FlyBase Gene Report: Hsap\HTT

(Farkas et al., 2023, Zsindely et al., 2023, Faragó et al., 2022, Yin et al., 2022, Chatterjee et al., 2021, Faragó et al., 2019, Lakra et al., 2019, Barbaro et al., 2015)

CEC

(Varga et al., 2019)

Hsap\HTT^Q48.ex1p.UAS

model of Huntington's disease

CEA

(Iijima-Ando et al., 2005)

Hsap\HTT^{171aa.138Q.UAS.Tag:HA}

model of Huntington's disease

CEA

(Arribat et al., 2013, Mugat et al., 2008)

Hsap\HTT^{UAS.103Q.mCherry}

model of Huntington's disease

CEA

(Poças et al., 2015)

model of neurodegenerative disease

CEA with Hsap\SNCA^UAS.EGFP

(Poças et al., 2015)

Hsap\HTT^{25Q.UAS.Cerulean}

model of Huntington's disease

CEA

(Recasens-Alvarez et al., 2021)

Hsap\HTT^{72Q.UAS.Emerald}

model of neurodegenerative disease

CEA

(Liu et al., 2018)

Hsap\HTT^{96Q.UAS.Cerulean}

model of Huntington's disease

CEA

(Lottes et al., 2024, Recasens-Alvarez et al., 2021)

Hsap\HTT^Q200.FL.UAS

model of Huntington's disease

CEA

(Greco et al., 2022, Onur et al., 2021, Al-Ramahi et al., 2017, Yao et al., 2015)

CEA with TEV\NIa^TEVp.UAS.cHa

(El-Daher et al., 2015)

Hsap\HTT^Q25.FL.UAS

model of Huntington's disease

CEA

(Chatterjee et al., 2021)

Hsap\HTT^{Q25.S13A.S16A.FL.UAS}

model of Huntington's disease

CEA

(Chatterjee et al., 2021)

Hsap\HTT^{Q25.S13D.S16D.FL.UAS}

model of Huntington's disease

CEA

(Chatterjee et al., 2021)

Hsap\HTT^{Q120.S13A.S16A.FL.UAS}

model of Huntington's disease

CEA

(Chatterjee et al., 2021)

Hsap\HTT^{Q120.S13D.S16D.FL.UAS}

model of Huntington's disease

CEA

(Chatterjee et al., 2021)

Hsap\HTT^Q25.ex1.UAS

model of Huntington's disease

CEA

(Chatterjee et al., 2021)

Hsap\HTT^{Q25.S13A.S16A.ex1.UAS}

model of Huntington's disease

CEA

(Chatterjee et al., 2021)

Hsap\HTT^{Q25.S13D.S16D.ex1.UAS}

model of Huntington's disease

CEA

(Chatterjee et al., 2021)

Hsap\HTT^Q50.ex1.UAS

model of Huntington's disease

CEA

(Lottes et al., 2024)

Hsap\HTT^{Q120.S13A.S16A.ex1.UAS}

model of Huntington's disease

CEA

(Chatterjee et al., 2021)

Hsap\HTT^{Q120.S13D.S16D.ex1.UAS}

model of Huntington's disease

CEA

(Chatterjee et al., 2021)

Hsap\HTT^118.Q120.UAS

model of Huntington's disease

CEA

(Chongtham et al., 2020)

Hsap\HTT^{171.Q120.UAS.Tag:HA}

model of Huntington's disease

CEA

(Chongtham et al., 2020)

Hsap\HTT^{171.Q120.UAS.Tag:CALI(TC)}

model of Huntington's disease

CEA

(Chongtham et al., 2020)

Hsap\HTT^{Q97.ex1.UAS.cAa}

model of Huntington's disease

CEA

(Ast et al., 2018)

Hsap\HTT^{Q100.UAS.mRFP(Unk)}

model of Huntington's disease

CEA

(Bason et al., 2019)

Hsap\HTT^GMR.Q75

model of Huntington's disease

CEA

(Jackson et al., 1998)

Hsap\HTT^GMR.Q120

model of Huntington's disease

CEA

(Haga-Yamanaka et al., 2024, Jimenez-Sanchez et al., 2015, Tamura et al., 2011, Underwood et al., 2010, Winslow et al., 2010, Wang et al., 2009, Ravikumar et al., 2008, Qi et al., 2007, Rusten et al., 2007, Hoshino et al., 2006, Jackson et al., 1998)

CEC

(Menzies et al., 2015, Takeuchi et al., 2015, Kuo et al., 2013, Bae et al., 2005)

CEC with Hsp110^UAS.cKa

(Kuo et al., 2013)

CEC with DnaJ-1^UAS.cKb

(Kuo et al., 2013)

CEC with Hsap\HSPA4L^UAS.cKa

(Kuo et al., 2013)

CEC with Hsap\DNAJB1^UAS.cKa

(Kuo et al., 2013)

CEC with CalpA^KK104532

(Menzies et al., 2015)

model of neurodegenerative disease

CEA

(Chan et al., 2000)

CEC

(Tonoki et al., 2009)

Hsap\HTT^Q93.ex1.UAS

model of Huntington's disease

CEA

(Oh et al., 2025, Lottes et al., 2024, Twyning et al., 2024, Campesan et al., 2023, Maurya and Tapadia, 2023, Onkar et al., 2023, Aditi et al., 2022, Dhankhar et al., 2022, Nandi et al., 2022, Rai and Tapadia, 2022, Singh and Agrawal, 2022, Xu et al., 2022, Khyati et al., 2021, Lin et al., 2021, Singh and Agrawal, 2021, Delfino et al., 2020, Vernizzi et al., 2020, Lin et al., 2019, Raj and Sarkar, 2019, Aron et al., 2018, Calpena et al., 2018, Dubey and Tapadia, 2018, Song et al., 2018, Zhang et al., 2018, Raj and Sarkar, 2017, Singh et al., 2017, Aditi et al., 2016, Breda et al., 2016, Chongtham and Agrawal, 2016, Ruetenik et al., 2016, Vicente Miranda et al., 2016, Besson et al., 2015, Varadarajan et al., 2015, Kumar et al., 2014, Maheshwari et al., 2014, Smith et al., 2014, O'Rourke et al., 2013, Xiao et al., 2013, Bodai et al., 2012, Dupont et al., 2012, Steinert et al., 2012, Campesan et al., 2011, Maher et al., 2011, Sleiman et al., 2011, Besson et al., 2010, Luthi-Carter et al., 2010, Menzies et al., 2010, Zhang et al., 2009, McLear et al., 2008, Mugat et al., 2008, Slepko et al., 2006, Agrawal et al., 2005, Lievens et al., 2005, Wolfgang et al., 2005, Steffan et al., 2001)

CEC

(Khalil et al., 2015, Vittori et al., 2014, Mason et al., 2013, Vashishtha et al., 2013, Sroka et al., 2009)

CEC with park¹

(Khalil et al., 2015)

CEC with Marf^RNAi.UAS.cUa

(Khalil et al., 2015)

CEC with porin^k05123

(Khalil et al., 2015)

model of neurodegenerative disease

CEA

(Richards et al., 2011, Mallik and Lakhotia, 2009, Liévens et al., 2008, Pallos et al., 2008, Wolfgang et al., 2005, Gunawardena et al., 2003, Steffan et al., 2001)

CEC

(Sajjad et al., 2014, Zhang et al., 2010, Sengupta and Lakhotia, 2006)

Hsap\HTT^{N548.Q128.UAS}

model of Huntington's disease

CEA

(Dubey et al., 2024, Nitta et al., 2023, Sharma et al., 2023, Prakash et al., 2022, Martin et al., 2021, Xu et al., 2019, Xu et al., 2019, Coelho et al., 2018, Akbergenova and Littleton, 2017, Gregory et al., 2017, Grima et al., 2017, Prakash et al., 2017, Arribat et al., 2013, Gohil et al., 2011, Rana et al., 2010, Ryoo et al., 2007, Lee et al., 2004)

CEC

(Lee et al., 2015, Godin et al., 2010)

CEA with TEV\NIa^TEVp.UAS.cHa

(El-Daher et al., 2015)

Hsap\HTT^Q97.ex1.UAS

model of Huntington's disease

CEA

(Huelsmeier et al., 2021, Saitoh et al., 2015, Steffan et al., 2004)

Hsap\HTT^NT.128Q.UAS

model of Huntington's disease

CEA

(Yao et al., 2015, Lu et al., 2014, Lu et al., 2013, Miller et al., 2012, Zhang et al., 2012, Al-Ramahi et al., 2007, Al-Ramahi et al., 2006)

Hsap\HTT^{Q108.ex1p.UAS}

model of Huntington's disease

CEA

(Iijima-Ando et al., 2005)

Hsap\HTT^{128Q.1-208.UAS}

model of Huntington's disease

CEA

(Gonzales et al., 2016, Gonzales and Yin, 2010)

Hsap\HTT^{128Q.1-336.UAS}

model of Huntington's disease

CEA

(Prange et al., 2024, Al-Ramahi et al., 2018, Al-Ramahi et al., 2017, Stroedicke et al., 2015, Shirasaki et al., 2012, Kaltenbach et al., 2007)

CEC

(Miller et al., 2010, Branco et al., 2008)

Hsap\HTT^{Q25.ex1.UAS.GFP}

model of Huntington's disease

CEA with Hsap\HTT^{Q91.ex1.QUAS.mCherry}

(Donnelly et al., 2020)

Hsap\HTT^{Q91.ex1.QUAS.mCherry}

model of Huntington's disease

CEA

(Davis et al., 2024, Pearce et al., 2015)

CEA with Hsap\HTT^{Q25.ex1.UAS.GFP}

(Donnelly et al., 2020)

CEA with Hsap\HTT^{Q138.ex1-12.QUAS.mRFP1}

(Donnelly et al., 2020)

Hsap\HTT^{Q91.ex1.UAS.mCherry}

model of Huntington's disease

CEA

(Donnelly et al., 2020)

