FlyBase Gene Report: Dmel\raptor

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Gene: Dmel\raptor

General Information

Symbol

Dmel\raptor

Species

D. melanogaster

Name

raptor

Annotation Symbol

CG4320

Feature Type

protein_coding_gene

FlyBase ID

FBgn0029840

Gene Model Status

Stock Availability

13 publicly available

Gene Summary

raptor (raptor) encodes a crucial component of target of rapamycin (TOR) complex 1, which is a conserved regulator of cell growth and metabolism. [Date last reviewed: 2018-10-11] (FlyBase Gene Snapshot)

All Summaries

Also Known As

dRaptor

Key Links

Genomic Location

Cytogenetic map

Sequence location

X:6,082,634..6,090,201 [-]

Recombination map

1-15

RefSeq locus

NC_004354 REGION:6082634..6090201

Sequence

Get Decorated FASTA

Genomic Maps

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (18 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables protein-macromolecule adaptor activity

inferred from biological aspect of ancestor with PANTHER:PTN000304084

(GO Reference Genome Project, 2011-)

Biological Process (15 terms)

Terms Based on Experimental Evidence (10 terms)

CV Term

Evidence

References

involved_in determination of adult lifespan

inferred from mutant phenotype

(Hatfield et al., 2015)

involved_in eclosion

inferred from mutant phenotype

(Hatfield et al., 2015)

involved_in insulin receptor signaling pathway

inferred from mutant phenotype

(Kockel et al., 2010, Wu et al., 2007)

involved_in larval midgut cell programmed cell death

inferred from mutant phenotype

(Xu et al., 2015)

involved_in muscle organ development

inferred from mutant phenotype

(Hatfield et al., 2015)

involved_in negative regulation of synaptic assembly at neuromuscular junction

inferred from mutant phenotype

(Natarajan et al., 2013)

involved_in oogenesis

inferred from mutant phenotype

(Wei and Lilly, 2014)

involved_in positive regulation of axon guidance

inferred from genetic interaction with FLYBASE:Rheb; FB:FBgn0041191

(Dimitroff et al., 2012)

involved_in positive regulation of cell size

inferred from mutant phenotype

(Sims et al., 2009)

involved_in TORC1 signaling

inferred from mutant phenotype

(Wang et al., 2012)

Terms Based on Predictions or Assertions (6 terms)

CV Term

Evidence

References

involved_in cellular response to amino acid stimulus

inferred from biological aspect of ancestor with PANTHER:PTN000304084

(GO Reference Genome Project, 2011-)

involved_in cellular response to starvation

inferred from biological aspect of ancestor with PANTHER:PTN000304084

(GO Reference Genome Project, 2011-)

involved_in positive regulation of cell growth

inferred from biological aspect of ancestor with PANTHER:PTN000304084

(GO Reference Genome Project, 2011-)

involved_in regulation of autophagy

inferred from biological aspect of ancestor with PANTHER:PTN000304084

(GO Reference Genome Project, 2011-)

involved_in TOR signaling

inferred from electronic annotation with InterPro:IPR004083

(InterPro Project Members, 2004-)

involved_in TORC1 signaling

inferred from biological aspect of ancestor with PANTHER:PTN000982815

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

part_of TORC1 complex

inferred from direct assay

(Wang et al., 2012)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000304084

(GO Reference Genome Project, 2011-)

part_of TORC1 complex

inferred from electronic annotation with InterPro:IPR004083

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000304084

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Pathway (FlyBase)

INSULIN-LIKE RECEPTOR SIGNALING PATHWAY CORE COMPONENTS

Protein Family (UniProt)

-

Protein Signatures (InterPro)

Summaries

Gene Snapshot

raptor (raptor) encodes a crucial component of target of rapamycin (TOR) complex 1, which is a conserved regulator of cell growth and metabolism. [Date last reviewed: 2018-10-11]

Pathway (FlyBase)

INSULIN-LIKE RECEPTOR SIGNALING PATHWAY CORE COMPONENTS -: The Insulin-like Receptor (IR) signaling pathway in Drosophila is initiated by the binding of an insulin-like peptides to the Insulin-like receptor (InR). (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989.)

