FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Dh31-R
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General Information
Symbol
Dmel\Dh31-R
Species
D. melanogaster
Name
Diuretic hormone 31 Receptor
Annotation Symbol
CG32843
Feature Type
protein_coding_gene
FlyBase ID
FBgn0052843
Gene Model Status
Current
Stock Availability
59 publicly available
Gene Summary
Diuretic hormone 31 Receptor (Dh31-R) encodes a protein that exhibits diuretic hormone receptor activity. It is involved in G protein-coupled receptor signaling pathwayS. [Date last reviewed: 2019-07-11] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Dh31R, Dh31-R1, Diuretic hormone 31 receptor 1

Key Links
Genomic Location
Cytogenetic map
49F15-50A1
Sequence location
Recombination map
2-68
RefSeq locus
NT_033778 REGION:13267798..13295927
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (11 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables diuretic hormone receptor activity
inferred from physical interaction with FLYBASE:Dh31; FB:FBgn0032048
(Johnson et al., 2005)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
enables calcitonin receptor activity
inferred from sequence or structural similarity
(Radford et al., 2002, Brody and Cravchik, 2000)
inferred from electronic annotation with InterPro:IPR003287
(InterPro Project Members, 2004-)
enables G protein-coupled peptide receptor activity
inferred from biological aspect of ancestor with PANTHER:PTN001737881
(GO Reference Genome Project, 2011-)
enables G protein-coupled receptor activity
(InterPro Project Members, 2004-)
enables neuropeptide receptor activity
inferred from sequence model
(Hewes and Taghert, 2001)
enables transmembrane signaling receptor activity
inferred from electronic annotation with InterPro:IPR017981
(InterPro Project Members, 2004-)
Biological Process (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in G protein-coupled receptor signaling pathway
inferred from direct assay
(Johnson et al., 2005)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN001737881
(GO Reference Genome Project, 2011-)
involved_in cell surface receptor signaling pathway
inferred from electronic annotation with InterPro:IPR017981
(InterPro Project Members, 2004-)
involved_in G protein-coupled receptor signaling pathway
inferred from electronic annotation with InterPro:IPR000832, InterPro:IPR003287, InterPro:IPR017983
(InterPro Project Members, 2004-)
inferred from sequence model
(Hewes and Taghert, 2001)
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in plasma membrane
inferred from direct assay
(Johnson et al., 2005)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in membrane
inferred from sequence model
(Hewes and Taghert, 2001)
(InterPro Project Members, 2004-)
inferred from sequence or structural similarity
(Brody and Cravchik, 2000)
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN001737881
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Diuretic hormone 31 Receptor (Dh31-R) encodes a protein that exhibits diuretic hormone receptor activity. It is involved in G protein-coupled receptor signaling pathwayS. [Date last reviewed: 2019-07-11]
Gene Group (FlyBase)
CLASS B GPCRs, SUBFAMILY B1 -
The B1 subfamily of Class B GPCRs are largely classical hormone receptors. (Adapted from FBrf0147071 and FBrf0221117).
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\Dh31-R for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry A0A0B4KF12)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Stop-codon suppression (UGA) postulated; FBrf0216884

Gene model reviewed during 5.44

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.49

Multiphase exon postulated: exon reading frame differs in alternative transcripts.

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Dh31-R-RA
FBtr0087755
NM_165979
3269
443
Dh31-R-RB
FBtr0330735
NM_001274021
3284
431
Dh31-R-RC
FBtr0330736
NM_001274022
3269
604
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Dh31-R-PA
FBpp0086868
48.9
443
7.70
A1Z9B7
NP_725278
AAN16138
Dh31-R-PB
FBpp0303579
47.7
431
7.72
A0A0B4KEN5
NP_001260950
AGB93482
Dh31-R-PC
FBpp0303580
65.8
604
7.51
A0A0B4KF12
NP_001260951
AGB93483
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dh31-R using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.60

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 16 -- 17
larval H-cell
(Fontana and Crews, 2012)
larval H-cell sib
(Fontana and Crews, 2012)
RNA-seq
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 16
ventral midline of embryo
(Fontana and Crews, 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
embryonic/larval Malpighian tubule Type I cell
(Johnson et al., 2005)
neuron | subset of larval central nervous system
(Johnson et al., 2005)
adult stage
adult Malpighian tubule principal cell
(Johnson et al., 2005)
neuron | subset of adult central nervous system
(Johnson et al., 2005)
Malpighian tubule
(Veenstra et al., 2008)
adult hindgut
(Veenstra et al., 2008)
adult midgut
(Veenstra et al., 2008)
crop
(Veenstra et al., 2008)
Additional Descriptive Data