Hsap\HTT^Q120.FL.UAS

model of Huntington's disease

CEA

(Chatterjee et al., 2021, Chongtham et al., 2020)

Hsap\HTT^Q120.ex1.UAS

model of Huntington's disease

CEA

(Chongtham et al., 2020)

Hsap\HTT^{Q138.ex1-12.QUAS.mRFP1}

model of Huntington's disease

CEA

(Donnelly et al., 2020)

CEA with Hsap\HTT^{Q91.ex1.QUAS.mCherry}

(Donnelly et al., 2020)

Hsap\HTT^{Q91.ex1.UAS.GFP}

model of Huntington's disease

CEA

(Davis et al., 2024)

Hsap\HTT^{Q97.ex1.UAS.mCherry}

model of Huntington's disease

CEA

(Branco-Santos et al., 2017)

Hsap\HTT^{Q97.T3D.ex1.UAS.mCherry}

model of Huntington's disease

CEA

(Branco-Santos et al., 2017)

Hsap\HTT^{Q97.S13D.ex1.UAS.mCherry}

model of Huntington's disease

CEA

(Branco-Santos et al., 2017)

Hsap\HTT^{Q97.S16D.ex1.UAS.mCherry}

model of Huntington's disease

CEA

(Branco-Santos et al., 2017)

Hsap\HTT^{Q97.T3A.ex1.UAS.mCherry}

model of Huntington's disease

CEA

(Branco-Santos et al., 2017)

Hsap\HTT^{Q97.S13A.ex1.UAS.mCherry}

model of Huntington's disease

CEA

(Branco-Santos et al., 2017)

Hsap\HTT^{Q97.S16A.ex1.UAS.mCherry}

model of Huntington's disease

CEA

(Branco-Santos et al., 2017)

Hsap\HTT^{Q72.ex1.UAS.cWa}

model of Huntington's disease

CEA

(Wen et al., 2020)

Hsap\HTT^{128Q.1-231.UAS}

model of Huntington's disease

CEA

(Hernandez et al., 2023, Reyes-Ortiz et al., 2023, Greco et al., 2022, Onur et al., 2021)

Hsap\HTT^{145Q.UAS.Tag:MYC}

model of Huntington's disease

CEA

(Xu et al., 2022)

Hsap\HTT^{Q46.ex1.UAS.IVS.EGFP}

model of Huntington's disease

CEA

(Drombosky et al., 2018)

Hsap\HTT^{Q97.ex1.UAS.IVS.EGFP}

model of Huntington's disease

CEA

(Drombosky et al., 2018)

Hsap\HTT^{ex1.βHP.UAS.IVS.mCh}

model of Huntington's disease

CEA

(Drombosky et al., 2018)

Hsap\HTT^{Q91.ex1.UAS.Tag:V5}

model of Huntington's disease

CEA

(Davis et al., 2024)

Hsap\HTT^{Q91.ex1.QUAS.GFP}

model of Huntington's disease

CEA

(Davis et al., 2024)

Hsap\HTT^{Q91.ex1.UAS.pHluorinE.tdTom}

model of Huntington's disease

CEA

(Davis et al., 2024)

Hsap\HTT^{Q120.UAS.Tag:HA}

model of Huntington's disease

CEA

(Lottes et al., 2024)

Hsap\HTT^{Q100.FL.167-586TEV.UAS.mCh}

model of Huntington's disease

CEA with TEV\NIa^TEVp.UAS.cHa

(El-Daher et al., 2015)

Hsap\HTT^{Q23.FL.167-586TEV.UAS.mCh}

model of Huntington's disease

CEA with TEV\NIa^TEVp.UAS.cHa

(El-Daher et al., 2015)

Hsap\HTT^{1722-3144.UAS.mCh}

model of Huntington's disease

CEA with TEV\NIa^TEVp.UAS.cHa

(El-Daher et al., 2015)

Hsap\HTT^{Q200.FL.167-586TEV.UAS}

model of Huntington's disease

CEA with TEV\NIa^TEVp.UAS.cHa

(El-Daher et al., 2015)

Hsap\HTT^{Q200.FL.586TEV.UAS}

model of Huntington's disease

CEA with TEV\NIa^TEVp.UAS.cHa

(El-Daher et al., 2015)

Hsap\HTT^{Q200.FL.167TEV.UAS}

model of Huntington's disease

CEA with TEV\NIa^TEVp.UAS.cHa

(El-Daher et al., 2015)

Hsap\HTT^Q127.UAS

model of Huntington's disease

CEA

(Singh et al., 2024)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 45 )

Allele

Disease

Interaction

References

Hsap\HTT^{Q46.ex1p.UAS.EGFP}

model of Huntington's disease

is ameliorated by CalpA^KK104532

(Menzies et al., 2015)

is ameliorated by CalpA^NIG.7563R

(Menzies et al., 2015)

is ameliorated by CalpA^NIG.18152R

(Menzies et al., 2015)

Hsap\HTT^{Q72.ex1p.UAS.EGFP}

model of amyloidosis

is ameliorated by unc-45^+t

(Melkani et al., 2013)

model of cardiomyopathy

is ameliorated by unc-45^+t

(Melkani et al., 2013)

model of Huntington's disease

is ameliorated by EDTP^GL01215

(Xiao and Qiu, 2019)

is ameliorated by EDTP^HMS01577

(Xiao and Qiu, 2019)

is ameliorated by Fmr1^GL00075

(Xu et al., 2019)

is ameliorated by Fmr1^HMS00248

(Xu et al., 2019)

Hsap\HTT^N548.Q0.UAS

ameliorates neurodegenerative disease

modeled by htt^RNAi.UAS

(Mugat et al., 2008)

ameliorates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Mugat et al., 2008)

modeled by Hsap\HTT^{171aa.138Q.UAS.Tag:HA}

(Mugat et al., 2008)

Hsap\HTT^Q20.ex1.UAS

exacerbates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Slepko et al., 2006)

Hsap\HTT^{Q103.ex1p.UAS.EGFP}

model of Huntington's disease

is ameliorated by EDTP^HMS01577

(Xiao et al., 2019)

is ameliorated by CG5001^UAS.Tag:HA

(Deo et al., 2024)

is ameliorated by P58IPK^UAS.Tag:HA

(Deo et al., 2024)

is ameliorated by Fmr1^GL00075

(Xu et al., 2019)

is ameliorated by Fmr1^HMS00248

(Xu et al., 2019)

Hsap\HTT^{Q15.UAS.mRFP1}

model of Huntington's disease

is exacerbated by Hip1^MI05905

(White et al., 2020)

Hsap\HTT^{Q138.UAS.mRFP1}

model of Huntington's disease

is ameliorated by Dfd⁶

(Weiss et al., 2012)

is ameliorated by Scr⁶

(Weiss et al., 2012)

is ameliorated by Scr^CP1

(Weiss et al., 2012)

is ameliorated by Ubx⁵¹

(Weiss et al., 2012)

is ameliorated by hzg^c02324

(Weiss et al., 2012)

is ameliorated by lab¹⁴

(Weiss et al., 2012)

is ameliorated by pb¹

(Weiss et al., 2012)

is ameliorated by Lkb1^4A4-2

(Schulte et al., 2011)

is ameliorated by orb2^UAS.A.EGFP

(Joag et al., 2020)

is ameliorated by orb2^UAS.B.EGFP

(Joag et al., 2020)

is exacerbated by orb2^RNAi.UAS.cUa

(Joag et al., 2020)

is ameliorated by Rab7^T22N.UAS

(Akbergenova and Littleton, 2017)

is ameliorated by Snx16^Δ1

(Akbergenova and Littleton, 2017)

is ameliorated by Snx16^Δ2

(Akbergenova and Littleton, 2017)

is ameliorated by gbb¹

(Akbergenova and Littleton, 2017)

is ameliorated by gbb²

(Akbergenova and Littleton, 2017)

is ameliorated by InR^UAS.Exel

(Tandon and Sarkar, 2021, Raj and Sarkar, 2019)

is ameliorated by Pi3K92E^CAAX.UAS

(Hansen et al., 2019)

is exacerbated by Pi3K92E^{D954A.UAS.Tag:MYC}

(Hansen et al., 2019)

is ameliorated by Nmnat^UAS.cZa

(Zhu et al., 2019)

is exacerbated by Nmnat^unspecified

(Zhu et al., 2019)

is ameliorated by Atx2^{KI.ΔcIDR-GFP}

(Huelsmeier et al., 2021)

is ameliorated by Hsap\HSPA1L^UAS.cWa

(Swinter et al., 2023)

is ameliorated by comt^KK104679

(Babcock and Ganetzky, 2015)

is ameliorated by Hsap\MYC^UAS.2

(Raj and Sarkar, 2017)

is ameliorated by Mmus\Bdnf^UAS.cHa

(Hana et al., 2024)

is ameliorated by Hsap\HIP1^UAS.Tag:HA

(Singh et al., 2024)

is ameliorated by mrj^UAS.cUa

(Singh et al., 2024)

Hsap\HTT^{Q138.UAS.EGFP,mRFP1}

model of Huntington's disease

is ameliorated by Myc^UAS.cZa

(Singh et al., 2014)

Hsap\HTT^Q96.UAS.GFP

model of Huntington's disease

is ameliorated by Rack1^KK109073

(Xie et al., 2021)

Hsap\HTT^{98Q.Ex1.UAS.EGFP.Tag:NLS(Unk)}

model of Huntington's disease

is ameliorated by Nup160^GD11413

(Doumanis et al., 2009)

is ameliorated by kri^GD11686

(Doumanis et al., 2009)

Hsap\HTT^103Q.Ex1.UAS

model of Huntington's disease

is ameliorated by Irbp^KK101447

(Tamura et al., 2011)

model of neurodegenerative disease

is ameliorated by TER94^GS10258

(Fujita et al., 2013)

