FlyBase Gene Report: Dmel\Arms

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Arms using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

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Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Arms in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Arms

View exonic expression by tissue for Dmel\Arms

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

37433/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261554

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261554

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG30387

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 5 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Arms

Transgenic constructs containing regulatory region of Arms

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(2R)Exel6074

(Ryder, 2004.4.26)

Df(2R)Exel6075

(Ryder, 2004.4.26)

Inferred from location ( 4 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal - majority die, with Scer\GAL4^pnr-MD237

Arms^GD2126

viable

Arms^e00881

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

Arms^GD17063

Sterility

Allele

fertile

Arms^e00881

Other Phenotypes

Allele

some die during pupal stage, with Scer\GAL4^pnr-MD237

Arms^GD2126

visible, with Scer\GAL4^pnr-MD237

Arms^GD2126

visible | adult stage, with Scer\GAL4^GMR.PFa

Arms^GD10065

Phenotype manifest in

Allele

autophagosome | adult stage | increased number, with Scer\GAL4^GMR.PFa

Arms^GD10065

eye, with Scer\GAL4^GMR.PFa

Arms^GD10065

interommatidial bristle | adult stage, with Scer\GAL4^GMR.PFa

Arms^GD10065

trichogen cell, with Scer\GAL4^pnr-MD237

Arms^GD2126

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (45)

Hsap\KIDINS220

11 of 14

Yes

Hsap\ANKS3

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\ANKRD28

1 of 14

Hsap\ANKRD30BL

1 of 14

Yes

Hsap\ANKRD33B

1 of 14

Yes

Hsap\ANKRD33

1 of 14

Yes

Hsap\ANKRD35

1 of 14

Yes

Hsap\ANKRD36C

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\PLA2G6

1 of 14

Hsap\POTEE

1 of 14

Hsap\RELA

1 of 14

3922

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (28)

Rnor\Kidins220

11 of 14

Yes

Rnor\Anks3

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Ankrd33

1 of 14

Yes

Rnor\Ankrd35

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Potem

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (30)

Mmus\Kidins220

10 of 14

Yes

Mmus\Anks3

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Ankrd33

1 of 14

Yes

Mmus\Ankrd35

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Nfkb1

1 of 14

Mmus\Nfkb2

1 of 14

Mmus\Nkpd1

1 of 14

Yes

Mmus\Rai14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (22)

Xtro\kidins220

10 of 13

Yes

Xtro\ankrd6

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\ankrd50

1 of 13

Xtro\anks3

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\slk

1 of 13

Xtro\XB5936512

1 of 13

Yes

Danio rerio (Zebrafish) (35)

Drer\kidins220b

11 of 14

Yes

Drer\kidins220a

10 of 14

Yes

Drer\anks3

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\ankhd1

1 of 14

Drer\ankk1

1 of 14

Drer\ankrd27

1 of 14

Yes

Drer\ankrd28b

1 of 14

Drer\ankrd33aa

1 of 14

Yes

Drer\ankrd33ab

1 of 14

Yes

Drer\ankrd33ba

1 of 14

Yes

Drer\ankrd33bb

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\trpa1b

1 of 14

Drer\zdhhc17

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (8)

Cele\kdin-1

11 of 14

Yes

Cele\C27A7.5

1 of 14

Cele\fem-1

1 of 14

Cele\M60.7

1 of 14

Yes

Cele\mask-1

1 of 14

Cele\mlt-2

1 of 14

Yes

Cele\mlt-3

1 of 14

Yes

Cele\unc-44

1 of 14

Anopheles gambiae (African malaria mosquito) (15)

Agam\AgaP_AGAP012141

11 of 12

Yes

Agam\AgaP_AGAP012913

3 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (7)

Atha\AT4G32250

1 of 13

Yes

Atha\AT5G14230

1 of 13

Yes

Atha\KEG

1 of 13

Yes

Atha\TPR10

1 of 13

Yes

Atha\XBAT31

1 of 13

Yes

Atha\XBAT32

1 of 13

Yes

Atha\XBAT33

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\HOS4

1 of 13

Yes

Scer\PHO81

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (1)

Ecol\yahD

1 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Arms. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (15)