Dh32-R protein is detected in principal cells of adult and larval Malpighian tubules. Dh32-R protein is detected in about 58 neurons of the larval central nervous system; 24 of these neurons coexpress Dh44-R1 protein and the neuropeptide corazonin (Crz). All larval Crz-positive neurons express Dh32-R protein. Both Dh32-R and Dh44-R1 proteins are detected in several somata in the dorsal part of the adult brain. All Crz-positive neurons in the adult CNS are also positive for both Dh32-R and Dh44-R1; while 2-4 Dh32-R-positive neurons do not coexpress either Dh44-R1 or Crz.

(Johnson et al., 2005)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in plasma membrane
inferred from direct assay
(Johnson et al., 2005)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Dh31-R in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 12 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Dh31-R
Transgenic constructs containing regulatory region of Dh31-R
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Inferred from location ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (47)
Hsap\CALCRL
12 of 14
Yes
Yes
Hsap\CALCR
10 of 14
No
Yes
Hsap\ADCYAP1R1
3 of 14
No
No
Hsap\CRHR1
3 of 14
No
No
Hsap\CRHR2
3 of 14
No
No
Hsap\GCGR
3 of 14
No
No
1  
Hsap\GHRHR
3 of 14
No
No
Hsap\GIPR
3 of 14
No
No
Hsap\GLP1R
3 of 14
No
No
Hsap\PTH2R
3 of 14
No
No
Hsap\SCTR
3 of 14
No
No
Hsap\VIPR1
3 of 14
No
No
Hsap\GLP2R
2 of 14
No
No
Hsap\LINC02210-CRHR1
2 of 14
No
No
Hsap\PTH1R
2 of 14
No
No
Hsap\VIPR2
2 of 14
No
No
Hsap\ADGRB1
1 of 14
No
No
Hsap\ADGRB2
1 of 14
No
No
Hsap\ADGRB3
1 of 14
No
No
Hsap\ADGRD1
1 of 14
No
No
Hsap\ADGRD2
1 of 14
No
No
Hsap\ADGRE1
1 of 14
No
No
Hsap\ADGRE2
1 of 14
No
No
Hsap\ADGRE3
1 of 14
No
No
Hsap\ADGRE4P
1 of 14
No
No
Hsap\ADGRE5
1 of 14
No
No
Hsap\ADGRF2
1 of 14
No
No
Hsap\ADGRF3
1 of 14
No
No
Hsap\ADGRF4
1 of 14
No
No
Hsap\ADGRF5
1 of 14
No
No
Hsap\ADGRG1
1 of 14
No
No
Hsap\ADGRG2
1 of 14
No
No
Hsap\ADGRG3
1 of 14
No
No
Hsap\ADGRG4
1 of 14
No
No
Hsap\ADGRG6
1 of 14
No
No
Hsap\ADGRG7
1 of 14
No
No
Hsap\ADGRL1
1 of 14
No
No
Hsap\ADGRL2
1 of 14
No
No
Hsap\ADGRL3
1 of 14
No
No
Hsap\ADGRL4
1 of 14
No
No
Hsap\CELSR1
1 of 14
No
No
Hsap\CELSR2
1 of 14
No
No
Hsap\CELSR3
1 of 14
No
No
Hsap\FBXO46
1 of 14
No
Yes
Hsap\FZD9
1 of 14
No
No
Hsap\INMT
1 of 14
No
Yes
Hsap\NNMT
1 of 14
No
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (18)
Rnor\Calcrl
11 of 14
Yes
Yes
Rnor\Calcr
11 of 14
Yes
Yes
Rnor\Adcyap1r1
3 of 14
No
No
Rnor\Crhr1
3 of 14
No
No
Rnor\Crhr2
3 of 14
No
No
Rnor\Gcgr
3 of 14
No
No
Rnor\Gipr
3 of 14
No
No
Rnor\Glp1r
3 of 14
No
No
Rnor\Pth1r
3 of 14
No
No
Rnor\Pth2r
3 of 14
No
No
Rnor\Sctr
3 of 14
No
No
Rnor\Glp2r
2 of 14
No
No
Rnor\Vipr1
2 of 14
No
No
Rnor\Vipr2
2 of 14
No
No
Rnor\Fbxo46
1 of 14
No
Yes
Rnor\Ghrhr
1 of 14
No
No
Rnor\Inmt
1 of 14
No
Yes
Rnor\Nnmt
1 of 14
No
Yes
Mus musculus (laboratory mouse) (18)
Mmus\Calcrl
11 of 14
Yes
Yes
Mmus\Calcr
11 of 14
Yes
Yes
Mmus\Adcyap1r1
3 of 14
No
No
Mmus\Crhr1
3 of 14
No
No
