FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\yki
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General Information
Symbol
Dmel\yki
Species
D. melanogaster
Name
yorkie
Annotation Symbol
CG4005
Feature Type
protein_coding_gene
FlyBase ID
FBgn0034970
Gene Model Status
Current
Stock Availability
35 publicly available
Gene Summary
yorkie (yki) encodes a transcriptional co-activator protein that is negatively regulated by Hippo signaling, which promotes its cytoplasmic localization. It functions together with DNA binding proteins, such as the product of sd, to activate transcription of a wide range of downstream targets, including genes that promote growth. [Date last reviewed: 2019-03-21] (FlyBase Gene Snapshot)
All Summaries
Also Known As

YAP

Key Links
Genomic Location
Cytogenetic map
60B7-60B8
Sequence location
Recombination map
2-106
RefSeq locus
NT_033778 REGION:24065975..24068485
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (33 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
enables 14-3-3 protein binding
inferred from physical interaction with FLYBASE:14-3-3ζ; FB:FBgn0004907,FLYBASE:14-3-3ε; FB:FBgn0020238
(Ren et al., 2010)
enables DNA-binding transcription factor binding
inferred from physical interaction with FLYBASE:sd; FB:FBgn0003345
(Goulev et al., 2008, Zhang et al., 2008)
inferred from physical interaction with FLYBASE:hth; FB:FBgn0001235
(Peng et al., 2009)
inferred from physical interaction with FLYBASE:ovo; FB:FBgn0003028
(Bohère et al., 2018)
enables kinase binding
inferred from physical interaction with UniProtKB:Q9VZI2
(Hu et al., 2016)
enables protein binding
inferred from physical interaction with UniProtKB:Q07436
(Hu et al., 2016)
inferred from physical interaction with UniProtKB:P25439
(Jin et al., 2013)
inferred from physical interaction with UniProtKB:P29310
(Oh and Irvine, 2008)
inferred from physical interaction with UniProtKB:P92177
(Oh and Irvine, 2008)
inferred from physical interaction with UniProtKB:P30052
(Goulev et al., 2008)
inferred from physical interaction with UniProtKB:P51140
(Varelas et al., 2010)
inferred from physical interaction with FLYBASE:Ncoa6; FB:FBgn0031698
(Qing et al., 2014)
enables transcription coactivator activity
inferred from direct assay
(Zhang et al., 2024, Cho et al., 2020, Liu et al., 2016, Qing et al., 2014, Oh et al., 2009, Goulev et al., 2008, Zhang et al., 2008, Hamaratoglu et al., 2006)
inferred from mutant phenotype
(Huang et al., 2005)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables transcription coactivator activity
inferred from biological aspect of ancestor with PANTHER:PTN000427153
(GO Reference Genome Project, 2011-)
Biological Process (22 terms)
Terms Based on Experimental Evidence (22 terms)
CV Term
Evidence
References
involved_in apical protein localization
inferred from genetic interaction with FLYBASE:Strn-Mlck; FB:FBgn0265045
(Xu et al., 2018)
involved_in border follicle cell migration
inferred from mutant phenotype
(Lucas et al., 2013)
involved_in cell competition in a multicellular organism
inferred from mutant phenotype
(Ziosi et al., 2010)
involved_in cell fate specification
inferred from mutant phenotype
(Jukam et al., 2013)
involved_in cell population proliferation
inferred from mutant phenotype
(Huang et al., 2005)
involved_in epidermal cell fate specification
inferred from genetic interaction with FLYBASE:bon; FB:FBgn0023097
(Zhao et al., 2023)
involved_in heart morphogenesis
inferred from mutant phenotype
(Yu et al., 2015)
involved_in hippo signaling
inferred from mutant phenotype
(Sun et al., 2019, Cho et al., 2018, Xu et al., 2018, Yu and Pan, 2018, Zhang et al., 2017, Ding et al., 2016, Fletcher et al., 2015, Koontz et al., 2013, Oh and Irvine, 2008, Wu et al., 2008)
inferred from mutant phenotype
(Huang et al., 2005)
inferred from direct assay
(Oh et al., 2009, Zhao et al., 2007)
inferred from genetic interaction with FLYBASE:wts; FB:FBgn0011739
(Poon et al., 2016)
involved_in imaginal disc morphogenesis
inferred from genetic interaction with FLYBASE:Mitf; FB:FBgn0263112
(Zhang et al., 2024)
involved_in morphogenesis of an epithelial sheet
inferred from mutant phenotype
(Thompson and Cohen, 2006)
involved_in negative regulation of apoptotic process
inferred from mutant phenotype
(Thompson and Cohen, 2006, Huang et al., 2005)
inferred from genetic interaction with UniProtKB:Q9VZI2
(Schoenherr et al., 2012)
involved_in positive regulation of cell population proliferation
inferred from mutant phenotype
(Ding et al., 2016, Fernández et al., 2014, Thompson and Cohen, 2006, Huang et al., 2005)
involved_in positive regulation of glial cell proliferation
inferred from mutant phenotype
(Reddy and Irvine, 2011)
involved_in positive regulation of growth
inferred from mutant phenotype
(Xu et al., 2018, Oh and Irvine, 2011)
involved_in positive regulation of imaginal disc growth
inferred from mutant phenotype
(Gerlach et al., 2018, Moeller et al., 2017, Dong et al., 2015)
inferred from direct assay
(Xu et al., 2018)
involved_in positive regulation of transcription by RNA polymerase II
inferred from direct assay
(Liu et al., 2016, Qing et al., 2014, Oh et al., 2009, Peng et al., 2009, Hamaratoglu et al., 2006)
inferred from mutant phenotype
(Yu et al., 2020, Bohère et al., 2018, Boone et al., 2016, Goulev et al., 2008, Huang et al., 2005)
involved_in R8 cell development
inferred from mutant phenotype
(Sang et al., 2021)
involved_in regulation of establishment of blood-brain barrier
inferred from mutant phenotype
(Li et al., 2017)
involved_in regulation of growth
inferred from mutant phenotype
(Nolo et al., 2006)
involved_in regulation of stem cell differentiation
inferred from mutant phenotype
(Huang et al., 2017)
involved_in regulation of stem cell proliferation
inferred from mutant phenotype
(Hsu et al., 2017, Li et al., 2015)
involved_in stem cell proliferation
inferred from direct assay
(Ren et al., 2010)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in hippo signaling
inferred from biological aspect of ancestor with PANTHER:PTN000427153
(GO Reference Genome Project, 2011-)
involved_in positive regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN000427153
(GO Reference Genome Project, 2011-)
Cellular Component (6 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Schoenherr et al., 2012)
located_in cytosol
inferred from direct assay
(Borreguero-Muñoz et al., 2019, Xu et al., 2018, Qing et al., 2014, Oh et al., 2009, Goulev et al., 2008, Oh and Irvine, 2008)
located_in lateral cell cortex
inferred from direct assay
(Xu et al., 2018)
located_in nucleus
inferred from genetic interaction with FLYBASE:wts; FB:FBgn0011739
(Xu et al., 2018)
inferred from direct assay
(Borreguero-Muñoz et al., 2019, Qing et al., 2014, Goulev et al., 2008, Oh and Irvine, 2008)
part_of RNA polymerase II transcription regulator complex
inferred from physical interaction with FLYBASE:sd; FB:FBgn0003345,FLYBASE:mask; FB:FBgn0290416
(Sidor et al., 2013)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in cell-cell junction
inferred from sequence or structural similarity with UniProtKB:P46938
(Gene Ontology Curators, 2002-)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the YAP1 family. (Q45VV3)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
yorkie (yki) encodes a transcriptional co-activator protein that is negatively regulated by Hippo signaling, which promotes its cytoplasmic localization. It functions together with DNA binding proteins, such as the product of sd, to activate transcription of a wide range of downstream targets, including genes that promote growth. [Date last reviewed: 2019-03-21]
Pathway (FlyBase)
HIPPO SIGNALING PATHWAY CORE COMPONENTS -
The Hippo signaling pathway is an intracellular kinase cascade in which hpo kinase in complex with sav, phosphorylates wts kinase which, in turn, phosphorylates yki transcriptional co-activator leading to its cytosolic retention. Activation of the Hippo pathway results in the down-regulation of cell proliferation and up-regulation of apoptosis, limiting tissue size. (Adapted from FBrf0224870).
Protein Function (UniProtKB)
Transcriptional coactivator which is the critical downstream regulatory target in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:16096061, PubMed:18313299, PubMed:22615583, PubMed:27462444). The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein (PubMed:16096061, PubMed:19900439). The Hippo/SWH signaling pathway inhibits the activity of the transcriptional complex formed by Scalloped (sd) and Yki and the target genes of this pathway include cyclin-E (cycE), diap1 and bantam (PubMed:16096061, PubMed:18313299). Regulates the expression of G1/S-specific CycE and diap1, thereby promoting cell proliferation and inhibiting apoptosis (PubMed:18313299). Required for transcriptional activity of sd in wing imaginal disks (PubMed:18313299). Induces expression of expression of vestigial (vg) in wing and haltere disks and the expression of transcription factor E2f (E2f) (PubMed:18313299).
(UniProt, Q45VV3)
Summary (Interactive Fly)

target of the Hippo-Warts pathway - ortholog of the mammalian transcriptional coactivator yes-associated protein - transcriptional coactivator that negatively regulates cell-cycle and cell-death regulators - fold formation at the compartment boundary of Drosophila wing requires Yki signaling to suppress JNK dependent apoptosis

Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\yki for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q45VV3)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.40

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.52

Gene model reviewed during 6.14

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
yki-RD
FBtr0290256
NM_138035
1369
343
yki-RF
FBtr0290258
NM_001043103
1525
395
yki-RG
FBtr0309372
NM_166657
1460
395
yki-RH
FBtr0452181
NM_001363931
1525
418
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
yki-PD
FBpp0288695
37.8
343
5.34
NP_611879
AAF47156
yki-PF
FBpp0288697
43.6
395
5.04
Q45VV3
NP_001036568
ABI31113
yki-PG
FBpp0301274
43.6
395
5.04
Q45VV3
NP_726414
AAM68300
yki-PH
FBpp0402906
46.2
418
5.37
H0RNA4
AWM95306
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

395 aa isoforms: yki-PF, yki-PG
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts (via WW domains) with wts (PubMed:16096061). Interacts (via N-terminus) with sd (via C-terminus) and this interaction enhances the transcriptional activity of sd (PubMed:18313299). The phosphorylated form interacts with 14-3-3epsilon and 14-3-3zeta (PubMed:18256197). Interacts with Ack and ex (PubMed:27462444).

(UniProt, Q45VV3)
Post Translational Modification

Its activity is regulated by multiple phosphorylation events (PubMed:16096061, PubMed:18256197, PubMed:19900439, PubMed:31857346). Phosphorylation at Ser-88, Ser-145 and Ser-227 negatively regulate its activity and restrict its nuclear localization (PubMed:19900439). Wts-mediated phosphorylation at Ser-145 promotes interaction with 14-3-3epsilon and 14-3-3zeta (PubMed:18256197). Phosphorylation at Ser-88 and Ser-227 regulate nuclear localization and activity independent of 14-3-3 association (PubMed:19900439). Phosphorylation at Ser-146 by Cdk7 promotes its stability by preventing ubiquitination by the DCX(DCAF12) complex (PubMed:31857346).

Ubiquitinated by the DCX(DCAF12) complex, leading to its degradation (PubMed:31857346). Phosphorylation at Ser-146 by Cdk7 prevents ubiquitination by the DCX(DCAF12) complex (PubMed:31857346).

(UniProt, Q45VV3)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\yki using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.12

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | faint | ubiquitous
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
larval brain neuropil glial cell
(Reddy and Irvine, 2011)
larval neuropil glial cell
(Reddy and Irvine, 2011)
adult subretinal glial cell
(Reddy and Irvine, 2011)
embryonic/larval optic stalk
(Reddy and Irvine, 2011)
cortical zone of lymph gland primary lobe | variable
(Ferguson and Martinez-Agosto, 2014)
embryonic/larval crystal cell
(Ferguson and Martinez-Agosto, 2014)
crystal cell primordium
(Ferguson and Martinez-Agosto, 2014)
Additional Descriptive Data

yki is expressed in glial cells in the central brain, the ventral nerve cord, the eye disc, and the optic stalk in larval eye discs.

