FlyBase Gene Report: Zzzz\CAG

(Dubey et al., 2024, Swinter et al., 2023, Dubey and Tapadia, 2018, Singh et al., 2017, Krench et al., 2016, Nelson et al., 2016, Yadav and Tapadia, 2013, Wang et al., 2012, Mallik and Lakhotia, 2009, Murata et al., 2008, Ghosh and Feany, 2004, Gunawardena et al., 2003, Taylor et al., 2003, Kazemi-Esfarjani and Benzer, 2002, Kazemi-Esfarjani and Benzer, 2000)

CEC

(Kuo et al., 2013, Arya et al., 2010, Sengupta and Lakhotia, 2006, Mizutani et al., 2005)

CEC with DnaJ-1^UAS.cKb

(Kuo et al., 2013)

CEC with Hsap\HSPA4L^UAS.cKa

(Kuo et al., 2013)

CEC with Hsp110^UAS.cKa

(Kuo et al., 2013)

CEC with Hsap\DNAJB1^UAS.cKa

(Kuo et al., 2013)

Zzzz\CAG^Q108.UAS

model of neurodegenerative disease

CEA

(Catterson et al., 2023, Gunawardena et al., 2003, Marsh et al., 2000)

model of Huntington's disease

CEC

(Kazantsev et al., 2002)

Zzzz\CAG^{Q108.UAS.Tag:MYC,Tag:FLAG}

model of neurodegenerative disease

CEA

(Berger et al., 2006)

Zzzz\CAG^{Q48.UAS.Tag:MYC,Tag:FLAG}

model of neurodegenerative disease

CEA

(Underwood et al., 2010, Steffan et al., 2001)

CEC

(Menzies et al., 2015)

model of Huntington's disease

CEA

(Jimenez-Sanchez et al., 2015, Ott et al., 2015, Lievens et al., 2005)

Zzzz\CAG^{93.UAS.Tag:MYC,Tag:FLAG}

model of neurodegenerative disease

CEA

(van Eyk et al., 2011)

Zzzz\CAG^{term.CAA.114.UAS}

DOES NOT model neurodegenerative disease

CEA

(van Eyk et al., 2011)

Zzzz\CAG^{Q79.GMR.Tag:FLAG}

model of neurodegenerative disease

CEA

(Higashiyama et al., 2002)

Zzzz\CAG^{Q92.GMR.Tag:FLAG}

model of neurodegenerative disease

CEA

(Manno et al., 2010, Nagai et al., 2003, Higashiyama et al., 2002)

CEC

(Koike et al., 2010)

Zzzz\CAG^{63Q.UAS.Tag:HA}

model of neurodegenerative disease

CEA

(Yeh et al., 2018, Kazemi-Esfarjani and Benzer, 2002)

Zzzz\CAG^{99.UAS.Tag:MYC,Tag:FLAG}

model of neurodegenerative disease

CEA

(Eyk et al., 2019, Lawlor et al., 2011, McLeod et al., 2005)

CEA with Zzzz\CTG^{rCUG.99.UAS.Tag:MYC,Tag:FLAG}

(Samaraweera et al., 2013)

Zzzz\CAG^{CAA.94.UAS.Tag:MYC,Tag:FLAG}

model of neurodegenerative disease

CEA

(van Eyk et al., 2011, McLeod et al., 2005)

Zzzz\CAG^term93.UAS

DOES NOT model neurodegenerative disease

CEA

(van Eyk et al., 2011)

model of neurodegenerative disease

CEA with sgg^UAS.cBa

(van Eyk et al., 2011)

Zzzz\CAG^{41Q.UAS.Tag:HA}

model of neurodegenerative disease

CEA

(Chou et al., 2021, Yeh et al., 2018)

CEC

(Chen et al., 2012)

Zzzz\CAG^{UAS.75Q.T:Avic\GFP.Tag:FLAG}

model of neurodegenerative disease

CEA

(Mugat et al., 2008)

Zzzz\CAG^{100.UAS.DsRed2}

model of neurodegenerative disease

CEA

(Peng et al., 2021, Zhang et al., 2018, Tsoi et al., 2011)

Zzzz\CAG^{250.UAS.DsRed2}

model of neurodegenerative disease

CEA

(Peng et al., 2021, Zhang et al., 2018, Shieh and Bonini, 2011)

Zzzz\CAG^{63Q.GMR.Tag:HA}

model of neurodegenerative disease

CEA

(Xie et al., 2021)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 14 )

