 of 14
Yes
No
Cele\hecd-1
1 of 14
Yes
No
Cele\hecw-1
1 of 14
Yes
No
Cele\herc-1
1 of 14
Yes
No
Cele\oxi-1
1 of 14
Yes
No
Cele\ubr-5
1 of 14
Yes
No
Cele\Y92H12A.2
1 of 14
Yes
No
Cele\yap-1
1 of 14
Yes
No
Anopheles gambiae (African malaria mosquito) (16)
Agam\KIBRLG
12 of 12
Yes
Yes
Agam\AgaP_AGAP000787
1 of 12
No
No
Agam\AgaP_AGAP000797
1 of 12
No
No
Agam\AgaP_AGAP001296
1 of 12
No
No
Agam\AgaP_AGAP001780
1 of 12
No
No
Agam\AgaP_AGAP005285
1 of 12
No
No
Agam\AgaP_AGAP005897
1 of 12
No
No
Agam\AgaP_AGAP006045
1 of 12
No
No
Agam\AgaP_AGAP009074
1 of 12
No
No
Agam\AgaP_AGAP009511
1 of 12
No
No
Agam\AgaP_AGAP009516
1 of 12
No
No
Agam\AgaP_AGAP010754
1 of 12
No
No
Agam\AgaP_AGAP011242
1 of 12
No
No
Agam\AgaP_AGAP011474
1 of 12
No
No
Agam\AgaP_AGAP011823
1 of 12
No
No
Agam\AgaP_AGAP012366
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (8)
Atha\AT2G30600
1 of 13
Yes
No
Atha\KAK
1 of 13
Yes
No
Atha\UPL1
1 of 13
Yes
No
Atha\UPL2
1 of 13
Yes
No
Atha\UPL4
1 of 13
Yes
No
Atha\UPL5
1 of 13
Yes
No
Atha\UPL6
1 of 13
Yes
No
Atha\UPL7
1 of 13
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (5)
Scer\HUL4
1 of 13
Yes
No
Scer\HUL5
1 of 13
Yes
No
Scer\RSP5
1 of 13
Yes
No
Scer\TOM1
1 of 13
Yes
No
Scer\UFD4
1 of 13
Yes
No
Schizosaccharomyces pombe (Fission yeast) (7)
Spom\mug30
1 of 12
Yes
No
Spom\ptr1
1 of 12
Yes
No
Spom\pub1
1 of 12
Yes
No
Spom\pub2
1 of 12
Yes
No
Spom\pub3
1 of 12
Yes
No
Spom\SPAC12B10.01c
1 of 12
Yes
No
Spom\SPAC167.07c
1 of 12
Yes
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:kibra. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (17)
CG3356
1 of 13
CG4238
1 of 13
CG5087
1 of 13
CG10508
1 of 13
ctrip
1 of 13
Hecw
1 of 13
HERC2
1 of 13
Herc4
1 of 13
HUWE1
1 of 13
hyd
1 of 13
Magi
1 of 13
Nedd4
1 of 13
Smurf
1 of 13
Su(dx)
1 of 13
Ube3a
1 of 13
Ufd4
1 of 13
yki
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 5 )
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    WWC1; WW and C2 domain containing 1
    13 of 14
    610533
       