(Reddy and Irvine, 2011)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Schoenherr et al., 2012)
located_in cytosol
inferred from direct assay
(Borreguero-Muñoz et al., 2019, Xu et al., 2018, Qing et al., 2014, Oh et al., 2009, Goulev et al., 2008, Oh and Irvine, 2008)
located_in lateral cell cortex
inferred from direct assay
(Xu et al., 2018)
located_in nucleus
inferred from genetic interaction with FLYBASE:wts; FB:FBgn0011739
(Xu et al., 2018)
inferred from direct assay
(Borreguero-Muñoz et al., 2019, Qing et al., 2014, Goulev et al., 2008, Oh and Irvine, 2008)
part_of RNA polymerase II transcription regulator complex
inferred from physical interaction with FLYBASE:sd; FB:FBgn0003345,FLYBASE:mask; FB:FBgn0290416
(Sidor et al., 2013)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\yki in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 24 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 131 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of yki
Transgenic constructs containing regulatory region of yki
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(2R)Exel6081
(Ryder, 2004.4.26)
Inferred from location ( 1 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
cell lethal | somatic clone
lethal
lethal, with Scer\GAL4en-e16E
lethal, with Scer\GAL4GMR.PF
lethal, with Scer\GAL4sd-SG29.1
lethal, with Scer\GAL4vg.PM
lethal (with ykiB5)
lethal (with ykiE271K)
lethal (with ykiF351I)
lethal (with ykiG347R)
lethal (with ykiP88L)
lethal (with ykiP295S)
lethal (with ykiR310X)
lethal (with ykiY282N)
lethal | embryonic stage
lethal | first instar larval stage
lethal | somatic clone
lethal - all die before end of larval stage, with Scer\GAL4sd-SG29.1
lethal - all die before end of larval stage | recessive
lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
lethal - all die before end of pupal stage, with Scer\GAL4repo.PU
lethal - all die before end of pupal stage (with ykiAcidA)
lethal - all die before end of pupal stage (with ykiB5)
lethal - all die during pupal stage, with Scer\GAL4ap-md544
partially lethal, with Scer\GAL4GMR.PF
partially lethal, with Scer\GAL4sd-SG29.1
partially lethal - majority die, with Scer\GAL4GMR.PF
viable
viable, with Scer\GAL4Mef2.PR
Sterility
Allele
female sterile, with Scer\GAL4C587
Other Phenotypes
Allele
abnormal cell migration, with Scer\GAL4slbo.2.6
abnormal cell migration | adult stage | progressive, with Scer\GAL4esg.PU
abnormal cell number | adult stage, with Scer\GAL4esg.PU
abnormal cell shape | somatic clone, with Scer\GAL4Act5C.PP
abnormal cell shape | somatic clone, with Scer\GAL4Tub.PU
abnormal cell size | somatic clone
abnormal eclosion, with Scer\GAL4sd-SG29.1
abnormal immune response | adult stage, with Scer\GAL4r4
abnormal immune response | adult stage, with Scer\GAL4yolk
abnormal locomotor behavior | adult stage, with Scer\GAL4NP5130
abnormal mitotic cell cycle | larval stage, with Scer\GAL4GMR.PU
abnormal mitotic cell cycle | somatic clone, with Scer\GAL4Act5C.PP
abnormal neuroanatomy | adult stage, with Scer\GAL4GMR.long, Scer\GAL4ey.PH
abnormal neuroanatomy | adult stage | progressive, with Scer\GAL4GMR.PF
abnormal neuroanatomy | larval stage, with Scer\GAL4C855a
abnormal neuroanatomy | larval stage | somatic clone - tissue specific, with Scer\GAL4Act5C.PI
abnormal neuroanatomy | somatic clone | third instar larval stage, with Scer\GAL4Tub.PU, Scer\GAL80ts.αTub84B
abnormal neuroanatomy | third instar larval stage, with Scer\GAL446F
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4Gli.PU
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4insc-Mz1407
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4repo.PU
abnormal planar polarity | adult stage, with Scer\GAL4ey.PH
abnormal size, with Scer\GAL4GMR.PF
abnormal size, with Scer\GAL4hh-Gal4
abnormal size, with Scer\GAL4ptc-559.1
abnormal size, with Scer\GAL4Tub.PU
abnormal size | adult stage
abnormal size | adult stage, with Scer\GAL4GMR.PF
abnormal size | adult stage, with Scer\GAL4GMR.PFa
abnormal size | adult stage, with Scer\GAL4GMR.PU
abnormal size | adult stage, with Scer\GAL4nub.PU
abnormal size | adult stage, with Scer\GAL4nub-AC-62
abnormal size | adult stage, with Scer\GAL4ptc.PU
abnormal size | adult stage, with Scer\GAL4tj.PU
abnormal size | larval stage, with Scer\GAL4dpp.blk1
abnormal size | larval stage, with Scer\GAL4dpp.PU
abnormal size | larval stage, with Scer\GAL4GMR.PFa
abnormal size | larval stage, with Scer\GAL4GMR.PU
abnormal size | larval stage, with Scer\GAL4hh.PU
abnormal size | larval stage, with Scer\GAL4moody.PU
abnormal size | larval stage (with ykiAcidA)
abnormal size | larval stage (with ykiB5)
abnormal size | larval stage | somatic clone
abnormal size | larval stage | somatic clone, with Scer\GAL4Tub.PU
abnormal size | somatic clone
abnormal size | somatic clone | third instar larval stage, with Scer\GAL4Act.PU
abnormal size | somatic clone | third instar larval stage, with Scer\GAL4Tub.PU, Scer\GAL80ts.αTub84B
abnormal size | third instar larval stage, with Scer\GAL4ap-md544
abnormal size | third instar larval stage, with Scer\GAL4e22c
abnormal size | third instar larval stage, with Scer\GAL4en.PU
abnormal size | third instar larval stage, with Scer\GAL4hh.PU
abnormal size | third instar larval stage, with Scer\GAL4hh-Gal4
abnormal size | third instar larval stage, with Scer\GAL4insc-Mz1407
abnormal size | third instar larval stage, with Scer\GAL4ptc-559.1
atrophy | oogenesis, with Scer\GAL4NP5130
atrophy | pupal stage, with Scer\GAL4Mef2.PR
decreased body size | adult stage
decreased cell death, with Scer\GAL4GMR.PF
decreased cell death | somatic clone, with Scer\GAL4Act5C.PP
decreased cell number | adult stage, with Scer\GAL4nub.PU
decreased cell number | germline clone | oogenesis
decreased cell number | somatic clone
decreased cell number | third instar larval stage, with Scer\GAL4repo.PU
decreased cell size, with Scer\GAL4tin.CΔ4
decreased cell size | adult stage, with Scer\GAL4nub.PU
decreased cell size | oogenesis | somatic clone
decreased occurrence of cell division | larval stage
decreased rate of adult locomotory behavior, with Scer\GAL4esg.PU
decreased size | adult stage, with Scer\GAL4esg.PU
decreased size | adult stage, with Scer\GAL4nub.PU
decreased size | pupal stage, with Scer\GAL4Mef2.PR
flightless, with Scer\GAL4Mef2.PR
flightless | female limited, with Scer\GAL4Mef2.PR
hyperplasia, with Scer\GAL4GMR.PF
hyperplasia | adult stage, with Scer\GAL4esg.PU
hyperplasia | adult stage, with Scer\GAL4NP5130
hyperplasia | somatic clone
hyperplasia | somatic clone, with Scer\GAL4αTub84B.PP
hyperplasia | third instar larval stage, with Scer\GAL4ptc-559.1
hyperplasia | third instar larval stage, with Scer\GAL4ptc.PU
hyperplasia | third instar larval stage, with Scer\GAL4rn-GAL4
increased cell death | somatic clone | third instar larval stage, with Scer\GAL4Act.PU
increased cell growth rate | somatic clone, with Scer\GAL4FRT.Rnor\Cd2.Act5C
increased cell number, with Scer\GAL4cv-c-C5
increased cell number, with Scer\GAL4FRT.Act5C
increased cell number, with Scer\GAL4GMR.PF
increased cell number, with Scer\GAL4NP5130, Scer\GAL80ts.αTub84B
increased cell number | adult stage, with Scer\GAL4esg.PU
increased cell number | adult stage, with Scer\GAL4Myo31DF.PU
increased cell number | adult stage, with Scer\GAL4NP5130
increased cell number | adult stage, with Scer\GAL4ptc.PU
increased cell number | adult stage | somatic clone, with Scer\GAL4Tub.PU
increased cell number | oogenesis, with Scer\GAL4VP16.nanos.UTR
increased cell number | pupal stage, with Scer\GAL4GMR.PF
increased cell number | pupal stage, with Scer\GAL4αTub84B.PL
increased cell number | somatic clone, with Scer\GAL4FRT.Act5C
increased cell number | somatic clone, with Scer\GAL4NP0001, Scer\GAL80ts.αTub84B
increased cell number | somatic clone, with Scer\GAL4NP5130
increased cell number | somatic clone, with Scer\GAL4αTub84B.PL
increased cell number | third instar larval stage, with Scer\GAL4repo.PU
increased cell size, with Scer\GAL4tin.CΔ4
increased cell size | somatic clone, with Scer\GAL4Tub.PU
increased cell size | somatic clone, with Scer\GAL4αTub84B.PP
increased occurrence of cell division | adult stage, with Scer\GAL4esg.PU
increased occurrence of cell division | adult stage, with Scer\GAL4NP0001
increased occurrence of cell division | adult stage, with Scer\GAL4NP5130
increased occurrence of cell division | adult stage | somatic clone, with Scer\GAL4NP5130
increased occurrence of cell division | larval stage, with Scer\GAL4GMR.PF
increased occurrence of cell division | larval stage, with Scer\GAL4GMR.PFa
increased occurrence of cell division | larval stage, with Scer\GAL4GMR.PU
increased occurrence of cell division | larval stage, with Scer\GAL4repo.PU
increased size | adult stage, with Scer\GAL4en.PU
increased size | adult stage, with Scer\GAL4GMR.PF
increased size | adult stage, with Scer\GAL4GMR.PFa
increased size | adult stage, with Scer\GAL4GMR.PU
increased size | adult stage, with Scer\GAL4ptc.PU
increased size | adult stage, with Scer\GAL4sd-SG29.1
increased size | larval stage, with Scer\GAL4ap.PU
increased size | larval stage, with Scer\GAL4hh.PU
increased size | larval stage, with Scer\GAL4nub.PU
increased size | larval stage, with Scer\GAL4ptc-559.1
increased size | larval stage, with Scer\GAL4ptc.PU
increased size | pupal stage, with Scer\GAL4Mef2.PR
increased size | third instar larval stage, with Scer\GAL4ptc.PU
neoplasia | adult stage, with Scer\GAL4GMR.PFa
neoplasia | adult stage, with Scer\GAL4GMR.PU
neoplasia | adult stage, with Scer\GAL4NP5130
neoplasia | adult stage | female, with Scer\GAL4C587
neoplasia | adult stage | female, with ykiB5
neoplasia | adult stage | female, with ykihs.PW
neoplasia | larval stage, with Scer\GAL4GMR.PU
neoplasia | larval stage | somatic clone, with Scer\GAL4Act5C.PI
neoplasia | somatic clone | third instar larval stage, with Scer\GAL4Act.PU
neoplasia | third instar larval stage, with Scer\GAL4Bx-MS1096
short lived, with Scer\GAL4esg.PU
short lived, with Scer\GAL4NP5130
some die during larval stage, with Scer\GAL4sd-SG29.1
some die during pupal stage, with Scer\GAL4pnr-MD237
some die during pupal stage, with Scer\GAL4repo.PU
visible, with Scer\GAL4ey.PH
visible, with Scer\GAL4GMR.PF
visible, with Scer\GAL4GMR.PF, Scer\GAL80αTub84B.PL
visible, with Scer\GAL4GMR.PU
visible, with Scer\GAL4NP5130
visible, with Scer\GAL4ptc-559.1
visible, with Scer\GAL4sd-SG29.1
visible, with Scer\GAL4tj.PU
visible, with Scer\GAL4Tub.PU
visible | adult stage
visible | adult stage, with Scer\GAL4en.PU
visible | adult stage, with Scer\GAL4esg.PU
visible | adult stage, with Scer\GAL4GMR.PF
visible | adult stage, with Scer\GAL4GMR.PFa
visible | adult stage, with Scer\GAL4GMR.PU
visible | adult stage, with Scer\GAL4NP5130
visible | adult stage, with Scer\GAL4nub.PU
visible | adult stage, with Scer\GAL4nub-AC-62
visible | adult stage, with Scer\GAL4ptc.PU
visible | adult stage, with Scer\GAL4sd-SG29.1
visible | adult stage, with Scer\GAL4Tub.PU
visible | somatic clone, with Scer\GAL4Tub.PU
Phenotype manifest in
Allele
abdominal nerve | third instar larval stage, with Scer\GAL446F
abdominal nerve | third instar larval stage, with Scer\GAL4Gli.PU
abdominal nerve | third instar larval stage, with Scer\GAL4repo.PU
adherens junction, with Scer\GAL4en-e16E
adult abdomen, with Scer\GAL4esg.PU
adult abdomen, with Scer\GAL4NP5130
adult abdomen, with Scer\GAL4Tub.PU
adult abdominal fat cell, with Scer\GAL4esg.PU
adult abdominal fat mass, with Scer\GAL4esg.PU
adult cuticle | somatic clone, with Scer\GAL4Act5C.PP
adult gut, with Scer\GAL4mex1.2.1
adult head | somatic clone
adult heart, with Scer\GAL4tin.CΔ4
adult hemolymph, with Scer\GAL4NP5130
adult midgut, with Scer\GAL4esg.PU
adult midgut, with Scer\GAL4NP5130
adult midgut epithelium, with Scer\GAL4NP5130
adult midgut epithelium | adult stage | somatic clone, with Scer\GAL4Tub.PU
adult midgut progenitor cell | chemical conditional, with Scer\GAL4NP0001
