FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\CenG1A
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General Information
Symbol
Dmel\CenG1A
Species
D. melanogaster
Name
Centaurin gamma 1A
Annotation Symbol
CG31811
Feature Type
protein_coding_gene
FlyBase ID
FBgn0028509
Gene Model Status
Current
Stock Availability
46 publicly available
Gene Summary
Centaurin gamma 1A (CenG1A) encodes a GTPase that may have a role in regulating the second to third instar larval transition, which is ecdysone signaling-dependent. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

BG:DS08220.1

Key Links
Genomic Location
Cytogenetic map
34D6-34E2
Sequence location
Recombination map
2-50
RefSeq locus
NT_033779 REGION:13835564..13898712
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (5 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables GTPase activator activity
inferred from mutant phenotype
(Gündner et al., 2014)
enables GTPase activity
inferred from direct assay
(Gündner et al., 2014)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables GTP binding
inferred from electronic annotation with InterPro:IPR001806
(InterPro Project Members, 2004-)
enables GTPase activator activity
inferred from sequence model
(Bernards, 2003)
inferred from biological aspect of ancestor with PANTHER:PTN002910880
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR001164
(InterPro Project Members, 2004-)
enables GTPase activity
inferred from electronic annotation with InterPro:IPR001806
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN002910880
(GO Reference Genome Project, 2011-)
Biological Process (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in medium-term memory
inferred from mutant phenotype
(Gross et al., 2015)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in membrane
inferred from sequence or structural similarity with UniProtKB:Q99490
(Gene Ontology Curators, 2002-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the centaurin gamma-like family. (Q9NGC3)
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
GTPase activity
RHEA 19669:
Summaries
Gene Snapshot
Centaurin gamma 1A (CenG1A) encodes a GTPase that may have a role in regulating the second to third instar larval transition, which is ecdysone signaling-dependent. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEINS -
ArfGAPs are GTPase activating proteins for ARF family GTPases. ARFGAPs contain a characteristic 130 amino acid module, the ArfGAP domain, originally defined as the minimal fragment possessing ArfGAP activity. (Adapted from FBrf0158741, PMID:15731001 and PMID:18809720).
UNCLASSIFIED GTPASES -
This group comprises GTPases that do not classify under other groups in FlyBase.
Protein Function (UniProtKB)
GTPase-activating protein for the ADP ribosylation factor family.
(UniProt, Q9NGC3)
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\CenG1A for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9NGC3)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.52

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
CenG1A-RA
FBtr0080547
NM_078838
3869
927
CenG1A-RB
FBtr0080546
NM_165067
4444
995
CenG1A-RC
FBtr0080548
NM_165068
3516
763
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
CenG1A-PA
FBpp0080124
101.3
927
9.66
NP_523562
AAF53349
CenG1A-PB
FBpp0080123
108.0
995
8.54
Q9NGC3
NP_723849
AAF53343
CenG1A-PC
FBpp0080125
82.5
763
9.33
NP_723850
AAF53350
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CenG1A using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.00

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
anlage in statu nascendi
(Fisher et al., 2012)
central brain anlage in statu nascendi
(Fisher et al., 2012)
ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
central brain primordium
(Fisher et al., 2012)
embryonic neuroblast of ventral nerve cord primordium
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
procephalic neuroblast
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
dorsal sensory complex proper primordium