Hsap\HTT^90.Q120.UAS

model of Huntington's disease

is ameliorated by His3.3A^{K14Q.UAS.Tag:FLAG}

(Faragó et al., 2022)

is exacerbated by His3.3A^{K14R.UAS.Tag:FLAG}

(Faragó et al., 2022)

is exacerbated by His3.3A^{K27Q.UAS.Tag:FLAG}

(Faragó et al., 2022)

is exacerbated by His3.3A^{K27R.UAS.Tag:FLAG}

(Faragó et al., 2022)

is ameliorated by His3.3A^{K9M.UAS.Tag:FLAG}

(Faragó et al., 2022)

is exacerbated by His3.3A^{K9Q.UAS.Tag:FLAG}

(Faragó et al., 2022)

is exacerbated by His3.3A^{K9R.UAS.Tag:FLAG}

(Faragó et al., 2022)

is ameliorated by Hat1^Δ57

(Varga et al., 2019)

is ameliorated by Yod1^UAS.Tag:FLAG

(Farkas et al., 2023)

is exacerbated by mir-1010^UAS.cSa

(Zsindely et al., 2023)

is ameliorated by mir-1010^UAS.cSa

(Zsindely et al., 2023)

is ameliorated by mir-137^UAS.cSa

(Zsindely et al., 2023)

is exacerbated by mir-219^UAS.cSb

(Zsindely et al., 2023)

is ameliorated by mir-305^UAS.pLUC

(Zsindely et al., 2023)

is ameliorated by Crtc^UAS.Tag:HA

(Yin et al., 2022)

Hsap\HTT^Q48.ex1p.UAS

model of Huntington's disease

is ameliorated by Hsc70-4^K71S.UAS

(Iijima-Ando et al., 2005)

is ameliorated by Mmus\Prkaca^hs.PJ

(Iijima-Ando et al., 2005)

is exacerbated by CrebB^S162

(Iijima-Ando et al., 2005)

Hsap\HTT^{171aa.138Q.UAS.Tag:HA}

model of Huntington's disease

is ameliorated by en^VP16.UAS

(Mugat et al., 2008)

is ameliorated by en^UAS.cTa

(Mugat et al., 2008)

is exacerbated by htt^RNAi.UAS

(Mugat et al., 2008)

is ameliorated by htt^{620aa.UAS.Tag:MYC}

(Mugat et al., 2008)

is ameliorated by Hsap\HTT^N548.Q0.UAS

(Mugat et al., 2008)

is ameliorated by ttk⁸⁰⁴

(Mugat et al., 2008)

is ameliorated by Hsap\HTT^P42.UAS.GFP

(Arribat et al., 2013)

Hsap\HTT^{25Q.UAS.Cerulean}

model of Huntington's disease

is exacerbated by RpS23^R67K

(Recasens-Alvarez et al., 2021)

Hsap\HTT^{72Q.UAS.Emerald}

model of neurodegenerative disease

is exacerbated by Tom40^GD5210

(Liu et al., 2018)

Hsap\HTT^Q200.FL.UAS

model of Huntington's disease

is ameliorated by DopEcR^KK111211

(Yao et al., 2015)

is ameliorated by PIP4K²⁹

(Al-Ramahi et al., 2017)

is ameliorated by PIP4K^RNAi.UAS.cUa

(Al-Ramahi et al., 2017)

is ameliorated by CRMP^GD4716

(Greco et al., 2022)

is ameliorated by Cont^GD12610

(Greco et al., 2022)

is ameliorated by GluRIA^GD3582

(Greco et al., 2022)

is exacerbated by Rop^RNAi.UAS.cUa

(Greco et al., 2022)

is exacerbated by SERCA^KK107371

(Greco et al., 2022)

is exacerbated by Vha36-3^KK112552

(Greco et al., 2022)

is ameliorated by Vha68-3^GD11527

(Greco et al., 2022)

is exacerbated by VhaAC39-1^GD9859

(Greco et al., 2022)

is ameliorated by arm⁸

(Greco et al., 2022)

is exacerbated by arm^UAS.Exel

(Greco et al., 2022)

Hsap\HTT^171.Q120.UAS

ameliorates Huntington's disease

modeled by Hsap\HTT^Q120.FL.UAS

(Chongtham et al., 2020)

Hsap\HTT^{Q97.ex1.UAS.cAa}

model of Huntington's disease

is ameliorated by Hsap\HSPA1L^UAS.cWa

(Ast et al., 2018)

Hsap\HTT^{Q100.UAS.mRFP(Unk)}

model of Huntington's disease

is ameliorated by Hsap\DNAJB6^UAS.Tag:V5

(Bason et al., 2019)

is ameliorated by Hsap\DNAJB6^{lexAop.Tag:V5}

(Bason et al., 2019)

Hsap\HTT^GMR.Q120

model of Huntington's disease

is exacerbated by Rab5^UAS.EGFP

(Ravikumar et al., 2008)

is exacerbated by Hsap\SNCA^UAS.cFa

(Winslow et al., 2010)

is ameliorated by Hsap\YAP1^ΔC61.UAS

(Hoshino et al., 2006)

is exacerbated by Vps25^A3

(Rusten et al., 2007)

is exacerbated by Vps28^D2

(Rusten et al., 2007)

is exacerbated by shrb^G5

(Rusten et al., 2007)

is ameliorated by Irbp^KK101447

(Tamura et al., 2011)

is ameliorated by Atg1^{ninaE.Tag:MYC}

(Wang et al., 2009)

is ameliorated by Tsc1^UAS.cGa

(Wang et al., 2009)

is ameliorated by Atg1^{W.Scer\UAS.T:Hsap\MYC}

(Wang et al., 2009)

is ameliorated by gig^UAS.cTa

(Wang et al., 2009)

is ameliorated by QC^GD6767

(Jimenez-Sanchez et al., 2015)

is ameliorated by isoQC^KK108983

(Jimenez-Sanchez et al., 2015)

is ameliorated by QC^KK109667

(Jimenez-Sanchez et al., 2015)

is ameliorated by Hsap\HTT^GMR.Q120

(Takeuchi et al., 2015)

is ameliorated by DnaJ-1^UAS.cTa

(Takeuchi et al., 2015)

is ameliorated by p53^5A-1-4

(Bae et al., 2005)

is ameliorated by DnaJ-1^UAS.cKb

(Kuo et al., 2013)

is ameliorated by CalpA^KK104532

(Menzies et al., 2015)

is exacerbated by Rnor\Hmgb1^UAS.cQa

(Qi et al., 2007)

is exacerbated by Psa^NIG.1009R

(Menzies et al., 2010)

is ameliorated by Psa^GMR.Ex.PK

(Menzies et al., 2010)

is ameliorated by Hsap\ATXN3^{fl.Q27.UAS.Tag:MYC}

(Warrick et al., 2005)

model of neurodegenerative disease

is ameliorated by DnaJ-1^UAS.Tag:FLAG

(Chan et al., 2000)

is ameliorated by Hsap\HSPA1L^UAS.cWa

(Chan et al., 2000)

is exacerbated by Rpn11^RNAi.UAS

(Tonoki et al., 2009)

is ameliorated by Rpn11^UAS.cTa

(Tonoki et al., 2009)

is exacerbated by Trpml¹

(Venkatachalam et al., 2008)

ameliorates Huntington's disease

modeled by Hsap\HTT^GMR.Q120

(Takeuchi et al., 2015)

Hsap\HTT^Q93.ex1.UAS

model of Huntington's disease

is ameliorated by Sirt2^5B-2-35

(Luthi-Carter et al., 2010)

is ameliorated by Hsap\SLC8B1^UAS.cTa

(Twyning et al., 2024)

is exacerbated by Itpr^90B.0

(Twyning et al., 2024)

is ameliorated by MCU¹

(Twyning et al., 2024)

is ameliorated by Axn^UAS.cUa

(Dupont et al., 2012)

is ameliorated by Wnt2^I

(Dupont et al., 2012)

is ameliorated by Wnt2^RJ

(Dupont et al., 2012)

is ameliorated by pan³

(Dupont et al., 2012)

is ameliorated by arm³

(Dupont et al., 2012)

is ameliorated by arm^G0192

(Dupont et al., 2012)

is exacerbated by arm^{S10.UAS.Tag:MYC}

(Dupont et al., 2012)

is ameliorated by pan²

(Dupont et al., 2012)

is ameliorated by wg¹

(Dupont et al., 2012)

is ameliorated by wg^Sp-1

(Dupont et al., 2012)

is ameliorated by Wnt2^O

(Dupont et al., 2012)

is ameliorated by Apc2^UAS.cUa

(Dupont et al., 2012)

is exacerbated by sgg^UAS.cBa

(Dupont et al., 2012)

is exacerbated by sgg^S9A.UAS

(Dupont et al., 2012)

is ameliorated by sgg^Y214F.UAS

(Dupont et al., 2012)

is ameliorated by G6pd^UAS.cLa

(Besson et al., 2015)

is ameliorated by Pfk^UAS.cTa

(Besson et al., 2015)

is ameliorated by Hsap\SLC2A3^UAS.cBa

(Besson et al., 2015)

is ameliorated by jp^UAS

(Calpena et al., 2018)

is exacerbated by jp^KK107921

(Calpena et al., 2018)

is ameliorated by Sirt1¹⁷

(Smith et al., 2014)

is exacerbated by Sirt1¹⁷

(Smith et al., 2014)

is ameliorated by htt^81aa.UAS

(Mugat et al., 2008)

is ameliorated by Hsap\HTT^N548.Q0.UAS

(Mugat et al., 2008)

is ameliorated by cd¹

(Campesan et al., 2011)

is ameliorated by cn³

(Campesan et al., 2011)

is ameliorated by cn^KK101938

(Campesan et al., 2011)

is ameliorated by v^KK108195

(Campesan et al., 2011)

is ameliorated by v^36f

(Campesan et al., 2011)

is exacerbated by htt^98E2

(Zhang et al., 2009)

is exacerbated by Hsap\HTT^Q20.ex1.UAS

(Slepko et al., 2006)

is ameliorated by Hsap\HTT^{C4sFv.UAS.Tag:HA}

(Wolfgang et al., 2005)