adult posterior midgut, with Scer\GAL4esg.PU
adult posterior midgut epithelium, with Scer\GAL4esg.PU
adult somatic muscle cell, with Ecol\lexASJH-1
adult somatic muscle cell, with Scer\GAL4NP5130
anterior-posterior compartment boundary of the wing disc, with Scer\GAL4ptc.PU
anterior-posterior compartment boundary of the wing disc | third instar larval stage, with Scer\GAL4ptc-559.1
autophagosome | cell non-autonomous | somatic clone | third instar larval stage, with Scer\GAL4Act.PU
border follicle cell, with Scer\GAL4slbo.2.6
developing neuron | ectopic | larval stage | somatic clone - tissue specific, with Scer\GAL4Act5C.PI
dorsal longitudinal indirect flight muscle, with Ecol\lexASJH-1
dorsal longitudinal indirect flight muscle, with Scer\GAL4NP5130
embryonic/larval CNS subperineurial glial cell | larval stage, with Scer\GAL4moody.PU
embryonic/larval optic stalk | third instar larval stage, with Scer\GAL4repo.PU
embryonic/larval PNS perineurial glial cell | third instar larval stage, with Scer\GAL446F
enteroblast of posterior adult midgut epithelium | cell non-autonomous | increased number | somatic clone, with Scer\GAL4esg.PU
enteroblast of posterior adult midgut epithelium | increased number, with Scer\GAL4esg.PU
enteroendocrine cell of posterior adult midgut epithelium | decreased number, with Scer\GAL4esg.PU
epithelial cell | somatic clone, with Scer\GAL4Act5C.PP
eye
eye, with Scer\GAL4ey.PH
eye, with Scer\GAL4GMR.PF
eye, with Scer\GAL4GMR.PF, Scer\GAL80αTub84B.PL
eye, with Scer\GAL4GMR.PFa
eye, with Scer\GAL4GMR.PU
eye, with Scer\GAL4ptc-559.1
eye, with Scer\GAL4salm.EPv
eye, with Scer\GAL4Tub.PU
eye | adult stage, with Scer\GAL4GMR.PF
eye | adult stage, with Scer\GAL4GMR.PFa
eye | adult stage, with Scer\GAL4GMR.PU
eye | pupal stage | somatic clone, with Scer\GAL4αTub84B.PL
eye | somatic clone
eye | somatic clone, with Scer\GAL4FRT.Act5C
eye | somatic clone, with Scer\GAL4Tub.PU
eye-antennal disc, with Scer\GAL4GMR.PF
eye-antennal disc | cell non-autonomous | somatic clone | third instar larval stage, with Scer\GAL4Act.PU
eye-antennal disc | somatic clone | third instar larval stage, with Scer\GAL4Act.PU
eye disc, with Scer\GAL4GMR.PF
eye disc, with Scer\GAL4GMR.PFa
eye disc, with Scer\GAL4GMR.PU
eye disc | larval stage, with Scer\GAL4GMR.PFa
eye disc | larval stage, with Scer\GAL4GMR.PU
eye disc | larval stage | somatic clone - tissue specific, with Scer\GAL4Act5C.PI
eye disc | somatic clone
eye disc | somatic clone, with Scer\GAL4Act5C.PP
eye disc | somatic clone, with Scer\GAL4Tub.PU
eye disc | somatic clone | third instar larval stage
eye disc | third instar larval stage, with Scer\GAL4ptc-559.1
eye disc | third instar larval stage, with Scer\GAL4repo.PU
eye disc posterior to the morphogenetic furrow, with Scer\GAL4GMR.PF
eye disc posterior to the morphogenetic furrow | larval stage, with Scer\GAL4GMR.PU
eye photoreceptor cell | progressive, with Scer\GAL4GMR.PF
fat body, with Scer\GAL4NP5130
female germline cell | decreased number | germline clone
filamentous actin, with Scer\GAL4ap.PU
first basal wing cell, with Scer\GAL4ptc.PU
follicle cell, with Scer\GAL4Act5C.PI
follicle cell | somatic clone
germarium, with Scer\GAL4C587
germarium, with Scer\GAL4VP16.nanos.UTR
germarium, with ykiB5
germarium, with ykihs.PW
haltere, with Scer\GAL4ptc-559.1
haltere | somatic clone
indirect flight muscle cell | pupal stage, with Scer\GAL4Mef2.PR
interommatidial bristle | increased number, with Scer\GAL4GMR.PF
interommatidial bristle | somatic clone, with Scer\GAL4FRT.Act5C
interommatidial cell | pupal stage, with Scer\GAL4GMR.PF
interommatidial cell | pupal stage, with Scer\GAL4αTub84B.PL
intestinal stem cell, with Scer\GAL4NP0001
intestinal stem cell | adult stage, with Scer\GAL4NP5130
intestinal stem cell | adult stage | somatic clone, with Scer\GAL4Tub.PU
intestinal stem cell | somatic clone
intestinal stem cell | somatic clone, with Scer\GAL4NP0001, Scer\GAL80ts.αTub84B
intestinal stem cell | somatic clone, with Scer\GAL4NP5130
intestinal stem cell of posterior adult midgut epithelium, with Scer\GAL4NP5130
intestinal stem cell of posterior adult midgut epithelium, with Scer\GAL4NP5130, Scer\GAL80ts.αTub84B
intestinal stem cell of posterior adult midgut epithelium | cell non-autonomous | increased number | somatic clone, with Scer\GAL4esg.PU
intestinal stem cell of posterior adult midgut epithelium | increased number, with Scer\GAL4esg.PU
intestinal stem cell of posterior adult midgut epithelium | somatic clone, with Scer\GAL4Tub.PU
larval brain | larval stage, with Scer\GAL4moody.PU
larval brain | third instar larval stage, with Scer\GAL4repo.PU
larval central nervous system | third instar larval stage, with Scer\GAL4insc-Mz1407
larval glial cell | third instar larval stage, with Scer\GAL4repo.PU
larval inner optic anlage, with Scer\GAL4C855a
larval optic anlage, with Scer\GAL4c768
larval outer optic anlage, with Scer\GAL4C855a
larval ventral nerve cord | somatic clone | third instar larval stage, with Scer\GAL4Tub.PU, Scer\GAL80ts.αTub84B
larval ventral nerve cord | third instar larval stage, with Scer\GAL4repo.PU
leg, with Scer\GAL4ptc-559.1
leg | somatic clone
mesonotum | somatic clone
mitochondrion, with Scer\GAL4NP5130
mitochondrion | adult stage, with Scer\GAL4NP5130
myofibril | pupal stage, with Scer\GAL4Mef2.PR
myotube | pupal stage, with Scer\GAL4Mef2.PR
nucleus | larval stage, with Scer\GAL4moody.PU
ommatidium | adult stage, with Scer\GAL4ey.PH
ovary, with Scer\GAL4NP5130
ovary | adult stage, with Scer\GAL4esg.PU
ovary | adult stage, with Scer\GAL4NP5130
perineurium | larval stage, with Scer\GAL4moody.PU
peripodial epithelium of eye disc | larval stage | somatic clone - tissue specific, with Scer\GAL4Act5C.PI
photoreceptor cell R8 of pale ommatidium, with Scer\GAL4GMR.long, Scer\GAL4ey.PH
photoreceptor cell R8 of yellow ommatidium, with Scer\GAL4GMR.long, Scer\GAL4ey.PH
pigment cell | increased number, with Scer\GAL4GMR.PF
PNS glial cell | third instar larval stage, with Scer\GAL4repo.PU
sarcomere | adult stage, with Scer\GAL4NP5130
septate junction | larval stage, with Scer\GAL4moody.PU
site of double-strand break | increased number, with Scer\GAL4ap.PU
subperineurial glial cell | third instar larval stage, with Scer\GAL4Gli.PU
T-tubule | adult stage, with Scer\GAL4NP5130
wing
wing, with Scer\GAL471B
wing, with Scer\GAL4cv-c-C5
wing, with Scer\GAL4en.PU
wing, with Scer\GAL4NP5130
wing, with Scer\GAL4nub.PU
wing, with Scer\GAL4nub-AC-62
wing, with Scer\GAL4ptc.PU
wing, with Scer\GAL4sd-SG29.1
wing, with Scer\GAL4tj.PU
wing | P-stage, with Scer\GAL4sd-SG29.1
wing | somatic clone
wing | somatic clone, with Scer\GAL4FRT.Act5C
wing blade, with Scer\GAL4ptc.PU
wing disc, with Scer\GAL4dpp.blk1
wing disc, with Scer\GAL4dpp.PU
wing disc, with Scer\GAL4hh.PU
wing disc, with Scer\GAL4hh-Gal4
wing disc, with Scer\GAL4nub.PU
wing disc, with Scer\GAL4ptc-559.1
wing disc (with ykiAcidA)
wing disc (with ykiB5)
wing disc | cell autonomous | somatic clone
wing disc | cell autonomous | somatic clone, with Scer\GAL4Tub.PU
wing disc | cell non-autonomous | somatic clone
wing disc | cell non-autonomous | somatic clone, with Scer\GAL4Tub.PU
wing disc | larval stage
wing disc | larval stage, with Scer\GAL4ap.PU
wing disc | larval stage, with Scer\GAL4ptc-559.1
wing disc | somatic clone
wing disc | somatic clone, with Scer\GAL4Act5C.PI
wing disc | somatic clone, with Scer\GAL4Act5C.PP
wing disc | somatic clone, with Scer\GAL4FRT.Act5C
wing disc | somatic clone, with Scer\GAL4Tub.PU
wing disc | somatic clone, with Scer\GAL4αTub84B.PL
wing disc | somatic clone | third instar larval stage, with Scer\GAL4Act.PU
wing disc | third instar larval stage
wing disc | third instar larval stage, with Scer\GAL4Bx-MS1096
wing disc | third instar larval stage, with Scer\GAL4ptc-559.1
wing disc | third instar larval stage, with Scer\GAL4rn-GAL4
wing disc dorsal compartment, with Scer\GAL4ap-md544
wing disc dorsal compartment | third instar larval stage, with Scer\GAL4ap-md544
wing disc posterior compartment, with Scer\GAL4hh.PU
wing disc posterior compartment, with Scer\GAL4hh-Gal4
wing disc posterior compartment | third instar larval stage, with Scer\GAL4e22c
wing disc posterior compartment | third instar larval stage, with Scer\GAL4en.PU
wing disc posterior compartment | third instar larval stage, with Scer\GAL4hh.PU
wing disc posterior compartment | third instar larval stage, with Scer\GAL4hh-Gal4
wing hinge primordium | third instar larval stage, with Scer\GAL4ptc-559.1
wing pouch | larval stage | somatic clone, with Scer\GAL4Act5C.PI
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (40)
Hsap\YAP1
11 of 14
Yes
Yes
16  
Hsap\WWTR1
9 of 14
No
Yes
1  
Hsap\HECW1
2 of 14
No
No
Hsap\HECW2
2 of 14
No
No
Hsap\NEDD4L
2 of 14
No
No
Hsap\SMURF1
2 of 14
No
No
Hsap\SMURF2
2 of 14
No
No
Hsap\WWOX
2 of 14
No
No
2  
Hsap\WWP1
2 of 14
No
No
2  
Hsap\WWP2
2 of 14
No
No
Hsap\AREL1
1 of 14
No
No
Hsap\ASCC1
1 of 14
No
No
1  
Hsap\BAG3
1 of 14
No
No
Hsap\GAS7
1 of 14
No
No
Hsap\HACE1
1 of 14
No
No
Hsap\HECTD1
1 of 14
No
No
Hsap\HECTD2
1 of 14
No
No
Hsap\HECTD3
1 of 14
No
No
Hsap\HERC3
1 of 14
No
No
1  
Hsap\HERC4
1 of 14
No
No
1  
Hsap\HERC5
1 of 14
No
No
Hsap\HERC6
1 of 14
No
No
Hsap\HUWE1
1 of 14
No
No
1  
Hsap\ITCH
1 of 14
No
No
Hsap\MAGI1
1 of 14
No
No
Hsap\MAGI2
1 of 14
No
No
Hsap\MAGI3
1 of 14
No
No
Hsap\MAGIX
1 of 14
No
No
Hsap\NEDD4
1 of 14
No
No
Hsap\PIN1
1 of 14
No
No
1  
Hsap\PIN1P1
1 of 14
No
No
Hsap\PLEKHA5
1 of 14
No
No
Hsap\PLEKHA7
1 of 14
No
No
Hsap\TRIP12
1 of 14
No
No
2  
Hsap\UBE3B
1 of 14
No
No
Hsap\UBE3C
1 of 14
No
No
Hsap\UBR5
1 of 14
No
No
Hsap\WWC1
1 of 14
No
No
1  
Hsap\WWC2
1 of 14
No
No
1  
Hsap\WWC3
1 of 14
No
No
3  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (30)
Rnor\Wwtr1
10 of 14
Yes
Yes
Rnor\Yap1
10 of 14
Yes
Yes
Rnor\Hecw1
2 of 14
No
No
Rnor\Hecw2
2 of 14
No
No
Rnor\Magi2
2 of 14
No
No
Rnor\Magi3
2 of 14
No
No
Rnor\Smurf1
2 of 14
No
No
Rnor\Wwox
2 of 14
No
No
Rnor\Wwp1
2 of 14
No
No
Rnor\Wwp2
2 of 14
No
No
Rnor\Arel1
1 of 14
No
No
Rnor\Bag3
1 of 14
No
No
Rnor\Hace1
1 of 14
No
No
Rnor\Hectd1
1 of 14
No
No
Rnor\Hectd3
1 of 14
No
No
Rnor\Herc3
1 of 14
No
No
Rnor\Herc6
1 of 14
No
No
Rnor\Itch
1 of 14
No
No
Rnor\Magi1
1 of 14
No
No
Rnor\Magix
1 of 14
No
No
Rnor\Nedd4l
1 of 14
No
No
Rnor\Nedd4
1 of 14
No
No
Rnor\Pin1
1 of 14
No
No
Rnor\Plekha5
1 of 14
No
No
Rnor\Smurf2
1 of 14
No
No
Rnor\Trip12
1 of 14
No
No
Rnor\Ube3a
1 of 14
No
No
Rnor\Ube3b
1 of 14
No
No
Rnor\Wwc1
1 of 14
No
No
Rnor\Wwc2
1 of 14
No
No
Mus musculus (laboratory mouse) (37)
Mmus\Yap1
11 of 14
Yes
Yes
Mmus\Wwtr1
9 of 14
No
Yes
Mmus\Hecw1
2 of 14
No
No
Mmus\Hecw2
2 of 14
No
No
Mmus\Itch
2 of 14
No
No
Mmus\Magi3
2 of 14
No
No
Mmus\Nedd4l
2 of 14
No
No
Mmus\Nedd4
2 of 14
No
No
Mmus\Smurf1
2 of 14
No
No
Mmus\Smurf2
2 of 14
No
No
Mmus\Wwox
2 of 14
No
No
Mmus\Wwp1
2 of 14
No
No
Mmus\Wwp2
2 of 14
No
No
Mmus\Arel1
1 of 14
No
No
Mmus\Bag3
1 of 14
No
No
Mmus\Gas7
1 of 14
No
No
Mmus\Hace1
1 of 14
No
No
Mmus\Hectd2
1 of 14
No
No
Mmus\Hectd3
1 of 14
No
No
Mmus\Herc3
1 of 14
No
No
Mmus\Herc4
1 of 14
No
No
Mmus\Herc6
1 of 14
No
No
Mmus\Huwe1
1 of 14
No
No
Mmus\Magi1
1 of 14
No
No
Mmus\Magi2
1 of 14
No
No
Mmus\Magix
1 of 14
No
No
Mmus\Pin1
1 of 14
No
No
Mmus\Pin1rt1
1 of 14
No
No
Mmus\Plekha5
1 of 14
No
No
Mmus\Plekha7
1 of 14
No
No
Mmus\Trip12
1 of 14
No
No
Mmus\Ube3a
1 of 14
No
No
Mmus\Ube3b
1 of 14
No
No
Mmus\Ube3c
1 of 14
No
No
Mmus\Ubr5
1 of 14
No
No
Mmus\Wwc1
1 of 14
No
No
Mmus\Wwc2
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (17)
Xtro\yap1
8 of 13
Yes
Yes
Xtro\wwtr1
4 of 13
No
Yes
Xtro\mblac1
3 of 13
No
No
Xtro\atp5f1c
1 of 13
No
No
Xtro\gatad2a
1 of 13
No
No
Xtro\itch
1 of 13
No
No
Xtro\nedd4l
1 of 13
No
No
Xtro\nmbr
1 of 13
No
No
Xtro\nrcam
1 of 13
No
No
Xtro\osr2
1 of 13
No
No
Xtro\pabpn1
1 of 13
No
No
Xtro\pin1
1 of 13
No
No
Xtro\tmem164
1 of 13
No
No
Xtro\tuba5
1 of 13
No
No
Xtro\wwc1
1 of 13
No
No
Xtro\wwp1
1 of 13
No
No
