FlyBase Gene Report: Dmel\Cdc7

General Information

Symbol

Dmel\Cdc7

Species

D. melanogaster

Name

Cdc7 kinase

Annotation Symbol

CG32742

Feature Type

protein_coding_gene

FlyBase ID

FBgn0028360

Gene Model Status

Current

Stock Availability

15 publicly available

Enzyme Name (EC)

Gene Summary

Cdc7 kinase (Cdc7) encodes a conserved protein kinase that is activated by the regulatory subunit encoded by chif during late G1/S of the cell cycle. The activated product of Cdc7 promotes the initiation of DNA replication through phosphorylation, and thereby activation, of the DNA helicase encoded by Mcm2 . [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Also Known As

l(1)G0148, l(1)G0149, l(1)G0461

Key Links

Genomic Location

Cytogenetic map

6C3-6C3

Sequence location

X:6,654,541..6,659,709 [+]

Recombination map

1-18

RefSeq locus

NC_004354 REGION:6654541..6659709

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (12 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables histone kinase activity

inferred from direct assay

(Stephenson et al., 2015)

enables protein kinase activity

inferred from direct assay

(Stephenson et al., 2015)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441

(InterPro Project Members, 2004-)

enables protein kinase activity

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR008271

(InterPro Project Members, 2004-)

enables protein serine/threonine kinase activity

inferred from biological aspect of ancestor with PANTHER:PTN005196447

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity with SGD:S000002175

(Stephenson et al., 2015)

Biological Process (5 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in eggshell chorion gene amplification

inferred from mutant phenotype

(Stephenson et al., 2015)

involved_in embryonic development via the syncytial blastoderm

inferred from mutant phenotype

(Seller and O'Farrell, 2018)

involved_in endomitotic cell cycle

inferred from mutant phenotype

(Stephenson et al., 2015)

involved_in positive regulation of DNA replication

inferred from mutant phenotype

(Stephenson et al., 2015)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in mitotic DNA damage checkpoint signaling

inferred from biological aspect of ancestor with PANTHER:PTN005196447

(GO Reference Genome Project, 2011-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

part_of Dbf4-dependent protein kinase complex

inferred from direct assay

(Stephenson et al., 2015)

located_in nucleus

inferred from direct assay

(Seller and O'Farrell, 2018)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN005196447

(GO Reference Genome Project, 2011-)

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN005196447

(GO Reference Genome Project, 2011-)

located_in nucleus

inferred from sequence or structural similarity with SGD:S000002175

(Stephenson et al., 2015)

Gene Group (FlyBase)

UNCLASSIFIED CONVENTIONAL PROTEIN KINASE DOMAIN KINASES

DBF4-DEPENDENT CDC7 KINASE COMPLEX

Protein Family (UniProt)

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (Q9W3Y1)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

protein serine/threonine kinase activity

Summaries

Gene Snapshot

Gene Group (FlyBase)

UNCLASSIFIED CONVENTIONAL PROTEIN KINASE DOMAIN KINASES -: This group comprises conventional protein kinase domain kinases that do not classify under other groups in FlyBase.
DBF4-DEPENDENT CDC7 KINASE COMPLEX -: The Dbf4-dependent Cdc7 kinase complex is a serine/threonine-protein kinase that phosphorylates components of the pre-replication complex during DNA replication initiation. (Adapted from FBrf0227432.)

Protein Function (UniProtKB)

Catalytic component of the Dbf4-dependent kinase (DDK) complex (PubMed:25451925). Phosphorylates components of the pre-replication complex, including Mcm2 and, to a lesser extent, Mcm4 (PubMed:25451925). Phosphorylates histones, including H3 and H2B (PubMed:25451925). Required for DNA replication and mitotic proliferation, including during the endoreplication and amplification stages of DNA replication in egg chamber follicle cells of the ovary (PubMed:25451925).