is ameliorated by Zzzz\scFv^{C4.UAS.Tag:HA}

(McLear et al., 2008, Wolfgang et al., 2005)

is ameliorated by Bmcp^UAS.cBa

(Besson et al., 2010)

is ameliorated by Hsap\UCP2^UAS.cFa

(Besson et al., 2010)

is ameliorated by Glut1^UAS.cBa

(Besson et al., 2010)

is ameliorated by Ctr1B^NIG.7459R

(Xiao et al., 2013)

is ameliorated by ATP7^EY07895

(Xiao et al., 2013, Cao et al., 2008)

is exacerbated by ATP7^GD3322

(Xiao et al., 2013)

is ameliorated by Rab11^UAS.EGFP

(Steinert et al., 2012)

is ameliorated by Psa^UAS.cSa

(Menzies et al., 2010)

is exacerbated by Psa^NIG.1009R

(Menzies et al., 2010)

is ameliorated by mav^GL01025

(Varadarajan et al., 2015)

is exacerbated by Hsf^GD16368

(Maheshwari et al., 2014)

is ameliorated by Hsap\KYAT1^{IVS.10xUAS.GFP}

(Breda et al., 2016)

is exacerbated by v^36f

(Breda et al., 2016)

is NOT ameliorated by Gcn5^UAS.cBa

(Bodai et al., 2012)

is exacerbated by Gcn5^E333st

(Bodai et al., 2012)

is exacerbated by nej³

(Bodai et al., 2012)

is NOT exacerbated by mof²

(Bodai et al., 2012)

is NOT exacerbated by enok²

(Bodai et al., 2012)

is ameliorated by Mmus\Bag1^UAS.Tag:FLAG

(Sroka et al., 2009)

is ameliorated by Kdm5¹⁰⁴²⁴

(Vashishtha et al., 2013)

is ameliorated by Mmus\Gpx1^UAS.cMa

(Mason et al., 2013)

is ameliorated by Glut1^d05758

(Vittori et al., 2014)

is exacerbated by Glut1^17J

(Vittori et al., 2014)

is exacerbated by Glut1^KK108683

(Vittori et al., 2014)

is exacerbated by Drp1^UAS.cDa

(Khalil et al., 2015)

is ameliorated by Pink1^UAS.Tag:HA

(Khalil et al., 2015)

is ameliorated by InR^UAS.Exel

(Raj and Sarkar, 2019)

is ameliorated by Rab8^{Q67L.UASp.YFP}

(Delfino et al., 2020)

is exacerbated by Rab8^{T22N.UASp.YFP}

(Delfino et al., 2020)

is ameliorated by Rab8^UASp.YFP

(Delfino et al., 2020)

is exacerbated by Usp12-46^KK108313

(Aron et al., 2018)

is ameliorated by Usp12-46^UAS.cAa

(Aron et al., 2018)

is ameliorated by Hsap\HSPA1L^UAS.cWa

(McLear et al., 2008)

is ameliorated by Su(var)2-10^zimp-2

(O'Rourke et al., 2013)

is ameliorated by srl^UAS.cTa

(Ruetenik et al., 2016)

is ameliorated by Sin3A⁰⁸²⁶⁹

(Steffan et al., 2001)

is ameliorated by trr³

(Song et al., 2018)

is exacerbated by E(z)⁶³

(Song et al., 2018)

is exacerbated by E(z)⁷³¹

(Song et al., 2018)

is ameliorated by trx¹

(Song et al., 2018)

is ameliorated by Jarid2^MB00996

(Song et al., 2018)

is ameliorated by Kdm4A^KG04636

(Song et al., 2018)

is ameliorated by Set2^RNAi.UAS

(Song et al., 2018)

is ameliorated by Utx¹

(Song et al., 2018)

is ameliorated by Utx²

(Song et al., 2018)

is exacerbated by ash1²²

(Song et al., 2018)

is exacerbated by esc⁵

(Song et al., 2018)

is exacerbated by gpp^XXV

(Song et al., 2018)

is exacerbated by gpp^X

(Song et al., 2018)

is ameliorated by trr¹

(Song et al., 2018)

is ameliorated by Kdm2^DG12810

(Song et al., 2018)

is ameliorated by Su(var)3-3^GD9296

(Song et al., 2018)

is exacerbated by Hsap\PPM1B^UAS.Tag:HA

(Nandi et al., 2022)

is ameliorated by Nil^HMC06011

(Nandi et al., 2022)

is exacerbated by Glo1^KK109109

(Vicente Miranda et al., 2016)

is exacerbated by Tpi^GD10138

(Vicente Miranda et al., 2016)

is ameliorated by Hsap\MYC^UAS.1

(Raj and Sarkar, 2017)

is ameliorated by Hsap\MYC^UAS.2

(Raj and Sarkar, 2017)

is ameliorated by Hsap\MYC^UAS.S

(Raj and Sarkar, 2017)

is ameliorated by Hsc70-4^HMS00152

(Rai and Tapadia, 2022)

is ameliorated by Hsc70-4^JF03136

(Rai and Tapadia, 2022)

is exacerbated by Hsc70-4^UAS.cEa

(Rai and Tapadia, 2022)

is ameliorated by Gs1^G3347

(Vernizzi et al., 2020)

is exacerbated by Gs1^HMS02002

(Vernizzi et al., 2020)

is ameliorated by Adgf-A^HMC06334

(Lin et al., 2021)

is ameliorated by Adgf-A^UAS.Tag:MYC

(Lin et al., 2021)

is ameliorated by Adgf-D^HMC04420

(Lin et al., 2021)

is ameliorated by Adk2^HMC05509

(Lin et al., 2021)

is ameliorated by Adk2^UAS.cPa

(Lin et al., 2021)

is ameliorated by AdoR^JF02687

(Lin et al., 2021)

is exacerbated by AdoR^UAS.cPa

(Lin et al., 2021)

is ameliorated by Ent1^HMJ21190

(Lin et al., 2021)

is ameliorated by Ent2^KK104419

(Lin et al., 2021)

is exacerbated by Ent2^UAS.cLa

(Lin et al., 2021)

is ameliorated by mod(mdg4)^HMS00795

(Lin et al., 2021)

is ameliorated by SERCA^KG00570

(Maurya and Tapadia, 2023)

is ameliorated by SERCA^RNAi.UAS.cUa

(Maurya and Tapadia, 2023)

is ameliorated by SERCA^RNAi.UAS.cUa

(Maurya and Tapadia, 2023)

is ameliorated by park^UAS.cGa

(Campesan et al., 2023)

is ameliorated by Cint\AOX^UAS.cFa

(Campesan et al., 2023)

is ameliorated by Drp1^UAS.cDa

(Campesan et al., 2023)

is ameliorated by Marf^KK105681

(Campesan et al., 2023)

is ameliorated by Pink1^UAS.cCa

(Campesan et al., 2023)

is ameliorated by Pink1^UAS.cUa

(Campesan et al., 2023)

is ameliorated by Scer\NDI1^UAS.cSa

(Campesan et al., 2023)

is ameliorated by park^{T187A.UAS.Tag:MYC}

(Campesan et al., 2023)

is ameliorated by Hsap\GYS1^9A.UAS

(Onkar et al., 2023)

is ameliorated by Hsap\GYS1^UAS.wt

(Onkar et al., 2023)

is ameliorated by Cul1^GL00561

(Lottes et al., 2024)

is ameliorated by Hsap\PEX19^{FV.UAS.Tag:HA}

(Oh et al., 2025)

is ameliorated by MESR4^EP386

(Cao et al., 2008)

is exacerbated by Tl^EP1051

(Cao et al., 2008)

is ameliorated by svr^EP356

(Cao et al., 2008)

is exacerbated by SNF4Aγ^EP3015b

(Cao et al., 2008)

is ameliorated by g^EP514

(Cao et al., 2008)

is exacerbated by SNF4Aγ^KG10152

(Cao et al., 2008)

is ameliorated by mub^EP3108

(Cao et al., 2008)

is ameliorated by Sumo^unspecified

(Steffan et al., 2004)

is exacerbated by Ubi-p63E^unspecified

(Steffan et al., 2004)

is ameliorated by Hsap\HTT^P42.UAS.GFP

(Arribat et al., 2013)

is ameliorated by Hsap\HTT^{P42.UAS.Tag:MYC}

(Arribat et al., 2013)

model of neurodegenerative disease

is ameliorated by Hsap\HTT^{C4sFv.UAS.Tag:HA}

(Wolfgang et al., 2005)

is ameliorated by Zzzz\scFv^{C4.UAS.Tag:HA}

(Wolfgang et al., 2005)

is exacerbated by Khc⁹

(Gunawardena et al., 2003)

is ameliorated by lncRNA:Hsrω^RNAi.Sym.UAS

(Mallik and Lakhotia, 2009)

is ameliorated by Sirt1¹⁷

(Pallos et al., 2008)

is ameliorated by HDAC1^5-5

(Pallos et al., 2008)

is ameliorated by Sirt2^5B-2-35

(Pallos et al., 2008)

is ameliorated by Sin3A⁰⁸²⁶⁹

(Steffan et al., 2001)

is NOT ameliorated by rl^Sem.C.UAS

(Liévens et al., 2008)

is ameliorated by Tpr2^UAS.cKa

(Liévens et al., 2008)

is ameliorated by DnaJ-1^UAS.cKa

(Liévens et al., 2008)

is ameliorated by mrj^UAS.cFa

(Liévens et al., 2008)

is ameliorated by Hsap\HSPA1L^UAS.cWa

(Liévens et al., 2008)

is ameliorated by Akt^UAS.Exel

(Liévens et al., 2008)

is ameliorated by Rab11^UAS.EGFP

(Richards et al., 2011)

is exacerbated by lncRNA:Hsrω⁰⁵²⁴¹

(Sengupta and Lakhotia, 2006)

is exacerbated by Hsp110⁰⁰⁰⁸²

(Zhang et al., 2010)

is exacerbated by Hsp110^S064906

(Zhang et al., 2010)

is ameliorated by Hsp110^UAS.cZa

(Zhang et al., 2010)

is exacerbated by Hsp110^S031820

(Zhang et al., 2010)

is exacerbated by Hsp110^S004112

(Zhang et al., 2010)

is exacerbated by Nipped-A^NC116

(Zhang et al., 2010)

is exacerbated by Nipped-A^NC186

(Zhang et al., 2010)

is ameliorated by DJ-1α^UAS.cMa

(Sajjad et al., 2014)

is ameliorated by yki^UAS.cHa

(Dubey and Tapadia, 2018)

is exacerbated by yki^RNAi.UAS.cUa

(Dubey and Tapadia, 2018)