Gene Group (FlyBase)

TORC1 COMPLEX -: TOR complex 1 (TORC1) is a target of rapamycin (Tor) kinase-containing complex that mediates the response to a variety of stimuli including stress, insulin-like peptides and amino acids. TORC1 regulates processes such as translation, cell growth and autophagy. It can be inhibited by rapamycin. (Adapted from FBrf0238220).

Summary (Interactive Fly)

component of the TORC1 complex that includes Tor and LST8 - Hdc and Unk bind to the TORC1 component Raptor and preferentially regulate Tor phosphorylation of S6k in a TORC1-dependent manner - regulates controls cell growth, proliferation, and metabolism

Interactive Fly

Gene Model and Products

Number of Transcripts

2

Number of Unique Polypeptides

1

Please see the JBrowse view of Dmel\raptor for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9W437)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.50

Gene model reviewed during 5.46

Multiphase exon postulated: this gene shares a region of coding sequence with an overlapping gene, but different reading frames are utilized in the overlapping coding region.

Shares 3' UTR with upstream gene.

Gene model reviewed during 5.56

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0332964

7072

1621

FBtr0345895

7097

1621

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

FBpp0305180

177.2

1621

8.34

FBpp0311819

177.2

1621

8.34

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1621 aa isoforms: raptor-PB, raptor-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Q9W437

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\raptor using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

raptor_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.77

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of TORC1 complex

inferred from direct assay

(Wang et al., 2012)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\raptor in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\raptor

View exonic expression by tissue for Dmel\raptor

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31543/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0029840

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0029840

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0029840

Flygut - An atlas of the Drosophila adult midgut

FBgn0029840

Images

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 2 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 15 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of raptor

Transgenic constructs containing regulatory region of raptor

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

(Ryder, 2004.4.26)

Inferred from location ( 18 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^pnr-MD237