Comment: reported as dorsal/lateral sensory complexes

(Fisher et al., 2012)
embryonic brain
(Fisher et al., 2012)
embryonic head sensory system
(Fisher et al., 2012)
embryonic/larval lymph gland
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
larval nervous system
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
ventral sensory complex primordium
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CenG1A in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 36 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of CenG1A
Transgenic constructs containing regulatory region of CenG1A
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Inferred from location ( 8 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (37)
Hsap\AGAP1
13 of 14
Yes
Yes
Hsap\AGAP3
12 of 14
No
Yes
Hsap\AGAP2
10 of 14
No
Yes
Hsap\AGAP4
8 of 14
No
Yes
Hsap\AGAP5
8 of 14
No
Yes
Hsap\AGAP6
7 of 14
No
Yes
Hsap\AGAP9
7 of 14
No
Yes
Hsap\AGAP11
7 of 14
No
Yes
Hsap\AGAP7P
5 of 14
No
Yes
Hsap\ACAP1
3 of 14
No
No
Hsap\ACAP2
3 of 14
No
No
Hsap\ACAP3
3 of 14
No
No
Hsap\ASAP1
3 of 14
No
No
Hsap\ASAP2
3 of 14
No
No
Hsap\ASAP3
3 of 14
No
No
1  
Hsap\AGFG1
2 of 14
No
No
Hsap\APPL1
2 of 14
No
Yes
Hsap\APPL2
2 of 14
No
Yes
Hsap\ARAP1
2 of 14
No
No
Hsap\ARAP2
2 of 14
No
No
Hsap\ARFGAP1
2 of 14
No
No
2  
Hsap\GIT1
2 of 14
No
No
Hsap\GIT2
2 of 14
No
No
Hsap\SMAP1
2 of 14
No
No
Hsap\SMAP2
2 of 14
No
No
Hsap\ADAP1
1 of 14
No
No
Hsap\ADAP2
1 of 14
No
No
Hsap\AGFG2
1 of 14
No
No
Hsap\ARAP3
1 of 14
No
No
Hsap\ARFGAP2
1 of 14
No
No
1  
Hsap\ARFGAP3
1 of 14
No
No
Hsap\ARHGAP10
1 of 14
No
No
Hsap\ARHGAP26
1 of 14
No
No
Hsap\ARHGAP42
1 of 14
No
No
Hsap\DOC2A
1 of 14
No
No
1  
Hsap\PRKCG
1 of 14
No
No
Hsap\RASAL1
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (24)
Rnor\Agap1
13 of 14
Yes
Yes
Rnor\Agap3
11 of 14
No
Yes
Rnor\Agap2
10 of 14
No
Yes
Rnor\Acap1
3 of 14
No
No
Rnor\Acap2
3 of 14
No
No
Rnor\Acap3
3 of 14
No
No
Rnor\Agfg1
2 of 14
No
No
Rnor\Appl2
2 of 14
No
Yes
Rnor\Asap1
2 of 14
No
No
Rnor\Asap2
2 of 14
No
No
Rnor\Asap3
2 of 14
No
No
Rnor\Git2
2 of 14
No
No
Rnor\Smap1
2 of 14
No
No
Rnor\Smap2
2 of 14
No
No
Rnor\Adap2
1 of 14
No
No
Rnor\Agfg2
1 of 14
No
No
Rnor\Appl1
1 of 14
No
Yes
Rnor\Arap1
1 of 14
No
No
Rnor\Arap2
1 of 14
No
No
Rnor\Arfgap1
1 of 14
No
No
Rnor\Arfgap2
1 of 14
No
No
Rnor\Arhgap26
1 of 14
No
No
Rnor\Arhgap42
1 of 14
No
No
Rnor\Git1
1 of 14
No
No
Mus musculus (laboratory mouse) (27)
Mmus\Agap1
12 of 14
Yes
Yes
Mmus\Agap3
12 of 14
Yes
Yes
Mmus\Agap2
10 of 14
No
Yes
Mmus\Acap1
3 of 14
No
No
Mmus\Acap3
3 of 14
No
No
Mmus\Asap1
3 of 14
No
No
Mmus\Asap2
3 of 14
No
No
Mmus\Asap3
3 of 14
No
No
Mmus\Acap2
2 of 14
No
No
Mmus\Agfg1
2 of 14
No
No
Mmus\Agfg2
2 of 14
No
No
Mmus\Appl1
2 of 14
No
Yes
Mmus\Appl2
2 of 14
No
Yes
Mmus\Arap1
2 of 14
No
No
Mmus\Arap2
2 of 14
No
No
Mmus\Git1
2 of 14
No
No
Mmus\Git2
2 of 14
No
No
Mmus\Smap1
2 of 14
No
No
Mmus\Smap2
2 of 14
No
No
Mmus\9030624G23Rik
1 of 14
No
Yes
Mmus\Adap1
1 of 14
No
No
Mmus\Adap2
1 of 14
No
No
Mmus\Arap3
1 of 14
No
No
Mmus\Arfgap1
1 of 14
No
No
Mmus\Arfgap2
1 of 14
No
No
Mmus\Arfgap3
1 of 14
No
No
Mmus\Arhgap26
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (18)
Xtro\agap1
7 of 13
Yes
Yes
Xtro\agap2
7 of 13
Yes
Yes
Xtro\agap3
5 of 13
No
Yes
Xtro\acap3
2 of 13
No
No
Xtro\asap1
2 of 13
No
No
Xtro\asap2
2 of 13
No
No
Xtro\XB5826631
2 of 13
No
No
Xtro\abce1
1 of 13
No
No
Xtro\acap1
1 of 13
No
No
Xtro\acap2
1 of 13
No
No
Xtro\arhgap10
1 of 13
No
No
Xtro\arhgap26
1 of 13
No
No
Xtro\asap3
1 of 13
No
Yes
Xtro\pcdh17
1 of 13
No
No
Xtro\prkcb
1 of 13
No
No
Xtro\senp5
1 of 13
No
No
Xtro\smap1
1 of 13
No
No
Xtro\smap2
1 of 13
No
No
Danio rerio (Zebrafish) (35)
Drer\agap1
13 of 14
Yes
Yes
Drer\agap2
11 of 14
No
Yes
Drer\agap3
11 of 14
No
Yes
Drer\acap2a
3 of 14
No
No
Drer\acap3a
3 of 14
No
No
Drer\asap2a
3 of 14
No
No
Drer\asap2b
3 of 14
No
No
Drer\unm_sa1614
3 of 14
No
No
Drer\zgc:162872
3 of 14
No
No
Drer\acap1
2 of 14
No
No
Drer\acap2b
2 of 14
No
No
Drer\acap3b
2 of 14
No
No
Drer\arap1a
2 of 14
No
No
Drer\asap1a
2 of 14
No
No
Drer\asap1b
2 of 14
No
No
Drer\asap3
2 of 14
No
No
Drer\git1
2 of 14
No
No
Drer\git2a
2 of 14
No
No
Drer\LOC100005008
2 of 14
No
No
Drer\smap1
2 of 14
No
No
Drer\smap2
2 of 14
No
No
Drer\agfg2
1 of 14
No
No
Drer\appl1
1 of 14
No
Yes
Drer\appl2
1 of 14
No
No
Drer\arap3
1 of 14
No
No
Drer\arfgap2
1 of 14
No
No
Drer\arfgap3
1 of 14
No
No
Drer\arhgap10
1 of 14
No
No
Drer\arhgap42a
1 of 14
No
No
Drer\git2b
1 of 14
No
No
Drer\hesx1
1 of 14
No
Yes
Drer\LOC569534
1 of 14
No
No
Drer\LOC110438288
1 of 14
No
Yes
Drer\ophn1
1 of 14
No
No
Drer\zgc:92360
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (9)
Cele\cnt-2
13 of 14
Yes
Yes
Cele\W09D10.1
3 of 14
No
No
Cele\cnt-1
2 of 14
No
No
Cele\git-1
2 of 14
No
No
Cele\K02B12.7
2 of 14
