FlyBase Gene Report: Dmel\Unc-115a

General Information

Symbol

Dmel\Unc-115a

Species

D. melanogaster

Name

Uncoordinated 115a

Annotation Symbol

CG31352

Feature Type

protein_coding_gene

FlyBase ID

FBgn0051352

Gene Model Status

Current

Stock Availability

9 publicly available

Gene Summary

Uncoordinated 115a (Unc-115a) encodes a protein involved in axon pathfinding in the visual system and the CNS. [Date last reviewed: 2019-03-21] (FlyBase Gene Snapshot)

All Summaries

Also Known As

dunc-115, unc-115

Key Links

Genomic Location

Cytogenetic map

85E4-85E5

Sequence location

3R:9,694,386..9,705,417 [-]

Recombination map

3-49

RefSeq locus

NT_033777 REGION:9694386..9705417

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables actin binding

inferred from sequence or structural similarity with UniProtKB:P09327

(Garcia et al., 2007)

inferred from electronic annotation with InterPro:IPR003128, InterPro:IPR036886

(InterPro Project Members, 2004-)

enables actin filament binding

inferred from biological aspect of ancestor with PANTHER:PTN001198097

(GO Reference Genome Project, 2011-)

Biological Process (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in axon guidance

inferred from mutant phenotype

(Garcia et al., 2007)

involved_in photoreceptor cell axon guidance

inferred from mutant phenotype

(Garcia et al., 2007)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in cytoskeleton organization

inferred from electronic annotation with InterPro:IPR003128, InterPro:IPR036886

(InterPro Project Members, 2004-)

involved_in lamellipodium assembly

inferred from biological aspect of ancestor with PANTHER:PTN001198097

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in nucleoplasm

inferred from high throughput direct assay

(Lye et al., 2014)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in actin cytoskeleton

inferred from biological aspect of ancestor with PANTHER:PTN001198097

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Uncoordinated 115a (Unc-115a) encodes a protein involved in axon pathfinding in the visual system and the CNS. [Date last reviewed: 2019-03-21]

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Unc-115a for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry E1JIH3)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.53

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.49

Gene model reviewed during 6.02

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Unc-115a-RA

FBtr0082092

NM_141673

3278

806

Unc-115a-RB

FBtr0300564

NM_001170102

3551

844

Unc-115a-RC

FBtr0300565

NM_001170103

3200

839

Unc-115a-RE

FBtr0339597

NM_001300328

3557

787

Unc-115a-RF

FBtr0344275

NM_001300329

3494

825

Unc-115a-RG

FBtr0344276

NM_001300330

3700

828

Unc-115a-RH

FBtr0344277

NM_001300331

3176

772

Unc-115a-RJ

FBtr0346714

NM_001170104

3299

813

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Unc-115a-PA

FBpp0081570

89.6

806

8.82

FBpp0289791

93.9

844

8.90

FBpp0289792

93.4

839

8.86

FBpp0308669

87.4

787

8.65

FBpp0310680

91.7

825

8.73

FBpp0310681

92.0

828

8.86

FBpp0310682

85.8

772

8.70

FBpp0312325

90.0

813

8.78

E1JIH1

NP_001163575

ACZ94872

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Unc-115a using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

1.21

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 6

mesoderm

(Garcia et al., 2007)

embryonic stage 7 -- 8

organism | faint | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

foregut primordium

(Fisher et al., 2012)

inclusive hindgut primordium

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

salivary gland body primordium

Comment: reported as salivary gland body specific anlage

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

amnioserosa

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 10

procephalic neuroblast

(Garcia et al., 2007)

embryonic ventral nerve cord

(Garcia et al., 2007)

embryonic stage 11 -- 12

embryonic leading edge cell primordium

Comment: reported as embryonic leading edge cell specific anlage

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

Malpighian tubule primordium

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

salivary gland body primordium

(Fisher et al., 2012)

somatic muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)

tracheal primordium

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

amnioserosa

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

trunk visceral muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)

embryonic stage 12

supraesophageal ganglion

(Garcia et al., 2007)

larval ventral nerve cord

(Garcia et al., 2007)

embryonic foregut

(Garcia et al., 2007)

embryonic/larval midgut primordium

(Garcia et al., 2007)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in nucleoplasm

inferred from high throughput direct assay

(Lye et al., 2014)

