FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\PlexB
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General Information
Symbol
Dmel\PlexB
Species
D. melanogaster
Name
Plexin B
Annotation Symbol
CG17245
Feature Type
protein_coding_gene
FlyBase ID
FBgn0025740
Gene Model Status
Current
Stock Availability
36 publicly available
Gene Summary
Plexin B (PlexB) encodes a transmembrane receptor for ligands including semaphorins, which signals via RhoGTPases. It can signal both attractive and repulsive axon guidance. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

plex

Key Links
Genomic Location
Cytogenetic map
101F1-101F1
Sequence location
Recombination map
4-0
RefSeq locus
NC_004353 REGION:32478..43778
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
Function
Gene Ontology (GO) Annotations (16 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables protein binding
inferred from physical interaction with UniProtKB:O96681
(Ayoob et al., 2006)
inferred from physical interaction with UniProtKB:Q24323
(Ayoob et al., 2006)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables semaphorin receptor activity
inferred from electronic annotation with InterPro:IPR013548, InterPro:IPR031148, InterPro:IPR046800
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN001098994
(GO Reference Genome Project, 2011-)
Biological Process (11 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in axon guidance
inferred from direct assay
(Ayoob et al., 2006)
inferred from mutant phenotype
(Hu et al., 2001)
inferred from genetic interaction with FLYBASE:Rac1; FB:FBgn0010333
(Hu et al., 2001)
involved_in dendrite self-avoidance
inferred from mutant phenotype
(Meltzer et al., 2016)
involved_in motor neuron axon guidance
inferred from mutant phenotype
(Cho et al., 2012)
involved_in olfactory bulb axon guidance
inferred from mutant phenotype
(Joo et al., 2013)
involved_in sensory neuron axon guidance
inferred from mutant phenotype
(Bates and Whitington, 2007)
inferred from genetic interaction with FLYBASE:Sema2a; FB:FBgn0011260
(Bates and Whitington, 2007)
Terms Based on Predictions or Assertions (8 terms)
CV Term
Evidence
References
involved_in motor neuron axon guidance
inferred from biological aspect of ancestor with PANTHER:PTN000504953
(GO Reference Genome Project, 2011-)
involved_in negative regulation of cell adhesion
inferred from biological aspect of ancestor with PANTHER:PTN001861955
(GO Reference Genome Project, 2011-)
involved_in positive regulation of axonogenesis
inferred from biological aspect of ancestor with PANTHER:PTN001861955
(GO Reference Genome Project, 2011-)
involved_in regulation of cell migration
inferred from biological aspect of ancestor with PANTHER:PTN001098994
(GO Reference Genome Project, 2011-)
involved_in regulation of cell shape
inferred from biological aspect of ancestor with PANTHER:PTN001861955
(GO Reference Genome Project, 2011-)
involved_in semaphorin-plexin signaling pathway
inferred from electronic annotation with InterPro:IPR031148
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN001098994
(GO Reference Genome Project, 2011-)
involved_in sensory neuron axon guidance
inferred from biological aspect of ancestor with PANTHER:PTN000504953
(GO Reference Genome Project, 2011-)
involved_in synapse assembly
inferred from biological aspect of ancestor with PANTHER:PTN001476678
(GO Reference Genome Project, 2011-)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in dendrite
inferred from direct assay
(Meltzer et al., 2016)
located_in plasma membrane
inferred from high throughput direct assay
(Tan et al., 2009)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN001098994
(GO Reference Genome Project, 2011-)
part_of semaphorin receptor complex
inferred from biological aspect of ancestor with PANTHER:PTN001098994
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the plexin family. (Q9V4A7)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Plexin B (PlexB) encodes a transmembrane receptor for ligands including semaphorins, which signals via RhoGTPases. It can signal both attractive and repulsive axon guidance. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
PLEXINS -
The Plexins are transmembrane axon guidance proteins that serve as receptors for semaphorins. (Adapted from FBrf0208160).
Protein Function (UniProtKB)
Transmembrane receptor that binds the molecular guidance cue Sema2a, to regulate axon guidance and possibly salivary gland positioning in embryos (PubMed:11604137, PubMed:16672342). Acts as a receptor for Sema2a and seems to transduce signal by suppressing Rac activity and enhancing Rho activity (PubMed:11604137, PubMed:16672342). As transmembrane receptor for Sema2a, involved in peripheral and central nervous system axon guidance (PubMed:11604137, PubMed:16672342, PubMed:27618755). Function in neurons is essential for adult survival, motor neuron survival, and is important for climbing behavior and activity (PubMed:37041188). During embryogenesis, plays an important role in correct salivary gland positioning (PubMed:27618755).
(UniProt, Q9V4A7)
Summary (Interactive Fly)