Mmus\Crhr2
3 of 14
No
No
Mmus\Gcgr
3 of 14
No
No
Mmus\Ghrhr
3 of 14
No
No
Mmus\Gipr
3 of 14
No
No
Mmus\Glp1r
3 of 14
No
No
Mmus\Pth1r
3 of 14
No
No
Mmus\Pth2r
3 of 14
No
No
Mmus\Sctr
3 of 14
No
No
Mmus\Vipr1
3 of 14
No
No
Mmus\Glp2r
2 of 14
No
No
Mmus\Vipr2
2 of 14
No
No
Mmus\Fbxo46
1 of 14
No
Yes
Mmus\Inmt
1 of 14
No
Yes
Mmus\Nnmt
1 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (24)
Xtro\calcrl
10 of 13
Yes
Yes
Xtro\calcr
9 of 13
No
Yes
Xtro\crhr1.1
2 of 13
No
No
Xtro\LOC100487239
2 of 13
No
No
Xtro\adcyap1r1
1 of 13
No
Yes
Xtro\adgrd2
1 of 13
No
No
Xtro\ccnl2
1 of 13
No
No
Xtro\celsr3
1 of 13
No
No
Xtro\chadl
1 of 13
No
No
Xtro\crhr1.2
1 of 13
No
No
Xtro\crhr2
1 of 13
No
No
Xtro\gcgr
1 of 13
No
No
Xtro\gipr
1 of 13
No
Yes
Xtro\glp1r
1 of 13
No
Yes
Xtro\lgmn
1 of 13
No
No
Xtro\LOC100492996
1 of 13
No
Yes
Xtro\LOC101735190
1 of 13
No
Yes
Xtro\pth1r
1 of 13
No
No
Xtro\pth2r
1 of 13
No
Yes
Xtro\s100pbp
1 of 13
No
Yes
Xtro\sctr
1 of 13
No
No
Xtro\tcf3
1 of 13
No
No
Xtro\vipr1
1 of 13
No
No
Xtro\zc4h2
1 of 13
No
No
Danio rerio (Zebrafish) (23)
Drer\calcr
11 of 14
Yes
Yes
Drer\calcrla
11 of 14
Yes
Yes
Drer\calcrlb
11 of 14
Yes
Yes
Drer\calcrl2
9 of 14
No
Yes
Drer\adcyap1r1b
3 of 14
No
No
Drer\gcgrb
3 of 14
No
No
Drer\gipr
3 of 14
No
No
Drer\LOC100335005
3 of 14
No
No
Drer\pth1r
3 of 14
No
No
Drer\pth2ra
3 of 14
No
No
Drer\vipr1a
3 of 14
No
No
Drer\vipr1b
3 of 14
No
No
Drer\adcyap1r1a
2 of 14
No
No
Drer\crhr1
2 of 14
No
No
Drer\gcgra
2 of 14
No
No
Drer\ghrhr2
2 of 14
No
No
Drer\ghrhra
2 of 14
No
No
Drer\ghrhrb
2 of 14
No
No
Drer\pth2rb
2 of 14
No
No
Drer\pth3r
2 of 14
No
No
Drer\vipr2
2 of 14
No
No
Drer\sctr
1 of 14
No
No
Drer\zgc:64002
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (6)
Cele\seb-2
4 of 14
Yes
No
Cele\seb-3
3 of 14
No
No
Cele\pdfr-1
2 of 14
No
No
Cele\anmt-2
1 of 14
No
Yes
Cele\lat-1
1 of 14
No
No
Cele\lat-2
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (7)
Agam\GPRCAL1
10 of 12
Yes
Yes
Agam\GPRCAL2
5 of 12
No
No
Agam\GPRCAL3
3 of 12
No
No
Agam\GPRDIH1
3 of 12
No
No
Agam\GPRDIH2
3 of 12
No
No
Agam\AgaP_AGAP000130
1 of 12
No
No
Agam\GPRSTN
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Dh31-R. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (7)
hec
9 of 13
Dh44-R1
4 of 13
Dh44-R2
4 of 13
Pdfr
4 of 13
Mayo
1 of 13
mthl3
1 of 13
stan
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    CALCR; calcitonin receptor
    model of  osteoporosis
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CALCRL; calcitonin receptor like receptor
    12 of 14
    114190
      CALCR; calcitonin receptor
      10 of 14
      114131
      ADCYAP1R1; ADCYAP receptor type I
      3 of 14
      102981
          CRHR1; corticotropin releasing hormone receptor 1
          3 of 14
          122561
              CRHR2; corticotropin releasing hormone receptor 2
              3 of 14
              602034
                  GCGR; glucagon receptor
                  3 of 14
                  138033
                   
