FlyBase Gene Report: Ncra\QF

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Gene: Ncra\QF

General Information

Symbol

Ncra\QF

Species

N. crassa

Name

Quinic acid utilization activator

Annotation Symbol

Feature Type

engineered_foreign_gene

FlyBase ID

FBgn0261910

Gene Model Status

Stock Availability

153 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Also Known As

QF

Foreign Gene Data

Foreign sequence; species == Neurospora crassa; gene == 'QF'; UniProtKB/Swiss- Prot:P11638 .

(FlyBase Curators, 1992-)

Summaries

Alleles, Insertions, Transgenic Constructs

Classical and Insertion Alleles ( 138 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 104 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Ncra\QF

Transgenic constructs containing regulatory region of Ncra\QF

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Myc^QUAS.cPa

Ncra\QF^Psc-ET40

lethal | heat sensitive, with shi^ts1.QUAS

viable, with Ncra\QS^αTub84B.PP, shi^ts1.QUAS

Other Phenotypes

Allele

abnormal locomotor behavior | adult stage, with Hsap\SNCA^QUAS.cOa

Ncra\QF^QF2.nSyb

abnormal locomotor behavior | larval stage | conditional, with Crei\ChR2^{T159C.10xQUAS.Tag:HA}, Ncra\QF^AD.nSyb

Ncra\QF^DBD.nSyb

abnormal locomotor behavior | larval stage | conditional, with Crei\ChR2^{T159C.10xQUAS.Tag:HA}, Ncra\QF^DBD.nSyb

abnormal locomotor behavior | larval stage | conditional, with Crei\ChR2^{T159C.10xQUAS.Tag:HA}, Ncra\QF^QF2w.AD.nSyb

Ncra\QF^DBD.nSyb

abnormal neuroanatomy | adult stage, with Hsap\GFAP^R79H.QUAS

Ncra\QF^sotv-ET31

abnormal neuroanatomy | adult stage, with Hsap\MAPT^{P301L.QUAS.0N4R}

Ncra\QF^QF2.nSyb

abnormal neuroanatomy | adult stage, with Hsap\RELA^AD.VT028327, Scer\GAL4^DBD.R22E04, Ten-m^QUAS.cHa, Ten-m^UAS.Tag:V5

Ncra\QF^Mz19

abnormal neuroanatomy | somatic clone, with Scer\GAL4^Mz19, Ten-m^GS9267, Ten-m^QUAS.cHa

Ncra\QF^Mz19.PH

abnormal neurophysiology | adult stage, with alka¹

Ncra\QF^Ir76b.1.5

abnormal neurophysiology | adult stage, with Hsap\MAPT^{P301L.QUAS.0N4R}

Ncra\QF^QF2w.nSyb

abnormal neurophysiology | adult stage | conditional, with Crei\ChR2^{T159C.10xQUAS.Tag:HA}

Ncra\QF^Mz19.PH

abnormal neurophysiology | adult stage | progressive, with Hsap\MAPT^{P301L.QUAS.0N4R}

Ncra\QF^QF2.nSyb

abnormal size | adult stage, with Hsap\SNCA^QUAS.cOa

Ncra\QF^QF2.nSyb

abnormal sleep | adult stage | progressive, with Hsap\MAPT^{P301L.QUAS.0N4R}

Ncra\QF^QF2.nSyb

abnormal smell perception, with Ncra\QS^UAS.cPa, Scer\GAL4^acj6-PG63, shi^ts1.QUAS

Ncra\QF^GH146.PP

abnormal smell perception, with shi^{ts1.-FRT.QUAS}

Ncra\QF^GH146.PP

abnormal smell perception, with shi^ts1.QUAS

Ncra\QF^GH146.PP

abnormal wound healing | larval stage, with Myc^QUAS.cPa

Ncra\QF^repo

bang sensitive, with Hsap\GFAP^R79H.QUAS

Ncra\QF^sotv-ET31

decreased cell number, with Hsap\SNCA^QUAS.cOa

Ncra\QF^QF2.nSyb

decreased cell number | adult stage, with Hsap\SNCA^QUAS.cOa

Ncra\QF^QF2.nSyb

decreased cell number | embryonic stage, with kay^DN.QUAS

Ncra\QF^srpHemo

decreased fecundity, with coch^QUASp.cVa

Ncra\QF^αTub67C.PV

decreased size | oogenesis, with coch^QUASp.cVa

Ncra\QF^αTub67C.PV

decreased sleep | adult stage, with Hsap\MAPT^{P301L.QUAS.0N4R}

Ncra\QF^QF2.nSyb

increased cell death | adult stage, with Hsap\GFAP^R79H.QUAS

Ncra\QF^sotv-ET31

increased cell death | adult stage, with Hsap\SNCA^QUAS.cOa

Ncra\QF^QF2.nSyb

increased cell death | adult stage | cell non-autonomous, with Hsap\GFAP^R79H.QUAS

Ncra\QF^sotv-ET31

melanotic necrosis | adult stage, with Dark^RNAi.QUAS

Ncra\QF^QF2.R11F02

paralytic | adult stage | heat sensitive, with Ncra\QF^AD.nSyb, shi^ts1.QUAS

Ncra\QF^DBD.nSyb

paralytic | adult stage | heat sensitive, with Ncra\QF^DBD.nSyb, shi^ts1.QUAS

paralytic | adult stage | heat sensitive, with Ncra\QF^QF2w.AD.nSyb, shi^ts1.QUAS