Hsap\HTT^{N548.Q128.UAS}

exacerbates neurodegenerative disease

modeled by dsh^Q108.UAS

(Lee et al., 2004)

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Lee et al., 2004)

model of Huntington's disease

is ameliorated by slmb^UAS.cGa

(Godin et al., 2010)

is exacerbated by rho-5^KO1

(Lee et al., 2015)

is ameliorated by rho-5^UAS.cZa

(Lee et al., 2015)

is ameliorated by Hsap\RHBDF1^UAS.cLa

(Lee et al., 2015)

is ameliorated by Atx2^KK100423

(Xu et al., 2019)

is exacerbated by Atx2^UAS.Tag:FLAG

(Xu et al., 2019)

is ameliorated by CrebA^JF02189

(Xu et al., 2019)

is ameliorated by Fmr1^GL00075

(Xu et al., 2019)

is ameliorated by Fmr1^HMS00248

(Xu et al., 2019)

is ameliorated by Atx2^HMS02726

(Xu et al., 2019)

is ameliorated by Atx2^HMS01392

(Xu et al., 2019)

is ameliorated by Hsap\HTT^P42.UAS.GFP

(Arribat et al., 2013)

is ameliorated by Hsap\HTT^{P42.UAS.Tag:MYC}

(Arribat et al., 2013)

is exacerbated by CrebB^JF02494

(Martin et al., 2021)

is ameliorated by Hsap\DNAJB1^UAS.cKa

(Prakash et al., 2022, Martin et al., 2021)

is ameliorated by Hsp68^UAS.cUa

(Martin et al., 2021)

is ameliorated by InR^K1409A.UAS

(Martin et al., 2021)

is ameliorated by Itpr^JF01957

(Martin et al., 2021)

is ameliorated by Pten^UAS.cUa

(Martin et al., 2021)

is ameliorated by Pyk^GL00099

(Martin et al., 2021)

is exacerbated by Rab5^KK102895

(Martin et al., 2021)

is ameliorated by Rab5^UAS.EGFP

(Martin et al., 2021)

is ameliorated by SERCA^HMS02878

(Martin et al., 2021)

is ameliorated by SERCA^JF01948

(Martin et al., 2021)

is ameliorated by foxo^UAS.cUa

(Martin et al., 2021)

is ameliorated by kto^HMS01062

(Martin et al., 2021)

is ameliorated by nej^GD8975

(Martin et al., 2021)

is ameliorated by nej^HMS01507

(Martin et al., 2021)

is ameliorated by nej^KK113191

(Martin et al., 2021)

is ameliorated by nej^RNAi.UAS.cSa

(Martin et al., 2021)

is ameliorated by pan^ΔN.UAS

(Martin et al., 2021)

is ameliorated by pygo^KK108114

(Martin et al., 2021)

is ameliorated by CG42306^GD11667

(Martin et al., 2021)

is ameliorated by Hsp110^UAS.cKa

(Martin et al., 2021)

is ameliorated by foxo^TM.UAS

(Martin et al., 2021)

is ameliorated by srl^EY05931

(Martin et al., 2021)

is ameliorated by Atg8a^UAS.GFP

(Sharma et al., 2023, Prakash et al., 2022)

is ameliorated by Clk^Jrk

(Xu et al., 2019)

is ameliorated by Stip1^HMS00779

(Xu et al., 2019)

is ameliorated by Stip1^HMS00965

(Xu et al., 2019)

is ameliorated by DnaJ-1^UAS.cKa

(Prakash et al., 2022)

is ameliorated by Hsap\HSPA1L^UAS.cWa

(Prakash et al., 2022)

is ameliorated by Hsc70-4^K71S.UAS

(Prakash et al., 2022)

is ameliorated by Hsp23^UAS.cKa

(Prakash et al., 2022)

is ameliorated by Atg5^UASp.EGFP

(Prakash et al., 2022)

is exacerbated by Ran^{T24N.UASp.Tag:HA}

(Grima et al., 2017)

is ameliorated by Ran^UASp.Tag:HA

(Grima et al., 2017)

Hsap\HTT^Q97.ex1.UAS

model of Huntington's disease

is exacerbated by ref(2)P^RNAi.UAS.cUa

(Saitoh et al., 2015)

is ameliorated by Atx2^{KI.ΔcIDR-GFP}

(Huelsmeier et al., 2021)

is exacerbated by Tbp^sI10

(Hsu et al., 2014)

is exacerbated by Tbp^UAS.cHa

(Hsu et al., 2014)

Hsap\HTT^NT.128Q.UAS

model of Huntington's disease

is ameliorated by S-Lap1^GD11904

(Lu et al., 2013)

is exacerbated by CG15445^KK104296

(Lu et al., 2013)

is ameliorated by Pvf1^d06222

(Lu et al., 2013)

is exacerbated by Pvf1^KG01713

(Lu et al., 2013)

is exacerbated by Sec61β⁰⁷²¹⁴

(Lu et al., 2013)

is exacerbated by Sec61γ^RNAi.UAS.cUa

(Lu et al., 2013)

is ameliorated by Hsap\NUB1^UAS.cLa

(Lu et al., 2013)

is ameliorated by Hsap\STUB1^UAS.cAa

(Al-Ramahi et al., 2006)

is ameliorated by Dgkε^GD1964

(Zhang et al., 2012)

is exacerbated by GAPcenA^f01044

(Yao et al., 2015)

is ameliorated by DopEcR^KK111211

(Yao et al., 2015)

is ameliorated by DopEcR^MI02790

(Yao et al., 2015)

is exacerbated by GAPcenA^KK101516

(Yao et al., 2015)

is ameliorated by tefu^atm-6

(Lu et al., 2014)

is ameliorated by Dsor1^S-1221

(Miller et al., 2012)

is ameliorated by Dsor1^GD9123

(Miller et al., 2012)

is ameliorated by Raf^GD9831

(Miller et al., 2012)

is ameliorated by Ras64B^GD1517

(Miller et al., 2012)

is ameliorated by dod^GD9274

(Miller et al., 2012)

is ameliorated by polo⁰¹⁶⁷³

(Miller et al., 2012)

Hsap\HTT^128Q.FL.UAS

model of Huntington's disease

is ameliorated by Ca-α1D^X10

(Romero et al., 2008)

is ameliorated by Syx1A^Δ229

(Romero et al., 2008)

is ameliorated by αSnap^M4

(Romero et al., 2008)

is ameliorated by cac^HC129

(Romero et al., 2008)

is ameliorated by Rop^G27

(Romero et al., 2008)

is ameliorated by Hap40^ko3

(Xu et al., 2022)

is ameliorated by Tip60^UAS.cUa

(Beaver et al., 2020)

is ameliorated by nbs¹

(Tuxworth et al., 2019)

is ameliorated by Su(var)205^UASp.cCa

(Casale et al., 2022)

is ameliorated by Su(var)3-9^UAS.EGFP

(Casale et al., 2022)

is ameliorated by Hsap\PRMT6^UAS.cSa

(Migazzi et al., 2021)

is ameliorated by Rab4^{UAS.mRFP(Unk)}

(White et al., 2020)

is ameliorated by Rac1^V12.UAS

(Vu et al., 2018)

is exacerbated by Pdk1^JF02807

(Na et al., 2023)

Hsap\HTT^{128Q.1-208.UAS}

model of Huntington's disease

is ameliorated by Pka-C2^KK110127

(Gonzales et al., 2016)

is ameliorated by Pka-C1^KK108966

(Gonzales et al., 2016)

is ameliorated by Pka-R1^BDK.UAS

(Gonzales et al., 2016)

Hsap\HTT^{128Q.1-336.UAS}

model of Huntington's disease

is exacerbated by M6^EY07032

(Kaltenbach et al., 2007)

is ameliorated by hts⁰¹¹⁰³

(Kaltenbach et al., 2007)

is exacerbated by Itpr^EY02522

(Kaltenbach et al., 2007)

is ameliorated by arm³

(Kaltenbach et al., 2007)

is ameliorated by arm^G0192

(Kaltenbach et al., 2007)

is ameliorated by Gpdh1^n1-5

(Kaltenbach et al., 2007)

is ameliorated by ND-PDSW^k10101

(Kaltenbach et al., 2007)

is exacerbated by zip⁰²⁹⁵⁷

(Kaltenbach et al., 2007)

is exacerbated by Gαi^EY10355

(Kaltenbach et al., 2007)

is ameliorated by Gαi^KG01907

(Kaltenbach et al., 2007)

is ameliorated by Itpr⁰⁵⁶¹⁶

(Kaltenbach et al., 2007)

is exacerbated by Dhc64C^4-19

(Kaltenbach et al., 2007)

is exacerbated by Asph^KG09881

(Kaltenbach et al., 2007)

is exacerbated by LamC^k11904

(Kaltenbach et al., 2007)

is ameliorated by αSnap^I1

(Kaltenbach et al., 2007)

is ameliorated by αSnap^M4

(Kaltenbach et al., 2007)

is ameliorated by faf^EP381

(Kaltenbach et al., 2007)

is ameliorated by porin^k05123

(Al-Ramahi et al., 2018, Kaltenbach et al., 2007)

is exacerbated by CLIP-190^KG07837

(Kaltenbach et al., 2007)

is ameliorated by Khc⁸

(Kaltenbach et al., 2007)

is exacerbated by Pgi²

(Kaltenbach et al., 2007)