No
No
Cele\F07F6.4
1 of 14
No
No
Cele\F07F6.7
1 of 14
No
Yes
Cele\F07F6.8
1 of 14
No
Yes
Cele\T04C9.1
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (12)
Agam\AgaP_AGAP009160
12 of 12
Yes
Yes
Agam\AgaP_AGAP000563
3 of 12
No
No
Agam\AgaP_AGAP012088
3 of 12
No
No
Agam\AgaP_AGAP006888
2 of 12
No
No
Agam\AgaP_AGAP007379
2 of 12
No
Yes
Agam\AgaP_AGAP007726
2 of 12
No
No
Agam\AgaP_AGAP000126
1 of 12
No
No
Agam\AgaP_AGAP003133
1 of 12
No
No
Agam\AgaP_AGAP010189
1 of 12
No
No
Agam\AgaP_AGAP012252
1 of 12
No
No
Agam\AgaP_AGAP012887
1 of 12
No
No
Agam\AgaP_AGAP013143
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (32)
Atha\AGD1
4 of 13
Yes
No
Atha\AGD2
4 of 13
Yes
No
Atha\AGD4
4 of 13
Yes
No
Atha\SFC
4 of 13
Yes
No
Atha\AGD5
2 of 13
No
No
Atha\AGD6
2 of 13
No
No
Atha\AGD8
2 of 13
No
No
Atha\AGD9
2 of 13
No
No
Atha\AGD13
2 of 13
No
Yes
Atha\AGD15
2 of 13
No
No
Atha\AT3G07940
2 of 13
No
No
Atha\RPA
2 of 13
No
No
Atha\ZAC
2 of 13
No
Yes
Atha\AGD7
1 of 13
No
No
Atha\AT1G22610
1 of 13
No
No
Atha\AT1G23140
1 of 13
No
No
Atha\AT1G48590
1 of 13
No
No
Atha\AT1G66360
1 of 13
No
No
Atha\AT1G70790
1 of 13
No
No
Atha\AT1G70810
1 of 13
No
No
Atha\AT1G73580
1 of 13
No
No
Atha\AT2G01540
1 of 13
No
No
Atha\AT3G61300
1 of 13
No
No
Atha\AT4G11610
1 of 13
No
No
Atha\AT4G32630
1 of 13
No
No
Atha\AT5G37740
1 of 13
No
No
Atha\AT5G47710
1 of 13
No
No
Atha\C2
1 of 13
No
No
Atha\EHB1
1 of 13
No
No
Atha\NIG
1 of 13
No
No
Atha\UBP20
1 of 13
No
No
Atha\ZIGA4
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (6)
Scer\AGE1
3 of 13
Yes
No
Scer\AGE2
2 of 13
No
No
Scer\GCS1
1 of 13
No
No
Scer\GLO3
1 of 13
No
No
Scer\GTS1
1 of 13
No
No
Scer\SPS18
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (6)
Spom\cnt5
3 of 12
Yes
No
Spom\cnt6
3 of 12
Yes
No
Spom\ucp3
3 of 12
Yes
No
Spom\SPAC824.09c
2 of 12
No
No
Spom\glo3
1 of 12
No
No
Spom\SPCC622.14
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:CenG1A. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (9)
Asap
5 of 13
CenB1A
5 of 13
ArfGAP1
3 of 13
CG8243
3 of 13
Git
3 of 13
ArfGAP3
2 of 13
drongo
2 of 13
Pkc53E
1 of 13
RhoGAP15B
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 4 )
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 4 )
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
AGAP1; ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
13 of 14
608651
      AGAP3; ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
      12 of 14
      616813
          AGAP2; ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
          10 of 14
          605476
              AGAP4; ArfGAP with GTPase domain, ankyrin repeat and PH domain 4
              8 of 14
              621155
                  AGAP5; ArfGAP with GTPase domain, ankyrin repeat and PH domain 5
                  8 of 14
                  621156
                      AGAP6; ArfGAP with GTPase domain, ankyrin repeat and PH domain 6
                      7 of 14
                      621157
                          AGAP9; ArfGAP with GTPase domain, ankyrin repeat and PH domain 9
                          7 of 14
                          621158
                              AGAP11; ArfGAP with GTPase domain, ankyrin repeat and PH domain 11
                              7 of 14
                              621159
                                  AGAP7P; ArfGAP with GTPase domain, ankyrin repeat and PH domain 7, pseudogene
                                  5 of 14
                                      ACAP1; ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
                                      3 of 14
                                      607763
                                          ACAP2; ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
                                          3 of 14
                                          607766
                                              ACAP3; ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
                                              3 of 14
                                                  ASAP1; ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
                                                  3 of 14
                                                  605953
                                                      ASAP2; ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
                                                      3 of 14
                                                      603817
                                                          ASAP3; ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
                                                          3 of 14
                                                          616594
                                                               