semaphorin domain protein, receptor for the secreted semaphorin Sema-2a - regulates axon extension from the sensory neuron cell body in regions of direct contact with oenocytes

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\PlexB for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9V4A7)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.39

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
PlexB-RA
FBtr0089179
NM_079877
6716
2051
PlexB-RB
FBtr0308297
NM_001258471
7050
2051
Additional Transcript Data and Comments
Reported size (kB)

12, 8 (northern blot)

(Winberg et al., 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
PlexB-PA
FBpp0088246
231.7
2051
6.65
Q9V4A7
NP_524616
AAF59374
PlexB-PB
FBpp0300616
231.7
2051
6.65
Q9V4A7
NP_001245400
AFH06760
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

2051 aa isoforms: PlexB-PA, PlexB-PB
Additional Polypeptide Data and Comments
Reported size (kDa)

2051 (aa)

(Winberg et al., 1998)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with PlexA. Interacts with Rho1 and with the active forms of Rac1 and Rac2. Interacts with Sema-2a.

(UniProt, Q9V4A7)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\PlexB using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.04

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
neuron
(Winberg et al., 1998)
myoblast
(Winberg et al., 1998)
embryonic stage 1 -- 6
organism | ubiquitous
(Winberg et al., 1998)
embryonic stage 9 -- 17
presumptive embryonic/larval central nervous system
(Winberg et al., 1998)
embryonic stage 15 -- 16
larval central nervous system
(Ayoob et al., 2006)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
(Winberg et al., 1998)
Additional Descriptive Data

PlexB transcripts are broadly distributed during early embryogenesis. Starting at the extended germ band stage, expression is strong in the CNS but is reduced elsewhere. After stage 15, transcripts are mainly restricted to the CNS where they are found in many neurons. Expression is also observed in myoblasts but does not persist in muscle fibers.