Ncra\QF^DBD.nSyb

paralytic | heat sensitive, with shi^ts1.QUAS

Ncra\QF^ET49

short lived, with Dark^RNAi.QUAS

Ncra\QF^QF2.R11F02

short lived, with Hsap\SNCA^QUAS.cOa

Ncra\QF^QF2.nSyb

Phenotype manifest in

Allele

adult antennal lobe, with Hsap\RELA^AD.VT028327, Scer\GAL4^DBD.R22E04, Ten-m^QUAS.cHa, Ten-m^UAS.Tag:V5

Ncra\QF^Mz19

adult brain, with Hsap\MAPT^{P301L.QUAS.0N4R}

Ncra\QF^QF2.nSyb

adult brain, with Hsap\SNCA^A53T.QUAS

Ncra\QF^QF2.nSyb

adult brain, with Hsap\SNCA^QUAS.cOa

Ncra\QF^QF2.nSyb

adult CNS glial cell, with Hsap\GFAP^R79H.QUAS

Ncra\QF^sotv-ET31

adult CSD interneuron | conditional, with Crei\ChR2^{T159C.10xQUAS.Tag:HA}

Ncra\QF^Mz19.PH

adult neuron | decreased number, with Hsap\SNCA^QUAS.cOa

Ncra\QF^QF2.nSyb

centrifugal neuron C2, with Hsap\MAPT^{P301L.QUAS.0N4R}

Ncra\QF^QF2.nSyb

dopaminergic medulla neuron, with Hsap\SNCA^QUAS.cOa

Ncra\QF^QF2.nSyb

dopaminergic medulla neuron | adult stage | decreased number, with Hsap\SNCA^QUAS.cOa

Ncra\QF^QF2.nSyb

embryonic/larval plasmatocyte | decreased number | embryonic stage, with kay^DN.QUAS

Ncra\QF^srpHemo

eye photoreceptor cell | adult stage, with Ctet\tetX^QUAS.cPa

Ncra\QF^{CarT-HA-T2A-QF2}

filamentous actin | adult stage, with Hsap\SNCA^QUAS.cOa

Ncra\QF^QF2.nSyb

germ band, with kay^DN.QUAS

Ncra\QF^srpHemo

larval multidendritic class IV neuron, with Myc^QUAS.cPa

Ncra\QF^repo

L-type sensillum L4, with alka¹

Ncra\QF^Ir76b.1.5

medulla, with Hsap\SNCA^QUAS.cOa

Ncra\QF^QF2.nSyb

medulla intrinsic columnar neuron | adult stage | decreased number, with Hsap\SNCA^QUAS.cOa

Ncra\QF^QF2.nSyb

mitochondrion | adult stage, with Hsap\SNCA^QUAS.cOa

Ncra\QF^QF2.nSyb

neuron | adult stage, with Hsap\SNCA^QUAS.cOa

Ncra\QF^QF2.nSyb

neuron | adult stage | cell non-autonomous, with Hsap\GFAP^R79H.QUAS

Ncra\QF^sotv-ET31

neuron projection, with Hsap\RELA^AD.VT028327, Scer\GAL4^DBD.R22E04, Ten-m^QUAS.cHa, Ten-m^UAS.Tag:V5

Ncra\QF^Mz19

outer medulla | adult stage, with Hsap\SNCA^QUAS.cOa

Ncra\QF^QF2.nSyb

ovary, with coch^QUASp.cVa

Ncra\QF^αTub67C.PV

plasmatocyte | P-stage, with Pvf2^QUAS.cWa

Ncra\QF^repo

pupal central nervous system, with Pvf2^QUAS.cWa

Ncra\QF^repo

retina | adult stage, with Hsap\MAPT^{P301L.QUAS.0N4R}

transmedullary neuron Tm3, with Hsap\MAPT^{P301L.QUAS.0N4R}

Ncra\QF^QF2.nSyb

vacuole | adult stage | increased number, with Hsap\MAPT^{P301L.QUAS.0N4R}

Ncra\QF^QF2.nSyb

vacuole | adult stage | increased number, with Hsap\SNCA^A53T.QUAS

Ncra\QF^QF2.nSyb

wing, with Dark^RNAi.QUAS

Ncra\QF^QF2.R11F02

Orthologs

Downloads

Download All DIOPT Orthologs

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

Class of Gene

engineered_foreign_gene

(FlyBase Curators, 1992-)

Stocks and Reagents

Stocks (153)

91997

w^*; P{Orco-QF2.P}2

51312

w^*; P{Ir76b-QF.1.5}2

607346

w^*; P{R24A10-QF2.L}JK22C

30014

w¹¹¹⁸; PBac{GH146-QF.P}11

30015

w¹¹¹⁸; PBac{GH146-QF.P}53

41573

w^*; PBac{Mz19-QF.H}VK00037

605139

w^*; P{dpp.blk-2A-QF2}attP2

57363

w^*; P{Ddc(FRT.stop)QF}attP2

57361

w^*; P{Ddc(FRT.stop)QF}attP40

57365

w^*; P{Trhn(FRT.stop)QF}attP2

51962

w¹¹¹⁸; P{αTub84B-QF2w.P}2/CyO

57358

w^*; P{Trhn(FRT.stop)QF}attP40

More stocks available...

Other Comments

Ncra\QF is a transcriptional activator that binds to a 16bp sequence found naturally in the Neurospora crassa qa gene cluster (copies of this 16bo sequence are referred to as Ncra\QUAS). Ncra\QF can thus be used to activate transcription of reporter constructs containing Ncra\QUAS regulatory sequences.

(Potter et al., 2010)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Ncra\QF

QF

(Choi et al., 2016, Neukomm et al., 2014, Petersen and Stowers, 2011, Stowers, 2011, Stowers, 2011.9.28, Potter et al., 2010)

qa-1F

(Potter et al., 2010)

Name Synonyms

Quinic acid utilization activator

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 0 )

References (248)