FlyBase Gene Report: Hsap\CHMP2B

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Gene: Hsap\CHMP2B

General Information

Symbol

Hsap\CHMP2B

Species

H. sapiens

Name

charged multivesicular body protein 2B

Annotation Symbol

Feature Type

engineered_foreign_gene

FlyBase ID

FBgn0261513

Gene Model Status

Stock Availability

1 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Also Known As

CHMP2B

Key Links

Foreign Gene Data

Foreign sequence; species == Homo sapiens; gene == CHMP2B; HGNC:24537.

(FlyBase Curators, 1992-)

Summaries

Alleles, Insertions, Transgenic Constructs

Classical and Insertion Alleles ( 0 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Hsap\CHMP2B

Transgenic constructs containing regulatory region of Hsap\CHMP2B

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^elav-C155

Hsap\CHMP2B^Intron5.UAS

lethal - all die before end of P-stage, with Scer\GAL4^nSyb.PS

Hsap\CHMP2B^Intron5.UAS

lethal - all die during embryonic stage, with Scer\GAL4^Tub.PU

Hsap\CHMP2B^WT.UAS

Other Phenotypes

Allele

abnormal locomotor behavior | third instar larval stage, with Scer\GAL4^nSyb.PS

Hsap\CHMP2B^Intron5.UAS

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^nSyb.PS

Hsap\CHMP2B^Intron5.UAS

abnormal phototaxis, with Scer\GAL4^ey.PH

Hsap\CHMP2B^{Intron5.UAS.N.Tag:FLAG}

abnormal phototaxis, with Scer\GAL4^GMR.PF

Hsap\CHMP2B^{Intron5.UAS.N.Tag:FLAG}

increased cell death, with Scer\GAL4^GMR.PF

increased cell death | third instar larval stage, with Scer\GAL4^nSyb.PS

Hsap\CHMP2B^Intron5.UAS

melanotic necrosis | adult stage, with Scer\GAL4^GMR.PF

Hsap\CHMP2B^Intron5.UAS

some die during embryonic stage, with Scer\GAL4^Tub.PU

Hsap\CHMP2B^WT.UAS

visible, with Scer\GAL4^GMR.PF

Hsap\CHMP2B^Intron5.UAS

visible, with Scer\GAL4^GMR.PU

Hsap\CHMP2B^Intron5.UAS

visible | adult stage, with Scer\GAL4^GMR.PF

Hsap\CHMP2B^Intron5.UAS

visible | adult stage, with Scer\GAL4^GMR.PU

Hsap\CHMP2B^Intron5.UAS

Phenotype manifest in

Allele

eye, with Scer\GAL4^ey.PH

Hsap\CHMP2B^{Intron5.UAS.N.Tag:FLAG}

eye, with Scer\GAL4^GMR.PF

eye, with Scer\GAL4^GMR.PU

Hsap\CHMP2B^Intron5.UAS

larval brain | third instar larval stage, with Scer\GAL4^nSyb.PS

Hsap\CHMP2B^Intron5.UAS

neuromuscular junction | third instar larval stage, with Scer\GAL4^nSyb.PS

Hsap\CHMP2B^Intron5.UAS

NMJ bouton | third instar larval stage, with Scer\GAL4^nSyb.PS

Hsap\CHMP2B^Intron5.UAS

ommatidium, with Scer\GAL4^ey.PH

Hsap\CHMP2B^{Intron5.UAS.N.Tag:FLAG}

ommatidium, with Scer\GAL4^GMR.PF

Hsap\CHMP2B^{Intron5.UAS.N.Tag:FLAG}

photoreceptor, with Scer\GAL4^GMR.PF

Hsap\CHMP2B^Intron5.UAS

retina, with Scer\GAL4^GMR.PF

Hsap\CHMP2B^WT.UAS

synapse | third instar larval stage, with Scer\GAL4^nSyb.PS

Hsap\CHMP2B^Intron5.UAS

Orthologs

Downloads

Download All DIOPT Orthologs

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Drosophila melanogaster (Fruit fly) (4)

14 of 14

Yes

Yes

0

3 of 14

No

No

0

3 of 14

No

No

0

2 of 14

No

No

0

Human Disease Associations

FlyBase Human Disease Model Reports

frontotemporal dementia and/or amyotrophic lateral sclerosis 7

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 3 )

Allele

Disease

Evidence

References

Hsap\CHMP2B^Intron5.UAS

model of frontotemporal dementia

CEA

(Yuva-Aydemir et al., 2019, West et al., 2018, West et al., 2015)

model of frontotemporal dementia and/or amyotrophic lateral sclerosis 7

CEC

(Jun et al., 2023, Lee et al., 2019)

CEA

(Chen et al., 2022, Lu et al., 2020, Wilson et al., 2020)

Hsap\CHMP2B^{Intron5.13xlexAop}

model of frontotemporal dementia and/or amyotrophic lateral sclerosis 7

CEA

(Fort-Aznar et al., 2020)