(Winberg et al., 1998)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in dendrite
inferred from direct assay
(Meltzer et al., 2016)
located_in plasma membrane
inferred from high throughput direct assay
(Tan et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\PlexB in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 10 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 30 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of PlexB
Transgenic constructs containing regulatory region of PlexB
Aberrations (Deficiencies and Duplications) ( 2 )
Inferred from experimentation ( 2 )
Gene disrupted in
Df(4)M101-62f
(Ayoob et al., 2006, Podemski et al., 2004)
Gene not disrupted in
Ts(1Lt;4Lt)FM7-A
(Maggert and Kindelay, 2025)
Inferred from location ( 2 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal (with Df(4)M101-62f)
partially lethal (with PlexBKG00878)
partially lethal (with PlexBMI15559-TG4.1)
partially lethal - majority die
partially lethal - majority die (with Df(4)M101-62f)
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal behavior | larval stage, with Scer\GAL4iav.PK
abnormal locomotor behavior | adult stage, with Scer\GAL4GMR37G12
abnormal locomotor behavior | adult stage, with Scer\GAL4VGlut1-OK371
abnormal neuroanatomy
abnormal neuroanatomy, with Scer\GAL4elav.PLu
abnormal neuroanatomy (with Df(4)M101-62f)
abnormal neuroanatomy | adult stage
abnormal neuroanatomy | adult stage, with Scer\GAL4GMR37G12
abnormal neuroanatomy | adult stage | cell autonomous | somatic clone, with Scer\GAL4GMR37G12
abnormal neuroanatomy | embryonic stage
abnormal neuroanatomy | embryonic stage, with Scer\GAL4elav.PU
abnormal neuroanatomy | embryonic stage, with Scer\GAL4iav.PK
abnormal neuroanatomy | embryonic stage, with Scer\GAL4sim.PS
abnormal neuroanatomy | pupal stage
abnormal neuroanatomy | third instar larval stage
abnormal neuroanatomy | third instar larval stage, with Scer\GAL421-7
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4221
abnormal neurophysiology | adult stage, with Scer\GAL4GMR37G12
abnormal sleep | adult stage | conditional, with Scer\GAL4GMR37G12
short lived (with PlexBKG00878)
short lived (with PlexBMI15559-TG4.1)
visible, with Scer\GAL4Mef2.PR
Phenotype manifest in
Allele
adult olfactory receptor neuron
adult protocerebral bridge 1 glomerulus-fan-shaped body-round body type a neuron
adult protocerebral bridge 1 glomerulus-fan-shaped body-round body type a neuron, with Scer\GAL4GMR37G12
adult protocerebral bridge 1 glomerulus-fan-shaped body-round body type a neuron | cell autonomous | somatic clone, with Scer\GAL4GMR37G12
chordotonal neuron, with Scer\GAL4iav.PK
dendrite | third instar larval stage
dendrite | third instar larval stage, with Scer\GAL421-7
dendrite | third instar larval stage, with Scer\GAL4221
ellipsoid body
ellipsoid body, with Scer\GAL4GMR37G12