Allele

Disease

Interaction

References

Zzzz\CAG^{127Q.UAS.Tag:HA}

model of neurodegenerative disease

is ameliorated by DnaJ-1^EU3500

(Kazemi-Esfarjani and Benzer, 2000)

is ameliorated by DnaJ-1^UAS.cKa

(Ghosh and Feany, 2004, Kazemi-Esfarjani and Benzer, 2000)

is ameliorated by Tpr2^UAS.cKa

(Kazemi-Esfarjani and Benzer, 2000)

is ameliorated by Tpr2^EU3220

(Kazemi-Esfarjani and Benzer, 2000)

is exacerbated by nej^P

(Taylor et al., 2003)

is ameliorated by nej^EP1179

(Taylor et al., 2003)

is ameliorated by nej^EP1149

(Taylor et al., 2003)

is exacerbated by Atx2^EP3145

(Ghosh and Feany, 2004)

is exacerbated by CG7231^EP2510

(Ghosh and Feany, 2004)

is exacerbated by Atx2^UAS.cSa

(Ghosh and Feany, 2004)

is ameliorated by Hsap\HSPA1L^UAS.cWa

(Ghosh and Feany, 2004)

is exacerbated by Hsc70-4^K71S.UAS

(Ghosh and Feany, 2004)

is ameliorated by Mlf^EU2490

(Kazemi-Esfarjani and Benzer, 2002)

is exacerbated by Khc⁹

(Gunawardena et al., 2003)

is ameliorated by Hsc70-4^UAS.cEa

(Gunawardena et al., 2003)

is exacerbated by lncRNA:Hsrω^EP3037

(Mallik and Lakhotia, 2009, Sengupta and Lakhotia, 2006)

is exacerbated by lncRNA:Hsrω^EP93D

(Mallik and Lakhotia, 2009, Sengupta and Lakhotia, 2006)

is ameliorated by lncRNA:Hsrω^RNAi.Sym.UAS

(Mallik and Lakhotia, 2009)

is exacerbated by Mdr49^HMS00400

(Yadav and Tapadia, 2013)

is exacerbated by Mdr50^HMS01448

(Yadav and Tapadia, 2013)

is exacerbated by Mdr65^HMS01449

(Yadav and Tapadia, 2013)

is ameliorated by G6pd^UAS.cLa

(Wang et al., 2012)

is ameliorated by Rpi^RNAi.Sym.UAS

(Wang et al., 2012)

is NOT ameliorated by Hsap\ATXN1L^UAS.Tag:FLAG

(Mizutani et al., 2005)

is exacerbated by lncRNA:Hsrω⁰⁵²⁴¹

(Sengupta and Lakhotia, 2006)

is exacerbated by PolE1^pl10R

(Sengupta and Lakhotia, 2006)

is ameliorated by Hsp60D^RNAi.Sym.UAS

(Arya et al., 2010)

is ameliorated by DnaJ-1^UAS.cKb

(Kuo et al., 2013)

is exacerbated by Hsp110^HMS01080

(Kuo et al., 2013)

is ameliorated by Hsap\DNAJB1^UAS.cKa

(Kuo et al., 2013)

is ameliorated by AttA^TRiP.cUa

(Dubey and Tapadia, 2018)

is ameliorated by CycE^UAS.cUa

(Dubey and Tapadia, 2018)

is ameliorated by Dif^TRiP.cUa

(Dubey and Tapadia, 2018)

is ameliorated by DptA^RNAi.UAS.cUa

(Dubey and Tapadia, 2018)

is ameliorated by Dro^RNAi.UAS

(Dubey and Tapadia, 2018)

is ameliorated by Drs^RNAi.UAS.cUa

(Dubey and Tapadia, 2018)

is ameliorated by Rel^TRiP.cUa

(Dubey and Tapadia, 2018)

is ameliorated by mir-ban^C.UAS.EGFP

(Dubey and Tapadia, 2018)

is ameliorated by yki^UAS.cHa

(Dubey and Tapadia, 2018)

is exacerbated by yki^RNAi.UAS.cUa

(Dubey and Tapadia, 2018)

is ameliorated by AttA^RNAi.UAS.cUa

(Dubey and Tapadia, 2018)

is ameliorated by Dif^RNAi.UAS.cUa

(Dubey and Tapadia, 2018)

is ameliorated by Rel^RNAi.UAS.cUa

(Dubey and Tapadia, 2018)

is ameliorated by Drp1^KG03815

(Swinter et al., 2023)

is ameliorated by RanGAP^EY21763

(Dubey et al., 2024)

is exacerbated by RanGAP^JF03244

(Dubey et al., 2024)

model of Huntington's disease

is ameliorated by Hsc70-4^HMS00152

(Rai and Tapadia, 2022)