                                                              Functional Complementation Data
                                                              Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                                              Interactions
                                                              Summary of Physical Interactions
                                                              Interaction Browsers
                                                              View in FlyBase Interactions Browser   View in MIST tool (external link)
                                                              Please see the Physical Interaction reports below for full details
                                                              protein-protein
                                                              Physical Interaction
                                                              Assay
                                                              References
                                                              CenG1A - AhcyL1
                                                              experimental knowledge based
                                                              (Guruharsha et al., 2011)
                                                              Summary of Genetic Interactions
                                                              Interaction Browsers
                                                              View in FlyBase Interactions Browser   View in MIST tool (external link)
                                                              Please look at the allele data for full details of the genetic interactions
                                                              Starting gene(s)
                                                              Interaction type
                                                              Interacting gene(s)
                                                              Reference
                                                              Starting gene(s)
                                                              Interaction type
                                                              Interacting gene(s)
                                                              Reference
                                                              Fmr1
                                                              suppressible
                                                              CenG1A
                                                              (Gross et al., 2015)
                                                              External Data
                                                              Linkouts
                                                              BioGRID - A database of protein and genetic interactions.
                                                              DroID - A comprehensive database of gene and protein interactions.
                                                              MIST (protein-protein) - An integrated Molecular Interaction Database
                                                              Pathways
                                                              Signaling Pathways (FlyBase)
                                                              Metabolic Pathways
                                                              FlyBase
                                                              External Links
                                                              External Data
                                                              Linkouts
                                                              KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                                              Class of Gene
                                                              Genomic Location and Detailed Mapping Data
                                                              Chromosome (arm)
                                                              2L
                                                              Recombination map
                                                              2-50
                                                              Cytogenetic map
                                                              34D6-34E2
                                                              Sequence location
                                                              FlyBase Computed Cytological Location
                                                              Cytogenetic map
                                                              Evidence for location
                                                              34D6-34E2
                                                              Limits computationally determined from genome sequence between P{lacW}Sosk05224&P{lacW}RpII33k05605 and P{lacW}l(2)34Fak00811&P{PZ}wb09437
                                                              Experimentally Determined Cytological Location
                                                              Cytogenetic map
                                                              Notes
                                                              References
                                                              34E1-34E2
                                                              (determined by in situ hybridisation)
                                                              (Ashburner et al., 1999, Spradling et al., 1999)
                                                              Experimentally Determined Recombination Data
                                                              Location