ellipsoid body | cell autonomous | somatic clone, with Scer\GAL4GMR37G12
embryonic/larval salivary gland | embryonic stage, with Scer\GAL4fkh.PH
fan-shaped body
fan-shaped body layer, with Scer\GAL4GMR37G12
fan-shaped body layer | cell autonomous | somatic clone, with Scer\GAL4GMR37G12
intermediate longitudinal fascicle, with Scer\GAL4elav.PU
intermediate longitudinal fascicle, with Scer\GAL4sim.PS
intermediate longitudinal fascicle | embryonic stage
larval intersegmental nerve
larval intersegmental nerve, with Scer\GAL4elav.PLu
larval intersegmental nerve (with Df(4)M101-62f)
larval intersegmental nerve branch ISNb of A1-7 | embryonic stage
larval multidendritic class I neuron | third instar larval stage, with Scer\GAL4221
larval multidendritic class IV neuron | third instar larval stage
larval multidendritic class IV neuron | third instar larval stage, with Scer\GAL421-7
larval segmental nerve branch SNa of A1-7
larval segmental nerve branch SNa of A1-7 (with Df(4)M101-62f)
larval segmental nerve branch SNa of A1-7 | embryonic stage
larval VL3/4 motor neuron, with Scer\GAL4elav.PLu
lch1 neuron
medial longitudinal fascicle
medial longitudinal fascicle (with Df(4)M101-62f)
MP1 tract
MP1 tract, with Scer\GAL4sim.PS
neuron projection | adult stage
neuron projection | adult stage, with Scer\GAL4GMR37G12
neuron projection | adult stage | cell autonomous | somatic clone, with Scer\GAL4GMR37G12
wing, with Scer\GAL4Mef2.PR
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (35)
Hsap\PLXNA1
8 of 14
Yes
No
Hsap\PLXNA2
8 of 14
Yes
No
Hsap\PLXNA3
8 of 14
Yes
No
1  
Hsap\PLXNB1
8 of 14
Yes
Yes
Hsap\PLXNB2
8 of 14
Yes
Yes
1  
Hsap\PLXNB3
8 of 14
Yes
Yes
1  
Hsap\PLXND1
8 of 14
Yes
Yes
Hsap\PLXNA4
7 of 14
No
No
1  
Hsap\PLXNC1
5 of 14
No
Yes
Hsap\MST1R
3 of 14
No
Yes
Hsap\MET
2 of 14
No
Yes
Hsap\ADAMTS9
1 of 14
No
No
Hsap\FGFR1
1 of 14
No
No
Hsap\PKHD1L1
1 of 14
No
Yes
Hsap\SEMA3A
1 of 14
No
No
Hsap\SEMA3B
1 of 14
No
No
Hsap\SEMA3C
1 of 14
No
No
Hsap\SEMA3D
1 of 14
No
No
Hsap\SEMA3E
1 of 14
No
No
Hsap\SEMA3F
1 of 14
No
No
Hsap\SEMA3G
1 of 14
No
No
Hsap\SEMA4A
1 of 14
No
No
1  
Hsap\SEMA4B
1 of 14
No
No
Hsap\SEMA4C
1 of 14
No
No
Hsap\SEMA4D
1 of 14
No
No
Hsap\SEMA4F
1 of 14
No
No
Hsap\SEMA4G
1 of 14
No
No
Hsap\SEMA5A
1 of 14
No
No
Hsap\SEMA5B
1 of 14
No
No
Hsap\SEMA6A
1 of 14
No
No
Hsap\SEMA6B
1 of 14
No
No
Hsap\SEMA6C
1 of 14
No
No
Hsap\SEMA6D
1 of 14
No
No
Hsap\SEMA7A
1 of 14
No
No
Hsap\SSPOP
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (12)
Rnor\Plxna1
8 of 14
Yes
No
Rnor\Plxna2
8 of 14
Yes
No
Rnor\Plxnb1
8 of 14
Yes
Yes
Rnor\Plxnb2
8 of 14
Yes
Yes
Rnor\Plxna3
7 of 14
No
No
Rnor\Plxna4
7 of 14
No
No
Rnor\Plxnb3
7 of 14
No
Yes
Rnor\Plxnd1
7 of 14
No
Yes
Rnor\Plxnc1
4 of 14
No
Yes
Rnor\Mst1r
3 of 14
No
Yes
Rnor\Met
2 of 14
No
Yes
Rnor\Sema6c
1 of 14
No
No
Mus musculus (laboratory mouse) (15)
Mmus\Plxna1
8 of 14
Yes
No
Mmus\Plxna3
