FlyBase Gene Report: Hsap\TARDBP

CEA

(Elden et al., 2010)

Hsap\TARDBP^Q331K.UAS

CEA

(Elden et al., 2010)

CEA

(Zhao et al., 2023, Solomon et al., 2018)

Hsap\TARDBP^UAS.YFP

CEA

(Elden et al., 2010)

CEA

(Berson et al., 2017)

Hsap\TARDBP^UAS.Tag:HA

model of neurodegenerative disease

CEA

(Gregory et al., 2012)

Hsap\TARDBP^{TDP-25.UAS.Tag:HA}

CEA

(Gregory et al., 2017)

model of motor neuron disease

CEA

(Ott et al., 2015)

model of neurodegenerative disease

CEA

(Gregory et al., 2012)

Hsap\TARDBP^{M.UAS.Tag:FLAG}

model of neurodegenerative disease

CEA

(Miguel et al., 2011)

CEC

(Chang and Dubnau, 2023)

CEA

(Azpurua et al., 2021, Couly et al., 2020, Park et al., 2020, Krug et al., 2017)

Hsap\TARDBP^mutNLS.UAS

model of neurodegenerative disease

CEA

(Miguel et al., 2011)

CEA

(Park et al., 2020)

Hsap\TARDBP^{ΔN251.UAS.EGFP}

Hsap\TARDBP^{S5A.ΔN251.UAS.EGFP}

CEA

(Li et al., 2011)

model of frontotemporal dementia

CEA

(Li et al., 2011)

CEA

(Li et al., 2011)

model of frontotemporal dementia

CEA

(Li et al., 2011)

Hsap\TARDBP^UAS.Tag:FLAG

CEA with TBPH^Δ23

(Romano et al., 2015)

Hsap\TARDBP^{AggIn.UAS.Tag:FLAG}

CEC

(Cacciottolo et al., 2019)

CEA

(Ikeda et al., 2024, Farrugia et al., 2022)

Hsap\TARDBP^{TDP-35.UAS.Tag:HA}

CEA

(Langellotti et al., 2016)

model of neurodegenerative disease

CEA

(Crippa et al., 2016)

Hsap\TARDBP^UAS.cIa

CEA

(Ihara et al., 2013)

CEA

(Matsukawa et al., 2021, Matsukawa et al., 2016)

Hsap\TARDBP^G298S.UAS

CEA

(Ihara et al., 2013)

CEA

(Godfrey et al., 2023, Lehmkuhl et al., 2021, Matsukawa et al., 2021, Coyne et al., 2017, Liu et al., 2017)

Hsap\TARDBP^{A315T.UAS.cIa}

CEA

(Ihara et al., 2013)

CEC

(Nitta et al., 2023)

Hsap\TARDBP^{M337V.UAS.cIa}

CEA

(Ihara et al., 2013)

Hsap\TARDBP^Q343R.UAS

CEA

(Ihara et al., 2013)

Hsap\TARDBP^NLSmt.UAS

CEA

(Ihara et al., 2013)

Hsap\TARDBP^{NLSmut.G298S.UAS}

CEA

(Matsukawa et al., 2016)

Hsap\TARDBP^{NLSmut.M337V.UAS}

CEA

(Ihara et al., 2013)

CEA

(Ihara et al., 2013)

Hsap\TARDBP^UAS.Tag:MYC

CEC

(Khalil et al., 2022)

CEA

(Singh et al., 2024, Lehmkuhl et al., 2021, Coyne et al., 2017)

Hsap\TARDBP^{NLSmut.UAS.Tag:MYC}

CEA

(Uechi et al., 2018)

model of neurodegenerative disease

CEA

(Crippa et al., 2016, Ritson et al., 2010)

Hsap\TARDBP^{Δ1-79.UAS.Tag:MYC}

CEA

(He et al., 2014)

model of neurodegenerative disease

CEA

(Ritson et al., 2010)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}

CEC

(Khalil et al., 2022)

CEA

(Glineburg et al., 2024, Hwang et al., 2024, Huber et al., 2023, Kankel et al., 2020, Zhang et al., 2020, Markmiller et al., 2018, Periz et al., 2015, He et al., 2014)

CEA

(Uechi et al., 2018, Crippa et al., 2016)

model of neurodegenerative disease

CEA

(Ritson et al., 2010)

Hsap\TARDBP^ΔN.UAS

CEA

(Ishiguro et al., 2017)

Hsap\TARDBP^{M337V.UAS.cLa}

CEA

(Coyne et al., 2017)

Hsap\TARDBP^{Q331K.UAS.cLa}

CEA

(Choksi et al., 2014)

CEA

(Coyne et al., 2017)

Hsap\TARDBP^ΔC.UAS

DOES NOT model amyotrophic lateral sclerosis

CEA

(Ishiguro et al., 2017)

Hsap\TARDBP^UAS.cLa

CEC

(Yusuff et al., 2023)

CEA

(Sanna et al., 2020)

Hsap\TARDBP^RRM.UAS

DOES NOT model amyotrophic lateral sclerosis

CEA

(Ishiguro et al., 2017)