is ameliorated by Eip75B^BG02576

(Kaltenbach et al., 2007)

is ameliorated by pnut^XP

(Kaltenbach et al., 2007)

is ameliorated by Rpt1^43Ed-1

(Kaltenbach et al., 2007)

is exacerbated by zip^IIX62

(Kaltenbach et al., 2007)

is exacerbated by shot³

(Kaltenbach et al., 2007)

is ameliorated by Eip75B^KG09026

(Kaltenbach et al., 2007)

is ameliorated by Ca-Ma2d^KG00260

(Kaltenbach et al., 2007)

is exacerbated by crol⁰⁴⁴¹⁸

(Kaltenbach et al., 2007)

is exacerbated by Pgi^nNC1

(Kaltenbach et al., 2007)

is exacerbated by faf^BX4

(Kaltenbach et al., 2007)

is exacerbated by Syx1A^EP3215

(Kaltenbach et al., 2007)

is ameliorated by arm^G0234

(Kaltenbach et al., 2007)

is exacerbated by Asph^ZCL1605

(Kaltenbach et al., 2007)

is exacerbated by shot^65-2

(Kaltenbach et al., 2007)

is exacerbated by CAP^KG00308

(Kaltenbach et al., 2007)

is exacerbated by Unc-76^G0423a

(Kaltenbach et al., 2007)

is exacerbated by 14-3-3ζ^EY06147

(Kaltenbach et al., 2007)

is ameliorated by pnut^KG00478

(Kaltenbach et al., 2007)

is ameliorated by porin^f03616

(Kaltenbach et al., 2007)

is ameliorated by αSnap^G8

(Kaltenbach et al., 2007)

is ameliorated by Mef2^KG01211a

(Kaltenbach et al., 2007)

is exacerbated by Lac^BG01462

(Kaltenbach et al., 2007)

is ameliorated by Mef2^X1

(Kaltenbach et al., 2007)

is exacerbated by Rpt1^EP2153

(Kaltenbach et al., 2007)

is ameliorated by Syx1A⁰⁶⁷³⁷

(Kaltenbach et al., 2007)

is ameliorated by Gpdh1^n1-4

(Kaltenbach et al., 2007)

is ameliorated by hts^k06121

(Kaltenbach et al., 2007)

is ameliorated by 14-3-3ε^j2B10

(Branco et al., 2008, Kaltenbach et al., 2007)

is ameliorated by hts^KG06777

(Kaltenbach et al., 2007)

is exacerbated by 14-3-3ε^UAS.cCa

(Branco et al., 2008, Kaltenbach et al., 2007)

is ameliorated by Chc¹

(Kaltenbach et al., 2007)

is exacerbated by CLIP-190^KG06490

(Kaltenbach et al., 2007)

is ameliorated by αSnap^P2

(Kaltenbach et al., 2007)

is exacerbated by Dhc64C^KG08838

(Kaltenbach et al., 2007)

is ameliorated by arm²

(Kaltenbach et al., 2007)

is ameliorated by Eip75B⁰⁷⁰⁴¹

(Kaltenbach et al., 2007)

is ameliorated by Khc^e02141

(Kaltenbach et al., 2007)

is exacerbated by Unc-76^G0333

(Kaltenbach et al., 2007)

is exacerbated by Lac^G00044

(Kaltenbach et al., 2007)

is exacerbated by LamC^G00158

(Kaltenbach et al., 2007)

is exacerbated by Src42A^E1

(Kaltenbach et al., 2007)

is exacerbated by Src42A^k10108

(Kaltenbach et al., 2007)

is ameliorated by Chc^BG02593a

(Kaltenbach et al., 2007)

is exacerbated by CAP^BG02184

(Kaltenbach et al., 2007)

is ameliorated by pnut⁰²⁵⁰²

(Kaltenbach et al., 2007)

is ameliorated by Eip75B^KG00139

(Kaltenbach et al., 2007)

is ameliorated by crol^EY08953

(Kaltenbach et al., 2007)

is ameliorated by Chc^G0438

(Kaltenbach et al., 2007)

is exacerbated by Ca-Ma2d^EY09750

(Kaltenbach et al., 2007)

is ameliorated by αSnap^M3

(Kaltenbach et al., 2007)

is ameliorated by Rpt1⁰⁵⁶⁴³

(Kaltenbach et al., 2007)

is ameliorated by Syx1A^Δ229

(Kaltenbach et al., 2007)

is exacerbated by 14-3-3ζ^EY03325

(Kaltenbach et al., 2007)

is ameliorated by M6^BG00390

(Kaltenbach et al., 2007)

is exacerbated by Src42A^KG02515

(Kaltenbach et al., 2007)

is exacerbated by Unc-76^G0310

(Kaltenbach et al., 2007)

is exacerbated by CCT1^c03987

(Shirasaki et al., 2012)

is exacerbated by CaMKII^GD9506

(Shirasaki et al., 2012)

is ameliorated by Hsp60A^EY01572

(Shirasaki et al., 2012)

is exacerbated by ND-30^GD5910

(Shirasaki et al., 2012)

is ameliorated by Hsp83⁰⁸⁴⁴⁵

(Shirasaki et al., 2012)

is exacerbated by 14-3-3ε^GD4108

(Shirasaki et al., 2012)

is ameliorated by ND-30^EY03664

(Shirasaki et al., 2012)

is ameliorated by Gαi^EY10355

(Shirasaki et al., 2012)

is exacerbated by 14-3-3ε^ex4

(Shirasaki et al., 2012)

is ameliorated by Vps35^GD11710

(Shirasaki et al., 2012)

is ameliorated by Mpcp2⁰⁰⁵⁶⁴

(Shirasaki et al., 2012)

is ameliorated by CG45062^GD2154

(Shirasaki et al., 2012)

is ameliorated by Hsp60C^GD12177

(Shirasaki et al., 2012)

is exacerbated by nrv2^k13315

(Shirasaki et al., 2012)

is exacerbated by 14-3-3ζ^GD16467

(Shirasaki et al., 2012)

is ameliorated by Hsap\CRMP1^UAS.Tag:MYC

(Stroedicke et al., 2015)

is ameliorated by CRMP^EY04380

(Stroedicke et al., 2015)

is ameliorated by DnaJ-1^EP411

(Branco et al., 2008)

is exacerbated by eff⁸

(Branco et al., 2008)

is ameliorated by Hsap\STUB1^UAS.cAa

(Branco et al., 2008)

is exacerbated by skd^L7062

(Branco et al., 2008)

is exacerbated by tara^EP3463

(Branco et al., 2008)

is exacerbated by cpo^EP3378

(Branco et al., 2008)

is ameliorated by pum^bem

(Branco et al., 2008)

is ameliorated by Diap1^{UAS.cHa.Tag:MYC}

(Branco et al., 2008)

is ameliorated by sov^KG00226

(Branco et al., 2008)

is ameliorated by Pi3K92E^UAS.Tag:MYC

(Branco et al., 2008)

is exacerbated by Hsc70-3^K97S.UAS

(Branco et al., 2008)

is exacerbated by Hsap\STUB1^UAS.cAa

(Branco et al., 2008)

is exacerbated by Sin3A^dQ4

(Branco et al., 2008)

is exacerbated by Sirt1^EP2300

(Branco et al., 2008)

is exacerbated by pum^EP3461

(Branco et al., 2008)

is ameliorated by 14-3-3ε^ex4

(Branco et al., 2008)

is exacerbated by RhoGAPp190^EP1357

(Branco et al., 2008)

is exacerbated by Diap1⁴

(Branco et al., 2008)

is ameliorated by Akt^UAS.Tag:HA

(Branco et al., 2008)

is exacerbated by Akt⁰⁴²²⁶

(Branco et al., 2008)

is exacerbated by mub^EP3623

(Branco et al., 2008)

is exacerbated by vib^EP651

(Branco et al., 2008)

is exacerbated by vib^EP513

(Branco et al., 2008)

is exacerbated by sov^EP1438

(Branco et al., 2008)

is ameliorated by sol^GD8164

(Miller et al., 2010)

is ameliorated by SppL^GD284

(Miller et al., 2010)

is ameliorated by Spp^RNAi.UAS

(Miller et al., 2010)

is ameliorated by CalpA^GD12275

(Miller et al., 2010)

is ameliorated by Mmp2^BG00958

(Miller et al., 2010)

is ameliorated by SppL^EY06831

(Miller et al., 2010)

is ameliorated by gol^GD3528

(Miller et al., 2010)

is ameliorated by Mmp2⁰²³⁵³

(Miller et al., 2010)

is exacerbated by sol^EY02771

(Miller et al., 2010)

is ameliorated by PIP4K²⁹

(Al-Ramahi et al., 2017)

is ameliorated by PIP4K^RNAi.UAS.cUa

(Al-Ramahi et al., 2017)

is ameliorated by Cbp53E^GD10584

(Al-Ramahi et al., 2018)

is exacerbated by Syngr^KK108648

(Al-Ramahi et al., 2018)

is ameliorated by Rop^G27

(Al-Ramahi et al., 2018)

is ameliorated by Dop2R^GD732

(Al-Ramahi et al., 2018)

is ameliorated by α-Man-Ia^EY00697

(Al-Ramahi et al., 2018)

is exacerbated by AP-1σ^KK108869

(Al-Ramahi et al., 2018)

is exacerbated by Dyb^KK109268

(Al-Ramahi et al., 2018)

is ameliorated by Rop^G4478

(Al-Ramahi et al., 2018)

is exacerbated by Exn^EP3042

(Al-Ramahi et al., 2018)

is ameliorated by ATP8A^KG03082

(Al-Ramahi et al., 2018)

is exacerbated by SERCA^KK107371

(Al-Ramahi et al., 2018)

is ameliorated by ATP8A^KG05950

(Al-Ramahi et al., 2018)

is ameliorated by AdoR^GD380

(Al-Ramahi et al., 2018)

is ameliorated by Fkbp12^GD6658

(Al-Ramahi et al., 2018)

is ameliorated by GluRIA^GD3582

(Al-Ramahi et al., 2018)