                                                              2-50

                                                              (FlyBase, 2016)

                                                              2-45.1

                                                              (Comeron et al., 2012)
                                                              Left of (cM)
                                                              Right of (cM)
                                                              Notes
                                                              Stocks and Reagents
                                                              Stocks (46)
                                                              Genomic Clones (44)
                                                              cDNA Clones (53)
                                                               

                                                              Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                                                              cDNA clones, fully sequenced
                                                              BDGP DGC clones
                                                              Other clones
                                                              Drosophila Genomics Resource Center cDNA clones

                                                              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                                              cDNA Clones, End Sequenced (ESTs)
                                                              BDGP DGC clones
                                                              Other clones
                                                              RNAi and Array Information
                                                              Linkouts
                                                              DRSC - Results frm RNAi screens
                                                              Antibody Information
                                                              Laboratory Generated Antibodies
                                                               
                                                              Commercially Available Antibodies
                                                               
                                                              Cell Line Information
                                                              Publicly Available Cell Lines
                                                               
                                                                Other Stable Cell Lines
                                                                 
                                                                  Other Comments

                                                                  Transcriptionally downregulated after 2h of insulin stimulation in Kc167 cells. Contains fkh response elements (FHREs) in the genomic upstream or intronic sequences.

                                                                  (Junger et al., 2003)

                                                                  dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                                                                  (Kiger et al., 2003)

                                                                  Area matching Drosophila EST AA390942.

                                                                  (Davies, 2001.3.15)
                                                                  Relationship to Other Genes
                                                                  Source for database merge of

                                                                  Source for merge of: cenG1A CG16867 CG7982

                                                                  (FlyBase, 1996-)

                                                                  Source for merge of: CG16866 CG16867 CG7982

                                                                  (FlyBase Genome Annotators, 2002-2003)
                                                                  Additional comments

                                                                  Annotations CG16866, CG16867 and CG7982 merged as CG31811 in release 3 of the genome annotation.

                                                                  (FlyBase Genome Annotators, 2002-2003)

                                                                  Source for merge of cenG1A CG16867 CG7982 was sequence comparison ( date:000501 ).