Hsap\TARDBP^UAS.cIb

CEA

(Ishiguro et al., 2017)

CEA

(Ueda et al., 2024, Godfrey et al., 2023)

CEC

(Nitta et al., 2023)

Hsap\TARDBP^{G298S.UAS.cIb}

CEA

(Ishiguro et al., 2017)

Hsap\TARDBP^UAS.cSa

CEC

(Barnard et al., 2024)

Hsap\TARDBP^{Q331K.UAS.cSa}

CEA

(Sreedharan et al., 2015)

Hsap\TARDBP^{12xQN.UAS.EGFP}

Hsap\TARDBP^{WT.DsR+.Tag:FLAG}

CEA

(Cragnaz et al., 2015)

CEA with TBPH^Δ23

(Cragnaz et al., 2015)

CEA with TBPH^GD6943

(Cragnaz et al., 2015)

Hsap\TARDBP^{G294A.DsR+.Tag:FLAG}

CEC

(Chang and Dubnau, 2023)

Hsap\TARDBP^{M337V.DsR+.Tag:FLAG}

CEA

(Lehmkuhl et al., 2021, Chang and Morton, 2017)

CEA

(Chang and Morton, 2017)

Hsap\TARDBP^UAS.cPa

CEA

(Pons et al., 2017)

Hsap\TARDBP^UAS.TDPBR

CEC

(Yusuff et al., 2023)

CEA

(Pons et al., 2018, Pons et al., 2017)

Hsap\TARDBP^{N267S.UAS.cMa}

CEA

(Miguel et al., 2018)

Hsap\TARDBP^{G298S.UAS.cMa}

CEA

(Miguel et al., 2018)

Hsap\TARDBP^{A315T.UAS.cLa}

CEA

(Miguel et al., 2018)

Hsap\TARDBP^{M337V.UAS.cMa}

CEA

(Miguel et al., 2018)

Hsap\TARDBP^{Q343R.UAS.cMa}

CEA

(Miguel et al., 2018)

Hsap\TARDBP^{N267S.UAS.TDPBR}

CEA

(Miguel et al., 2018)

Hsap\TARDBP^{G298S.UAS.TDPBR}

CEA

(Miguel et al., 2018)

Hsap\TARDBP^{A315T.UAS.TDPBR}

CEA

(Miguel et al., 2018)

Hsap\TARDBP^{M337V.UAS.TDPBR}

CEA

(Miguel et al., 2018)

Hsap\TARDBP^{Q343R.UAS.TDPBR}

CEA

(Miguel et al., 2018)

Hsap\TARDBP^UAS.cDa

CEC

(Duan et al., 2019)

CEA

(Deng et al., 2022, Sun et al., 2018)

Hsap\TARDBP^{A315T.UAS.Venus}

Hsap\TARDBP^{A315T.UAS.RFP(Unk)}

CEA

(Alami et al., 2014)

Hsap\TARDBP^{M337V.UAS.Venus}

model of amyotrophic lateral sclerosis type 9

CEA

(Alami et al., 2014)

CEA

(Xu et al., 2019, Guo et al., 2011)

CEC

(Wang et al., 2019, Xu et al., 2019)

Hsap\TARDBP^UAS.cUa

Hsap\TARDBP^{UAS.cKa.Tag:FLAG}

CEA

(Krupp et al., 2023, Liu et al., 2017, Saitoh et al., 2015)

CEC with Hsap\ATXN2^32Q.UAS

(Lee et al., 2020)

Hsap\TARDBP^{G298S.UAS.Tag:FLAG}

CEA

(Khalil et al., 2017)

CEA

(Khalil et al., 2017)

Hsap\TARDBP^{UAS.cWa.Tag:MYC}

Hsap\TARDBP^{D169G.UAS.Tag:MYC}

CEA

(Wang et al., 2020)

Hsap\TARDBP^{NLSmut.UAS.cWa.Tag:MYC}

CEA

(Wang et al., 2020)

Hsap\TARDBP^{NESmut.UAS.cWa.Tag:MYC}

CEA

(Wang et al., 2020)

CEA

(Wang et al., 2020)

Hsap\TARDBP^WT.UAS.cZa

CEA

(Zhao et al., 2021)

Hsap\TARDBP^T199A.UAS

CEA

(Zhao et al., 2021)

Hsap\TARDBP^T233A.UAS

CEA

(Zhao et al., 2021)

Hsap\TARDBP^2TA.UAS

CEA

(Zhao et al., 2021)

Hsap\TARDBP^UAS.CO

Hsap\TARDBP^{F4L.12xQN.UAS.Tag:FLAG}

CEC

(Yusuff et al., 2023)

Hsap\TARDBP^{G294A.UAs.Tag:MYC}

CEA

(Cragnaz et al., 2021)

Hsap\TARDBP^{Δ321-366.UAS.Tag:HA}

CEA

(He et al., 2014)

Hsap\TARDBP^{opto.UAS.mCherry}

CEA

(He et al., 2014)

CEA

(Otte et al., 2020)

Hsap\TARDBP^UAS.mCherry

CEA

(Otte et al., 2020)

