FlyBase Gene Report: Dmel\CG34434

General Information

Symbol

Dmel\CG34434

Species

D. melanogaster

Name

Annotation Symbol

CG34434

Feature Type

protein_coding_gene

FlyBase ID

FBgn0250904

Gene Model Status

Current

Stock Availability

3 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Key Links

Genomic Location

Cytogenetic map

5A8-5A8

Sequence location

X:5,614,554..5,616,370 [-]

Recombination map

1-12

RefSeq locus

NC_004354 REGION:5614554..5616370

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (0 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CG34434 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9W4B0)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene merge+split based on EST/cDNA data

Gene model reviewed during 5.39

Gene model reviewed during 5.51

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CG34434-RB

FBtr0112735

NM_001103417

1691

460

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

CG34434-PB

FBpp0111647

45.1

460

4.00

Q9W4B0

NP_001096887

AAF46046

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9W4B0

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG34434 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG34434_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

2.56

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CG34434 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CG34434

View exonic expression by tissue for Dmel\CG34434

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0250904

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31472/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0250904

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0250904

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0250904

Flygut - An atlas of the Drosophila adult midgut

FBgn0250904

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 1 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 2 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CG34434

Transgenic constructs containing regulatory region of CG34434

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 13 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

CG34434^f02362

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CG34434^GD13645

viable, with Scer\GAL4^Mef2.PR

CG34434^GD13645

viable, with Scer\GAL4^pnr-MD237

CG34434^GD13645

Sterility

Allele

fertile

CG34434^f02362

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (4)

Hsap\MYL1

1 of 14

Yes

Hsap\MYL4

1 of 14

Yes

Hsap\MYL6B

1 of 14

Yes

Hsap\MYL6

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (3)

Rnor\Myl1

1 of 14

Yes

Rnor\Myl3

1 of 14

Yes

Rnor\Myl4

1 of 14

Yes

Mus musculus (laboratory mouse) (5)

Mmus\Myl1

1 of 14

Yes

Mmus\Myl3

1 of 14

Yes

Mmus\Myl4

1 of 14

Yes

Mmus\Myl6b

1 of 14

Yes

Mmus\Myl6

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (2)

Xtro\LOC101734362

1 of 13

Yes

Xtro\LOC101734875

1 of 13

Yes

Danio rerio (Zebrafish) (7)

Drer\cmlc1

1 of 14

Yes

Drer\myl1

1 of 14

Yes

Drer\myl4

1 of 14

Yes

Drer\myl6

1 of 14

Yes

Drer\myl13

1 of 14

Yes

Drer\mylz3

1 of 14

Yes

Drer\zgc:153867

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (2)

Cele\mlc-5

1 of 14

Yes

Cele\mlc-6

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (0)

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:CG34434. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (4)

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

CG34434 - Lmpt

two hybrid

(Hu et al., 2017.6.13)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0250904

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene_with_edited_transcript

(Graveley et al., 2011)

nuclear_gene

(FlyBase Genome Annotators, 2007)

protein_coding_gene

(FlyBase Genome Annotators, 2007)

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-12

Cytogenetic map

5A8-5A8

Sequence location

X:5,614,554..5,616,370 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

5A8-5A8

Limits computationally determined from genome sequence between P{EP}CG3249^EP1400 and P{EP}Tre1^EP496

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-12

(FlyBase, 2016)

1-14.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (3)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

18546

w¹¹¹⁸ PBac{WH}CG34434^f02362

VDRC

v102263

P{KK111280}VIE-260B

v23550

w¹¹¹⁸; P{GD13645}v23550

Genomic Clones (19)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (11)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

IP03738

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0250904

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0250904

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

The CG34434 gene may have been derived from the Cpr47Ef gene by retroposition.

(Chen et al., 2012)

The CG34434 gene may have been derived from the Cpr47Ef gene by retroposition sometime after the divergence of the Sophophora and Drosophila subgenera.

(Zhang et al., 2010)

Annotation CG15780 has been split in release 5.2 of the genome annotation. Sequences from the 3' half of release 5.1 annotation CG15780 are present in release 5.2 annotation CG34435. Sequences from the 5' half of release 5.1 annotation CG15780 have been merged with sequences from release 5.1 annotation CG17763 to form release 5.2 annotation CG34434 (although the reading frame of this new annotation is different from much of that present in release 5.1 annotation CG15780).

(FlyBase Genome Annotators, 2007)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CG15780

(Erclik et al., 2008, Negre et al., 2006)

CG17763

CG34434

(Hu et al., 2017.6.13, dos Santos, 2014, Reinhardt et al., 2013, Chen et al., 2012, Zhang et al., 2010, Keleman et al., 2009.8.5, FlyBase Genome Annotators, 2007)

Name Synonyms

CG17763

Secondary FlyBase IDs

FBgn0085463
FBan0015780
FBgn0029776
FBgn0029777

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 21 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

31472

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

CZ484868

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

AAF46046

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9W4B0

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9W4B0

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9W4B0

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0250904

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31472/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0250904

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0250904

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG34434

MARRVEL_MODEL - MARRVEL (model organism gene)

31472

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0250904

DroID - A comprehensive database of gene and protein interactions.

FBgn0250904

DRSC - Results frm RNAi screens

FBgn0250904

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG34434_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0250904

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0250904

Flygut - An atlas of the Drosophila adult midgut

FBgn0250904

References (25)

The following external sites may use different assemblies or annotations than FlyBase.

2.56

Report Sections