raptor^GD5138

lethal - all die before end of pupal stage, with Scer\GAL4^how-24B

lethal - all die during P-stage, with Scer\GAL4^Mef2.PR

raptor^GD5138

lethal - all die during pupal stage, with Scer\GAL4^Mef2.PR

partially lethal, with Scer\GAL4^tin.CΔ4

raptor^GD5138

partially lethal - majority die, with Scer\GAL4^c179

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

raptor^GD5138

Sterility

Allele

female sterile, with Scer\GAL4^{VP16.nanos.UTR}

raptor^HMS00124

female sterile, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

raptor^HMS00124

Other Phenotypes

Allele

abnormal cell cycle | oogenesis, with Scer\GAL4^nanos.PG

abnormal locomotor behavior | adult stage, with Scer\GAL4^c179

abnormal neuroanatomy | adult stage, with Scer\GAL4^pnr-MD237

raptor^HMS00124

abnormal neuroanatomy | adult stage | somatic clone

raptor^del

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^elav.PLu

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^elav-C155

raptor^JF01088

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^VGlut1-OK371

raptor^JF01088

abnormal size, with Scer\GAL4^nub-AC-62

raptor^NIG.4320R

abnormal size | adult stage, with Scer\GAL4^eya.enh1+E+2

abnormal size | adult stage, with Scer\GAL4^pnr-MD237

raptor^HMS00124

abnormal size | third instar larval stage, with Scer\GAL4^NP0001

raptor^JF01088

abnormal starvation stress response | larval stage, with Scer\GAL4^Cg.PU

raptor^JF01088

abnormal stress response | adult stage, with Scer\GAL4^repo

raptor^GD5138

abnormal stress response | oogenesis, with Scer\GAL4^nanos.PG

decreased body size | adult stage, with Scer\GAL4^Ilp2.PR

decreased cell number, with Scer\GAL4^nub-AC-62

raptor^NIG.4320R

decreased cell size, with Scer\GAL4^nub-AC-62

raptor^NIG.4320R

decreased cell size | larval stage, with Scer\GAL4^Cg.PA

raptor^HMS02306

increased cell death | third instar larval stage, with Scer\GAL4^NP0001

raptor^JF01088

increased occurrence of cell division | larval stage, with Scer\GAL4^en.PU

raptor^JF01088

majority die during pupal stage, with Scer\GAL4^c179

short lived, with Scer\GAL4^Mhc.F3-580

some die during pharate adult stage, with Scer\GAL4^c179

visible, with Scer\GAL4^ap-md544

raptor^RNAi.Sym.UAS

visible | adult stage, with Scer\GAL4^eya.enh1+E+2

Phenotype manifest in

Allele

axon | adult stage, with Scer\GAL4^repo

raptor^GD5138

dendrite | adult stage | somatic clone

raptor^del

distal medullary amacrine neuron Dm8a | adult stage | somatic clone

raptor^del

embryonic/larval fat body | larval stage, with Scer\GAL4^Cg.PA

raptor^HMS02306

embryonic/larval fat body | larval stage, with Scer\GAL4^Cg.PU

raptor^JF01088

embryonic/larval midgut | third instar larval stage, with Scer\GAL4^NP0001

raptor^JF01088

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^elav-C155

raptor^JF01088

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^VGlut1-OK371

raptor^JF01088

eye, with Scer\GAL4^eya.enh1+E+2

female germline stem cell, with Scer\GAL4^nanos.PG

gastric caecum | third instar larval stage, with Scer\GAL4^NP0001

raptor^JF01088

mechanosensory neuron of posterior dorsocentral bristle, with Scer\GAL4^pnr-MD237

raptor^HMS00124

neuron projection | adult stage, with Scer\GAL4^pnr-MD237

raptor^HMS00124

NMJ bouton | third instar larval stage, with Scer\GAL4^elav.PLu

raptor^JF01088

NMJ bouton | third instar larval stage, with Scer\GAL4^elav.PU

raptor^RNAi.Sym.UAS

NMJ bouton | third instar larval stage, with Scer\GAL4^elav-C155

raptor^JF01088

NMJ bouton | third instar larval stage, with Scer\GAL4^VGlut1-OK371

raptor^JF01088

ovary, with Scer\GAL4^{VP16.nanos.UTR}

raptor^HMS00124

synapse | adult stage, with Scer\GAL4^pnr-MD237

raptor^HMS00124

wing, with Scer\GAL4^ap-md544

raptor^RNAi.Sym.UAS

wing, with Scer\GAL4^nub-AC-62

raptor^NIG.4320R

wing disc posterior compartment, with Scer\GAL4^en.PU

raptor^JF01088

wing nerve, with Scer\GAL4^repo

raptor^GD5138

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (1)

14 of 14

Yes

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (1)

14 of 14

Yes

Yes

Mus musculus (laboratory mouse) (1)

14 of 14

Yes

Yes

Xenopus tropicalis (Western clawed frog) (2)

8 of 13

Yes

Yes

1 of 13

No

Yes

Danio rerio (Zebrafish) (1)

13 of 14

Yes

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

10 of 14

Yes

Yes

Anopheles gambiae (African malaria mosquito) (1)

Agam\AgaP_AGAP010035

12 of 12

Yes

Yes

Arabidopsis thaliana (thale-cress) (2)

13 of 13

Yes

Yes

13 of 13

Yes

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

12 of 13

Yes

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

12 of 12

Yes

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:raptor. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

ameliorates brain glioma

modeled by btl::Egfr^λ.UAS, Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}

(Read et al., 2009)

raptor^KK108260

ameliorates high grade glioma

modeled by Hsap\EGFR^Δ.UAS, Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}

(Formica et al., 2021)

raptor^HMS02306

ameliorates carcinoma

modeled by N^CA.UAS.cUa, l(2)gl^GD4047

(Jevitt et al., 2021)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

RPTOR; regulatory associated protein of MTOR complex 1

14 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

anti tag coimmunoprecipitation, anti tag western blot

(Tsokanos et al., 2016)

anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation, peptide massfingerprinting

(Wang et al., 2012, Glatter et al., 2011)

raptor - PRAS40

anti tag coimmunoprecipitation, peptide massfingerprinting, anti tag western blot