is ameliorated by Hsc70-4^JF03136

(Rai and Tapadia, 2022)

is exacerbated by Hsc70-4^UAS.cEa

(Rai and Tapadia, 2022)

is ameliorated by Atg5^RNAi.UAS.cUa

(Maurya and Tapadia, 2023)

is ameliorated by Diap1^RNAi.UAS.cUa

(Maurya and Tapadia, 2023)

is ameliorated by SERCA^KG00570

(Maurya and Tapadia, 2023)

is exacerbated by SERCA^UAS.cUa

(Maurya and Tapadia, 2023)

is exacerbated by Sod2^RNAi.UAS.cUa

(Maurya and Tapadia, 2023)

is ameliorated by Atg5^RNAi.UAS.cUa

(Maurya and Tapadia, 2023)

Zzzz\CAG^Q108.UAS

model of Huntington's disease

is ameliorated by Zzzz\CAG^{Su3.UAS.Tag:MYC}

(Kazantsev et al., 2002)

is ameliorated by Hsap\HTT^{Su3.Scer\UAS.T:Zzzz\CAG,T:Hsap\MYC}

(Kazantsev et al., 2002)

model of neurodegenerative disease

is exacerbated by LanB1^EP-600

(Catterson et al., 2023)

Zzzz\CAG^{Q108.UAS.Tag:MYC,Tag:FLAG}

model of Huntington's disease

is ameliorated by Hsap\HTT^{Su3.Scer\UAS.T:Zzzz\CAG,T:Hsap\MYC}

(Kazantsev et al., 2002)

is ameliorated by Zzzz\CAG^{Su3.UAS.Tag:MYC}

(Kazantsev et al., 2002)

Zzzz\CAG^{Q48.UAS.Tag:MYC,Tag:FLAG}

model of neurodegenerative disease

is exacerbated by Sod2^UAS.cMa

(Underwood et al., 2010)

is exacerbated by Sod1^UAS.cAa

(Underwood et al., 2010)

is ameliorated by CalpA^KK104532

(Menzies et al., 2015)

model of Huntington's disease

is ameliorated by QC^GD6767

(Jimenez-Sanchez et al., 2015)

is ameliorated by QC^KK109667

(Jimenez-Sanchez et al., 2015)

is ameliorated by isoQC^KK108983

(Jimenez-Sanchez et al., 2015)

is ameliorated by Hsap\HTT^{Su3.Scer\UAS.T:Zzzz\CAG,T:Hsap\MYC}

(Kazantsev et al., 2002)

is ameliorated by Zzzz\CAG^{Su3.UAS.Tag:MYC}

(Kazantsev et al., 2002)

Zzzz\CAG^{93.UAS.Tag:MYC,Tag:FLAG}

model of neurodegenerative disease

is exacerbated by sgg^UAS.cBa

(van Eyk et al., 2011)

is exacerbated by mod(mdg4)^GD16547

(van Eyk et al., 2011)

is NOT exacerbated by Mef2^GD5039

(van Eyk et al., 2011)

Zzzz\CAG^{Q76.UAS.EGFP,Tag:FLAG}

model of neurodegenerative disease

is exacerbated by Cul1^GD9650

(Chen et al., 2019)

is exacerbated by FipoQ^NIG.2010R

(Chen et al., 2019)

Zzzz\CAG^{Q92.GMR.Tag:FLAG}

model of neurodegenerative disease

is exacerbated by Hsap\VCP^A232E.UAS

(Manno et al., 2010)

is exacerbated by Hsap\VCP^R155P.UAS

(Manno et al., 2010)

is exacerbated by Hsap\VCP^T761E.UAS

(Manno et al., 2010)

is exacerbated by Hsap\VCP^R155H.UAS

(Manno et al., 2010)

is ameliorated by Hsap\VCP^UAS.cMa

(Manno et al., 2010)

is ameliorated by TER94^26-8

(Higashiyama et al., 2002)

is exacerbated by TER94^UAS.cHa

(Higashiyama et al., 2002)

is ameliorated by Mmmm\VCP^UAS.cKa

(Koike et al., 2010)

is ameliorated by Hsap\PQBP1^UAS.CFP

(Nagai et al., 2003)

Zzzz\CAG^{99.UAS.Tag:MYC,Tag:FLAG}

model of neurodegenerative disease

is ameliorated by CPV\CrPV-1A^{UASp.Tag:FLAG}

(Eyk et al., 2019)

is ameliorated by Hsap\ADAR^UAS.p110.cHa

(Eyk et al., 2019)

is ameliorated by Hsap\ADAR^UAS.p150.cHa

(Eyk et al., 2019)