Hsap\CHMP2B^{Intron5.UAS.Tag:FLAG}

model of frontotemporal dementia and/or amyotrophic lateral sclerosis 7

CEA

(Deng et al., 2022)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

Hsap\CHMP2B^Intron5.UAS

model of frontotemporal dementia

is exacerbated by Rab8¹

(West et al., 2015)

is ameliorated by Rab8^UAS.cWa

(West et al., 2015)

is exacerbated by Rab8^RNAi.UAS

(West et al., 2015)

is exacerbated by Akt³

(West et al., 2018)

is exacerbated by Akt⁰⁴²²⁶

(West et al., 2018)

is ameliorated by POSH⁷⁴

(West et al., 2018)

is exacerbated by Akt^HMS00007

(West et al., 2018)

is ameliorated by POSH^HMC05588

(West et al., 2018)

is exacerbated by Akt^{ΔPH.UAS.Tag:Myr(Unk)}

(West et al., 2018)

model of frontotemporal dementia and/or amyotrophic lateral sclerosis 7

is ameliorated by zip¹

(Jun et al., 2023)

is ameliorated by zip^GD1566

(Jun et al., 2023)

is ameliorated by zip^GL00623

(Jun et al., 2023)

is exacerbated by spas^HMC03560

(Chen et al., 2022)

is exacerbated by spas^JF02724

(Chen et al., 2022)

is ameliorated by N^l1N-ts1

(Wilson et al., 2020)

is exacerbated by IKKε^GL00160

(Lu et al., 2020)

is ameliorated by IKKε^{UAS.ORF.Tag:HA}

(Lu et al., 2020)

is exacerbated by IKKε^alice

(Lu et al., 2020)

is exacerbated by TER94^k15502

(Lu et al., 2020)

is exacerbated by ctp^GD4688

(Lu et al., 2020)

is exacerbated by ctp^KK115493

(Lu et al., 2020)

is exacerbated by hook¹¹

(Lu et al., 2020)

is exacerbated by hook⁷

(Lu et al., 2020)

is exacerbated by hook^GD12598

(Lu et al., 2020)

is exacerbated by spn-F²

(Lu et al., 2020)

is exacerbated by spn-F^HMC06087

(Lu et al., 2020)

Hsap\CHMP2B^{Intron5.13xlexAop}

model of frontotemporal dementia and/or amyotrophic lateral sclerosis 7

is exacerbated by BoYb^HMJ23886

(Fort-Aznar et al., 2020)

is exacerbated by SoYb^G19414

(Fort-Aznar et al., 2020)

is exacerbated by piwi¹

(Fort-Aznar et al., 2020)

is exacerbated by piwi²

(Fort-Aznar et al., 2020)

is exacerbated by piwi^HMS00606

(Fort-Aznar et al., 2020)

is exacerbated by vret^HP36220

(Fort-Aznar et al., 2020)

Hsap\CHMP2B^{Intron5.UAS.Tag:FLAG}

exacerbates amyotrophic lateral sclerosis type 10

modeled by Hsap\TARDBP^UAS.cDa

(Deng et al., 2022)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

Class of Gene

engineered_foreign_gene

(FlyBase Curators, 1992-)

(FlyBase Curators, 1992-)

Stocks and Reagents

Stocks (1)

92060

y¹ w^*; PBac{UAS-hCHMP2B.HA}VK00037

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

FlyBase curator comment: Name changed to reflect current HGNC name (19th Nov. 2012).

(FlyBase Curators, 1992-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

CHMP2.5

(HGNC Curators and FlyBase Curators, 2013-)

CHMP2B

(Chen et al., 2022, West et al., 2018, Celniker and Bellen, 2017-, West et al., 2015, Cheruiyot et al., 2014, HGNC Curators and FlyBase Curators, 2013-, Lu et al., 2013, Ahmad et al., 2009, FlyBase Curators, 1992-)

DKFZP564O123

(HGNC Curators and FlyBase Curators, 2013-)

Hsap\CHMP2B

VPS2B

(HGNC Curators and FlyBase Curators, 2013-)

Name Synonyms

Homo sapiens chromatin modifying protein 2B

VPS2 homolog B (S. cerevisiae)

(HGNC Curators and FlyBase Curators, 2013-)

charged multivesicular body protein 2B

(HGNC Curators and FlyBase Curators, 2013-)

chromatin modifying protein 2B

(HGNC Curators and FlyBase Curators, 2013-)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 6 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

25978

Other crossreferences

Ensembl_Homo_sapiens -

ENSG00000083937

HUGO Gene Nomenclature Committee -

CHMP2B; charged multivesicular body protein 2B

MARRVEL - MARRVEL (human gene)

CHMP2B

OMIM_GENE - Online Mendelian Inheritance in Man (Genes)

CHARGED MULTIVESICULAR BODY PROTEIN 2B; CHMP2B

OMIM_PHENOTYPE - Online Mendelian Inheritance in Man (Phenotypes)

FRONTOTEMPORAL DEMENTIA AND/OR AMYOTROPHIC LATERAL SCLEROSIS 7; FTDALS7

References (18)