      WWC2; WW and C2 domain containing 2
      13 of 14
      620110
           
          WWC3; WWC family member 3
          12 of 14
          301089
               
              Functional Complementation Data
              Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
              Interactions
              Summary of Physical Interactions
              Summary of Genetic Interactions
              Interaction Browsers
              View in FlyBase Interactions Browser   View in MIST tool (external link)
              Please look at the allele data for full details of the genetic interactions
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              kibra
              enhanceable
              crb
              (Su et al., 2017, Ling et al., 2010)
              kibra
              suppressible
              CycE
              (Baumgartner et al., 2010, Tseng and Hariharan, 2002)
              kibra
              suppressible
              Diap1
              (Baumgartner et al., 2010)
              kibra
              suppressible
              Diap1|CycE
              (Baumgartner et al., 2010)
              kibra
              enhanceable
              ex
              (Lucas et al., 2013, Baumgartner et al., 2010, Yu et al., 2010)
              kibra
              suppressible
              ex
              (Su et al., 2017, Genevet et al., 2010)
              kibra
              suppressible
              hpo
              (Genevet et al., 2010, Genevet et al., 2010)
              kibra
              enhanceable
              Mer
              (Baumgartner et al., 2010, Yu et al., 2010)
              kibra
              suppressible
              Mer
              (Genevet et al., 2010)
              kibra
              suppressible
              sav
              (Yu et al., 2010)
              kibra
              suppressible
              Tao
              (Poon et al., 2011)
              kibra
              enhanceable
              Tao
              (Poon et al., 2011)
              kibra
              suppressible
              yki
              (Baumgartner et al., 2010, Genevet et al., 2010)
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              crb
              suppressible
              kibra
              (Pojer et al., 2021, Su et al., 2017)
              Dcr-2|Snr1
              suppressible
              kibra
              (Jeibmann et al., 2014)
              ex
              suppressible
              kibra
              (Tokamov et al., 2021, Su et al., 2017, Genevet et al., 2010)
              ex
              enhanceable
              kibra
              (Lucas et al., 2013, Yu et al., 2010)
              H
              enhanceable
              kibra
              (Müller et al., 2005)
              Mer
              enhanceable
              kibra
              (Yu et al., 2010)
              Mnat9
              suppressible
              kibra
              (Mok and Choi, 2022)
              mtm
              enhanceable
              kibra
              (Hu et al., 2022)
              pnr
              enhanceable
              kibra
              (Pena-Rangel et al., 2002)
              Snr1
              suppressible
              kibra
              (Jeibmann et al., 2014)
              TER94
              suppressible
              kibra
              (Li et al., 2024)
              External Data
              Subunit Structure (UniProtKB)
              Forms a complex with Mer and Ex. Interacts (via domain WW 1) with Ex (via RXPPXY motif). Interacts with Mer, Sav, Hpo and Wts.
              (UniProt, Q9VFG8 )
              Linkouts
              DroID - A comprehensive database of gene and protein interactions.
              MIST (genetic) - An integrated Molecular Interaction Database
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Pathways
              Signaling Pathways (FlyBase)
              Metabolic Pathways
              FlyBase
              External Links
              External Data
              Linkouts
              KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              SignaLink - A signaling pathway resource with multi-layered regulatory networks.
              Class of Gene
              Genomic Location and Detailed Mapping Data
              Chromosome (arm)
              3R
              Recombination map
              3-56
              Cytogenetic map
              88D1-88D1
              Sequence location
              FlyBase Computed Cytological Location
              Cytogenetic map
              Evidence for location
              88D1-88D1
              Left limit from in situ hybridisation (FBrf0067338) Right limit from in situ hybridisation (FBrf0067338); Limits computationally determined from genome sequence between P{PZ}put10460 and P{EP}CG33967EP666
              Experimentally Determined Cytological Location
              Cytogenetic map
              Notes
              References
              88D1-88D2
              (determined by in situ hybridisation)
              (Spradling et al., 1999)
              67B1-67B2
              (BDGP Project Members, 1994-1999)
              88D-88D
              (determined by in situ hybridisation)
              (Cooley et al., 1988)
              Experimentally Determined Recombination Data
              Location

              3-56

              (FlyBase, 2016)

              3-54.5

              (Comeron et al., 2012)
              Left of (cM)
              Right of (cM)
              Notes
              Stocks and Reagents
              Stocks (45)
              Genomic Clones (30)
              cDNA Clones (49)
               

              Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

              cDNA clones, fully sequenced
              BDGP DGC clones
              Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              Antibody Information
              Laboratory Generated Antibodies
               

              polyclonal

              (Genevet et al., 2010, Yu et al., 2010)
              Commercially Available Antibodies
               
              Cell Line Information
              Publicly Available Cell Lines
               
                Other Stable Cell Lines
                 
                  Other Comments

                  RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

                  (Boutros et al., 2004)
                  Relationship to Other Genes
                  Source for database merge of

                  Source for merge of: kibra l(3)neo42

                  (Baumgartner et al., 2010)

                  Source for merge of: CG7552 CG12600

                  (FlyBase Genome Annotators, 2005)
                  Additional comments

                  Annotations CG7552 and CG12600 merged as CG33967 in release 4.3 of the genome annotation.

                  (FlyBase Genome Annotators, 2005)
                  Nomenclature History
                  Source for database identify of