Xtro\wwp2
1 of 13
No
No
Danio rerio (Zebrafish) (31)
Drer\yap1
11 of 14
Yes
Yes
Drer\wwtr1
10 of 14
No
Yes
Drer\hecw1b
2 of 14
No
No
Drer\hecw2a
2 of 14
No
No
Drer\smurf1
2 of 14
No
No
Drer\smurf2
2 of 14
No
No
Drer\wwc3
2 of 14
No
No
Drer\wwp2
2 of 14
No
No
Drer\bag3
1 of 14
No
No
Drer\hectd2
1 of 14
No
No
Drer\herc3
1 of 14
No
No
Drer\herc4
1 of 14
No
No
Drer\herc5.1
1 of 14
No
No
Drer\herc5.2
1 of 14
No
No
Drer\herc5.4
1 of 14
No
No
Drer\itcha
1 of 14
No
No
Drer\itchb
1 of 14
No
No
Drer\LOC556872
1 of 14
No
No
Drer\LOC103909792
1 of 14
No
No
Drer\magi2a
1 of 14
No
No
Drer\magi3a
1 of 14
No
No
Drer\nedd4a
1 of 14
No
No
Drer\nedd4l
1 of 14
No
No
Drer\pin1
1 of 14
No
No
Drer\plekha5
1 of 14
No
No
Drer\plekha7a
1 of 14
No
No
Drer\trip12
1 of 14
No
No
Drer\ube3a
1 of 14
No
No
Drer\ube3b
1 of 14
No
No
Drer\wwc1
1 of 14
No
No
Drer\wwox
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (11)
Cele\yap-1
5 of 14
Yes
Yes
Cele\Y92H12A.2
2 of 14
No
No
Cele\etc-1
1 of 14
No
No
Cele\hecd-1
1 of 14
No
No
Cele\hecw-1
1 of 14
No
No
Cele\herc-1
1 of 14
No
No
Cele\magi-1
1 of 14
No
No
Cele\oxi-1
1 of 14
No
No
Cele\pinn-1
1 of 14
No
No
Cele\ubr-5
1 of 14
No
No
Cele\wwp-1
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (21)
Agam\AgaP_AGAP006045
11 of 12
Yes
Yes
Agam\AgaP_AGAP000787
2 of 12
No
No
Agam\AgaP_AGAP009074
2 of 12
No
No
Agam\AgaP_AGAP011242
2 of 12
No
No
Agam\AgaP_AGAP000797
1 of 12
No
No
Agam\AgaP_AGAP001296
1 of 12
No
No
Agam\AgaP_AGAP001780
1 of 12
No
No
Agam\AgaP_AGAP003133
1 of 12
No
No
Agam\AgaP_AGAP004321
1 of 12
No
No
Agam\AgaP_AGAP005285
1 of 12
No
No
Agam\AgaP_AGAP005897
1 of 12
No
No
Agam\AgaP_AGAP006574
1 of 12
No
No
Agam\AgaP_AGAP008423
1 of 12
No
No
Agam\AgaP_AGAP009511
1 of 12
No
No
Agam\AgaP_AGAP009516
1 of 12
No
No
Agam\AgaP_AGAP010754
1 of 12
No
No
Agam\AgaP_AGAP011474
1 of 12
No
No
Agam\AgaP_AGAP011823
1 of 12
No
No
Agam\AgaP_AGAP012366
1 of 12
No
No
Agam\AgaP_AGAP013475
1 of 12
No
No
Agam\KIBRLG
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (8)
Atha\AT2G30600
1 of 13
Yes
No
Atha\KAK
1 of 13
Yes
No
Atha\UPL1
1 of 13
Yes
No
Atha\UPL2
1 of 13
Yes
No
Atha\UPL4
1 of 13
Yes
No
Atha\UPL5
1 of 13
Yes
No
Atha\UPL6
1 of 13
Yes
No
Atha\UPL7
1 of 13
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (6)
Scer\ESS1
1 of 13
Yes
No
Scer\HUL4
1 of 13
Yes
No
Scer\HUL5
1 of 13
Yes
No
Scer\RSP5
1 of 13
Yes
No
Scer\TOM1
1 of 13
Yes
No
Scer\UFD4
1 of 13
Yes
No
Schizosaccharomyces pombe (Fission yeast) (8)
Spom\pub1
2 of 12
Yes
No
Spom\pub3
2 of 12
Yes
No
Spom\mug30
1 of 12
No
No
Spom\pin1
1 of 12
No
No
Spom\ptr1
1 of 12
No
No
Spom\pub2
1 of 12
No
No
Spom\SPAC12B10.01c
1 of 12
No
No
Spom\SPAC167.07c
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:yki. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (20)
Hecw
2 of 13
Magi
2 of 13
Nedd4
2 of 13
Smurf
2 of 13
Su(dx)
2 of 13
CG3356
1 of 13
CG4238
1 of 13
CG5087
1 of 13
CG10508
1 of 13
CG42788
1 of 13
ctrip
1 of 13
dod
1 of 13
HERC2
1 of 13
Herc4
1 of 13
HUWE1
1 of 13
hyd
1 of 13
kibra
1 of 13
Ube3a
1 of 13
Ufd4
1 of 13
Wwox
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 15 )
Allele
Disease
Evidence
References
ykiUAS.cHa
model of  cancer
CEA
(Liu et al., 2022, Yang et al., 2022, Nagarkar et al., 2020, Ziosi et al., 2010)
CEA with pnutGD1512
(Gerlach et al., 2018)
model of  neurodegenerative disease
CEA
(Napoletano et al., 2011)
model of  carcinoma
CEA
(Groth et al., 2020, Pérez et al., 2015)
CEA with l(2)gl4
(Singh et al., 2022)
model of  heart disease
CEA
(Karekar et al., 2021)
ykiHMS00041
model of  carcinoma
CEA
(Bhattacharya et al., 2024)
ykiS168A.UAS.cUa
model of  cancer
CEA
(Jang et al., 2017)
ykiS168A.UAS.EGFP,Tag:HA
model of  cancer
CEA
(Yeom et al., 2021, Yeom et al., 2020, Bunker et al., 2015)
ykiUAS.cOa.Tag:V5
model of  carcinoma
CEA with l(2)gl4
(Enzo et al., 2015)
ykiS168A.UAS.Tag:V5
model of  cancer
CEA
(Hodgson et al., 2021, Santabárbara-Ruiz and Léopold, 2021)
model of  ovarian cancer
CEA
(Hall et al., 2010)
ykiS111A.S168A.S250A.UAS.Tag:V5
model of  intestinal cancer
CEA
(Xu et al., 2024, Pranoto et al., 2023, Saavedra et al., 2023, Wang et al., 2023, Kim et al., 2022, Bajpai et al., 2020)
model of  cancer
CEA
(Pranoto and Kwon, 2024, Xu et al., 2023, Chen et al., 2022, Ding et al., 2021, Lee et al., 2021)
CEA with hopTum.UAS
(Ding et al., 2021)
model of  neurodegenerative disease
CEA
(Napoletano et al., 2011)
model of  carcinoma
CEA
(Singh et al., 2022)
CEA with scribHMJ21977
(Snigdha et al., 2021)
model of  nephrolithiasis
CEA
(Xu et al., 2024)
ykiUAS.cUa
model of  cancer
CEA with RhoBTBHMC03199
(Nguyen et al., 2020)
CEA with RhoBTBVSH330130
(Nguyen et al., 2020)
CEA with Lkb1KK108675
(Nguyen et al., 2020)
CEA with Lkb1HMS01351
(Nguyen et al., 2020)
CEA with Lkb1GL00019
(Nguyen et al., 2020)
CEA with Lkb1VSH330167
(Nguyen et al., 2020)
CEA
(Guo et al., 2020)
yki3SA.UAS.cUa
model of  cancer
CEA
(Lodge et al., 2021)
ykiUAS.UTR.Tag:MYC
model of  cancer
CEA
(Guo et al., 2020)
ykiUAS.UTR-M1.Tag:MYC
model of  cancer
CEA
(Guo et al., 2020)
ykiUAS.UTR-M2.Tag:MYC
model of  cancer
CEA
(Guo et al., 2020)
yki3SA.lexAop.Tag:V5
model of  cancer
CEA
(Lee et al., 2021)
yki3SA.lexAop.Tag:Myr(Unk),GFP
model of  cancer
CEA
(Chen et al., 2022)
yki3SA.lexAop.sfGFP
model of  intestinal cancer
CEA
(Xu et al., 2024, Saavedra et al., 2023)
Potential Models Based on Orthology ( 1 )
Modifiers Based on Experimental Evidence ( 19 )
Allele
Disease
Interaction
References
ykiRNAi.N.UAS
ameliorates  cancer
modeled by Ras85DV12.UAS
(Waghmare et al., 2024)
exacerbates  Alzheimer's disease 1
modeled by Hsap\APPAβ42.UAS.cUa
(Irwin et al., 2020)
ykiRNAi.C.UAS
ameliorates  cancer
modeled by Ras85DV12.UAS
(Waghmare et al., 2024)
ykiUAS.cHa
ameliorates  neurodegenerative disease
modeled by ft8
(Napoletano et al., 2011)
modeled by Zzzz\CAG127Q.UAS.Tag:HA
(Dubey and Tapadia, 2018)
modeled by Hsap\HTTQ93.ex1.UAS
(Dubey and Tapadia, 2018)
exacerbates  carcinoma
modeled by hpo3D
(Pérez et al., 2015)
model of  carcinoma
is ameliorated by Atg1UAS.cSa
(Pérez et al., 2015)
is exacerbated by Cdk9UAS.ORF
(Nagarkar et al., 2020)
is exacerbated by HeximKK104531
(Nagarkar et al., 2020)
is exacerbated by NELF-BKK100078
(Nagarkar et al., 2020)
is exacerbated by Nelf-AKK101005
(Nagarkar et al., 2020)
is exacerbated by bin3KK106875
(Nagarkar et al., 2020)
model of  cancer
is ameliorated by MycGD1419
(Ziosi et al., 2010)
is exacerbated by sdUAS.cSa
(Ziosi et al., 2010)
is ameliorated by Hsc70-3UAS.ORF.Tag:HA
(Yang et al., 2022)
is ameliorated by Xbp1UAS.s.Tag:V5
(Yang et al., 2022)
is ameliorated by Ire1UAS.Tag:V5
(Yang et al., 2022)
ykiB5
ameliorates  neurodegenerative disease
modeled by ft8
(Napoletano et al., 2011)
ameliorates  cancer
modeled by scrib1
(Bunker et al., 2015)
modeled by Ras85DV12.UAS, Rox8GD11645
(Guo et al., 2020)
ameliorates  brain cancer
modeled by l(3)mbtGM76
(Richter et al., 2011)
ykiNIG.4005R
ameliorates  cancer
modeled by shotGL01286
(Jain et al., 2019)
ykiHMS00041
ameliorates  cancer
modeled by dlg1GD4689, Ras85DV12.UAS
(Katheder et al., 2017)
ameliorates  high grade glioma
modeled by PtenRNAi.Exel.UAS, Ras85DV12.cUa.UAS
(Gangwani et al., 2020)
modeled by Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS), btl::Egfrλ.UAS
(Vigneswaran et al., 2021)
DOES NOT ameliorate  cancer
modeled by HipkUAS.Tag:HA
(Blaquiere et al., 2018)
model of  carcinoma
is ameliorated by AktHMS06047
(Bhattacharya et al., 2024)
is ameliorated by ImpL2HMC05809
(Bhattacharya et al., 2024)
is ameliorated by Pi3K92EHMC05152
(Bhattacharya et al., 2024)
is ameliorated by mTorTED.UAS
(Bhattacharya et al., 2024)
ykiGD11187
ameliorates  intestinal cancer
modeled by Ptp61FHMS00421
(Liu et al., 2022)
ameliorates  kidney disease
modeled by sdtNIG.15342R
(Weide et al., 2017)
modeled by sdtHMS01652
(Weide et al., 2017)
ykiKK109756
ameliorates  colorectal cancer
modeled by SH3PX1d1
(Zhang et al., 2019)
ameliorates  high grade glioma
modeled by Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS), btl::Egfrλ.UAS
(Vigneswaran et al., 2021)
ykiS168A.UAS.cUa
model of  cancer
is ameliorated by lzUAS.cBa
(Jang et al., 2017)
is exacerbated by trioUAS.cUa
(Jang et al., 2017)
ykiS168A.UAS.EGFP,Tag:HA
model of  cancer
is exacerbated by GlnRSKK109443
(Yeom et al., 2020)
is ameliorated by AlaRSGD8009
(Yeom et al., 2020)
is exacerbated by ArgRSGD14098
(Yeom et al., 2020)
is ameliorated by AsnRSGD7064
(Yeom et al., 2020)
is ameliorated by AsnRSKK100240
(Yeom et al., 2020)
is ameliorated by AspRSGD1339
(Yeom et al., 2020)
is exacerbated by CysRSGD13923
(Yeom et al., 2020)
is exacerbated by GluProRSGD11635
(Yeom et al., 2020)
is ameliorated by GlyRSKK107421
(Yeom et al., 2020)
is exacerbated by HisRSKK102374
(Yeom et al., 2020)
is exacerbated by LysRSKK101852
(Yeom et al., 2020)
is exacerbated by SerRS-mGD12798
(Yeom et al., 2020)
is exacerbated by ThrRSGD1342
(Yeom et al., 2020)
is exacerbated by TyrRSGD11353
(Yeom et al., 2020)
is ameliorated by Ilp8MI00727
(Yeom et al., 2021)
is ameliorated by ImpL2GD6004
(Yeom et al., 2021)
is ameliorated by Lgr3Δ50
(Yeom et al., 2021)
is ameliorated by Ilp8KK112161
(Yeom et al., 2021)
exacerbates  cancer
modeled by HipkUAS.Tag:HA
(Blaquiere et al., 2018)
exacerbates  carcinoma
modeled by NkapGD11807
(Guo et al., 2024)
ykiUAS.cOa.Tag:V5
ameliorates  Alzheimer's disease 1
modeled by Hsap\APPAβ42.UAS.cUa
(Irwin et al., 2020)
ykiS111A.S168A.S250A.UAS.Tag:V5
model of  intestinal cancer
is ameliorated by Ilp2UAS.cUa
(Wang et al., 2023)
is ameliorated by ImpL2NIG.15009R
(Wang et al., 2023)
is ameliorated by mewJF02694
(Bajpai et al., 2020)
is ameliorated by rheaHM05161
(Bajpai et al., 2020)
is ameliorated by vgTONDU.UAS
(Bajpai et al., 2020)
is ameliorated by whdHMS00040
(Saavedra et al., 2023)
is exacerbated by zfh2EAB
(Pranoto et al., 2023)
is ameliorated by ImpL2HMC05809
(Pranoto et al., 2023)
is ameliorated by Mmp1JF01336
(Pranoto et al., 2023)
is ameliorated by NDN.UAS.cUa
(Pranoto et al., 2023)
is ameliorated by upd2HMS00901
(Pranoto et al., 2023)
is ameliorated by upd2HMS00948
(Pranoto et al., 2023)
is ameliorated by Pvf1KK112211
(Xu et al., 2024)
model of  cancer
is ameliorated by foxoTM.UAS
(Lee et al., 2021)
is ameliorated by panΔN.UAS
(Lee et al., 2021)
is ameliorated by wgHMS00794
(Lee et al., 2021)
is ameliorated by wgJF01257
(Lee et al., 2021)
is ameliorated by AktHMS00007
(Lee et al., 2021)
is ameliorated by ITPGD3825
(Xu et al., 2023)
is ameliorated by ITPJF01817
(Xu et al., 2023)
is ameliorated by ImpL2HMC05809
(Chen et al., 2022)
is ameliorated by upd3HMS00646
(Ding et al., 2021)
is ameliorated by Stat92EHMS00035
(Ding et al., 2021)
is ameliorated by domeGD2612
(Ding et al., 2021)
is ameliorated by hopHMS00761
(Ding et al., 2021)
ykiJF03119
ameliorates  Noonan syndrome
modeled by Hsap\RAF1gof.UAS
(Yu et al., 2015)
ykiUAS.cUa
ameliorates  peroxisome biogenesis disorder 2A
modeled by Pex5GD14972
(Pinelli et al., 2024)
model of  cancer
is ameliorated by Rox8EY02351
(Guo et al., 2020)
ykiRNAi.UAS.cUa
ameliorates  cancer
modeled by scribGD11666
(Ding et al., 2021)
exacerbates  neurodegenerative disease
modeled by Zzzz\CAG127Q.UAS.Tag:HA
(Dubey and Tapadia, 2018)
modeled by Hsap\HTTQ93.ex1.UAS
(Dubey and Tapadia, 2018)
ykiUAS.UTR.Tag:MYC
model of  cancer
is ameliorated by Rox8EY02351
(Guo et al., 2020)
ykiUAS.UTR-M2.Tag:MYC
model of  cancer
is ameliorated by Rox8EY02351
(Guo et al., 2020)
yki3SA.lexAop.Tag:Myr(Unk),GFP
model of  cancer
is ameliorated by AktΔPH.UAS.Tag:Myr(Unk)
(Chen et al., 2022)
is ameliorated by PGRP-SC2UAS.cGa
(Chen et al., 2022)
is ameliorated by RelHMS00070
(Chen et al., 2022)
yki3SA.lexAop.sfGFP
model of  intestinal cancer
is ameliorated by AktΔPH.UAS.Tag:Myr(Unk)
(Saavedra et al., 2023)
is ameliorated by REPTORNIG.13624R
(Saavedra et al., 2023)
is ameliorated by PvrHMS01662
(Xu et al., 2024)
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
YAP1; Yes1 associated transcriptional regulator
11 of 14
YES1-ASSOCIATED TRANSCRIPTIONAL REGULATOR; YAP1
 