8 of 14
Yes
No
Mmus\Plxna4
8 of 14
Yes
No
Mmus\Plxnb1
8 of 14
Yes
Yes
Mmus\Plxnb2
8 of 14
Yes
Yes
Mmus\Plxnb3
8 of 14
Yes
Yes
Mmus\Plxnd1
8 of 14
Yes
Yes
Mmus\Plxna2
7 of 14
No
No
Mmus\Plxnc1
5 of 14
No
Yes
Mmus\Met
3 of 14
No
Yes
Mmus\Mst1r
3 of 14
No
Yes
Mmus\Sema6a
1 of 14
No
No
Mmus\Sema6b
1 of 14
No
No
Mmus\Sema6c
1 of 14
No
No
Mmus\Sema6d
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (25)
Xtro\plxna2
6 of 13
Yes
No
Xtro\plxnb3
6 of 13
Yes
Yes
Xtro\plxnb2
5 of 13
No
Yes
Xtro\mau2
4 of 13
No
No
Xtro\plxna1
4 of 13
No
No
Xtro\plxnb1
4 of 13
No
Yes
Xtro\plxna3
3 of 13
No
No
Xtro\plxna4
3 of 13
No
No
Xtro\LOC100496572
2 of 13
No
Yes
Xtro\mst1r
2 of 13
No
No
Xtro\acp5
1 of 13
No
Yes
Xtro\ankrd13b
1 of 13
No
No
Xtro\dok2
1 of 13
No
No
Xtro\met
1 of 13
No
Yes
Xtro\plxnc1
1 of 13
No
Yes
Xtro\plxnd1
1 of 13
No
No
Xtro\polr2h
1 of 13
No
No
Xtro\sema3b
1 of 13
No
No
Xtro\sema4c
1 of 13
No
No
Xtro\sema4d
1 of 13
No
No
Xtro\sema4g
1 of 13
No
No
Xtro\sema5b
1 of 13
No
No
Xtro\sema6b
1 of 13
No
No
Xtro\sema6c
1 of 13
No
No
Xtro\sema6d
1 of 13
No
No
Danio rerio (Zebrafish) (27)
Drer\plxna4
8 of 14
Yes
No
Drer\plxnb2b
8 of 14
Yes
Yes
Drer\plxnb3
8 of 14
Yes
Yes
Drer\plxna1a
7 of 14
No
No
Drer\plxna1b
7 of 14
No
No
Drer\plxna2
7 of 14
No
No
Drer\plxna3
7 of 14
No
No
Drer\plxnb1a
7 of 14
No
Yes
Drer\plxnb1b
7 of 14
No
Yes
Drer\plxnb2a.1
7 of 14
No
Yes
Drer\plxnb2a.2
4 of 14
No
Yes
Drer\plxnb2a.3
4 of 14
No
Yes
Drer\met
3 of 14
No
Yes
Drer\plxnd1
3 of 14
No
Yes
Drer\mst1ra
2 of 14
No
No
Drer\ephb1
1 of 14
No
No
Drer\LOC101883382
1 of 14
No
Yes
Drer\LOC108179158
1 of 14
No
Yes
Drer\mst1rb
1 of 14
No
No
Drer\pkhd1l1.1
1 of 14
No
Yes
Drer\plxnc1
1 of 14
No
No
Drer\sema3aa
1 of 14
No
No
Drer\sema4bb
1 of 14
No
No
Drer\sema5a
1 of 14
No
No
Drer\sema6d
1 of 14
No
No
Drer\sema6dl
1 of 14
No
No
Drer\si:ch211-113g11.6
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (7)
Cele\plx-2
6 of 14
Yes
Yes
Cele\plx-1
5 of 14
No
No
Cele\adt-1
1 of 14
No
No
Cele\adt-2
1 of 14
No
No
Cele\mab-20
1 of 14
No
No
Cele\smp-1
1 of 14
No
No
Cele\smp-2
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (7)
Agam\AgaP_AGAP011139
12 of 12
Yes
Yes
Agam\AgaP_AGAP000064
4 of 12
No
No
Agam\AgaP_AGAP002424
1 of 12
No
No
Agam\AgaP_AGAP005742
1 of 12
No
No
Agam\AgaP_AGAP006634
1 of 12
No
No
Agam\AgaP_AGAP006636
1 of 12
No
No
Agam\AgaP_AGAP008656
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:PlexB. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (6)
PlexA
8 of 13
Sema1a
1 of 13
Sema1b
1 of 13
Sema2a
1 of 13
Sema2b
1 of 13
Sema5c
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 3 )
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 2 )
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
PLXNA1; plexin A1
8 of 14
601055
    PLXNA2; plexin A2
    8 of 14
    601054
        PLXNA3; plexin A3
        8 of 14
        300022
             
