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FB2026_01
,
released March 12, 2026
cell-adhesion molecules (CAMs) - Ig and fibronectin domains proteins - The genes are adjacent to one another and co-ordinately regulated - Echinoid acts to antagonize Egf receptor signaling - Friend of echinoid exhibits interaction with the Notch pathway
Please see the JBrowse view of Dmel\fred for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.47
Gene model reviewed during 5.55
Alternative translation stop created by use of multiphasic reading frames within coding region.
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\fred using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
fred protein is abundant in the morphogenetic furrow. It is enriched in photoreceptors relative to the surrounding interommatidial cells early in rotation. The localization of fred in R3 and R4 is dynamic during the first half of rotation. At the initiation of rotation (rows 4-5), fred is localized in a double-horseshoe pattern, outlining photoreceptors R3 and R4, except where they abut R2 and R5. One row, or 1.5 hours, later, fred becomes restricted to the lateral edge of the R4 cell and the R3/R4 boundary. fred levels remain high in R1, R6 and at the R7/R8 interface as they are recruited into the photoreceptor cluster in row 6. By row 7, fred is no longer detectable at the R3/R4 boundary but remains at the lateral edge of R4, the R7/R8 interface and in R1 and R6. Following recruitment of the cone cells fred is present at the interfaces between both the cone cells and the photoreceptors and the cone cells and interommatidial cells.
JBrowse - Visual display of RNA-Seq signals
View Dmel\fred in JBrowse2-11
2-10.8
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: CG12675 CG3393 CG3390
Annotation CG3390 split into CG31773, CG31774 (fred) in release 3 of the genome annotation. In addition CG31774 contains sequences corresponding to release 2 annotations CG12675 and CG3393.