is ameliorated by GluRIA^KK101533

(Al-Ramahi et al., 2018)

is exacerbated by AstC-R2^GD17055

(Al-Ramahi et al., 2018)

is ameliorated by CG1354^GD8048

(Al-Ramahi et al., 2018)

is exacerbated by Hipk^EY12599

(Al-Ramahi et al., 2018)

is exacerbated by Shal^KK100264

(Al-Ramahi et al., 2018)

is exacerbated by Hk^KK109058

(Al-Ramahi et al., 2018)

is exacerbated by CG5355^KK100768

(Al-Ramahi et al., 2018)

is ameliorated by Synd^EP877

(Al-Ramahi et al., 2018)

is ameliorated by CG8916^GD3383

(Al-Ramahi et al., 2018)

is exacerbated by CRMP^GD4716

(Al-Ramahi et al., 2018)

is ameliorated by Hs6st^KK101636

(Al-Ramahi et al., 2018)

is ameliorated by Synd^EY07010

(Al-Ramahi et al., 2018)

is exacerbated by Hsp110⁰⁰⁰⁸²

(Al-Ramahi et al., 2018)

is exacerbated by Hsp110^EY00671

(Al-Ramahi et al., 2018)

is exacerbated by CRMP^supI2

(Al-Ramahi et al., 2018)

is ameliorated by Ca-β⁰⁴⁰⁰⁸

(Al-Ramahi et al., 2018)

is ameliorated by CanA1^GD8366

(Al-Ramahi et al., 2018)

is ameliorated by IP3K2^GD8778

(Al-Ramahi et al., 2018)

is ameliorated by Vha68-3^GD11527

(Al-Ramahi et al., 2018)

is exacerbated by Ids^KK101391

(Al-Ramahi et al., 2018)

is ameliorated by Itpr^GD1676

(Al-Ramahi et al., 2018)

is exacerbated by Zyx^GD10696

(Al-Ramahi et al., 2018)

is exacerbated by LIMK1^GD9586

(Al-Ramahi et al., 2018)

is exacerbated by Cdk5α^KK100567

(Al-Ramahi et al., 2018)

is exacerbated by bru3^KK111663

(Al-Ramahi et al., 2018)

is exacerbated by CenG1A^KK104806

(Al-Ramahi et al., 2018)

is exacerbated by Lcch3^KK100854

(Al-Ramahi et al., 2018)

is exacerbated by Ddr^GD7334

(Al-Ramahi et al., 2018)

is ameliorated by cac^HC129

(Al-Ramahi et al., 2018)

is exacerbated by Dh44-R2^GD15731

(Al-Ramahi et al., 2018)

is exacerbated by MESK2^GD9083

(Al-Ramahi et al., 2018)

is exacerbated by cact^KG00376

(Al-Ramahi et al., 2018)

is exacerbated by MYPT-75D^{HM.UAS.Tag:MYC,Tag:polyHis}

(Al-Ramahi et al., 2018)

is exacerbated by cact^KG07677

(Al-Ramahi et al., 2018)

is exacerbated by Mdh1^EY08761

(Al-Ramahi et al., 2018)

is ameliorated by Msp300^DG03312

(Al-Ramahi et al., 2018)

is exacerbated by capt^KK103925

(Al-Ramahi et al., 2018)

is exacerbated by Nak^GD12597

(Al-Ramahi et al., 2018)

is ameliorated by dac⁹

(Al-Ramahi et al., 2018)

is ameliorated by Nckx30C^GD1040

(Al-Ramahi et al., 2018)

is exacerbated by endos^GD10576

(Al-Ramahi et al., 2018)

is exacerbated by NfI^GD4283

(Al-Ramahi et al., 2018)

is exacerbated by endos^KK108642

(Al-Ramahi et al., 2018)

is ameliorated by Pcmt^GD8637

(Al-Ramahi et al., 2018)

is exacerbated by enok^GD4037

(Al-Ramahi et al., 2018)

is exacerbated by Pde1c^c04487

(Al-Ramahi et al., 2018)

is exacerbated by l(2)efl^GD11341

(Al-Ramahi et al., 2018)

is ameliorated by Pde4^dnc-M14

(Al-Ramahi et al., 2018)

is ameliorated by Pkc53E^GD11984

(Al-Ramahi et al., 2018)

is exacerbated by l(2)efl^KK108279

(Al-Ramahi et al., 2018)

is ameliorated by Plc21C^GD11359

(Al-Ramahi et al., 2018)

is ameliorated by loco^GD1282

(Al-Ramahi et al., 2018)

is exacerbated by Ppn^KK101228

(Al-Ramahi et al., 2018)

is exacerbated by Prp40^EP719

(Al-Ramahi et al., 2018)

is exacerbated by maf-S^KK102044

(Al-Ramahi et al., 2018)

is ameliorated by Rab3^{Q80L.UASp.YFP}

(Al-Ramahi et al., 2018)

is exacerbated by mbc^GD6965

(Al-Ramahi et al., 2018)

is ameliorated by RhoGAP71E^j6B9

(Al-Ramahi et al., 2018)

is exacerbated by para^GD3392

(Al-Ramahi et al., 2018)

is ameliorated by Ric^GD13919

(Al-Ramahi et al., 2018)

is ameliorated by Rok¹

(Al-Ramahi et al., 2018)

is ameliorated by polo⁰¹⁶⁷³

(Al-Ramahi et al., 2018)

is ameliorated by Rok^GD1522

(Al-Ramahi et al., 2018)

is ameliorated by shi¹

(Al-Ramahi et al., 2018)

is ameliorated by slo^GD244

(Al-Ramahi et al., 2018)

is ameliorated by sr^KK107677

(Al-Ramahi et al., 2018)

is exacerbated by tau^KK109359

(Al-Ramahi et al., 2018)

Hsap\HTT^{Q91.ex1.QUAS.mCherry}

model of Huntington's disease

is exacerbated by drpr^Δ5

(Pearce et al., 2015)

is exacerbated by Crk^GD8583

(Pearce et al., 2015)

is exacerbated by Crk^KK108690

(Pearce et al., 2015)

is exacerbated by Rac1^GD17411

(Pearce et al., 2015)

is exacerbated by Ced-12^GD4186

(Pearce et al., 2015)

is exacerbated by Shark^RNAi.UAS.WIZ

(Pearce et al., 2015)

is exacerbated by bsk^GD10555

(Pearce et al., 2015)

is exacerbated by drpr^RNAi.UAS

(Pearce et al., 2015)

is exacerbated by Ets21C^HMS01989

(Davis et al., 2024)

is exacerbated by NijA^HMC02381

(Davis et al., 2024)

is exacerbated by NijA^HMC02999

(Davis et al., 2024)

is ameliorated by Rab10^JF02058

(Davis et al., 2024)

is exacerbated by Rab23^HMJ30257

(Davis et al., 2024)

is exacerbated by Vha68-3^HMS02647

(Davis et al., 2024)

Hsap\HTT^Q120.FL.UAS

model of Huntington's disease

is ameliorated by Hsap\HTT^171.Q120.UAS

(Chongtham et al., 2020)

Hsap\HTT^{P42.UAS.Tag:MYC}

ameliorates Huntington's disease

modeled by Hsap\HTT^{N548.Q128.UAS}

(Arribat et al., 2013)

modeled by Hsap\HTT^Q93.ex1.UAS

(Arribat et al., 2013)

Hsap\HTT^P42.UAS.GFP

ameliorates Huntington's disease

modeled by Hsap\HTT^{171aa.138Q.UAS.Tag:HA}

(Arribat et al., 2013)

modeled by Hsap\HTT^{N548.Q128.UAS}

(Arribat et al., 2013)

modeled by Hsap\HTT^Q93.ex1.UAS

(Arribat et al., 2013)

Hsap\HTT^{Q97.ex1.UAS.mCherry}

model of Huntington's disease

is ameliorated by Pp1α-96A^HMS02477

(Branco-Santos et al., 2017)

is ameliorated by Pp1-87B^HMS00409

(Branco-Santos et al., 2017)

Hsap\HTT^{Q97.T3D.ex1.UAS.mCherry}

model of Huntington's disease

is exacerbated by Pp1α-96A^HMS02477

(Branco-Santos et al., 2017)

Hsap\HTT^{Q97.S13D.ex1.UAS.mCherry}

model of Huntington's disease

is ameliorated by Pp1α-96A^HMS02477

(Branco-Santos et al., 2017)

Hsap\HTT^{Q97.S16D.ex1.UAS.mCherry}

model of Huntington's disease

is ameliorated by Pp1α-96A^HMS02477

(Branco-Santos et al., 2017)

Hsap\HTT^{Q97.S13A.ex1.UAS.mCherry}

model of Huntington's disease

is ameliorated by Pp1α-96A^HMS02477

(Branco-Santos et al., 2017)

Hsap\HTT^{Q97.S16A.ex1.UAS.mCherry}

model of Huntington's disease

is ameliorated by Pp1α-96A^HMS02477

(Branco-Santos et al., 2017)

Hsap\HTT^{Q72.ex1.UAS.cWa}

model of Huntington's disease

is exacerbated by Hsap\MAPT^UAS.cWa

(Wen et al., 2020)

is ameliorated by tau^KO

(Wen et al., 2020)