(UniProt, Q9W3Y1)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Cdc7 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9W3Y1)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.52

Gene model reviewed during 5.56

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Cdc7-RA

FBtr0070950

NM_167080

3103

700

Cdc7-RB

FBtr0343377

NM_001298021

2962

699

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Cdc7-PA

FBpp0070911

78.7

700

9.52

FBpp0310032

78.5

699

9.59

X2JCT3

NP_001284950

AHN59421

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Component of the Dbf4-dependent kinase (DDK) complex consisting of Cdc7 and the Dbf4 ortholog chif (PubMed:25451925). Interacts with chif (via the processed polypeptide Chiffon-A); the interaction is direct (PubMed:25451925, PubMed:30559249).

(UniProt, Q9W3Y1)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9W3Y1

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cdc7 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.82

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of Dbf4-dependent protein kinase complex

inferred from direct assay

(Stephenson et al., 2015)

located_in nucleus

inferred from direct assay

(Seller and O'Farrell, 2018)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Cdc7 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Cdc7

View exonic expression by tissue for Dmel\Cdc7

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31598/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0028360

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0028360

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0028360

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32742

Flygut - An atlas of the Drosophila adult midgut

FBgn0028360

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 14 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Cdc7

Transgenic constructs containing regulatory region of Cdc7

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(1)Exel6240

(Ryder, 2004.4.26)

Df(1)f08054-d09974

(Casad et al., 2012)

Inferred from location ( 27 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

Cdc7^G0148

lethal | adult stage

Cdc7^G0461

lethal | pharate adult stage

lethal | pupal stage

lethal | recessive

lethal - all die before end of prepupal stage

Cdc7^G0149

lethal - all die during embryonic stage | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

Cdc7^GL00585

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

Sterility

Allele

female semi-sterile, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

Cdc7^GL00585

fertile

Other Phenotypes

Allele

abnormal endomitotic cell cycle | somatic clone

Cdc7^G0148

abnormal mitotic cell cycle | embryonic stage | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

Cdc7^GL00585

decreased occurrence of cell division | somatic clone

Cdc7^G0148

some die during prepupal stage | recessive

Cdc7^G0149

visible, with Scer\GAL4^pnr-MD237

Cdc7^GD13997

Phenotype manifest in

Allele

embryo | maternal effect, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

Cdc7^GL00585

follicle cell | somatic clone

Cdc7^G0148

larva | third instar larval stage

Cdc7^G0149

nucleus | embryonic stage | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

Cdc7^GL00585

trichogen cell, with Scer\GAL4^pnr-MD237

Cdc7^GD13997

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (27)

Hsap\CDC7

12 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (18)

Rnor\Cdc7

12 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (24)

Mmus\Cdc7

11 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (18)

Xtro\cdc7

7 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (30)

Drer\cdc7

12 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (14)

Cele\cdc-7

8 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (14)

Agam\AgaP_AGAP002110

10 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (36)

Atha\AT4G16970

7 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\CAK1AT

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (10)

Scer\CDC7

11 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (10)

Spom\spo4

11 of 12

Yes

8 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Cdc7. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (25)

11 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

dco

2 of 13

gish

2 of 13

aurA

1 of 13

bsd

1 of 13

CaMKI

1 of 13

Cdk5

1 of 13

gek

1 of 13

Mps1

1 of 13

nmo

1 of 13

p38a

1 of 13

Pak

1 of 13

Pdk1

1 of 13

S6kII

1 of 13

sff

1 of 13

Sik3

1 of 13

sti

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CDC7; cell division cycle 7

12 of 14

603311

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Cdc7 - Mcm2

enzymatic study, autoradiography

(Stephenson et al., 2015)

Cdc7 - chif

pull down, anti tag western blot, anti tag coimmunoprecipitation, multidimensional protein identification technology, two hybrid, enzymatic study, autoradiography

(Torres-Zelada et al., 2019, Stephenson et al., 2015)

Cdc7 - dpa

enzymatic study, autoradiography

(Stephenson et al., 2015)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Cdc7

suppressible

Rif1

(Seller and O'Farrell, 2018)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Rif1

enhanceable

Cdc7

(Seller and O'Farrell, 2018)

External Data

Subunit Structure (UniProtKB)

(UniProt, Q9W3Y1 )

Linkouts

BioGRID - A database of protein and genetic interactions.

58085

DroID - A comprehensive database of gene and protein interactions.