                  Source for identity of: kibra CG33967

                  (Yu et al., 2010)
                  Nomenclature comments
                  Etymology
                  Synonyms and Secondary IDs (18)
                  Reported As
                  Symbol Synonym
                  CG12600
                  (Perkins et al., 2009)
                  CG33967
                  (Ashwal-Fluss et al., 2014, Jeibmann et al., 2014, Cole et al., 2012.7.6, Ni et al., 2010.12.1, Reis et al., 2010, Yu et al., 2010, Ayroles et al., 2009, Keleman et al., 2009.8.5, Southall and Brand, 2009, Nicholson et al., 2008, Ni et al., 2008, Buszczak et al., 2007, Maia et al., 2007)
                  CG7552
                  (Christis and Munro, 2012, Sun et al., 2006, Müller et al., 2005, Stanyon et al., 2004, Giot et al., 2003, Ringrose et al., 2003, Mirth and Akam, 2002, Pena-Rangel et al., 2002, Tseng and Hariharan, 2002)
                  DmKibra
                  (Wennmann et al., 2014)
                  Kbr
                  (Cho and Jiang, 2021, Andersen et al., 2013, Liu et al., 2012, Zhao et al., 2011)
                  Kib
                  (Tokamov et al., 2024, Bonello et al., 2023, Tokamov et al., 2021, Fletcher et al., 2018, Richardson and Portela, 2017, Vedanayagam and Garrigan, 2015, Johnston, 2013, Lucas et al., 2013, Matsui and Lai, 2013)
                  Kibra
                  (Kim et al., 2023, Kong et al., 2022, Gogia et al., 2021, Pojer et al., 2021, Gou et al., 2020, Wang et al., 2020, Bonfini et al., 2016, Fallahi et al., 2016, Cao et al., 2015, Dong et al., 2015, Irvine and Harvey, 2015, Jin et al., 2015, Thompson and Sahai, 2015, Deng et al., 2013, Lucas et al., 2013, Yu and Guan, 2013, Fausti et al., 2012, Harvey and Hariharan, 2012, Poernbacher et al., 2012, Yoshihama et al., 2012, Yue et al., 2012, Boggiano et al., 2011, Chan et al., 2011, Genevet and Tapon, 2011, Halder and Johnson, 2011, Poon et al., 2011, Salah and Aqeilan, 2011, Baumgartner et al., 2010, Baumgartner et al., 2010)
                  ORE-2
                  (Maia et al., 2007)
                  RE26350
                  (Pena-Rangel et al., 2002)
                  WWC1
                  (van Soldt and Cardoso, 2020)
                  kbr
                  (Yatsenko et al., 2020, Ikmi et al., 2014)
                  kib
                  (Li et al., 2024, Badmos et al., 2021, Sang et al., 2021, Aguilar-Aragon et al., 2020, Su et al., 2017, Fletcher et al., 2015, Robbins et al., 2014, Lucas et al., 2013, Fletcher et al., 2012, Jukam and Desplan, 2011)
                  kibra
                  (Kroeger et al., 2024, Lee et al., 2024, Barbaste et al., 2023, Hu et al., 2022, Liu et al., 2022, Perlegos et al., 2022, Yang et al., 2022, Bonfini et al., 2021, Ferguson et al., 2021, Melamed and Kalderon, 2020, Albert et al., 2018, Forest et al., 2018, Gusareva et al., 2018, Lee et al., 2018, Li-Kroeger et al., 2018, Anderson et al., 2017, Clandinin and Owens, 2016-, Gene Disruption Project members, 2016-, Williams et al., 2016, Aerne et al., 2015, Fletcher et al., 2015, Wang and Baker, 2015, Zaessinger et al., 2015, Huang and Kalderon, 2014, Ikmi et al., 2014, Jeibmann et al., 2014, Robbins et al., 2014, Khan et al., 2013, Kwon et al., 2013, Webber et al., 2013, Bao et al., 2011, Reddy and Irvine, 2011, Salah and Aqeilan, 2011, Genevet et al., 2010, Genevet et al., 2010, Ling et al., 2010, Yu et al., 2010, Yu et al., 2010)
                  l(3)02404
                  (Spradling et al., 1999)
                  l(3)j5C3
                  l(3)neo42
                  Name Synonyms
                  Kibra
                  (Gou et al., 2023, Chen et al., 2020, Fujisawa et al., 2020, Romine et al., 2019, Fulford et al., 2018, Sadeqzadeh et al., 2014, Konsavage and Yochum, 2013, Rister et al., 2013, Bao et al., 2011, Yan et al., 2011)
                  kib
                  (Aguilar-Aragon et al., 2020)
                  kibra
                  (Hu et al., 2016, Harvey et al., 2013, Kwon et al., 2013, Jukam and Desplan, 2011, Yu et al., 2010)
                  kibra ortholog
                  lethal (3) neo42
                  Secondary FlyBase IDs
                  • FBgn0053967
                  • FBgn0038254
                  • FBgn0038255
                  • FBtr0082970
                  • FBpp0082429
                  • FBtr0083022
                  • FBpp0082481
                  • FBgn0010779
                  • FBgn0011381
                  • FBgn0011475
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  Study result (0)
                  Result
                  Result Type
                  Title
                  External Crossreferences and Linkouts ( 51 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                  UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                  Other crossreferences
                  AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                  DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                  EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                  FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  MARRVEL_MODEL - MARRVEL (model organism gene)
                  Linkouts
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                  DroID - A comprehensive database of gene and protein interactions.
                  DRSC - Results frm RNAi screens
                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                  FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                  Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                  KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                  MIST (genetic) - An integrated Molecular Interaction Database
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                  References (179)