Expression Deduced from Reporters

Reporter: PBac{566.P.SVS-1}Unc-115a^CPTI100017

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

pedunculus of adult mushroom body

(Knowles-Barley, 2011.8.24)

adult brain | ubiquitous

Comment: expression heightened in some areas and major tracts and lowered in ellipsoid body and fan-shaped body

(Knowles-Barley, 2011.8.24)

calyx of adult mushroom body

(Knowles-Barley, 2011.8.24)

adult optic lobe | restricted

(Knowles-Barley, 2011.8.24)

Reporter: PBac{602.P.SVS-1}Unc-115a^CPTI000905

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

calyx of adult mushroom body

(Knowles-Barley, 2011.8.24)

lamina

(Knowles-Barley, 2011.8.24)

adult brain cell body rind

(Knowles-Barley, 2011.8.24)

adult median bundle

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Unc-115a in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Unc-115a

View exonic expression by tissue for Dmel\Unc-115a

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0051352

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

261629/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0051352

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0051352

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0051352

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG31352

Flygut - An atlas of the Drosophila adult midgut

FBgn0051352

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 9 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Unc-115a

Transgenic constructs containing regulatory region of Unc-115a

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

Unc-115a^KG03651

viable, with Scer\GAL4^pnr-MD237

Unc-115a^GD17287

Sterility

Allele

fertile

Unc-115a^KG03651

Other Phenotypes

Allele

abnormal neuroanatomy | embryonic stage

Unc-115a^KG03651

abnormal neuroanatomy | third instar larval stage

Unc-115a^KG03651

visible, with Scer\GAL4^pnr-MD237

Unc-115a^GD17287

Phenotype manifest in

Allele

embryonic VNC neuromere

Unc-115a^KG03651

eye photoreceptor cell

Unc-115a^KG03651

lamina plexus

Unc-115a^KG03651

larval longitudinal connective

Unc-115a^KG03651

larval segmental nerve

Unc-115a^KG03651

mesonotum, with Scer\GAL4^pnr-MD237

Unc-115a^GD17287

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (78)

Hsap\ABLIM3

13 of 14

Yes

Hsap\ABLIM1

12 of 14

Yes

Hsap\ABLIM2

12 of 14

Yes

Hsap\DMTN

5 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (39)

Rnor\Ablim3

13 of 14

Yes

Rnor\Ablim2

12 of 14

Yes

Rnor\Ablim1

7 of 14

Yes

Rnor\Dmtn

4 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (38)

Mmus\Ablim3

13 of 14

Yes

Mmus\Ablim1

12 of 14

Yes

Mmus\Ablim2

11 of 14

Yes

Mmus\Dmtn

5 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (42)

Xtro\ablim2

9 of 13

Yes

Xtro\ablim3

7 of 13

Yes

Xtro\ablim1

6 of 13

Yes

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\zyx

1 of 13

Danio rerio (Zebrafish) (42)

Drer\ablim1b

12 of 14

Yes

Drer\ablim2

12 of 14

Yes

Drer\ablim3

12 of 14

Yes

Drer\ablim1a

11 of 14

Yes

Drer\dmtn

5 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (30)

Cele\unc-115

11 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (34)

Agam\AgaP_AGAP005425

12 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (11)

Atha\VLN1

2 of 13

Yes

Atha\VLN3

2 of 13

Yes

Atha\VLN4

2 of 13

Yes

Atha\VLN5

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\PXL1

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\pxl1

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Unc-115a. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (35)

Unc-115b

12 of 13

1 of 13

Awh

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Dll

1 of 13

ems

1 of 13

esn

1 of 13

jub

1 of 13

Lim1

1 of 13

Lim3

1 of 13

LIMK1

1 of 13

lms

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Pax

1 of 13

Pph13

1 of 13

qua

1 of 13

Rassf

1 of 13

stck

1 of 13

Svil

1 of 13

tup

1 of 13

Zasp52

1 of 13

zfh2

1 of 13

Zyx

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ABLIM3; actin binding LIM protein family member 3

13 of 14

611305

ABLIM1; actin binding LIM protein 1

12 of 14

602330

ABLIM2; actin binding LIM protein family member 2

12 of 14

612544

DMTN; dematin actin binding protein

5 of 14

125305

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Unc-115a - Deaf1

two hybrid

(Hu et al., 2017.6.13)

Unc-115a - Gtpbp2

two hybrid

(Hu et al., 2017.6.13)

Unc-115a - Mad1

two hybrid

(Hu et al., 2017.6.13)

Unc-115a - kel

proximity-dependent biotin identification, Identification by mass spectrometry

(Mannix et al., 2019)

RNA-protein

Physical Interaction

Assay

References

Unc-115a - Caper

anti tag coimmunoprecipitation, full identification by RNA sequencing, quantitative reverse transcription pcr

(Titus et al., 2023)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

brm

suppressible

Unc-115a

(Tegeder et al., 2019)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

76449

DroID - A comprehensive database of gene and protein interactions.