WWTR1; WW domain containing transcription regulator 1
9 of 14
607392
       
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please see the Physical Interaction reports below for full details
      RNA-RNA
      Physical Interaction
      Assay
      References
      yki - mir-7
      luminiscence technology
      (Yu et al., 2020)
      yki - mir-8
      fluorescence technology
      (Sander et al., 2018)
      RNA-protein
      Physical Interaction
      Assay
      References
      yki - Rox8
      anti tag coimmunoprecipitation, quantitative reverse transcription pcr
      (Guo et al., 2020)
      protein-protein
      Physical Interaction
      Assay
      References
      yki - 14-3-3ε
      anti tag coimmunoprecipitation, anti tag western blot, protein complementation assay, peptide massfingerprinting
      (Srivastava et al., 2021, Wang et al., 2016, Hu et al., 2014, Kwon et al., 2013, Wehr et al., 2013, Ren et al., 2010, Oh and Irvine, 2008)
      yki - 14-3-3ζ
      anti tag coimmunoprecipitation, anti tag western blot, peptide massfingerprinting, western blot
      (Srivastava et al., 2021, Wang et al., 2016, Hu et al., 2014, Kwon et al., 2013, Ren et al., 2010, Oh and Irvine, 2008, Dong et al., 2007)
      yki - Ack
      pull down, peptide massfingerprinting, anti tag coimmunoprecipitation, western blot, anti tag western blot
      (Hu et al., 2016, Kwon et al., 2013, Schoenherr et al., 2012)
      yki - Akt
      enzymatic study, western blot
      (Li et al., 2022)
      yki - Atpα
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Kwon et al., 2013)
      yki - Bap111
      anti bait coimmunoprecipitation, peptide massfingerprinting
      (Oh et al., 2013)
      yki - CG15117
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Kwon et al., 2013)
      yki - CG2186
      anti tag coimmunoprecipitation, anti tag western blot, peptide massfingerprinting
      (Kwon et al., 2013, Kwon et al., 2013)
      yki - CG31705
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Kwon et al., 2013)
      yki - CG9581
      anti tag coimmunoprecipitation, peptide massfingerprinting, anti tag western blot
      (Kwon et al., 2013, Kwon et al., 2013)
      yki - CalpA
      anti tag coimmunoprecipitation, Identification by mass spectrometry, anti tag western blot
      (Zhai et al., 2024)
      yki - CalpB
      anti tag coimmunoprecipitation, anti tag western blot
      (Zhai et al., 2024)
      yki - Cdk7
      enzymatic study, western blot
      (Cho et al., 2020)
      yki - Cpsf5
      anti tag coimmunoprecipitation, peptide massfingerprinting, anti tag western blot
      (Kwon et al., 2013, Kwon et al., 2013)
      yki - Cpsf6
      anti tag coimmunoprecipitation, anti tag western blot, peptide massfingerprinting
      (Kwon et al., 2013, Kwon et al., 2013)
      yki - DCAF12
      anti tag coimmunoprecipitation, anti tag western blot
      (Cho et al., 2020)
      yki - EMC1
      anti tag coimmunoprecipitation, peptide massfingerprinting, anti tag western blot
      (Kwon et al., 2013, Kwon et al., 2013)
      yki - EcR
      coimmunoprecipitation, western blot
      (Zhang et al., 2015)
      yki - Eip75B
      proximity ligation assay, fluorescence microscopy, anti tag coimmunoprecipitation, western blot
      (Wang et al., 2024)
      yki - Fs(2)Ket
      pull down, peptide massfingerprinting
      (Wang et al., 2016)
      yki - Helz
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Kwon et al., 2013)
      yki - Hipk
      enzymatic study, autoradiography, anti tag coimmunoprecipitation, anti tag western blot
      (Steinmetz et al., 2021, Chen and Verheyen, 2012)
      yki - Hsc70-3
      proximity ligation assay, fluorescence microscopy, anti tag coimmunoprecipitation, anti tag western blot, peptide massfingerprinting
      (Yang et al., 2022, Kwon et al., 2013, Kwon et al., 2013)
      yki - Inos
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Kwon et al., 2013)
      yki - Ist1
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Kwon et al., 2013)
      yki - Kap-α1
      anti tag coimmunoprecipitation, anti tag western blot, pull down, peptide massfingerprinting
      (Wang et al., 2016)
      yki - Lasp
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Kwon et al., 2013)
      yki - Leash
      anti tag coimmunoprecipitation, anti tag western blot, peptide massfingerprinting
      (Shen et al., 2018, Kwon et al., 2013, Kwon et al., 2013, Kwon et al., 2013)
      yki - MED1
      anti bait coimmunoprecipitation, peptide massfingerprinting
      (Oh et al., 2013)
      yki - MED15
      anti bait coimmunoprecipitation, peptide massfingerprinting
      (Oh et al., 2013)
      yki - MED19
      anti bait coimmunoprecipitation, peptide massfingerprinting
      (Oh et al., 2013)
      yki - MED23
      anti bait coimmunoprecipitation, peptide massfingerprinting
      (Oh et al., 2013)
      yki - MED31
      anti bait coimmunoprecipitation, peptide massfingerprinting
      (Oh et al., 2013)
      yki - Mad
      anti tag coimmunoprecipitation, anti tag western blot, western blot
      (Srivastava et al., 2021, Oh and Irvine, 2011, Alarcón et al., 2009)
      yki - Mitf
      anti tag coimmunoprecipitation, anti tag western blot
      (Zhang et al., 2024)
      yki - N
      proximity ligation assay, fluorescence microscopy
      (Wang et al., 2024)
      yki - Ncoa6
      anti tag coimmunoprecipitation, anti tag western blot, pull down, western blot
      (Srivastava et al., 2021, Oh et al., 2014, Qing et al., 2014)
      yki - Pax
      anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, anti tag western blot
      (Jiang et al., 2025)
      yki - Pen
      pull down, peptide massfingerprinting
      (Wang et al., 2016)
      yki - Polr2A
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Kwon et al., 2013)
      yki - Prp4k
      enzymatic study, autoradiography
      (Cho et al., 2018)
      yki - Ptp61F
      anti tag coimmunoprecipitation, anti tag western blot, western blot
      (Liu et al., 2022)
      yki - Rae1
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Kwon et al., 2013)
      yki - Rbf
      anti tag coimmunoprecipitation, anti tag western blot, anti bait coimmunoprecipitation
      (Rader et al., 2023)
      yki - RhoGAP15B
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Kwon et al., 2013)
      yki - RpS15Ab
      experimental knowledge based
      (Guruharsha et al., 2011)
      yki - Sec31
      anti tag coimmunoprecipitation, peptide massfingerprinting, anti tag western blot
      (Kwon et al., 2013, Kwon et al., 2013)
      yki - Ssk
      anti tag coimmunoprecipitation, anti tag western blot
      (Chen et al., 2020)
      yki - Strn-Mlck
      anti tag coimmunoprecipitation, anti tag western blot
      (Xu et al., 2018)
      yki - Su(H)
      proximity ligation assay, fluorescence microscopy
      (Wang et al., 2024)
      yki - Tgi
      anti tag coimmunoprecipitation, peptide massfingerprinting, molecular sieving, molecular weight, pull down, anti tag western blot, two hybrid, isothermal titration calorimetry, predetermined participant, Identification by mass spectrometry, nuclear magnetic resonance
      (Srivastava et al., 2021, Vissers et al., 2020, Nyarko, 2018, Guo et al., 2013, Koontz et al., 2013, Kwon et al., 2013)
      yki - Trl
      anti tag coimmunoprecipitation, anti tag western blot, anti bait coimmunoprecipitation, western blot, pull down, peptide massfingerprinting
      (Srivastava et al., 2021, Oh et al., 2013)
      yki - Usp10
      anti tag coimmunoprecipitation, anti tag western blot
      (Gao et al., 2019)
      yki - Usp7
      anti tag coimmunoprecipitation, anti tag western blot, pull down, western blot
      (Sun et al., 2024, Sun et al., 2019)
      yki - Wbp2
      anti tag coimmunoprecipitation, anti tag western blot, peptide massfingerprinting, pull down
      (Srivastava et al., 2021, Hu et al., 2016, Kwon et al., 2013, Zhang et al., 2011)
      yki - bon
      anti tag coimmunoprecipitation, anti tag western blot, pull down, Identification by mass spectrometry
      (Zhao et al., 2023)
      yki - brm
      anti bait coimmunoprecipitation, peptide massfingerprinting, anti tag coimmunoprecipitation, anti tag western blot
      (Zhu et al., 2015, Jin et al., 2013, Oh et al., 2013)
      yki - caz
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Kwon et al., 2013)
      yki - cbt
      anti tag coimmunoprecipitation, western blot, anti tag western blot
      (Srivastava et al., 2021, Ruiz-Romero et al., 2015)
      yki - ci
      anti tag coimmunoprecipitation, anti tag western blot
      (Li et al., 2015)
      yki - dsh
      anti tag coimmunoprecipitation, tag visualisation
      (Varelas et al., 2010)
      yki - ed
      anti tag coimmunoprecipitation, anti tag western blot
      (Yue et al., 2012)
      yki - ex
      anti tag coimmunoprecipitation, anti tag western blot, pull down, peptide massfingerprinting, Identification by mass spectrometry, anti bait coimmunoprecipitation, western blot
      (Wang et al., 2022, Srivastava et al., 2021, Hu et al., 2016, Kwon et al., 2013, Badouel et al., 2009, Oh et al., 2009)
      yki - foxo
      anti tag coimmunoprecipitation, anti tag western blot, anti bait coimmunoprecipitation, western blot, pull down
      (Sun et al., 2024)
      yki - hpo
      anti tag coimmunoprecipitation, peptide massfingerprinting, anti tag western blot
      (Srivastava et al., 2021, Dent et al., 2015, Oh et al., 2009)
      yki - hth
      anti tag coimmunoprecipitation, anti tag western blot
      (Srivastava et al., 2021, Peng et al., 2009)
      yki - mask
      anti tag coimmunoprecipitation, anti tag western blot
      (Sansores-Garcia et al., 2013, Sidor et al., 2013)
      yki - mesh
      anti tag coimmunoprecipitation, anti tag western blot
      (Chen et al., 2020)
      yki - mop
      pull down, peptide massfingerprinting, anti tag coimmunoprecipitation, tandem affinity purification, Identification by mass spectrometry, anti tag western blot
      (Hu et al., 2016, Kwon et al., 2013, Gilbert et al., 2011)
      yki - mor
      anti tag coimmunoprecipitation, anti tag western blot, anti bait coimmunoprecipitation, peptide massfingerprinting, pull down, western blot
      (Srivastava et al., 2021, Oh et al., 2013)
      yki - nerfin-1
      anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based, anti tag western blot
      (Guo et al., 2019, Rhee et al., 2014)
      yki - osa
      anti bait coimmunoprecipitation, peptide massfingerprinting
      (Jin et al., 2013)
      yki - ovo
      anti tag coimmunoprecipitation, anti tag western blot
      (Bohère et al., 2018)
      yki - p53
      anti tag coimmunoprecipitation, anti tag western blot
      (Di Cara et al., 2015)
      yki - sd
      fluorescent resonance energy transfer, anti tag coimmunoprecipitation, anti tag western blot, surface plasmon resonance, predetermined participant, two hybrid, peptide massfingerprinting, anti bait coimmunoprecipitation, pull down, autoradiography, western blot
      (Sun et al., 2024, Zhai et al., 2024, Mesrouze et al., 2022, Srivastava et al., 2021, Bajpai et al., 2020, Mesrouze et al., 2020, Guo et al., 2019, Cho et al., 2018, Zhang et al., 2017, Li et al., 2015, Ikmi et al., 2014, Cagliero et al., 2013, Guo et al., 2013, Kwon et al., 2013, Oh et al., 2013, Goulev et al., 2008, Wu et al., 2008, Zhang et al., 2008)
      yki - tai
      coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation, peptide massfingerprinting
      (Zhang et al., 2015, Kwon et al., 2013)
      yki - trr
      pull down, western blot
      (Oh et al., 2014)
      yki - tsr
      proximity ligation assay, fluorescence microscopy, anti tag coimmunoprecipitation, western blot, bimolecular fluorescence complementation
      (Skouloudaki et al., 2019)
      yki - vg
      anti tag coimmunoprecipitation, anti tag western blot
      (Li et al., 2015)
      yki - wts
      anti tag coimmunoprecipitation, anti tag western blot, enzymatic study, autoradiography, peptide massfingerprinting, western blot, two hybrid, pull down
      (Zhao et al., 2023, Srivastava et al., 2021, Hao et al., 2020, Hu et al., 2016, Hu et al., 2014, Kwon et al., 2013, Sansores-Garcia et al., 2013, Badouel et al., 2009, Oh et al., 2009, Zhang et al., 2009, Wu et al., 2008, Dong et al., 2007, Huang et al., 2005)
      Summary of Genetic Interactions
      Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      yki
      suppressible
      14-3-3ε
      (Ren et al., 2010)
      yki
      enhanceable
      14-3-3ε
      (Ren et al., 2010)
      yki|14-3-3ζ
      suppressible
      14-3-3ε
      (Ren et al., 2010)
      yki
      enhanceable
      14-3-3ζ
      (Ren et al., 2010)
      yki
      suppressible
      14-3-3ζ
      (Ren et al., 2010)
      yki|14-3-3ε
      suppressible
      14-3-3ζ
      (Ren et al., 2010)
      yki
      suppressible
      14-3-3ζ|14-3-3ε
      (Ren et al., 2010)
      yki
      enhanceable
      Ack
      (Hu et al., 2016)
      yki|hid
      suppressible
      Ack
      (Schoenherr et al., 2012)
      yki
      suppressible
      Acn
      (Tyra et al., 2020)
      yki
      suppressible
      Akt
      (Saavedra et al., 2023)
      yki
      suppressible
      AlaRS
      (Yeom et al., 2020)
      yki
      suppressible
      AsnRS
      (Yeom et al., 2020)
      yki
      suppressible
      AspRS
      (Yeom et al., 2020)
      yki
      suppressible
      Atg1
      (Tyra et al., 2020)
      yki
      suppressible
      BEAF-32
      (Jukam et al., 2016)
      yki
      enhanceable
      brm
      (Jin et al., 2013)
      yki
      suppressible
      brm
      (Jin et al., 2013)
      RpS3|yki
      suppressible
      bsk
      (Wada et al., 2021)
      yki|pnut
      enhanceable
      bsk
      (Gerlach et al., 2018)
      yki