(Pallares-Cartes et al., 2012, Glatter et al., 2011)

raptor - REPTOR

anti tag coimmunoprecipitation, anti tag western blot

(Tiebe et al., 2015)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Glatter et al., 2011)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Glatter et al., 2011)

raptor - Socs36E

anti tag coimmunoprecipitation, anti tag western blot

(Kang et al., 2018)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Glatter et al., 2011)

anti tag coimmunoprecipitation, anti tag western blot

(Tsokanos et al., 2016)

anti tag coimmunoprecipitation, anti tag western blot

(Li et al., 2019)

anti tag coimmunoprecipitation, anti tag western blot, peptide massfingerprinting, anti bait coimmunoprecipitation

(Tsokanos et al., 2016, Wang et al., 2012, Glatter et al., 2011)

anti tag coimmunoprecipitation, anti tag western blot, peptide massfingerprinting

(Li et al., 2019, Glatter et al., 2011)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Resnik-Docampo and de Celis, 2011)

suppressible

(Lee and Chung, 2007)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Zhang et al., 2014)

suppressible

(Wong et al., 2015)

enhanceable

(Resnik-Docampo and de Celis, 2011)

suppressible

(Breznak et al., 2023)

Pi3K92E|btl::Egfr

suppressible

(Read et al., 2009)

suppressible

(Dimitroff et al., 2012)

suppressible

(Lee and Chung, 2007)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0029840

MIST (genetic) - An integrated Molecular Interaction Database

31543

MIST (protein-protein) - An integrated Molecular Interaction Database

31543

Pathways

Signaling Pathways (FlyBase)

INSULIN-LIKE RECEPTOR SIGNALING PATHWAY CORE COMPONENTS

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

X

Recombination map

1-15

Cytogenetic map

Sequence location

X:6,082,634..6,090,201 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

5D4-5D4

Limits computationally determined from genome sequence between P{EP}EP1457^EP1457&P{EP}CG5928^EP1083 and P{EP}EP1311&P{EP}EP1384

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-15

(FlyBase, 2016)

1-15.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (13)

Aberrations including deletions of this gene Aberrations including duplications of this gene

53726

w^*; P{UAS-raptor.HA}2

31528

y¹ v¹; P{TRiP.JF01087}attP2

31529

y¹ v¹; P{TRiP.JF01088}attP2

81753

y¹ v¹; P{TKO.GS04721}attP40

41912

y¹ v¹; P{TRiP.HMS02306}attP40

84181

y¹ v¹; M{WKO.P1-D1}ZH-86Fb/TM3, Sb¹

34814

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00124}attP2

4320R-2

4320R-4

HMS02306

y¹ v¹; P{TRiP.HMS02306}attP40/CyO

v106491

P{KK108260}VIE-260B

v13112

w¹¹¹⁸; P{GD5138}v13112/CyO

More stocks available...

Genomic Clones (16)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (18)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD12356

Other clones

MIP06744

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0029840

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0029840

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Tsokanos et al., 2016)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

RNAi screen using dsRNA made from templates generated with primers directed against this gene results in chromosome misalignment on the metaphase spindle when assayed in S2 cells in the presence of Cdc27 dsRNA. This phenotype cannot be observed when the screen is performed without Cdc27 dsRNA.

(Goshima et al., 2007)

dsRNA made from templates generated with primers directed against this gene results in a reduced mean cell diameter and a corresponding decrease in S6k phosphorylation. Silencing raptor generates a cell-expression profile similar to that of rapamycin-treated cells.

(Guertin et al., 2006)

dsRNA made from templates generated with primers directed against this gene used to treat S2 cells.

(Yang et al., 2006)

dsRNA made from templates generated with primers directed against this gene decreases S6k phosphorylation but increases Akt1 phosphorylation in S2 cells.