FBgn0051352

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Miscellaneous transport and binding events

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-49

Cytogenetic map

85E4-85E5

Sequence location

3R:9,694,386..9,705,417 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

85E4-85E5

Limits computationally determined from genome sequence between P{EP}Crc^EP3006 and P{lacW}s2681

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-49

(FlyBase, 2016)

3-46.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (9)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

40839

y¹ v¹; P{TRiP.HMS02005}attP40

59227

y¹ w^*; Mi{MIC}Unc-115a^MI13898

12941

y¹ w^67c23; P{SUPor-P}Unc-115a^KG03651 ry⁵⁰⁶

Kyoto

115057

w¹¹¹⁸; PBac{602.P.SVS-1}Unc-115a^CPTI000905

115358

w¹¹¹⁸; PBac{566.P.SVS-1}Unc-115a^CPTI100017

31352R-1

v106405

v49112

w¹¹¹⁸; P{GD17287}v49112/TM3

v342328

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD02105}attP40/CyO-GFP

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (130)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

SD01878

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0051352

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0051352

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: CG31352 anon-WO0140519.21

(FlyBase, 1996-)

Additional comments

Source for merge of CG31352 anon-WO0140519.21 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

The CG31332 and CG31352 annotations represent two very similar neighbouring genes located on 3R, which are related to the C. elegans unc-115 gene. These two genes were erroneously annotated as non-overlapping transcripts of a single "CG9489" annotation in release 2 of the genome annotation, but this was subsequently corrected in release 3.2 of the genome annotation so that each gene is represented by a separate annotation (CG31332 and CG31352).

(FlyBase, 1992-)

Nomenclature History

Source for database identify of

Nomenclature comments

FBrf0201664 uses the symbol "Dunc-115" to refer to the CG31352 annotation. However, the "unc-115" symbol was previously used in FlyBase to refer to the CG31332 annotation. To try to avoid further confusion, CG31352 has been renamed to "Unc-115a" and CG31332 has been renamed to "Unc-115b" to reflect that both genes show similarity to the C. elegans unc-115 gene.

(FlyBase, 2009-)

Etymology

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

CG31352

(Aradska et al., 2015, Kwak et al., 2013, Chen et al., 2012, Hazelett et al., 2012, Irion, 2012, Japanese National Institute of Genetics, 2012.5.21, Cammarato et al., 2011, Friedman et al., 2011, Zhan et al., 2011, Buffin and Gho, 2010, Knowles-Barley et al., 2010, Zhang et al., 2010, Keleman et al., 2009.8.5, Edwards et al., 2006)

CG9489

(Garcia et al., 2007, Hsieh et al., 2007)

Dunc-115

(Garcia et al., 2007)

Unc-115a

(She et al., 2021, Ke and Hsu, 2019, Mannix et al., 2019, Hu et al., 2017.6.13, Aradska et al., 2015, Gene Disruption Project members, 2015-, Pézeron et al., 2014, Kwon et al., 2013)

anon-WO0140519.21

dunc-115

(Roblodowski and He, 2017, Garcia and He, 2002)

unc-115

(Chintapalli et al., 2013, Hartmann et al., 2011)

unc-115a

(Titus et al., 2023)

unc-15a

(Dorogova et al., 2020)

Name Synonyms

Uncoordinated 115a

Secondary FlyBase IDs

FBgn0037733
FBgn0044663
FBgn0063633

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 64 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

261629

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

E1JIH3

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

E1JIH3

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0051352

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

261629/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0051352

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0051352

FlyMine - An integrated database for Drosophila genomics

FBgn0051352

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG31352

MARRVEL_MODEL - MARRVEL (model organism gene)

261629

Linkouts

BioGRID - A database of protein and genetic interactions.

76449

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0051352

DroID - A comprehensive database of gene and protein interactions.

FBgn0051352

DRSC - Results frm RNAi screens

FBgn0051352

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0051352

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0051352

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG31352

Flygut - An atlas of the Drosophila adult midgut

FBgn0051352

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0051352

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC012552

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Miscellaneous transport and binding events

References (60)

The following external sites may use different assemblies or annotations than FlyBase.

1.21

Report Sections