      suppressible
      BuGZ
      (Wan et al., 2015)
      yki
      suppressible
      cact
      (Liu et al., 2016)
      yki
      suppressible
      caup
      (Barrios et al., 2015)
      yki
      enhanceable
      chb
      (Gerlach et al., 2018)
      yki|srl
      suppressible
      CycE
      (Sew et al., 2025)
      yki
      enhanceable
      dap
      (Sew et al., 2025)
      yki
      enhanceable
      dia
      (Gerlach et al., 2018)
      RpS3|yki
      suppressible
      Diap1
      (Wada et al., 2021)
      yki
      suppressible
      Diap1
      (Kaya-Çopur et al., 2021, Neto-Silva et al., 2010, Thompson and Cohen, 2006)
      RpS3|yki
      suppressible
      Dronc
      (Wada et al., 2021)
      yki
      enhanceable
      ed
      (Yue et al., 2012)
      RpS3|yki
      suppressible
      egr
      (Wada et al., 2021)
      yki
      suppressible
      ex|wts|hpo
      (Oh et al., 2009)
      yki
      suppressible
      ex|hpo
      (Oh et al., 2009)
      yki
      suppressible
      GlyRS
      (Yeom et al., 2020)
      RpS3|yki
      suppressible
      grnd
      (Wada et al., 2021)
      RpS3|yki
      suppressible
      hep
      (Wada et al., 2021)
      yki
      suppressible
      Hipk
      (Chen and Verheyen, 2012)
      yki
      enhanceable
      Hipk
      (Chen and Verheyen, 2012)
      yki
      suppressible
      hpo
      (Yeom et al., 2020, Oh and Irvine, 2009)
      yki
      enhanceable
      hpo
      (Jin et al., 2012)
      wts|yki
      suppressible
      Hrb27C
      (Mach et al., 2018)
      yki
      suppressible
      Hrb27C
      (Mach et al., 2018)
      Rbf|yki
      suppressible
      hth
      (Rader et al., 2023)
      yki
      suppressible
      hth
      (Reddy and Irvine, 2011)
      yki
      suppressible
      Ilp2
      (Wang et al., 2023)
      yki
      suppressible
      ImpL2
      (Saavedra et al., 2023, Wang et al., 2023, Kwon et al., 2015)
      yki
      enhanceable
      Incenp
      (Gerlach et al., 2018)
      yki
      suppressible
      JMJD5
      (Shalaby et al., 2017)
      yki
      suppressible
      Leash
      (Kwon et al., 2013)
      brk|yki|tkv
      enhanceable
      Mad
      (Oh and Irvine, 2011)
      yki
      suppressible
      Mad
      (Oh and Irvine, 2011, Reddy and Irvine, 2011)
      yki
      enhanceable
      Mad
      (Oh and Irvine, 2011)
      yki
      enhanceable
      Marf
      (Sew et al., 2025)
      yki|srl
      suppressible
      Marf
      (Sew et al., 2025)
      srl|yki
      enhanceable
      Marf
      (Sew et al., 2025)
      yki
      suppressible
      mew
      (Bajpai et al., 2020)
      yki
      suppressible
      mir-ban
      (Huang et al., 2014, Morrison and Halder, 2010, Neto-Silva et al., 2010, Nolo et al., 2006, Thompson and Cohen, 2006)
      yki
      suppressible
      Mmp1
      (Pranoto et al., 2023)
      yki
      suppressible
      mop
      (Gilbert et al., 2011)
      yki
      suppressible
      Myc
      (Reddy and Irvine, 2011, Neto-Silva et al., 2010, Ziosi et al., 2010)
      yki
      enhanceable
      N
      (Pranoto et al., 2023)
      yki
      suppressible
      N
      (Pranoto et al., 2023)
      yki
      suppressible
      N|ImpL2
      (Pranoto et al., 2023)
      yki
      suppressible
      nanos
      (Zhang et al., 2015)
      yki
      suppressible
      Ncoa6::sd
      (Qing et al., 2014)
      yki
      suppressible
      Ncoa6
      (Qing et al., 2014)
      yki
      suppressible
      NO66
      (Shalaby et al., 2017)
      yki
      suppressible
      Ntan1
      (Zülbahar et al., 2018)
      yki
      enhanceable
      Ntan1
      (Zülbahar et al., 2018)
      yki|srl
      suppressible
      Opa1
      (Sew et al., 2025)
      yki
      enhanceable
      Opa1
      (Sew et al., 2025)
      yki
      enhanceable
      par-1
      (Huang et al., 2013)
      yki
      enhanceable
      pbl
      (Gerlach et al., 2018)
      l(2)gl|yki
      suppressible
      Pfk
      (Enzo et al., 2015)
      yki
      suppressible
      piwi
      (Zhang et al., 2015)
      yki
      enhanceable
      pnut
      (Gerlach et al., 2018)
      yki
      enhanceable
      Prp4k
      (Cho et al., 2018)
      yki
      suppressible
      Prp4k
      (Cho et al., 2018)
      RpS3|yki
      suppressible
      puc
      (Wada et al., 2021)
      yki
      suppressible
      rhea
      (Bajpai et al., 2020)
      yki
      suppressible
      rl
      (Yu et al., 2015)
      yki
      suppressible
      RnrL
      (Gerhold et al., 2011)
      yki
      suppressible
      Rox8
      (Guo et al., 2020)
      yki
      enhanceable
      RpS3
      (Wada et al., 2021)
      yki
      enhanceable
      RtGEF
      (Dent et al., 2015)
      yki
      suppressible
      sd
      (Li et al., 2015, Yu et al., 2015, Zhang et al., 2015, Koontz et al., 2013, Reddy and Irvine, 2011, Ziosi et al., 2010, Wu et al., 2008, Zhang et al., 2008)
      yki
      enhanceable
      sd
      (Ziosi et al., 2010, Wu et al., 2008)
      RtGEF|yki
      suppressible
      sd
      (Dent et al., 2015)
      tai|yki
      suppressible
      sd
      (Zhang et al., 2015)
      yki
      enhanceable
      Smox
      (Hevia et al., 2017)
      yki
      enhanceable
      Smurf
      (Cao et al., 2014)
      yki
      suppressible
      sqh
      (Xu et al., 2018)
      yki
      enhanceable
      srl
      (Sew et al., 2025)
      yki
      suppressible
      Strn-Mlck
      (Xu et al., 2018)
      yki
      suppressible
      syd
      (Ahmad et al., 2021)
      yki
      suppressible
      tai
      (Zhang et al., 2015)
      yki
      enhanceable
      tai
      (Zhang et al., 2015)
      RpS3|yki
      suppressible
      Tak1
      (Wada et al., 2021)
      yki
      enhanceable
      Tao
      (Poon et al., 2011)
      yki
      suppressible
      Tgi
      (Li et al., 2015, Yu et al., 2015, Koontz et al., 2013)
      sd|yki
      suppressible
      Tgi
      (Guo et al., 2013)
      yki
      enhanceable
      tkv
      (Oh and Irvine, 2011)
      yki
      enhanceable
      tkv|Mad
      (Oh and Irvine, 2011)
      yki
      suppressible
      Trl
      (Rader et al., 2023)
      yki
      suppressible
      trr
      (Qing et al., 2014)
      yki
      suppressible
      upd2
      (Pranoto et al., 2023)
      N|yki
      suppressible
      upd2
      (Pranoto et al., 2023)
      yki
      enhanceable
      Utx
      (Shalaby et al., 2017)
      yki
      suppressible
      vg
      (Bajpai et al., 2020, Li et al., 2015, Wu et al., 2008)
      yki
      suppressible
      whd
      (Saavedra et al., 2023)
      yki
      suppressible
      wts|hpo
      (Oh and Irvine, 2009, Oh et al., 2009)
      yki
      enhanceable
      zfh2
      (Pranoto et al., 2023)
      yki
      suppressible
      zip
      (Xu et al., 2018)
      yki
      suppressible
      Zrf1
      (Shun Li et al., 2025)
      yki
      suppressible
      βggt-I
      (Sorrentino et al., 2014)
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Ack
      enhanceable
      yki
      (Hu et al., 2016)
      Ack
      suppressible
      yki
      (Hu et al., 2016)
      BEAF-32
      suppressible
      yki
      (Jukam et al., 2016)
      brk
      suppressible
      yki
      (Oh and Irvine, 2011)
      ci
      suppressible
      yki
      (Li et al., 2015)
      cpa
      suppressible
      yki
      (Sansores-Garcia et al., 2011)
      crb
      suppressible
      yki
      (Pojer et al., 2021)
      Cul4
      suppressible
      yki
      (Ly et al., 2019)
      dachs|ft
      enhanceable
      yki
      (Brittle et al., 2012)
      dia
      suppressible
      yki
      (Sansores-Garcia et al., 2011)
      dlg1|Ras85D
      enhanceable
      yki
      (Willecke et al., 2011)
      ed
      suppressible
      yki
      (Yue et al., 2012)
      EMC1
      suppressible
      yki
      (Shi et al., 2023)
      EMC3
      suppressible
      yki
      (Shi et al., 2023)
      ft
      suppressible
      yki
      (Napoletano et al., 2011, Bennett and Harvey, 2006, Silva et al., 2006, Willecke et al., 2006)
      gang-of-four
      suppressible
      yki
      (Beam and Moberg, 2010)
      hid
      suppressible
      yki
      (Schoenherr et al., 2012)
      Hipk
      suppressible
      bsk|yki
      (Blaquiere et al., 2018)
      Hipk
      enhanceable
      yki
      (Blaquiere et al., 2018)
      Hipk
      suppressible
      yki
      (Blaquiere et al., 2018)
      hoka
      suppressible
      yki
      (Izumi et al., 2021)
      hpo
      suppressible
      yki
      (Verghese et al., 2012, Oh and Irvine, 2008, Zhao et al., 2007, Huang et al., 2005)
      hpo|ci
      suppressible
      yki
      (Li et al., 2015)
      htl
      suppressible
      yki
      (Rose et al., 2022)
      kibra
      suppressible
      yki
      (Baumgartner et al., 2010, Genevet et al., 2010)
      kis
      suppressible
      yki
      (Gervais et al., 2019)
      kst
      suppressible
      yki
      (Pojer et al., 2021)
      l(2)gl|vg
      suppressible
      yki
      (Khan et al., 2013)
      l(3)mbt
      suppressible
      yki
      (Richter et al., 2011)
      Mad
      suppressible
      yki
      (Oh and Irvine, 2011)
      Mad|tkv
      enhanceable
      yki
      (Oh and Irvine, 2011)
      mahj
      suppressible
      yki
      (Ly et al., 2019)
      mats
      enhanceable
      yki
      (Keder et al., 2015)
      Mer
      suppressible
      yki
      (Reddy and Irvine, 2011)
      mir-285
      suppressible
      yki
      (Li et al., 2017)
      Mitf
      suppressible
      yki
      (Zhang et al., 2024)
      Mnat9
      suppressible
      yki
      (Mok and Choi, 2022)
      mop
      suppressible
      yki
      (Gilbert et al., 2011)
      Myc
      enhanceable
      yki
      (Reddy and Irvine, 2011)
      Nkap
      enhanceable
      yki
      (Guo et al., 2024)
      Ntan1
      suppressible
      yki
      (Zülbahar et al., 2018)
      par-1
      suppressible
      yki
      (Huang et al., 2013)
      Patronin
      suppressible
      yki
      (Yang and Choi, 2021)
      Pex5
      suppressible
      yki
      (Pinelli et al., 2024)
      Pez
      suppressible
      yki
      (Poernbacher et al., 2012)
      pic
      suppressible
      yki
      (Ly et al., 2019)
      pnut
      enhanceable
      yki
      (Gerlach et al., 2018)
      ptc
      suppressible
      yki
      (Kagey et al., 2012)
      Pten|Ras85D
      suppressible
      yki
      (Gangwani et al., 2020)
      Pten|Ras85D
      suppressible
      Tep1|yki
      (Gangwani et al., 2020)
      Rab21
      suppressible
      yki
      (Nassari et al., 2022)
      Ras85D
      enhanceable
      yki
      (Willecke et al., 2011)
      Ras85D|dlg1
      suppressible
      yki
      (Katheder et al., 2017)
      Ras85D|Rox8
      suppressible
      yki
      (Guo et al., 2020)
      Ras85D|emei
      suppressible
      yki
      (Ma et al., 2020)
      rl
      suppressible
      yki
      (Rose et al., 2022)
      RPA3
      suppressible
      yki
      (Zhou and Luo, 2013)
      RpS3
      suppressible
      yki
      (Wada et al., 2021)
      RpS3
      enhanceable
      yki
      (Wada et al., 2021)
      scrib
      suppressible
      yki
      (Bunker et al., 2015)
      sd
      enhanceable
      yki
      (Wu et al., 2008)
      SH3PX1
      suppressible
      yki
      (Zhang et al., 2019)
      slmb
      suppressible
      yki
      (Skwarek et al., 2014)
      Smox
      suppressible
      yki
      (Hevia et al., 2017)
      Smox
      enhanceable
      yki
      (Hevia et al., 2017)
      Src64B
      suppressible
      yki
      (Fernández et al., 2014)
      Strn-Mlck
      suppressible
      yki
      (Xu et al., 2018)
      synr
      suppressible
      yki
      (Sulekh et al., 2024)
      Syx7
      suppressible
      yki
      (Boone et al., 2016)
      Tao
      suppressible
      yki
      (Poon et al., 2016, Huang et al., 2014, Boggiano et al., 2011)
      TER94
      suppressible
      yki
      (Li et al., 2024)
      tkv
      suppressible
      yki
      (Oh and Irvine, 2011)
      Toll-7
      suppressible
      yki
      (Ding et al., 2022)
      twi
      suppressible
      yki
      (Rose et al., 2022)
      vg
      suppressible
      yki
      (Li et al., 2015, Wu et al., 2008)
      wg
      suppressible
      yki
      (Ewen-Campen and Perrimon, 2024)
      wts
      enhanceable
      yki
      (Mach et al., 2018)
      wts
      suppressible
      yki
      (Poon et al., 2016, Ren et al., 2010)
      wts|hpo
      suppressible
      yki
      (Huang et al., 2005)
      α-Spec
      suppressible
      yki
      (Pojer et al., 2021)
      External Data
      Subunit Structure (UniProtKB)
      Interacts (via WW domains) with wts (PubMed:16096061). Interacts (via N-terminus) with sd (via C-terminus) and this interaction enhances the transcriptional activity of sd (PubMed:18313299). The phosphorylated form interacts with 14-3-3epsilon and 14-3-3zeta (PubMed:18256197). Interacts with Ack and ex (PubMed:27462444).
      (UniProt, Q45VV3 )
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      FlyBase
      External Links
      External Data
      Linkouts
      KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      SignaLink - A signaling pathway resource with multi-layered regulatory networks.
      Class of Gene
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      2R
      Recombination map
      2-106
      Cytogenetic map
      60B7-60B8
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      60B7-60B8
      Limits computationally determined from genome sequence between P{lacW}Phmk07623&P{lacW}tsrk05633 and P{EP}EP503
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      Experimentally Determined Recombination Data
      Location