Ank2

3 of 13

CG10011

3 of 13

mask

3 of 13

Ank

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Dif

1 of 13

Fem-1

1 of 13

m-cup

1 of 13

nompC

1 of 13

plu

1 of 13

Rel

1 of 13

TrpA1

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

KIDINS220; kinase D interacting substrate 220

11 of 14

615759

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Arms

suppressible

Cat

(Liao et al., 2023)

Arms

enhanceable

(Liao et al., 2023)

Arms

suppressible

IKKβ

(Liao et al., 2023)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0261554

MIST (protein-protein) - An integrated Molecular Interaction Database

37433

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-94

Cytogenetic map

57D8-57D11

Sequence location

2R:21,295,652..21,310,411 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

57D8-57D11

Limits computationally determined from genome sequence between P{EP}CG4266^EP2258 and P{EP}CG30394^EP962&P{lacW}dom^k08108

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-94

(FlyBase, 2016)

2-101.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (12)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

17898

w¹¹¹⁸; PBac{RB}Arms^e00881

25309

w¹¹¹⁸; Mi{ET1}Arms^MB05883

31737

y¹ v¹; P{TRiP.HM04046}attP2

43111

y¹ w^*; Mi{MIC}Arms^MI07277

67477

y¹ w^*; Mi{Trojan-GAL4.0}Arms^{MI07277-TG4.0}

66370

y¹ w^*; Mi{PT-GFSTF.0}Arms^{MI07277-GFSTF.0}/CyO

NIG-Fly

10074R-2

P{NIG.10074R}2

30386R-3

P{NIG.30386R}3

HMJ21104

y¹ v¹; P{TRiP.HMJ21104}attP40/CyO

2RG-0369

y² VhaAC39-1^cho-1 v¹; P{U6-Arms.NIG.sgRNA}attP40/CyO

VDRC

v105645

P{KK101314}VIE-260B

v48313

w¹¹¹⁸; P{GD17063}v48313

Genomic Clones (20)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (33)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

IP15286

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0261554

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0261554

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R⁺ cells.

(Boutros et al., 2004)

New annotation (CG30386) in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG30386 CG30387

(FlyBase Genome Annotators, 2010)

Source for merge of: CG10074 CG15665

(FlyBase Genome Annotators, 2002-2003)

Additional comments

Annotations CG30386 and CG30387 merged as CG42672 in release 5.25 of the genome annotation.

(FlyBase Genome Annotators, 2010)

Annotations CG10074 and CG15665 merged as CG30387 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Nomenclature History

Source for database identify of

Source for identity of: Arms CG42672

(Liao et al., 2023)

Nomenclature comments

Etymology

The gene is named 'Arms' based on human orthology.

(Liao et al., 2023)

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

ARMS

(Liao et al., 2023)

Arms

CG10074

(Ibrahim et al., 2013)

CG15665

(Boutros et al., 2004)

CG30386

(Japanese National Institute of Genetics, 2012.5.21)

CG30387

(Japanese National Institute of Genetics, 2012.5.21, Hazelett et al., 2009, Keleman et al., 2009.8.5, Ni et al., 2008, Stuart et al., 2007, Friedman and Perrimon, 2006)

CG42672

(Yamamoto et al., 2024, Fabre et al., 2022, National Institute of Genetics Fly Stocks, 2022-, Pang et al., 2021, FlyBase Genome Annotators, 2019-, Harbison et al., 2019, Gene Disruption Project members, 2016-, Gene Disruption Project members, 2015-, FlyBase Genome Annotators, 2010, Ni et al., 2010.12.1)

KIDINS220

(Jin et al., 2020)

dARMS

(Liao et al., 2023)

Name Synonyms

Ankyrin repeat-rich membrane spanning

Secondary FlyBase IDs

FBgn0050386
FBgn0050387
FBgn0034615
FBgn0034616

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 93 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

37433

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9W2I0

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9W2I0

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

37433/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261554

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261554

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG42672

MARRVEL_MODEL - MARRVEL (model organism gene)

37433

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0261554

DroID - A comprehensive database of gene and protein interactions.

FBgn0261554

DRSC - Results frm RNAi screens

FBgn0261554

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0261554

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG30387

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC012347

MIST (protein-protein) - An integrated Molecular Interaction Database

37433

References (46)

The following external sites may use different assemblies or annotations than FlyBase.

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