Zzzz\CAG^{CAA.94.UAS.Tag:MYC,Tag:FLAG}

model of neurodegenerative disease

is exacerbated by mod(mdg4)^GD16547

(van Eyk et al., 2011)

is NOT exacerbated by Mef2^GD5039

(van Eyk et al., 2011)

is exacerbated by sgg^UAS.cBa

(van Eyk et al., 2011)

Zzzz\CAG^{41Q.UAS.Tag:HA}

model of neurodegenerative disease

is ameliorated by Ptpmeg2^UAS.Tag:FLAG

(Chou et al., 2021)

is ameliorated by Atg7^UAS.cCa

(Chen et al., 2012)

is exacerbated by Atg7^GD11671

(Chen et al., 2012)

is exacerbated by Hsp27^GD11327

(Chen et al., 2012)

is ameliorated by Hsp27^UAS.Tag:HA

(Chen et al., 2012)

Zzzz\CAG^{Su3.UAS.Tag:MYC}

ameliorates Huntington's disease

modeled by Zzzz\CAG^Q108.UAS

(Kazantsev et al., 2002)

modeled by Zzzz\CAG^{Q48.UAS.Tag:MYC,Tag:FLAG}

(Kazantsev et al., 2002)

modeled by Zzzz\CAG^{Q108.UAS.Tag:MYC,Tag:FLAG}

(Kazantsev et al., 2002)

Zzzz\CAG^{100.UAS.DsRed2}

model of neurodegenerative disease

is exacerbated by U2af50^RNAi.UAS.cUa

(Tsoi et al., 2011)

Zzzz\CAG^{250.UAS.DsRed2}

model of neurodegenerative disease

is ameliorated by wech^E546

(Shieh and Bonini, 2011)

is ameliorated by Hsap\HSPA1L^UAS.cWa

(Shieh and Bonini, 2011)

is ameliorated by Tpr2^EB7-1A

(Shieh and Bonini, 2011)

is ameliorated by orb2^B8-S

(Shieh and Bonini, 2011)

Zzzz\CAG^{63Q.GMR.Tag:HA}

model of neurodegenerative disease

is ameliorated by Rack1^KK109073

(Xie et al., 2021)

is ameliorated by Kcmf1^HMS00511

(Xie et al., 2021)

is ameliorated by Rack1^1.8

(Xie et al., 2021)

is ameliorated by Rack1^s12

(Xie et al., 2021)

is ameliorated by poe^HMS00739

(Xie et al., 2021)

is ameliorated by rl^UAS.Tag:FLAG

(Xie et al., 2021)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

Class of Gene

engineered_foreign_region

Stocks and Reagents

Stocks (5)

Bloomington

68393

w^*; P{UAS-Q108}16

51674

w^* P{UAS-Q48.myc.flag}42

30544

w¹¹¹⁸; P{UAS-Zzzz\CAG.63Q}2

30549

w¹¹¹⁸; P{UAS-Zzzz\CAG.20Q}3

30540

w^*; P{ninaE-GAL4.D}2; P{UAS-41Q.HA}3

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (18)

Reported As

Symbol Synonym

CAG

(Zhang et al., 2018, Nelson et al., 2016, van Eyk et al., 2012, Lawlor et al., 2011, Tsoi et al., 2011, Le Mée et al., 2008, McLeod et al., 2005)

CAG repeat

(van Eyk et al., 2011, McLeod et al., 2005)

Q127

(Krench et al., 2016)

Q92

(Nagai et al., 2003)

Zzzz\CAG

poly-Q

(Himalian et al., 2022)

polyQ

(van Eyk et al., 2012, van Eyk et al., 2011, Wong et al., 2008, Slepko et al., 2002, Marsh et al., 2000)

rCAG

(Samaraweera et al., 2013, Lawlor et al., 2012, van Eyk et al., 2011)

rCAG-100

(Samaraweera et al., 2013)

Name Synonyms

CAG repeat

(Jimenez-Sanchez et al., 2015)

Polyglutamine

(van Eyk et al., 2012)

polyQ repeats

(Singh et al., 2017)

polyglutamine

(Underwood et al., 2010, Iijima-Ando and Iijima, 2007)

polyglutamine repeat

polyglutamine stretch

(Berger et al., 2006)

polyglutamines

(Menzies et al., 2015)

rCAG repeat

(Wong et al., 2014)

rCAG.rCUG

(Denton et al., 2020)

toxic polyglutamine

(Chang et al., 2011)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 0 )

References (105)

Report Sections