Hsap\TARDBP^{A382T.UAS.cEPa}

CEC

(Ervilha Pereira et al., 2023)

Hsap\TARDBP^UAS.cEPa

CEC

(Ervilha Pereira et al., 2023)

Hsap\TARDBP^{M337V.UAS.cEPa}

Hsap\TARDBP^{W385IfsTer10.UAS}

CEC

(Ervilha Pereira et al., 2023)

DOES NOT model amyotrophic lateral sclerosis type 10

CEC

(Ervilha Pereira et al., 2023)

model of myopathy

CEA

(Ervilha Pereira et al., 2023)

Hsap\TARDBP^gl.CO

CEC

(Yusuff et al., 2023)

Hsap\TARDBP^UAS.cLPa

CEA

(Lo Piccolo et al., 2023)

Hsap\TARDBP^{G348C.UAS.cLPa}

CEA

(Lo Piccolo et al., 2023)

Hsap\TARDBP^UAS.cDb

CEA

(Droppelmann et al., 2024)

Hsap\TARDBP^UAS.EGFP

Hsap\TARDBP^{UAS.Tag:HA,RFP(Unk)}

CEA

(Glineburg et al., 2024)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 54 )

Allele

Disease

Interaction

References

is exacerbated by Lon^GD14030

(Wang et al., 2019)

is exacerbated by Lon^RNAi.UAS.cUa

(Wang et al., 2019)

exacerbates C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis

modeled by Zzzz\poly-GR^PO-36.UAS

(Li et al., 2023)

modeled by Zzzz\poly-GR^{80.UAS.Tag:FLAG}

(Li et al., 2023)

modeled by Zzzz\GGGGCC^36.UAS

(Li et al., 2023)

Hsap\TARDBP^WT.UAS

is exacerbated by Gem3^ΔN.UAS

(Cacciottolo et al., 2019)

Hsap\TARDBP^G287S.UAS

is ameliorated by RyR^KK101716

(Park et al., 2020)

Hsap\TARDBP^UAS.cHa

is ameliorated by Dad^j1E4

(Deshpande et al., 2016)

is ameliorated by Rab11^N124I.UAS

(Deshpande et al., 2016)

is exacerbated by Hsap\UBQLN1^UAS.cHa

(Hanson et al., 2010)

is ameliorated by Itpr^90B.0

(Kim et al., 2012)

is ameliorated by Itpr^ug3

(Kim et al., 2012)

is ameliorated by Itpr^sv35

(Kim et al., 2012)

is ameliorated by TBPH^Δ142

(Zhan et al., 2013)

is ameliorated by stg^EY12388

(Zhan et al., 2013)

Hsap\TARDBP^{UAS.x10.Tag:FLAG}

is ameliorated by Itpr^90B.0

(Balasubramanian and Srinivasan, 2020)

is ameliorated by Itpr^ug3

(Balasubramanian and Srinivasan, 2020)

ameliorates amyotrophic lateral sclerosis

modeled by TBPH^Δ23, TBPH¹

(Baldwin et al., 2016)

Hsap\TARDBP^UAS.YFP.cEa

is ameliorated by Fmr1^UAS.YFP

(Coyne et al., 2015)

is exacerbated by Fmr1^GD1288

(Coyne et al., 2015)

is exacerbated by Fmr1^Δ50M

(Coyne et al., 2015)

is ameliorated by BacA\p35^UAS.cHa

(Estes et al., 2011)

is ameliorated by Hsap\HSPA1L^UAS.cWa

(Estes et al., 2011)

is exacerbated by Prosβ2^1.UAS

(Estes et al., 2011)

is ameliorated by futsch^EP1419

(Coyne et al., 2014)

is exacerbated by Pabp2⁵⁵

(Chou et al., 2015)

Hsap\TARDBP^{M337V.UAS.x10.Tag:FLAG}

is exacerbated by Pfk^HMS01324

(Manzo et al., 2019)

is ameliorated by Pfk^UAS.cTa

(Manzo et al., 2019)

is ameliorated by dlp^UAS.cBa

(Godfrey et al., 2023)

is ameliorated by Hsap\IDH3A^UAS.cUa

(Loganathan et al., 2022)

is ameliorated by Idh3a^UAS.cUa

(Loganathan et al., 2022)

ameliorates amyotrophic lateral sclerosis

modeled by TBPH^Δ23, TBPH¹

(Baldwin et al., 2016)

Hsap\TARDBP^WT.UAS.GFP

model of neurodegenerative disease

is exacerbated by Usp8^KK100733

(Hans et al., 2014)

is exacerbated by Gem3^ΔN.UAS

(Cacciottolo et al., 2019)

Hsap\TARDBP^{A315T.UAS.YFP}

is exacerbated by Prosβ2^1.UAS

(Estes et al., 2011)

is ameliorated by Hsap\HSPA1L^UAS.cWa

(Estes et al., 2011)

is ameliorated by BacA\p35^UAS.cHa

(Estes et al., 2011)

is exacerbated by Pabp2⁵⁵

(Chou et al., 2015)

Hsap\TARDBP^{D169G.UAS.YFP}

is exacerbated by Pabp2⁵⁵

(Chou et al., 2015)