                  GHRHR; growth hormone releasing hormone receptor
                  3 of 14
                  139191
                  GIPR; gastric inhibitory polypeptide receptor
                  3 of 14
                  137241
                      GLP1R; glucagon like peptide 1 receptor
                      3 of 14
                      138032
                          PTH2R; parathyroid hormone 2 receptor
                          3 of 14
                          601469
                              SCTR; secretin receptor
                              3 of 14
                              182098
                                  VIPR1; vasoactive intestinal peptide receptor 1
                                  3 of 14
                                  192321
                                      Functional Complementation Data
                                      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                      Interactions
                                      Summary of Physical Interactions
                                      Interaction Browsers
                                      Summary of Genetic Interactions
                                      Interaction Browsers
                                      Starting gene(s)
                                      Interaction type
                                      Interacting gene(s)
                                      Reference
                                      Starting gene(s)
                                      Interaction type
                                      Interacting gene(s)
                                      Reference
                                      External Data
                                      Linkouts
                                      DroID - A comprehensive database of gene and protein interactions.
                                      Pathways
                                      Signaling Pathways (FlyBase)
                                      Metabolic Pathways
                                      FlyBase
                                      External Links
                                      External Data
                                      Linkouts
                                      KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                      Class of Gene
                                      Genomic Location and Detailed Mapping Data
                                      Chromosome (arm)
                                      2R
                                      Recombination map
                                      2-68
                                      Cytogenetic map
                                      49F15-50A1
                                      Sequence location
                                      FlyBase Computed Cytological Location
                                      Cytogenetic map
                                      Evidence for location
                                      49F15-50A1
                                      Limits computationally determined from genome sequence between P{EP}DpEP358 and P{lacW}drkk13809&P{EP}mip120EP606
                                      Experimentally Determined Cytological Location
                                      Cytogenetic map
                                      Notes
                                      References
                                      Experimentally Determined Recombination Data
                                      Location

                                      2-68

                                      (FlyBase, 2016)

                                      2-71.9

                                      (Comeron et al., 2012)
                                      Left of (cM)
                                      Right of (cM)
                                      Notes
                                      Stocks and Reagents
                                      Stocks (59)
                                      Genomic Clones (39)
                                      cDNA Clones (112)
                                       

                                      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                                      cDNA clones, fully sequenced
                                      BDGP DGC clones
                                      Other clones
                                      Drosophila Genomics Resource Center cDNA clones

                                      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                      cDNA Clones, End Sequenced (ESTs)
                                      BDGP DGC clones
                                      Other clones
                                      RNAi and Array Information
                                      Linkouts
                                      DRSC - Results frm RNAi screens
                                      Antibody Information
                                      Laboratory Generated Antibodies
                                       

                                      polyclonal

                                      (Goda et al., 2018, Johnson et al., 2005)
                                      Commercially Available Antibodies
                                       
                                      Cell Line Information
                                      Publicly Available Cell Lines
                                       
                                        Other Stable Cell Lines
                                         
                                          Other Comments
                                          Relationship to Other Genes
                                          Source for database merge of

                                          Source for merge of: CG32843 anon-WO0170980.136 anon-WO0170980.137

                                          (FlyBase, 1996-)

                                          Source for merge of: CG17415 CG17043

                                          (FlyBase Genome Annotators, 2002-2003)
                                          Additional comments

                                          Annotations CG17415 and CG17043 merged as CG32843 in release 3 of the genome annotation.

                                          (FlyBase Genome Annotators, 2002-2003)

                                          Source for merge of CG32843 anon-WO0170980.136 anon-WO0170980.137 was sequence comparison ( date:051113 ).