      2-106

      (FlyBase, 2016)

      2-109.9

      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (35)
      Genomic Clones (16)
       

      Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

      cDNA Clones (57)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      Antibody Information
      Laboratory Generated Antibodies
       

      polyclonal

      (Shi et al., 2023, Tyra et al., 2020, Hu et al., 2016, Wang et al., 2016, Ikmi et al., 2014, Lin et al., 2014, Oh and Irvine, 2008)
      Commercially Available Antibodies
       
      Cell Line Information
      Publicly Available Cell Lines
       
      Other Stable Cell Lines
       

      • New stable cell line derived from S2-unspecified : S2 cells were stably transfected with yki and sd constructs.

        (Vissers et al., 2018)

      • New stable cell line derived from S2-unspecified : Stable S2-yki-SBP and S2-bon-SBP cell lines were created, which are S2 cells containing streptavidin-binding peptide (SBP)-flagged yki or bon. The S2 cells were obtained from the laboratory of Spyros Artavanis-Tsakonas.

        (Zhao et al., 2023)
      Other Comments

      yki promotes transcription by recruiting a histone methyltransferase complex.

      (Oh et al., 2014)

      The competitive properties of yki-expressing cells is extremely reduced when they are surrounded by cells expressing very high amounts of dm.

      (Ziosi et al., 2010)

      yki regulates expression of the ban miRNA.

      (Nolo et al., 2006)

      yki is a kinase substrate of wts, becoming phosphorylated by wts upon activation of the hpo pathway.

      (Huang et al., 2005)

      dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

      (Kiger et al., 2003)
      Relationship to Other Genes
      Source for database merge of
      Additional comments
      Nomenclature History
      Source for database identify of

      Source for identity of: yki CG4005

      (Jukam, 2006.3.1, Huang et al., 2005)
      Nomenclature comments
      Etymology

      This gene is named "yorkie" after Yorkshire Terriers, one of the World's smallest breeds of pet dogs, according to its loss-of-function phenotype.