Hsap\TARDBP^{G298S.UAS.YFP}

is ameliorated by Fmr1^UAS.YFP

(Coyne et al., 2015)

is exacerbated by Fmr1^GD1288

(Coyne et al., 2015)

is exacerbated by Fmr1^Δ50M

(Coyne et al., 2015)

is ameliorated by futsch^EP1419

(Coyne et al., 2014)

is exacerbated by Pabp2⁵⁵

(Chou et al., 2015)

is exacerbated by Pfk^HMS01324

(Manzo et al., 2019)

is ameliorated by Pfk^UAS.cTa

(Manzo et al., 2019)

is ameliorated by Hsap\IDH3A^UAS.cUa

(Loganathan et al., 2022)

is ameliorated by Idh3a^UAS.cUa

(Loganathan et al., 2022)

Hsap\TARDBP^UAS.cEa

is exacerbated by Hsap\ATXN2^64CAA.UAS

(McGurk et al., 2021)

is exacerbated by Hsap\ATXN2^64CAG.UAS

(McGurk et al., 2021)

is ameliorated by Ptp61F^HMS00421

(Lee et al., 2020)

is ameliorated by Rack1^HMS01173

(Zhao et al., 2023)

is ameliorated by GstO2^A.UAS

(Cha et al., 2020)

is ameliorated by Marf^UAS.cUa

(Altanbyek et al., 2016)

is exacerbated by Marf^RNAi.UAS.cUa

(Altanbyek et al., 2016)

is ameliorated by Opa1^UAS.cUa

(Altanbyek et al., 2016)

is ameliorated by Drp1^DN.UAS.cUa

(Altanbyek et al., 2016)

is exacerbated by Marf^RNAi.UAS.cUa

(Altanbyek et al., 2016)

is ameliorated by Hsc70-4^UAS.cEa

(Berson et al., 2017)

is ameliorated by Hsp68^UAS.cUa

(Berson et al., 2017)

is ameliorated by Kdm5^HM05155

(Berson et al., 2017)

is exacerbated by Set1^HMS00581

(Berson et al., 2017)

is exacerbated by Chd1^HMS01142

(Berson et al., 2017)

is exacerbated by Wdr82^HMS00718

(Berson et al., 2017)

is exacerbated by ash2^EY03971

(Berson et al., 2017)

is ameliorated by Chd1^UAS.cMa

(Berson et al., 2017)

is ameliorated by Hsc70-3^UAS.cEa

(François-Moutal et al., 2022)

is ameliorated by Tnks^NIG.4719R

(McGurk et al., 2018)

is ameliorated by Ice1^SH09112.N

(Chung et al., 2018)

is exacerbated by Su(Tpl)^G4098

(Chung et al., 2018)

is ameliorated by Su(Tpl)^HMS00277

(Chung et al., 2018)

is ameliorated by Su(Tpl)^S-192

(Chung et al., 2018)

is ameliorated by ear^HMS00107

(Chung et al., 2018)

is ameliorated by lilli^A17-2

(Chung et al., 2018)

is ameliorated by lncRNA:Hsrω⁶⁶

(Chung et al., 2018)

is ameliorated by lncRNA:Hsrω^HMC05093

(Chung et al., 2018)

is ameliorated by snRNA:U12^HMC03841

(Chung et al., 2018)

is ameliorated by Ref1^HMS01301

(Berson et al., 2019)

is exacerbated by hfp^HMS00094

(Berson et al., 2019)

is ameliorated by swm^HMC03677

(Berson et al., 2019)

is exacerbated by nonA^HMC03675

(Koch and Nagoshi, 2025)

is exacerbated by nonA^HMJ23111

(Koch and Nagoshi, 2025)

is ameliorated by Atx2^X1

(Elden et al., 2010)

is exacerbated by Atx2^EP3145

(Elden et al., 2010)

is ameliorated by PEK^GL00030

(Kim et al., 2014)

is ameliorated by pAbp^JF03104

(Kim et al., 2014)

is exacerbated by pAbp^UAS.cSa

(Kim et al., 2014)

is exacerbated by Hsap\ATXN2^32Q.UAS

(Kim et al., 2014)

is ameliorated by Rox8^HMS00472

(Kim et al., 2014)

is exacerbated by PPP1R15^HMS00811

(Kim et al., 2014)

Hsap\TARDBP^Q331K.UAS

is ameliorated by Rack1^HMS01173

(Zhao et al., 2023)

Hsap\TARDBP^UAS.Tag:HA

model of neurodegenerative disease

is ameliorated by CG14207^EP1348

(Gregory et al., 2012)

Hsap\TARDBP^{TDP-25.UAS.Tag:HA}

is ameliorated by Hsap\CLU^UAS.cGa

(Gregory et al., 2017)

model of neurodegenerative disease

is ameliorated by CG14207^EP1348

(Gregory et al., 2012)

