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FB2026_01
,
released March 12, 2026
Syd-1, Syd1, DSyd-1
master organizer of active zone assembly, regulates pre- and postsynaptic maturation, neuromuscular junction
Please see the JBrowse view of Dmel\RhoGAP100F for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.52
Gene model reviewed during 5.41
Gene model reviewed during 5.53
Multiphase exon postulated: exon reading frame differs in alternative transcripts; overlap >20aa.
None of the polypeptides share 100% sequence identity.
Interacts (via PDZ domain) with Nrx-1; may recruit Nrx-1 to the presynaptic active zone.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\RhoGAP100F using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Expression in stage P3 pupal leg discs is restricted to presumptive tarsal joints.
RhoGAP100F transcript is expressed in the embryonic central nervous system. In the adult, it is found throughout the brain, co-localising with the presynaptic marker brp. In the mushroom bodies, RhoGAP100F is found opposite the postsynaptic acetylcholine receptor nAChRalpha7. In the larva, it is found in the presynaptic active zone of the neuromuscular junction, where it forms clusters surrounding the centre of the active zone as defined by brp. In these clusters it co-localises closely with Liprin-α.
RhoGAP100F protein is expressed as discrete puncta in the presynaptic active zone in the mushroom body calyx of larva and adults.
RhoGAP100F protein was identified from extracts of adult heads as a 195kDa protein.
JBrowse - Visual display of RNA-Seq signals
View Dmel\RhoGAP100F in JBrowse3-102
3-99.1
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Loss of RhoGAP100F function disrupts two distinct phases of presynaptic development in the R7 photoreceptor cell axons, resulting in two phenotypes: termination before the M6 medulla target layer, and projection of extensions beyond the M6 medulla layer.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