            PLXNB1; plexin B1
            8 of 14
            601053
                PLXNB2; plexin B2
                8 of 14
                604293
                     
                    PLXNB3; plexin B3
                    8 of 14
                    300214
                         
                        PLXND1; plexin D1
                        8 of 14
                        604282
                          PLXNA4; plexin A4
                          7 of 14
                          604280
                               
                              PLXNC1; plexin C1
                              5 of 14
                              604259
                                  MST1R; macrophage stimulating 1 receptor
                                  3 of 14
                                  600168
                                    Functional Complementation Data
                                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                    Interactions
                                    Summary of Physical Interactions
                                    Summary of Genetic Interactions
                                    Interaction Browsers
                                    View in FlyBase Interactions Browser   View in MIST tool (external link)
                                    Please look at the allele data for full details of the genetic interactions
                                    Starting gene(s)
                                    Interaction type
                                    Interacting gene(s)
                                    Reference
                                    PlexB
                                    suppressible
                                    Pak
                                    (Hu et al., 2001)
                                    PlexB
                                    suppressible
                                    PlexA
                                    (Ayoob et al., 2006)
                                    PlexB
                                    suppressible
                                    Rac1
                                    (Hu et al., 2001)
                                    PlexB
                                    suppressible
                                    Rho1
                                    (Hu et al., 2001)
                                    PlexB
                                    enhanceable
                                    Sema2a
                                    (Bates and Whitington, 2007)
                                    PlexB
                                    enhanceable
                                    trio
                                    (Hu et al., 2001)
                                    Starting gene(s)
                                    Interaction type
                                    Interacting gene(s)
                                    Reference
                                    Rac1
                                    enhanceable
                                    PlexB
                                    (Hu et al., 2001)
                                    Sema2a
                                    enhanceable
                                    PlexB
                                    (Bates and Whitington, 2007)
                                    Sema2a
                                    suppressible
                                    PlexB
                                    (Ayoob et al., 2006)
                                    External Data
                                    Subunit Structure (UniProtKB)
                                    Interacts with PlexA. Interacts with Rho1 and with the active forms of Rac1 and Rac2. Interacts with Sema-2a.
                                    (UniProt, Q9V4A7 )
                                    Linkouts
                                    BioGRID - A database of protein and genetic interactions.
                                    DroID - A comprehensive database of gene and protein interactions.
                                    MIST (genetic) - An integrated Molecular Interaction Database
                                    MIST (protein-protein) - An integrated Molecular Interaction Database
                                    Pathways
                                    Signaling Pathways (FlyBase)
                                    Metabolic Pathways
                                    FlyBase
                                    External Links
                                    External Data
                                    Linkouts
                                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                    Class of Gene
                                    Genomic Location and Detailed Mapping Data
                                    Chromosome (arm)
                                    4
                                    Recombination map
                                    4-0
                                    Cytogenetic map
                                    101F1-101F1
                                    Sequence location
                                    FlyBase Computed Cytological Location
                                    Cytogenetic map
                                    Evidence for location
                                    101F1-101F1
                                    Experimentally Determined Cytological Location
                                    Cytogenetic map
                                    Notes
                                    References
                                    101F-101F
                                    (Winberg, 1998.11.13)
                                    101F-101F
                                    (determined by in situ hybridisation)
                                    (Winberg et al., 1998)
                                    Experimentally Determined Recombination Data
                                    Location

                                    4-0

                                    (FlyBase, 2016)
                                    Left of (cM)
                                    Right of (cM)
                                    Notes
                                    Stocks and Reagents
                                    Stocks (36)
                                    Genomic Clones (6)
                                     

                                    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                                    cDNA Clones (107)
                                     

                                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                                    cDNA clones, fully sequenced
                                    BDGP DGC clones
                                    Other clones
                                      Drosophila Genomics Resource Center cDNA clones

                                      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                      cDNA Clones, End Sequenced (ESTs)
                                      BDGP DGC clones
                                      Other clones
                                      RNAi and Array Information
                                      Linkouts
                                      DRSC - Results frm RNAi screens
                                      Antibody Information
                                      Laboratory Generated Antibodies
                                       

                                      polyclonal

                                      (Sweeney et al., 2011, Wu et al., 2011)
                                      Commercially Available Antibodies
                                       
                                      Cell Line Information
                                      Publicly Available Cell Lines
                                       
                                        Other Stable Cell Lines
                                         
                                          Other Comments

                                          PlexB functions cell autonomously in guiding the lateral cluster and v'ch1 axons.

                                          (Bates and Whitington, 2007)

                                          plexB is essential for normal SNa motor axons bundle formation and pathfinding.

                                          (Ayoob et al., 2006)

                                          plexB is required for plexin mediated axon guidance.