Hsap\TARDBP^{M.UAS.Tag:FLAG}

is ameliorated by Hsap\SIGMAR1^UAS.cCa

(Couly et al., 2020)

is ameliorated by RyR^KK101716

(Park et al., 2020)

is ameliorated by MED11^HMS01094

(Azpurua et al., 2021)

is ameliorated by CG2186^HMS01090

(Azpurua et al., 2021)

is ameliorated by CG30379^HMS01567

(Azpurua et al., 2021)

is ameliorated by CG7309^HMC02417

(Azpurua et al., 2021)

is ameliorated by CG8034^HMS00331

(Azpurua et al., 2021)

is ameliorated by CG9451^HMS01016

(Azpurua et al., 2021)

is ameliorated by Chd1^HMS01142

(Azpurua et al., 2021)

is exacerbated by Chd1^HMS01142

(Azpurua et al., 2021)

is ameliorated by tomb^HMS01557

(Azpurua et al., 2021)

is ameliorated by Gγ30A^HMS01362

(Azpurua et al., 2021)

is ameliorated by Hel25E^HMS00076

(Azpurua et al., 2021)

is ameliorated by Hsp70Bb^HMS00900

(Azpurua et al., 2021)

is ameliorated by MED15^HMS00522

(Azpurua et al., 2021)

is ameliorated by MED21^HMS01211

(Azpurua et al., 2021)

is ameliorated by MED22^HMS01047

(Azpurua et al., 2021)

is ameliorated by Br140^HMC04342

(Azpurua et al., 2021)

is ameliorated by MED27^HMS01050

(Azpurua et al., 2021)

is ameliorated by MED28^HMS00458

(Azpurua et al., 2021)

is ameliorated by MED31^HMS01048

(Azpurua et al., 2021)

is ameliorated by MED8^HMS01275

(Azpurua et al., 2021)

is ameliorated by SF2^HMS00358

(Azpurua et al., 2021)

is ameliorated by SF2^gRNA.pCFD3-1

(Azpurua et al., 2021)

is ameliorated by SF2^gRNA.pCFD3-2

(Azpurua et al., 2021)

is ameliorated by Su(Tpl)^HMS00277

(Azpurua et al., 2021)

is ameliorated by Taf1^HMS00416

(Azpurua et al., 2021)

is ameliorated by Taf9^HMS00336

(Azpurua et al., 2021)

is ameliorated by ash1^HMS00582

(Azpurua et al., 2021)

is ameliorated by br^HMS00042

(Azpurua et al., 2021)

is ameliorated by e(y)3^HMS00337

(Azpurua et al., 2021)

is ameliorated by enok^HMS02048

(Azpurua et al., 2021)

is ameliorated by enok^HMS02165

(Azpurua et al., 2021)

is ameliorated by mor^HMS01267

(Azpurua et al., 2021)

is ameliorated by msk^HMS00020

(Azpurua et al., 2021)

is ameliorated by msk^gRNA.pCFD3-1

(Azpurua et al., 2021)

is ameliorated by msk^gRNA.pCFD3-2

(Azpurua et al., 2021)

is ameliorated by nito^HMS00166

(Azpurua et al., 2021)

is ameliorated by polybromo^HMS00531

(Azpurua et al., 2021)

is ameliorated by lok^GD4190

(Krug et al., 2017)

Hsap\TARDBP^UAS.Tag:FLAG

ameliorates neurodegenerative disease

modeled by TBPH^Δ23

(Feiguin et al., 2009)

Hsap\TARDBP^{TDP-35.UAS.Tag:HA}

is exacerbated by Gem3^ΔN.UAS

(Cacciottolo et al., 2019)

is exacerbated by Chchd2^null

(Ikeda et al., 2024)

model of neurodegenerative disease

is ameliorated by Hsp67Bc^UAS.Tag:V5

(Crippa et al., 2016)

Hsap\TARDBP^GMR.PJ

exacerbates spinocerebellar ataxia 1

modeled by Hsap\ATXN1^82Q.UAS

(Tazelaar et al., 2020)

Hsap\TARDBP^UAS.cIa

is NOT exacerbated by Hsap\PFN1^UAS.cMa

(Matsukawa et al., 2016)

is exacerbated by Hsap\PFN1^C71G.UAS

(Matsukawa et al., 2016)

is exacerbated by Hsap\PFN1^M114T.UAS

(Matsukawa et al., 2016)

is NOT exacerbated by chic^NIG.9553R

(Matsukawa et al., 2016)

is ameliorated by Hsap\NEAT1^UAS.1

(Matsukawa et al., 2021)

Hsap\TARDBP^G298S.UAS

is ameliorated by Hsap\NEAT1^UAS.1

(Matsukawa et al., 2021)

is ameliorated by dlp^UAS.cBa

(Lehmkuhl et al., 2021)

is ameliorated by dlp^GLC01658

(Lehmkuhl et al., 2021)

is ameliorated by Csp^+t12.3

(Coyne et al., 2017)

is ameliorated by Csp^H45Q.UAS

(Coyne et al., 2017)

is ameliorated by Hsc70-4^{wt.UAS.Tag:HA}

(Coyne et al., 2017)

is ameliorated by shi^UAS.cUa

(Coyne et al., 2017)

is exacerbated by Rab5^EY10619

(Liu et al., 2017)

is exacerbated by Rab5^UASp.YFP

(Liu et al., 2017)

is exacerbated by Rab7^Gal4-KO

(Liu et al., 2017)

is exacerbated by Rab7^{Q67L.UAS.Venus}

(Liu et al., 2017)

is exacerbated by Rab7^{T22N.UAS.Venus}

(Liu et al., 2017)