                                          (FlyBase, 1996-)
                                          Nomenclature History
                                          Source for database identify of

                                          Source for identity of: Dh31-R1 CG32843

                                          (Johnson et al., 2005)

                                          Source for identity of: Dh31-R Dh31-R1

                                          (FlyBase, 2009-)
                                          Nomenclature comments

                                          Although named as 'DH31-R1' in FBrf0184113, a later paper by the same author (FBrf0208781) refers to the gene as 'DH31R', as it is now known to encode the only Dh31 receptor in D. melanogaster. Therefore, removed the '1' suffix from the FlyBase gene symbol as this is superfluous and wrongly suggests there are additional Dh31-R genes.

                                          (FlyBase, 2009-)
                                          Etymology
                                          Synonyms and Secondary IDs (21)
                                          Reported As
                                          Symbol Synonym
                                          CG17043
                                          (Hauser et al., 2006, Metpally and Sowdhamini, 2005, Wang et al., 2004)
                                          CG17415
                                          (Liang et al., 2017, Duvall and Taghert, 2012, Nässel and Winther, 2010, Hector et al., 2009, Hauser et al., 2006, Hauser et al., 2006, Johnson et al., 2005, Mertens et al., 2005, Mertens et al., 2005, Wang et al., 2004, Radford et al., 2002, Harmar, 2001)
                                          CG32843
                                          (Mao et al., 2024, Kondo et al., 2020, Yu et al., 2016, Ashwal-Fluss et al., 2014, Li et al., 2013, Younger et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Jungreis et al., 2011, Keleman et al., 2009.8.5, Perkins et al., 2009.1.15, Cardoso et al., 2006, Hyun et al., 2005)
                                          DH31
                                          (Kula-Eversole et al., 2010)
                                          DH31-R
                                          (Yan et al., 2025, Nässel and Vanden Broeck, 2016, Hector et al., 2009)
                                          DH31-R1
                                          (Mazzotta et al., 2020, Johnson et al., 2005)
                                          DH31R
                                          (Nässel, 2025, Kula-Eversole et al., 2010)
                                          Dh31-R
                                          (Asahina and Zelikowsky, 2025, Agard et al., 2024, Moriya et al., 2024, Corthals et al., 2023, Kurogi et al., 2023, Schlichting et al., 2022, Taghert, 2022, Dow et al., 2021, Liu et al., 2021, McLaughlin et al., 2021, Kondo et al., 2020, Zarubin et al., 2020, Goda and Hamada, 2019, Hajji et al., 2019, Rao and Deng, 2019.10.23)
                                          Dh31-R1
                                          (Crocker et al., 2016, Caers et al., 2012, Jumbo-Lucioni et al., 2010, Kula-Eversole et al., 2010)
                                          Dh31R
                                          (Medina et al., 2025, Yapici, 2025, Lyu et al., 2023, Kannangara et al., 2021, Deng et al., 2019, Takeda et al., 2018)
                                          Dh31r
                                          (Goda et al., 2023, Goda et al., 2019, Goda et al., 2018)
                                          DmeCG32843
                                          (Cardoso et al., 2006)
                                          anon-WO0170980.136
                                          anon-WO0170980.137
                                          dh31-R1
                                          (Duvall and Taghert, 2012)
                                          Name Synonyms
                                          CG32843
                                          Calcitonin-like diuretic hormone receptor
                                          (Caers et al., 2012)
                                          DH31 Receptor
                                          (Choi et al., 2009)
                                          DH31-receptor
                                          (Veenstra et al., 2008)
                                          DH31 receptor
                                          (Johnson et al., 2005)
                                          Diuretic hormone 31 Receptor
                                          (Yu et al., 2016)
                                          Diuretic hormone 31 receptor 1
                                          (Saad and Hipfner, 2021)
                                          Secondary FlyBase IDs
                                          • FBgn0033824
                                          • FBgn0033825
                                          • FBgn0046596
                                          • FBgn0046597
                                          Datasets (0)
                                          Study focus (0)
                                          Experimental Role
                                          Project
                                          Project Type
                                          Title
                                          Study result (0)
                                          Result
                                          Result Type
                                          Title
                                          External Crossreferences and Linkouts ( 50 )
                                          Sequence Crossreferences
                                          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                          Other crossreferences
                                          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                          FlyMine - An integrated database for Drosophila genomics
                                          InterPro - A database of protein families, domains and functional sites
                                          KEGG Genes - Molecular building blocks of life in the genomic space.
                                          MARRVEL_MODEL - MARRVEL (model organism gene)
                                          Linkouts
                                          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                          DroID - A comprehensive database of gene and protein interactions.
                                          DRSC - Results frm RNAi screens
                                          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                          Flygut - An atlas of the Drosophila adult midgut
                                          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                          KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                          References (115)