FBgn0028360

MIST (protein-protein) - An integrated Molecular Interaction Database

31598

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9W3Y1

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-18

Cytogenetic map

6C3-6C3

Sequence location

X:6,654,541..6,659,709 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

6C3-6C3

Limits computationally determined from genome sequence between P{EP}EP1402&P{EP}CG15893^EP1634 and P{EP}Ctr1A^EP1364&P{EP}EP1445

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

6B-6C

(determined by in situ hybridisation) 6C1--2 (determined by in situ hybridisation) 6B (determined by in situ hybridisation)

(Peter et al., 2002)

6B-6C

(determined by in situ hybridisation)

(Schäfer et al., 1999.12.2)

6B-6B

(determined by in situ hybridisation) 6C1--2 (determined by in situ hybridisation)

(Schäfer et al., 1999.8.12)

Experimentally Determined Recombination Data

Location

1-18

(FlyBase, 2016)

1-18.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (15)

Genomic Clones (10)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (119)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

AT30978

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0028360

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0028360

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of S phase cells and an increase in the proportion of G2/M phase cells are seen.

(Bettencourt-Dias et al., 2004)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Relationship to Other Genes

Source for database merge of

Source for merge of: l(1)G0148 l(1)G0461 CG32742 l(1)G0149

(Peter et al., 2002)

Source for merge of: l(1)G0148 anon-WO03040301.250

(FlyBase, 1996-)

Source for merge of: CG8655 CG8656

(FlyBase Genome Annotators, 2002-2003)

Additional comments

Annotations CG8655 and CG8656 merged as CG32742 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Source for merge of l(1)G0148 anon-WO03040301.250 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: Cdc7 l(1)G0148

(Stephenson et al., 2015)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (14)

Reported As

Symbol Synonym

CG32742

(Hosono et al., 2015, Stephenson et al., 2015, Schertel et al., 2013, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Pan and Zhang, 2009, Bettencourt-Dias et al., 2004)

CG8655

(Gorski et al., 2003, Peter et al., 2002)

CG8656

CT25076

(Morrison et al., 2000)

Cdc7

(Cho and O'Farrell, 2025, Zhang et al., 2023, Ishii et al., 2022, Ostalé et al., 2021, Torres-Zelada and Weake, 2021, Galander and Marston, 2020, Adhikari et al., 2019, Gene Disruption Project members, 2018-, Podolsky et al., 2018, Blythe and Wieschaus, 2015)

L(1)G0148

(Soshnev et al., 2013)

anon-WO03040301.250

cdc7

(Huang et al., 2021, Parker et al., 2020, Seller and O'Farrell, 2018, Stephenson et al., 2015, Bonke et al., 2013)

cdc7-related

(Li and White, 2003)

l(1)G0148

(Chen et al., 2016, Stephenson et al., 2015, Bischof, 2014.10.20, Luck et al., 2014, Sopko et al., 2014, Bonke et al., 2013, Kwon et al., 2013, Schertel et al., 2013, Casad et al., 2012)

l(1)G0149

(Schäfer et al., 1999.8.12)

l(1)G0461

(Schäfer et al., 1999.12.2)

Name Synonyms

Cdc7 kinase

lethal (1) G0148

Secondary FlyBase IDs

FBgn0028359
FBgn0029883
FBgn0029884
FBgn0040156
FBgn0052742
FBgn0066815

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 38 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

31598

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9W3Y1

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9W3Y1

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9W3Y1

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31598/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0028360

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0028360

FlyMine - An integrated database for Drosophila genomics

FBgn0028360

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG32742

MARRVEL_MODEL - MARRVEL (model organism gene)

31598

Linkouts

BioGRID - A database of protein and genetic interactions.

58085

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0028360

DroID - A comprehensive database of gene and protein interactions.

FBgn0028360

DRSC - Results frm RNAi screens

FBgn0028360

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0028360

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0028360

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32742

Flygut - An atlas of the Drosophila adult midgut

FBgn0028360

MIST (protein-protein) - An integrated Molecular Interaction Database

31598

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9W3Y1

References (75)

The following external sites may use different assemblies or annotations than FlyBase.

0.82

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