Hsap\TARDBP^NLSmt.UAS

is NOT exacerbated by Hsap\PFN1^M114T.UAS

(Matsukawa et al., 2016)

is NOT exacerbated by Hsap\PFN1^UAS.cMa

(Matsukawa et al., 2016)

is NOT exacerbated by Hsap\PFN1^C71G.UAS

(Matsukawa et al., 2016)

Hsap\TARDBP^UAS.Tag:MYC

is ameliorated by CG5445^UAS.cUa

(Uechi et al., 2018)

is exacerbated by CG5445^NIG.5445R

(Uechi et al., 2018)

exacerbates neurodegenerative disease

modeled by TER94^R152H.UAS.R

(Ritson et al., 2010)

Hsap\TARDBP^{NLSmut.UAS.Tag:MYC}

is ameliorated by dlp^UAS.cBa

(Lehmkuhl et al., 2021)

is ameliorated by dlp^GLC01658

(Lehmkuhl et al., 2021)

is ameliorated by Csp^+t12.3

(Coyne et al., 2017)

is ameliorated by Csp^H45Q.UAS

(Coyne et al., 2017)

is ameliorated by Hsc70-4^{wt.UAS.Tag:HA}

(Coyne et al., 2017)

is ameliorated by shi^UAS.cUa

(Coyne et al., 2017)

ameliorates neurodegenerative disease

modeled by Zzzz\CGG^90.UAS.EGFP

(He et al., 2014)

exacerbates neurodegenerative disease

modeled by TER94^R152H.UAS.R

(Ritson et al., 2010)

modeled by Zzzz\CGG^90.UAS.EGFP

(He et al., 2014)

model of neurodegenerative disease

is ameliorated by Hsp67Bc^UAS.Tag:V5

(Crippa et al., 2016)

Hsap\TARDBP^{NESmut.UAS.Tag:MYC}

exacerbates neurodegenerative disease

modeled by TER94^R152H.UAS.R

(Ritson et al., 2010)

Hsap\TARDBP^{M337V.UAS.Tag:MYC}

is ameliorated by Fs(2)Ket^EY06666

(Khalil et al., 2022)

is exacerbated by Fs(2)Ket^GL01273

(Khalil et al., 2022)

is exacerbated by Fs(2)Ket^HMS02872

(Khalil et al., 2022)

is exacerbated by Fs(2)Ket^JF02721

(Khalil et al., 2022)

is exacerbated by Fs(2)Ket^KK100714

(Khalil et al., 2022)

is ameliorated by Fs(2)Ket^{UAS.cKa.Tag:V5}

(Khalil et al., 2022)

is ameliorated by cdm^UAS.cGa

(Khalil et al., 2022)

is exacerbated by βTub85D^HMC06040

(Huber et al., 2023)

is exacerbated by CG5382^HMC05570

(Huber et al., 2023)

is ameliorated by Cth^HMS03027

(Huber et al., 2023)

is ameliorated by Had1^KK108568

(Huber et al., 2023)

is ameliorated by Hpr1^GD9706

(Huber et al., 2023)

is ameliorated by Klp61F^HMS00552

(Huber et al., 2023)

is ameliorated by MED23^HMS01135

(Huber et al., 2023)

is ameliorated by Ndc1^HMC06378

(Huber et al., 2023)

is ameliorated by Nmnat^JF03337

(Huber et al., 2023)

is ameliorated by PNKP^HMS01919

(Huber et al., 2023)

is ameliorated by Pex19^HMC03104

(Huber et al., 2023)

is ameliorated by Polr2K^HMS05951

(Huber et al., 2023)

is ameliorated by Qsox2^JF02857

(Huber et al., 2023)

is ameliorated by STUB1^HMS00889

(Huber et al., 2023)

is exacerbated by c12.1^HMS00382

(Huber et al., 2023)

is exacerbated by hyd^HMS00343

(Huber et al., 2023)

is exacerbated by mRNA-cap^HMS00631

(Huber et al., 2023)

is ameliorated by osa^HMS01738

(Huber et al., 2023)

is exacerbated by wapl^HMS05805

(Huber et al., 2023)

is ameliorated by Ube4B^JF02691

(Periz et al., 2015)

is ameliorated by Pka-R2^d02258

(Kankel et al., 2020)

is ameliorated by Ask1^HMS00464

(Kankel et al., 2020)

is ameliorated by Pld^HMS00529

(Kankel et al., 2020)

is ameliorated by Atx-1^f01201

(Kankel et al., 2020)

is ameliorated by Hsp110^d03562

(Kankel et al., 2020)

is ameliorated by Setx^f05408

(Kankel et al., 2020)

is exacerbated by Strip^e04482

(Kankel et al., 2020)

is exacerbated by dco^d06510

(Kankel et al., 2020)

is exacerbated by glo^f02674

(Kankel et al., 2020)