      (Huang et al., 2005)
      Synonyms and Secondary IDs (12)
      Reported As
      Symbol Synonym
      CG4005
      (National Institute of Genetics Fly Stocks, 2022-, Vigneswaran et al., 2021, Hosono et al., 2015, Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Perkins et al., 2009, Robertson, 2001.5.6)
      YAP
      (Sahu and Mondal, 2020, Wang et al., 2020, Tudrej et al., 2019, Jukam et al., 2013, Yu et al., 2013, Nagaraj et al., 2012)
      YKI
      (Arbones et al., 2019, Ferrandon, 2013, Harvey and Hariharan, 2012, Zeng et al., 2010)
      Yap
      (Lim et al., 2021, Zhou et al., 2020)
      Yap/Taz
      (van Soldt and Cardoso, 2020)
      Yki
      (Dong and Cheng, 2025, Li et al., 2025, Singh et al., 2025, Bhattacharya et al., 2024, Lee et al., 2024, Leung et al., 2024, Li et al., 2024, Murthy et al., 2024, Nagata and Igaki, 2024, Portela et al., 2024, Saez-Carrion et al., 2024, Tokamov et al., 2024, Xu et al., 2024, Zhai et al., 2024, Gilhaus et al., 2023, Golubev et al., 2023, Kasiah and McNeill, 2023, Kim et al., 2023, Maurya and Tapadia, 2023, Petsakou et al., 2023, Shi et al., 2023, Zhai et al., 2023, Zhu et al., 2023, Almeida Machado Costa et al., 2022, Enomoto and Igaki, 2022, Hu et al., 2022, Kong et al., 2022, Kumar and Baker, 2022, Li et al., 2022, Liu et al., 2022, Mesrouze et al., 2022, Tarikere et al., 2022, Wang et al., 2022, Yang et al., 2022, Zhang and Edgar, 2022, Alvarez-Ochoa et al., 2021, Bailey et al., 2021, Besen-McNally et al., 2021, Bilder et al., 2021, Boumard and Bardin, 2021, Cho and Jiang, 2021, Dillard et al., 2021, Ding et al., 2021, Gogia et al., 2021, Gong et al., 2021, Hodgson et al., 2021, Ito and Igaki, 2021, Johnson, 2021, Kong et al., 2021, Lam Wong and Verheyen, 2021, Li and Hidalgo, 2021, Lodge et al., 2021, Meiler et al., 2021, Muñoz-Nava et al., 2021, Paci and Mao, 2021, Paraskevopoulos and McGuigan, 2021, Snigdha et al., 2021, Srivastava et al., 2021, Strutt and Strutt, 2021, Vigano et al., 2021, Baker, 2020, Blanco et al., 2020, Coelho, 2020, Deng et al., 2020, Fulford and McNeill, 2020, Gangwani et al., 2020, Gou et al., 2020, Gutiérrez-Martínez et al., 2020, Jang et al., 2020, Jasper, 2020, Kanda and Igaki, 2020, Khan et al., 2020, La Marca and Richardson, 2020, López-Gay et al., 2020, Mesrouze et al., 2020, Mohammadi et al., 2020, Nguyen et al., 2020, Parker and Struhl, 2020, Skouloudaki et al., 2020, Vizcaya-Molina et al., 2020, Yu et al., 2020, Borreguero-Muñoz et al., 2019, Fulford et al., 2019, Gao et al., 2019, Gjelsvik et al., 2019, Gokhale and Pfleger, 2019, Kim et al., 2019, Ly et al., 2019, Meltzer et al., 2019, Mirzoyan et al., 2019, Politano et al., 2019, Sidor et al., 2019, Sun et al., 2019, Xu et al., 2019, Bae and Luo, 2018, Bohère et al., 2018, Cong et al., 2018, Elbediwy and Thompson, 2018, Enomoto et al., 2018, Fletcher et al., 2018, Fulford et al., 2018, Gou et al., 2018, He et al., 2018, Kim and Jho, 2018, Martín and Morata, 2018, Perochon et al., 2018, Richardson and Portela, 2018, Sander et al., 2018, Shen et al., 2018, Simón-Carrasco et al., 2018, Tsuboi et al., 2018, Xu et al., 2018, Baker, 2017, Di Giacomo et al., 2017, Hariharan and Serras, 2017, Hu et al., 2017, Jang et al., 2017, Karaiskos et al., 2017, Li et al., 2017, Liu and Jin, 2017, Liu and Jin, 2017, Ma et al., 2017, Moeller et al., 2017, Pascual et al., 2017, Richardson and Portela, 2017, Shalaby et al., 2017, Shu and Deng, 2017, Song et al., 2017, Tue et al., 2017, Weide et al., 2017, Xu et al., 2017, Yamamoto et al., 2017, Zaytseva and Quinn, 2017, Zhang et al., 2017, Atkins et al., 2016, Becker et al., 2016, Fallahi et al., 2016, Hergovich, 2016, Hu et al., 2016, Jiang et al., 2016, Ko et al., 2016, Meng et al., 2016, Padash Barmchi et al., 2016, Pan et al., 2016, Saadin and Starz-Gaiano, 2016, Simon et al., 2016, Tamori et al., 2016, Viets et al., 2016, Yadav et al., 2016, Cao et al., 2015, Dent et al., 2015, Enomoto et al., 2015, Enomoto et al., 2015, Figueroa-Clarevega and Bilder, 2015, Gaspar et al., 2015, Grifoni and Bellosta, 2015, Grifoni et al., 2015, Irvine and Harvey, 2015, Li et al., 2015, Morata and Ballesteros-Arias, 2015, Sopko et al., 2015, Su, 2015, Wang et al., 2015, Zheng et al., 2015, Amoyel and Bach, 2014, Bilak et al., 2014, Bossuyt et al., 2014, Cao et al., 2014, Chen et al., 2014, Hu et al., 2014, Ikmi et al., 2014, Qing et al., 2014, Robbins et al., 2014, Sadeqzadeh et al., 2014, Slattery et al., 2014, Andersen et al., 2013, Bausek, 2013, Degoutin et al., 2013, Enderle and McNeill, 2013, Gallant, 2013, Guo et al., 2013, Huang et al., 2013, Jin et al., 2013, Khan et al., 2013, Levayer and Moreno, 2013, Lucas et al., 2013, Matsui and Lai, 2013, Ren et al., 2013, Sidor et al., 2013, Slattery et al., 2013, Wong et al., 2013, Yin et al., 2013, Yu and Guan, 2013, Yu et al., 2013, Zoranovic et al., 2013, Amoyel and Bach, 2012, Chen et al., 2012, Fausti et al., 2012, Jin et al., 2012, Liu et al., 2012, Tokusumi et al., 2012, Worley et al., 2012, Yue et al., 2012, Baker, 2011, Chan et al., 2011, Genevet and Tapon, 2011, Gilbert et al., 2011, Halder and Johnson, 2011, Laprise, 2011, Losick et al., 2011, Oh and Irvine, 2011, Parker, 2011, Rauskolb et al., 2011, Richter et al., 2011, Salah and Aqeilan, 2011, Truscott et al., 2011, Zhang et al., 2011, Zhao et al., 2011, Grzeschik et al., 2010, Hall et al., 2010, Ho et al., 2010, Ren et al., 2010, Yu et al., 2010, Hamaratoglu et al., 2009, Oh and Irvine, 2009, Zhang et al., 2009, Dutta and Baehrecke, 2008, Rogulja et al., 2008, Shimizu et al., 2008, Zhai et al., 2008, Zhang et al., 2008, Zhang et al., 2008, Wei et al., 2007, Wei et al., 2007, Edgar, 2006, Hariharan, 2006, Polesello et al., 2006, Willecke et al., 2006)
      Yorkie
      (Neophytou and Pitsouli, 2022, Dobens et al., 2021, Ai et al., 2020, Cui et al., 2020, Denton et al., 2020, Li Zheng et al., 2020, Luckhart and Riehle, 2020, Neal et al., 2020)
      yap
      (Bennett and Harvey, 2006)
      yki
      (Kong et al., 2025, Kong et al., 2025, Martinez, 2025, Merle et al., 2025, Montemurro et al., 2025, Park et al., 2025, Shun Li et al., 2025, Yu et al., 2025, Collins et al., 2024, Gao et al., 2024, Guo et al., 2024, Ju et al., 2024, Luo et al., 2024, Manning et al., 2024, Miao et al., 2024, Mitchell et al., 2024, Sun et al., 2024, Wen et al., 2024, Ewen-Campen et al., 2023, Fulford et al., 2023, Ku et al., 2023, Nagai et al., 2023, Pino-Jiménez et al., 2023, Saavedra et al., 2023, Stanković et al., 2023, Wang et al., 2023, Xu et al., 2023, Zhao et al., 2023, Zhou and Boutros, 2023, Antonica et al., 2022, Crucianelli et al., 2022, Ding et al., 2022, Ding et al., 2022, Gao et al., 2022, Gera et al., 2022, Jiang et al., 2022, Kim et al., 2022, Li et al., 2022, Logeay et al., 2022, Rose et al., 2022, Sebastian et al., 2022, Agrawal et al., 2021, Badmos et al., 2021, Bonfini et al., 2021, Cong et al., 2021, Ding et al., 2021, García-López et al., 2021, Izumi et al., 2021, Keegan and Hughes, 2021, Lee et al., 2021, Pojer et al., 2021, Sang et al., 2021, Santabárbara-Ruiz and Léopold, 2021, Sharp et al., 2021, Strassburger et al., 2021, Tavares et al., 2021, Tokamov et al., 2021, Wada et al., 2021, Xu et al., 2021, Yang and Choi, 2021, Yeom et al., 2021, Zecca and Struhl, 2021, Bajpai and Sinha, 2020, Bajpai et al., 2020, Bakshi and Joshi, 2020, Blanco et al., 2020, Chen et al., 2020, Funk et al., 2020, Gogia et al., 2020, Guo et al., 2020, Hao et al., 2020, Hayashi et al., 2020, Irwin et al., 2020, Koranteng et al., 2020, Li and Hidalgo, 2020, Li et al., 2020, Ma et al., 2020, Parra and Johnston, 2020, Rust and Nystul, 2020, Ueoka et al., 2020, Venugopal et al., 2020, Vissers et al., 2020, Yatsenko et al., 2020, Yeom et al., 2020, Zhou et al., 2020, Alégot et al., 2019, Arbouzova et al., 2019, Banerjee et al., 2019, Boulan et al., 2019, Chang et al., 2019, Fahey-Lozano et al., 2019, Francis et al., 2019, Gao et al., 2019, Gaspar et al., 2019, Gerlach et al., 2019, Gervais et al., 2019, Grendler et al., 2019, Guo et al., 2019, Hall et al., 2019, Herrera and Bach, 2019, Jain et al., 2019, Khadilkar and Tanentzapf, 2019, Khezri and Rusten, 2019, Kim and Choi, 2019, Ma et al., 2019, Matsui et al., 2019, Moreno et al., 2019, Nie et al., 2019, Ramanathan et al., 2019, Saavedra and Perrimon, 2019, Sarpal et al., 2019, Schaub et al., 2019, Singh et al., 2019, Skouloudaki et al., 2019, Snigdha et al., 2019, Song et al., 2019, Texada et al., 2019, Wang and Baker, 2019, Wong et al., 2019, Xie et al., 2019, Yamamoto et al., 2019, Yee et al., 2019, Zhang et al., 2019, Albert et al., 2018, Azuma et al., 2018, Billmann et al., 2018, Campbell et al., 2018, Cho et al., 2018, Crossman et al., 2018, Donohoe et al., 2018, Forest et al., 2018, Gene Disruption Project members, 2018-, Gou et al., 2018, Katsukawa et al., 2018, Li et al., 2018, Nyarko, 2018, Reilein et al., 2018, Sarkar et al., 2018, Tsai et al., 2018, Wang and Baker, 2018, Wang et al., 2018, Yu and Pan, 2018, Zülbahar et al., 2018, Anderson et al., 2017, Arata et al., 2017, Hevia et al., 2017, Houtz et al., 2017, Katheder et al., 2017, Li et al., 2017, Ma et al., 2017, Moon et al., 2017, Rossi et al., 2017, Su et al., 2017, Transgenic RNAi Project members, 2017-, Upadhyay et al., 2017, Wells et al., 2017, Zhang et al., 2017, Zhang et al., 2017, Atkins et al., 2016, Barron and Moberg, 2016, Boone et al., 2016, Chan et al., 2016, Corty et al., 2016, Deng et al., 2016, Harris et al., 2016, Huang et al., 2016, Jahanshahi et al., 2016, Kuleesha et al., 2016, Liu et al., 2016, Losick et al., 2016, Mao et al., 2016, Moulton and Letsou, 2016, Park et al., 2016, Poon et al., 2016, Sakuma et al., 2016, Sarov et al., 2016, Suijkerbuijk et al., 2016, Willsey et al., 2016, Barrios et al., 2015, Dent et al., 2015, Di Cara et al., 2015, Doggett et al., 2015, Dong et al., 2015, Enomoto et al., 2015, Enzo et al., 2015, Fletcher et al., 2015, Gailite et al., 2015, Keder et al., 2015, Kwon et al., 2015, Kwon et al., 2015, Li et al., 2015, Meserve and Duronio, 2015, Parker and Struhl, 2015, Pasco et al., 2015, Patel et al., 2015, Sun et al., 2015, Vrabioiu and Struhl, 2015, Wan et al., 2015, Wang and Baker, 2015, Wittkorn et al., 2015, Wong et al., 2015, Yu et al., 2015, Zaessinger et al., 2015, Zhang et al., 2015, Zhang et al., 2015, Zhu et al., 2015, Boyle et al., 2014, Djabrayan et al., 2014, Ferguson and Martinez-Agosto, 2014, Fernández et al., 2014, Handke et al., 2014, Huang and Kalderon, 2014, Huang et al., 2014, Huang et al., 2014, Ikmi et al., 2014, Johnston, 2014, Li et al., 2014, Lin et al., 2014, Rauskolb et al., 2014, Rhee et al., 2014, Sing et al., 2014, Skwarek et al., 2014, Sorrentino et al., 2014, Tipping and Perrimon, 2014, Huang et al., 2013, Ilanges et al., 2013, Jukam et al., 2013, Jukam et al., 2013, Khan et al., 2013, Koontz et al., 2013, Kwon et al., 2013, Kwon et al., 2013, Kwon et al., 2013, Lin et al., 2013, Losick et al., 2013, Marcinkevicius and Zallen, 2013, Oh et al., 2013, Repiso et al., 2013, Tamori and Deng, 2013, Webber et al., 2013, Wehr et al., 2013, Yu et al., 2013, Yu et al., 2013, Zhang and Cohen, 2013, Zhou and Luo, 2013, Chen and Verheyen, 2012, Herranz et al., 2012, Kagey et al., 2012, Nagaraj et al., 2012, Poernbacher et al., 2012, Poon et al., 2012, Schoenherr et al., 2012, Verghese et al., 2012, Ye et al., 2012, Zhai et al., 2012, Zhang et al., 2012, Bao et al., 2011, Boggiano et al., 2011, Chen et al., 2011, Fernández et al., 2011, Gerhold et al., 2011, Gilbert et al., 2011, Grusche et al., 2011, Kawamori et al., 2011, Napoletano et al., 2011, Reddy and Irvine, 2011, Willecke et al., 2011, Zhang et al., 2011, Baumgartner et al., 2010, Baumgartner et al., 2010, Beam and Moberg, 2010, Benseñor et al., 2010, Chen et al., 2010, Das Thakur et al., 2010, Estella and Mann, 2010, Fang and Adler, 2010, Genevet et al., 2010, Genevet et al., 2010, Ho et al., 2010, Menéndez et al., 2010, Milton et al., 2010, Morrison and Halder, 2010, Neto-Silva et al., 2010, Nicolay et al., 2010, Reddy et al., 2010, Ren et al., 2010, Ribeiro et al., 2010, Robinson et al., 2010, Shaw et al., 2010, Varelas et al., 2010, Yu et al., 2010, Zecca and Struhl, 2010, Ziosi et al., 2010, Badouel et al., 2009, Genevet et al., 2009, Gilbert et al., 2009, Gilbert et al., 2009, Hamaratoglu et al., 2009, Peng et al., 2009, Zhang et al., 2009, Zhao et al., 2009, Baena-Lopez et al., 2008, Goulev et al., 2008, Nicolay and Frolov, 2008, Oh and Irvine, 2008, Sun et al., 2008, Wu et al., 2008, Yu et al., 2008, Zhao et al., 2008, Dong et al., 2007, Meignin et al., 2007, Polesello and Tapon, 2007, Shcherbata et al., 2007, Zhao et al., 2007, Bennett and Harvey, 2006, Cho et al., 2006, Emoto et al., 2006, Silva, 2006, Silva et al., 2006)
      yorkie
      (Nefedova et al., 2022, Ishibashi et al., 2020)
      Name Synonyms
      Yorki
      (Sun et al., 2015)
      Yorkie
      (Gujar and Wang, 2025, Gou et al., 2023, Koehler and Huber, 2023, Huang et al., 2022, Ahmad et al., 2021, Mohajan et al., 2021, Chen et al., 2020, Ding et al., 2020, Manning et al., 2020, Texada et al., 2020, Arbones et al., 2019, Ahmed-de-Prado and Baonza, 2018, Gou et al., 2018, Kon, 2018, Lee et al., 2018, Moon et al., 2018, Di Giacomo et al., 2017, Liu et al., 2017, Upadhyay et al., 2017, Zaytseva and Quinn, 2017, Atkins et al., 2016, Becker et al., 2016, Boone et al., 2016, Chan et al., 2016, Corty et al., 2016, Hergovich, 2016, Hirabayashi, 2016, Ko et al., 2016, Hariharan, 2015, Kwon et al., 2015, Thompson, 2015, Wong et al., 2015, Zhu et al., 2015, Cao et al., 2014, Handke et al., 2014, Li et al., 2014, Robbins et al., 2014, Sadeqzadeh et al., 2014, Ayyaz and Jasper, 2013, Bausek, 2013, Huang et al., 2013, Jukam et al., 2013, Khan et al., 2013, Konsavage and Yochum, 2013, Kwon et al., 2013, Lawrence and Casal, 2013, Levayer and Moreno, 2013, Losick et al., 2013, Lucas et al., 2013, Repiso et al., 2013, Slattery et al., 2013, Yang and Hata, 2013, Zhou and Luo, 2013, Amoyel and Bach, 2012, Chen et al., 2012, Fausti et al., 2012, Jin et al., 2012, Mirth and Shingleton, 2012, Nagaraj et al., 2012, Schoenherr et al., 2012, Zhang et al., 2012, Bao et al., 2011, Halder and Johnson, 2011, Laprise, 2011, Poon et al., 2011, Reddy and Irvine, 2011, Baumgartner et al., 2010, Fang and Adler, 2010, Genevet et al., 2010, Grzeschik et al., 2010, Ho et al., 2010, Milton et al., 2010, Neto-Silva et al., 2010, Ren et al., 2010, Robinson et al., 2010, Varelas et al., 2010, Yu et al., 2010, Zecca and Struhl, 2010, Ziosi et al., 2010, Alarcón et al., 2009, Badouel et al., 2009, Hamaratoglu et al., 2009, Oh and Irvine, 2009, Oh et al., 2009, Zhang et al., 2009, Dutta and Baehrecke, 2008, Oh and Irvine, 2008, Zhang et al., 2008, Dong et al., 2007, Hamaratoglu et al., 2007, Meignin et al., 2007, Polesello and Tapon, 2007, Wei et al., 2007, Willecke et al., 2007, Cho et al., 2006, Colombani et al., 2006, Edgar, 2006, Hariharan, 2006, Polesello et al., 2006, Thompson and Cohen, 2006, Willecke et al., 2006)
      yorki
      (Ilanges et al., 2013)
      yorkie
      (Vigneswaran et al., 2021, Arora and Ligoxygakis, 2020, Gerlach and Herranz, 2020, Li et al., 2020, Brown et al., 2019, Khadilkar and Tanentzapf, 2019, McSharry and Beitel, 2019, Papadopoulos et al., 2019, Dubey and Tapadia, 2018, Bielmeier et al., 2016, Losick et al., 2016, Barrios et al., 2015, Di Cara et al., 2015, Pasco et al., 2015, Fernández et al., 2014, Rhee et al., 2014, Harvey et al., 2013, Tamori and Deng, 2013, Zhang and Cohen, 2013, Graves et al., 2012, Verghese et al., 2012, Chen et al., 2011, Gerhold et al., 2011, Benseñor et al., 2010, Chen et al., 2010, Das Thakur et al., 2010, Fang and Adler, 2010, Menéndez et al., 2010, Morrison and Halder, 2010, Reddy et al., 2010, Zeng et al., 2010, Peng et al., 2009, Zhang et al., 2009, Goulev et al., 2008, Huang et al., 2008, Sun et al., 2008, Jukam and Desplan, 2007, Bennett and Harvey, 2006, Jukam, 2006.3.1, Jukam et al., 2006, Nolo et al., 2006, Huang et al., 2005)
      Secondary FlyBase IDs
        Datasets (1)
        Study focus (1)
        Experimental Role
        Project
        Project Type
        Title
        • bait_protein
        Hippo_Pathway_interaction_map
        Interaction map generated by purification of Hippo pathway factors, with identification of copurifying proteins by mass spectrometry.
        Study result (0)
        Result
        Result Type
        Title
        External Crossreferences and Linkouts ( 53 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
        FlyMine - An integrated database for Drosophila genomics
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL - MARRVEL (model organism gene)
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
        KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        SignaLink - A signaling pathway resource with multi-layered regulatory networks.
        References (818)