                                          (Hu et al., 2001)
                                          Relationship to Other Genes
                                          Source for database merge of

                                          Source for merge of: plex plexB

                                          (Winberg, 1999.9.3)
                                          Additional comments
                                          Nomenclature History
                                          Source for database identify of

                                          Source for identity of: plexB CG17245

                                          (Li, 1999.11)

                                          Source for identity of: PlexB plexB

                                          (FlyBase, 2009-)
                                          Nomenclature comments
                                          Etymology
                                          Synonyms and Secondary IDs (15)
                                          Reported As
                                          Symbol Synonym
                                          CG17245
                                          (Justice et al., 2019, Koya and Meller, 2015, Ni et al., 2010.12.1, Perkins et al., 2009)
                                          PLEXB
                                          (Slack et al., 2010)
                                          Plex B
                                          (Koya and Meller, 2015)
                                          PlexB
                                          (Zang and Bashaw, 2023, Fourth Chromosome Resource Project and Newfeld, 2022-, Orr et al., 2022, Bilder et al., 2021, Everetts et al., 2021, Frank et al., 2020, Justice et al., 2019, Rozbesky et al., 2019, Stedden et al., 2019, Yang and Chien, 2019, La Fortezza et al., 2018, Orr et al., 2017, Stessman et al., 2017, Transgenic RNAi Project members, 2017-, Hanlon and Andrew, 2016, Roh et al., 2016, Shen et al., 2016, Syed et al., 2016, Zwarts et al., 2016, Dialynas et al., 2015, Cantera et al., 2014, Chak and Kolodkin, 2014, Emerson et al., 2013, Cho et al., 2012, Jeong et al., 2012, Yang and Terman, 2012, Sweeney et al., 2011, Wu et al., 2011, Wu et al., 2011, Bates and Whitington, 2007, Sousa-Neves et al., 2005, Grunwald and Klein, 2002, Terman et al., 2002, Terman et al., 2002, Hu et al., 2001, Whitford and Ghosh, 2001, Yu and Kolodkin, 1999, Winberg et al., 1998)
                                          plex
                                          (Locke et al., 1999, Locke et al., 1998)
                                          plex B
                                          (Zlatic et al., 2009)
                                          plexB
                                          (Fischer et al., 2024, Guajardo et al., 2019, Grice et al., 2018, Hernandez-Fleming et al., 2017, Meltzer et al., 2016, Dialynas et al., 2015, Joo et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Riddle et al., 2012, Shin and Diantonio, 2011, Carrillo et al., 2010, Deng et al., 2009, Tan et al., 2009, Bates and Whitington, 2007, Magalhaes et al., 2007, Stuart et al., 2007, Ayoob et al., 2006, Masly et al., 2006)
                                          Name Synonyms
                                          Plexin B
                                          Plexin-B
                                          (Govek et al., 2005)
                                          PlexinB
                                          (Vonhoff and Keshishian, 2017, Vonhoff and Keshishian, 2017)
                                          plexin
                                          (Locke et al., 2000)
                                          plexin B
                                          plexin and met-hepatocyte growth factor receptor-like
                                          (Locke et al., 1998)
                                          plexin-B
                                          (Driessens et al., 2001)
                                          plexinB
                                          (Hanlon and Andrew, 2016, Ismat et al., 2008, Masly et al., 2006)
                                          Secondary FlyBase IDs
                                          • FBgn0024198
                                          Datasets (0)
                                          Study focus (0)
                                          Experimental Role
                                          Project
                                          Project Type
                                          Title
                                          Study result (0)
                                          Result
                                          Result Type
                                          Title
                                          External Crossreferences and Linkouts ( 56 )
                                          Sequence Crossreferences
                                          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                          Other crossreferences
                                          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                          FlyMine - An integrated database for Drosophila genomics
                                          InterPro - A database of protein families, domains and functional sites
                                          KEGG Genes - Molecular building blocks of life in the genomic space.
                                          MARRVEL_MODEL - MARRVEL (model organism gene)
                                          Linkouts
                                          BioGRID - A database of protein and genetic interactions.
                                          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                          DroID - A comprehensive database of gene and protein interactions.
                                          DRSC - Results frm RNAi screens
                                          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                          Flygut - An atlas of the Drosophila adult midgut
                                          FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                                          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                                          MIST (genetic) - An integrated Molecular Interaction Database
                                          MIST (protein-protein) - An integrated Molecular Interaction Database
                                          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                          References (124)