is ameliorated by heca^d10800

(Kankel et al., 2020)

is ameliorated by orb^d06989

(Kankel et al., 2020)

is ameliorated by pum^d04225

(Kankel et al., 2020)

is exacerbated by sas^d07239

(Kankel et al., 2020)

is ameliorated by d10800^d10800

(Kankel et al., 2020)

is exacerbated by Smox^JF02320

(Zhang et al., 2020)

is ameliorated by Usp7^HMS01187

(Zhang et al., 2020)

is exacerbated by babo^HMS02033

(Zhang et al., 2020)

is ameliorated by Dbct^KO

(Hwang et al., 2024)

is ameliorated by Dbct^TKO.GS01842

(Hwang et al., 2024)

is ameliorated by Rbp6^d08411

(Markmiller et al., 2018)

is ameliorated by Rox8^e04432

(Markmiller et al., 2018)

is ameliorated by Su(var)205^c06825

(Markmiller et al., 2018)

is ameliorated by bel^GL00205

(Markmiller et al., 2018)

is ameliorated by shep^d07053

(Markmiller et al., 2018)

is exacerbated by SFV\nsp3^UAS.mApple

(Glineburg et al., 2024)

is ameliorated by CG5445^UAS.cUa

(Uechi et al., 2018)

is exacerbated by CG5445^NIG.5445R

(Uechi et al., 2018)

is ameliorated by Rpn11^UAS.cTa

(Uechi et al., 2018)

is ameliorated by Hsp67Bc^UAS.Tag:V5

(Crippa et al., 2016)

exacerbates neurodegenerative disease

modeled by Zzzz\CGG^90.UAS.EGFP

(He et al., 2014)

Hsap\TARDBP^ΔN.UAS

ameliorates spinocerebellar ataxia 31

modeled by Zzzz\UGGAA^W.UAS

(Ishiguro et al., 2017)

modeled by Zzzz\UGGAA^S.UAS

(Ishiguro et al., 2017)

Hsap\TARDBP^{M337V.UAS.cLa}

is ameliorated by Hsc70-4^{wt.UAS.Tag:HA}

(Coyne et al., 2017)

Hsap\TARDBP^{Q331K.UAS.cLa}

is exacerbated by dco^UAS.cUa

(Choksi et al., 2014)

is ameliorated by Hsc70-4^{wt.UAS.Tag:HA}

(Coyne et al., 2017)

Hsap\TARDBP^ΔC.UAS

ameliorates spinocerebellar ataxia 31

modeled by Zzzz\UGGAA^W.UAS

(Ishiguro et al., 2017)

modeled by Zzzz\UGGAA^S.UAS

(Ishiguro et al., 2017)

Hsap\TARDBP^UAS.cLa

ameliorates fragile X-associated tremor/ataxia syndrome

modeled by Zzzz\CGG^90.UAS.EGFP

(Galloway et al., 2014)

is ameliorated by HDAC1^GD4513

(Sanna et al., 2020)

Hsap\TARDBP^RRM.UAS

DOES NOT ameliorate spinocerebellar ataxia 31

modeled by Zzzz\UGGAA^W.UAS

(Ishiguro et al., 2017)

modeled by Zzzz\UGGAA^S.UAS

(Ishiguro et al., 2017)

Hsap\TARDBP^UAS.cIb

is ameliorated by Zzzz\UGGAA^W.UAS

(Ishiguro et al., 2017)

is ameliorated by Zzzz\UGGAA^22.UAS

(Ishiguro et al., 2017)

ameliorates spinocerebellar ataxia 31

modeled by Zzzz\UGGAA^W.UAS

(Ishiguro et al., 2017)

modeled by Zzzz\UGGAA^S.UAS

(Ishiguro et al., 2017)

is exacerbated by DCTN1-p150^RNAi.AP.UAS

(Ueda et al., 2024)

is exacerbated by DCTN2-p50^GD13758

(Ueda et al., 2024)

is exacerbated by DCTN2-p50^KK107476

(Ueda et al., 2024)

is exacerbated by Dhc64C^GD12258

(Ueda et al., 2024)

is exacerbated by Khc^GD12278

(Ueda et al., 2024)

is exacerbated by Klc^GD11649

(Ueda et al., 2024)

is exacerbated by robl^GD12965

(Ueda et al., 2024)

is exacerbated by robl^KK109229

(Ueda et al., 2024)

Hsap\TARDBP^{G298S.UAS.cIb}

is ameliorated by Zzzz\UGGAA^22.UAS

(Ishiguro et al., 2017)

Hsap\TARDBP^UAS.cSa

is exacerbated by Hsap\ANXA11^{G175R.UAS.Tag:MYC}

(Barnard et al., 2024)

is exacerbated by Hsap\ANXA11^{R235Q.UAS.Tag:MYC}

(Barnard et al., 2024)

is exacerbated by Hsap\ANXA11^UAS.Tag:MYC

(Barnard et al., 2024)