(Yang et al., 2006)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: raptor CG4320

(Sarbassov et al., 2004)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

4320

(Ravi et al., 2009)

CG4320

(Rodrigues et al., 2022, Moskalev et al., 2018, Hosono et al., 2015, Lin et al., 2015, Fukuoh et al., 2014, Glatter et al., 2011, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Chang et al., 2008, Ni et al., 2008, Goshima et al., 2007, Ginalski et al., 2004, Sarbassov et al., 2004)

dRAPTOR

(Erdogan et al., 2016)

dRap

(Wu et al., 2007)

dRaptor

(Liu et al., 2017, Sanchez et al., 2016, Pallares-Cartes et al., 2012, Lindquist et al., 2011, Dekanty et al., 2010, Guertin et al., 2006, Inoki and Guan, 2006, Yang et al., 2006, Sarbassov et al., 2005)

raptor

(Amartuvshin et al., 2025, Qin et al., 2025, Shafer, 2025, Clémot et al., 2024, Rodríguez-Vázquez et al., 2024, Breznak et al., 2023, Gui et al., 2023, Nieken et al., 2023, Sanal et al., 2023, Kakanj et al., 2022, Martin et al., 2022, Rodrigues et al., 2022, Bonfini et al., 2021, Formica et al., 2021, Hsu et al., 2021, Kim and O'Connor, 2021, Ohhara et al., 2021, Demakova et al., 2020, Luo et al., 2020, Zeng et al., 2020, Kim et al., 2019, Li et al., 2019, Meltzer et al., 2019, Transgenic RNAi Project members, 2017-, Agrawal et al., 2016, David-Morrison et al., 2016, Kuleesha et al., 2016, Li et al., 2016, Sarov et al., 2016, Aradska et al., 2015, Lin et al., 2015, Schmitt et al., 2015, Takáts et al., 2015, Tiebe et al., 2015, Wong et al., 2015, Xu et al., 2015, Banreti et al., 2014, Bjordal et al., 2014, Doherty et al., 2014, Hasygar and Hietakangas, 2014, Sopko et al., 2014, Natarajan et al., 2013, O'Farrell et al., 2013, Sen et al., 2013, Shin et al., 2013, Dimitroff et al., 2012, Tokusumi et al., 2012, Zitserman et al., 2012, Glatter et al., 2011, Lindquist et al., 2011, Resnik-Docampo and de Celis, 2011, Tang et al., 2011, Fernández-Ayala et al., 2010, Ayroles et al., 2009, Read et al., 2009, Chang et al., 2008, Choi et al., 2008, Zhou et al., 2008, Lee and Chung, 2007)

raptor/CG4320

(Friedman and Perrimon, 2006)

Name Synonyms

RAPTOR

(Lee et al., 2020, Géminard et al., 2009)

Raptor

(Nelson et al., 2025, Yang et al., 2021, Nagy et al., 2015, Nässel et al., 2015, Zhang et al., 2011, Lee et al., 2008)

TORC1

(Kim and O'Connor, 2021)

dRaptor

(Moskalev et al., 2018, Lindquist et al., 2011, Read et al., 2009, Wu et al., 2007, Wullschleger, 2006, Yang et al., 2006, Sarbassov et al., 2004, Sarbassov et al., 2004)

raptor

(Heigwer et al., 2023, Kakanj et al., 2022, Álvarez-Rendón et al., 2018, Lin et al., 2017, Kučerová et al., 2016, Vinayagam et al., 2016, Doherty et al., 2014, Wang et al., 2012, White et al., 2011, Telonis-Scott et al., 2009, Chang et al., 2008, Sarbassov et al., 2004, Sarbassov et al., 2004)

target of rapamycin (TOR)-associated protein

(Goshima et al., 2007)

Secondary FlyBase IDs

Datasets (1)

Study focus (1)

Experimental Role

Project

Project Type

Title

bait_protein

PPI_InR-Tor_interaction_map

interactome

Interaction map generated by purification of insulin pathway factors, with identification of copurifying proteins by mass spectrometry.

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 47 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

31543

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9W437

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9W437

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9W437

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31543/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0029840

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0029840

FlyMine - An integrated database for Drosophila genomics

FBgn0029840

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG4320

MARRVEL_MODEL - MARRVEL (model organism gene)

31543

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0029840

DroID - A comprehensive database of gene and protein interactions.

FBgn0029840

DRSC - Results frm RNAi screens

FBgn0029840

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

raptor_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0029840

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0029840

Flygut - An atlas of the Drosophila adult midgut

FBgn0029840

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0029840

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC006548

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (genetic) - An integrated Molecular Interaction Database

31543

MIST (protein-protein) - An integrated Molecular Interaction Database

31543

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (173)