                                                                  (FlyBase, 1996-)
                                                                  Nomenclature History
                                                                  Source for database identify of

                                                                  Source for identity of: BG:DS08220.1 CG7982

                                                                  (Guan, 1999.11)

                                                                  Source for identity of: CenG1A cenG1A

                                                                  (FlyBase, 2009-)
                                                                  Nomenclature comments
                                                                  Etymology
                                                                  Synonyms and Secondary IDs (16)
                                                                  Reported As
                                                                  Symbol Synonym
                                                                  AGAP
                                                                  (Schlacht et al., 2013)
                                                                  BG:DS08220.1
                                                                  (Ashburner et al., 1999)
                                                                  CG16866
                                                                  (Stanyon et al., 2004)
                                                                  CG16867
                                                                  CG31811
                                                                  (National Institute of Genetics Fly Stocks, 2022-, Zeledon et al., 2019, Keleman et al., 2009.8.5, Ni et al., 2008, Quinones-Coello, 2007)
                                                                  CG7982
                                                                  CenG1A
                                                                  (Gilbert et al., 2024, Lewis et al., 2023, Praschberger et al., 2023, Ding et al., 2022, Furuya et al., 2022, National Institute of Genetics Fly Stocks, 2022-, Agrawal et al., 2021, Michki et al., 2021, Onur et al., 2021, Zeledon et al., 2019, Matsumoto et al., 2018, Gene Disruption Project members, 2016-, Urbach et al., 2016, Carnes et al., 2015, Gross et al., 2015, Bakal et al., 2007)
                                                                  CenG1a
                                                                  (Carbone et al., 2016)
                                                                  cenG
                                                                  (Somogyi et al., 2010)
                                                                  cenG1A
                                                                  (Fanara et al., 2023, Guan et al., 2019, Al-Ramahi et al., 2018, Gündner et al., 2014, Neville et al., 2014, Sen et al., 2013, Sen et al., 2013, Izutsu et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Murray et al., 2012, Buffin and Gho, 2010, Kazemian et al., 2010, Southall and Brand, 2009, Bakal et al., 2007, Quinones-Coello, 2007, Stuart et al., 2007, Moorman et al., 2006)
                                                                  cenG1a
                                                                  (Jayanandanan et al., 2011, Roote, 2009.11.24)
                                                                  ceng1A
                                                                  (Gündner et al., 2014, Hendrick, 2000.4.8)
                                                                  Name Synonyms
                                                                  Centaurin gamma
                                                                  (Gündner et al., 2014)
                                                                  Centaurin gamma 1A
                                                                  (Urbach et al., 2016, Carnes et al., 2015)
                                                                  centaurin gamma 1A
                                                                  (Buffin and Gho, 2010, Burnette et al., 2005, Harbison et al., 2005, Hendrick, 2000.4.8)
                                                                  centaurin gamma-1A
                                                                  (Gross et al., 2015)
                                                                  Secondary FlyBase IDs
                                                                  • FBgn0027879
                                                                  • FBgn0032534
                                                                  • FBgn0040976
                                                                  • FBgn0051811
                                                                  Datasets (0)
                                                                  Study focus (0)
                                                                  Experimental Role
                                                                  Project
                                                                  Project Type
                                                                  Title
                                                                  Study result (0)
                                                                  Result
                                                                  Result Type
                                                                  Title
                                                                  External Crossreferences and Linkouts ( 77 )
                                                                  Sequence Crossreferences
                                                                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                                                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                                                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                                                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                                                  UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                                                  UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                                                  Other crossreferences
                                                                  AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                                                  BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                                                  DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                                                  EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                                                  FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                                                  FlyMine - An integrated database for Drosophila genomics
                                                                  InterPro - A database of protein families, domains and functional sites
                                                                  KEGG Genes - Molecular building blocks of life in the genomic space.
                                                                  MARRVEL_MODEL - MARRVEL (model organism gene)
                                                                  Linkouts
                                                                  BioGRID - A database of protein and genetic interactions.
                                                                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                                                  DroID - A comprehensive database of gene and protein interactions.
                                                                  DRSC - Results frm RNAi screens
                                                                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                                                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                                                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                                                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                                                  Flygut - An atlas of the Drosophila adult midgut
                                                                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                                                  KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                                                  MIST (protein-protein) - An integrated Molecular Interaction Database
                                                                  References (101)