Hsap\TARDBP^{Q331K.UAS.cSa}

is ameliorated by htk³⁹

(Sreedharan et al., 2015)

is ameliorated by sgg^J11

(Sreedharan et al., 2015)

is ameliorated by htk⁷¹

(Sreedharan et al., 2015)

is ameliorated by xmas⁴⁵

(Sreedharan et al., 2015)

is ameliorated by xmas^f04114

(Sreedharan et al., 2015)

is ameliorated by htk⁴⁷

(Sreedharan et al., 2015)

Hsap\TARDBP^{D169G.UAS.cVBa}

modeled by TBPH^Δ142, TBPH^Δ23

(Vanden Broeck et al., 2015)

Hsap\TARDBP^UAS.cVBa

modeled by TBPH^Δ142, TBPH^Δ23

(Vanden Broeck et al., 2015)

Hsap\TARDBP^{12xQN.UAS.EGFP}

modeled by TBPH^{UAS.cCa.Tag:FLAG}

(Cragnaz et al., 2014)

Hsap\TARDBP^UAS.TDPBR

is ameliorated by CG42724^HMC04044

(Pons et al., 2018)

is ameliorated by CG42724^HMS00621

(Pons et al., 2018)

is exacerbated by CG42724^UY5237

(Pons et al., 2018)

is exacerbated by Hsap\SRSF1^UAS.cAa

(Pons et al., 2017)

is exacerbated by Rbp1^GD9289

(Pons et al., 2017)

is ameliorated by SF2^GD12097

(Pons et al., 2017)

is exacerbated by SF2^UAS.GFP

(Pons et al., 2017)

is exacerbated by Sf3b1^GD8837

(Pons et al., 2017)

Hsap\TARDBP^UAS.cDa

is ameliorated by Parg^UAS.cHa

(Duan et al., 2019)

is ameliorated by Parp1^HMC04658

(Duan et al., 2019)

is ameliorated by Pink1^HMS01707

(Sun et al., 2018)

is ameliorated by park^UAS.cGa

(Sun et al., 2018)

is ameliorated by CHMP2B^HM05017

(Deng et al., 2022)

is ameliorated by CHMP2B^HMS01844

(Deng et al., 2022)

is exacerbated by Hsap\CHMP2B^{Intron5.UAS.Tag:FLAG}

(Deng et al., 2022)

Hsap\TARDBP^CTR.UAS

Hsap\TARDBP^{A315T.UAS.RFP(Unk)}

modeled by TBPH^Δ23

(Donde et al., 2019)

is exacerbated by Lon^GD14030

(Wang et al., 2019)

is exacerbated by Lon^RNAi.UAS.cUa

(Wang et al., 2019)

Hsap\TARDBP^UAS.cUa

is exacerbated by ref(2)P^RNAi.UAS.cUa

(Saitoh et al., 2015)

is exacerbated by Rab5^EY10619

(Liu et al., 2017)

is exacerbated by Rab7^Gal4-KO

(Liu et al., 2017)

is exacerbated by Rab7^{Q67L.UAS.Venus}

(Liu et al., 2017)

is exacerbated by Rab7^{T22N.UAS.Venus}

(Liu et al., 2017)

is ameliorated by SF2^RNAi.UAS.cUa

(Krupp et al., 2023)

Hsap\TARDBP^{UAS.cKa.Tag:FLAG}

modeled by TBPH^Δ23

(Strah et al., 2020)

Hsap\TARDBP^{G298S.UAS.Tag:FLAG}

is ameliorated by Drp1¹

(Khalil et al., 2017)

is ameliorated by Marf^{UAS.cSa.Tag:HA}

(Khalil et al., 2017)

Hsap\TARDBP^{F4L.12xQN.UAS.Tag:FLAG}

is ameliorated by Drp1¹

(Khalil et al., 2017)

is ameliorated by Marf^{UAS.cSa.Tag:HA}

(Khalil et al., 2017)

Hsap\TARDBP^{G294A.UAs.Tag:MYC}

modeled by TBPH^{UAS.cCa.Tag:FLAG}

(Cragnaz et al., 2021)

exacerbates neurodegenerative disease

modeled by Zzzz\CGG^90.UAS.EGFP

(He et al., 2014)

Hsap\TARDBP^{UAS.cHa.Tag:HA}

ameliorates neurodegenerative disease

modeled by Zzzz\CGG^90.UAS.EGFP

(He et al., 2014)

Hsap\TARDBP^{FFLL.UAS.Tag:HA}

ameliorates neurodegenerative disease

modeled by Zzzz\CGG^90.UAS.EGFP

(He et al., 2014)

Hsap\TARDBP^{Δ321-366.UAS.Tag:HA}

exacerbates neurodegenerative disease

modeled by Zzzz\CGG^90.UAS.EGFP

(He et al., 2014)

Hsap\TARDBP^{W385IfsTer10.UAS}

modeled by TBPH^Δ23

(Ervilha Pereira et al., 2023)

Hsap\TARDBP^UAS.cDb

is ameliorated by Hsap\ARHGEF28^{NF242.UAS.Tag:FLAG}

(Droppelmann et al., 2024)

is ameliorated by Hsap\ARHGEF28^UAS.Tag:MYC

(Droppelmann et al., 2024)

Hsap\TARDBP^UAS.EGFP