Hsap\HTT^{128Q.1-231.UAS}

model of Huntington's disease

is ameliorated by NfI^JF02219

(Reyes-Ortiz et al., 2023)

is ameliorated by NfI^MI06280

(Reyes-Ortiz et al., 2023)

is ameliorated by Abl^UAS.cFa

(Onur et al., 2021)

is ameliorated by AnxB10^d03410

(Onur et al., 2021)

is ameliorated by CG43373^KK110535

(Onur et al., 2021)

is ameliorated by CG8916^GD3383

(Onur et al., 2021)

is ameliorated by CenG1A^MI06024

(Onur et al., 2021)

is exacerbated by Jra^NIG.2275R

(Onur et al., 2021)

is ameliorated by Nrx-1^MI02579

(Onur et al., 2021)

is exacerbated by Pkc53E^GD11984

(Onur et al., 2021)

is ameliorated by PlexA^NIG.11081R

(Onur et al., 2021)

is ameliorated by Pvr^GD75

(Onur et al., 2021)

is ameliorated by RhoBTB^VSH330130

(Onur et al., 2021)

is exacerbated by SH3PX1^NIG.6757R

(Onur et al., 2021)

is exacerbated by Snap25^NIG.17676R

(Onur et al., 2021)

is exacerbated by Spn42De^KK103216

(Onur et al., 2021)

is ameliorated by Sytβ^KK112599

(Onur et al., 2021)

is ameliorated by cora¹⁴

(Onur et al., 2021)

is ameliorated by dpn^GFP.FPTB

(Onur et al., 2021)

is ameliorated by ena^{UASp.B.mCherry}

(Onur et al., 2021)

is ameliorated by mGluR^NIG.11144R

(Onur et al., 2021)

is exacerbated by mahe^GD17235

(Onur et al., 2021)

is ameliorated by nmdyn-D7^GD13902

(Onur et al., 2021)

is ameliorated by sif^NIG.5406R

(Onur et al., 2021)

is ameliorated by trn^S064117

(Onur et al., 2021)

is exacerbated by tsr^N121

(Onur et al., 2021)

is ameliorated by vlc^k01109

(Onur et al., 2021)

is ameliorated by zld^GFP.FPTB

(Onur et al., 2021)

is ameliorated by Itgbn^HM05089

(Hernandez et al., 2023)

is ameliorated by Itgbn^HMJ23472

(Hernandez et al., 2023)

is ameliorated by if^HMC06096

(Hernandez et al., 2023)

is ameliorated by if^HMS01872

(Hernandez et al., 2023)

is ameliorated by if^JF02695

(Hernandez et al., 2023)

is ameliorated by if^MI12214

(Hernandez et al., 2023)

is ameliorated by if^WKO.P1-D4

(Hernandez et al., 2023)

is ameliorated by mew^HMS02849

(Hernandez et al., 2023)

is ameliorated by mew^JF02694

(Hernandez et al., 2023)

is ameliorated by mew^TKO.GS00808

(Hernandez et al., 2023)

is ameliorated by mys^HMS00043

(Hernandez et al., 2023)

is ameliorated by mys^JF02819

(Hernandez et al., 2023)

is ameliorated by scb^HMS01873

(Hernandez et al., 2023)

Hsap\HTT^{Q97.ex1.UAS.IVS.EGFP}

model of Huntington's disease

is ameliorated by Hsap\HTT^{ex1.βHP-P12.UAS.IVS.mCh}

(Drombosky et al., 2018)

is ameliorated by Hsap\HTT^{ex1.βHP-P2.UAS.IVS.mCh}

(Drombosky et al., 2018)

Hsap\HTT^{ex1.βHP-P2.UAS.IVS.mCh}

ameliorates Huntington's disease

modeled by Hsap\HTT^{Q97.ex1.UAS.IVS.EGFP}

(Drombosky et al., 2018)

Hsap\HTT^{ex1.βHP-P12.UAS.IVS.mCh}

ameliorates Huntington's disease

modeled by Hsap\HTT^{Q97.ex1.UAS.IVS.EGFP}

(Drombosky et al., 2018)

Hsap\HTT^{Q91.ex1.UAS.pHluorinE.tdTom}

model of Huntington's disease

is ameliorated by drpr^gRNA.U6

(Davis et al., 2024)

Hsap\HTT^Q127.UAS

model of Huntington's disease

is ameliorated by Arp3^UASp.GFP

(Singh et al., 2024)

is ameliorated by Hsap\HIP1^UAS.Tag:HA

(Singh et al., 2024)

is ameliorated by mrj^UAS.cUa

(Singh et al., 2024)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Dmel gene

Ortholog showing functional complementation

Supporting References

htt

Hsap\HTT

(Rui et al., 2015, Mugat et al., 2008)

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Hsap\HTT - CG5001

anti tag coimmunoprecipitation, anti tag western blot

(Deo et al., 2024)

Hsap\HTT - Hap40

anti tag coimmunoprecipitation, anti tag western blot

(Xu et al., 2022)

Hsap\HTT - P58IPK

anti tag coimmunoprecipitation, anti tag western blot

(Deo et al., 2024)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

Class of Gene

engineered_foreign_gene

Stocks and Reagents

Stocks (71)

Bloomington

68417

w^*; P{UAS-HTT.ex1.Q97}3

68413

w^*; P{UAS-HTT.ex1.Q50}Y4

68418

w^*; P{UAS-HTT.ex1.Q93}4F1

68403

w^*; P{UAS-HTT.FL.Q120.His}2

68419

w^*; P{UAS-HTT.ex1.Q97.K6R}7

68423

w^*; P{UAS-HTT.ex1.Q97.3KR}2

68424

w^*; P{UAS-HTT.ex1.Q97.3KQ}3

56771

w^*; P{UAS-HTT.96Q.Cerulean}2

58360

w^*; P{UAS-HTT.25Q.Cerulean}2

68412

w^*; P{UAS-HTT.ex1.Q20}111F1L

68414

w^*; M{UAS-HTT.ex1.Q25}ZH-51D

68421

w^*; P{UAS-HTT.ex1.Q97.K15R}1

More stocks available...

Other Comments

Expression of Hsap\YAP1 in vivo seems to play a protective role against the toxicity of mutant Hsap\HD in HD pathology.

(Hoshino et al., 2006)

A Drosophila model for Huntington's disease has been developed. The age of onset and severity of neuronal degeneration correlate with length of polyglutamine tract in the Hsap\HD protein, and nuclear accumulation of the Hsap\HD protein.

(Jackson et al., 1998)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (22)

Reported As

Symbol Synonym

APP

(Hu et al., 2014)

(HGNC Curators and FlyBase Curators, 2013-, McConoughey et al., 2010, Menzies et al., 2010, Bahadorani and Hilliker, 2008, Kaltenbach et al., 2007, Riley, 2006)

(Qurashi et al., 2012)

HTT

(Dorogova and Fedorova, 2025, Nitta et al., 2023, Tang and More, 2023, Nandi et al., 2022, Nayak and Mishra, 2022, Riccardi et al., 2022, Riccardi et al., 2022, Singh and Agrawal, 2022, Martin et al., 2021, Faragó et al., 2019, Lakra et al., 2019, Xu et al., 2019, Ast et al., 2018, Chen et al., 2018, Drombosky et al., 2018, Song et al., 2018, Vu et al., 2018, Branco-Santos et al., 2017, Fernius et al., 2017, Prakash et al., 2017, Krench et al., 2016, Quinti et al., 2016, Smalley et al., 2016, Vicente Miranda et al., 2016, Barbaro et al., 2015, El-Daher et al., 2015, Jimenez-Sanchez et al., 2015, McGurk et al., 2015, Menzies et al., 2015, Stroedicke et al., 2015, Varadarajan et al., 2015, Lu et al., 2014, Maheshwari et al., 2014, Quinn, 2014.7.18, Trujillo et al., 2014, Vittori et al., 2014, HGNC Curators and FlyBase Curators, 2013-, Lu et al., 2013, Ravikumar et al., 2008)

HTTN

(Al-Ramahi et al., 2018)

HTTex1

(Hervás et al., 2020, Ast et al., 2018)

Hsap\HD

Hsap\HTT

(Sousa et al., 2023, Bertapelle et al., 2022, Bhattacharjee et al., 2019, Coelho and Moreno, 2019, Kovács et al., 2017, Breda et al., 2016, Sameni et al., 2016, Jia et al., 2012)

Htt

(Victor Atoki et al., 2025, Atienzar-Aroca et al., 2024, Barwell et al., 2023, Dhankhar et al., 2023, Sharma et al., 2023, Zsindely et al., 2023, Benoit et al., 2022, Hegde and Srivastava, 2022, Tello et al., 2022, Joy et al., 2021, Subhan and Siddique, 2021, Bolus et al., 2020, Bono-Yagüe et al., 2020, Denton et al., 2020, Joag et al., 2020, Varga et al., 2020, Bason et al., 2019, Raj and Sarkar, 2019, Rodriguez-Fernandez et al., 2019, Zhu et al., 2019, Arabit et al., 2018, Coelho et al., 2018, Song et al., 2018, Yeh et al., 2018, Zhang et al., 2018, Akbergenova and Littleton, 2017, Daldin et al., 2017, Gregory et al., 2017, Raj and Sarkar, 2017, Singh et al., 2017, Sowade and Jahn, 2017, Chongtham and Agrawal, 2016, Lewis and Smith, 2016, Weiss and Littleton, 2016, Babcock and Ganetzky, 2015, Besson et al., 2015, Heidari et al., 2015, Jimenez-Sanchez et al., 2015, Menzies et al., 2015, Poças et al., 2015, Takeuchi et al., 2015, Yao et al., 2015, Hsu et al., 2014, Sajjad et al., 2014, Singh et al., 2014, Smith et al., 2014, Fujita et al., 2013, Fujita et al., 2013, Sinadinos et al., 2013, Bodai et al., 2012, Shirasaki et al., 2012, Sontag et al., 2012, Weiss et al., 2012, Zhang et al., 2012, Campesan et al., 2011, Gohil et al., 2011, Kirilly et al., 2011, Maher et al., 2011, Richards et al., 2011, Schulte et al., 2011, Tsoi et al., 2011, Wu et al., 2011, Gonzales and Yin, 2010, Luthi-Carter et al., 2010, Nisoli et al., 2010, Rana et al., 2010, Winslow et al., 2010, Wu et al., 2010, Branco et al., 2008, Fujikake et al., 2008, Liévens et al., 2008, Mugat et al., 2008, Pallos et al., 2008, Ravikumar et al., 2008, Al-Ramahi et al., 2007, Mahoney et al., 2007, Ryoo et al., 2007, Al-Ramahi et al., 2006, Boeddrich et al., 2006, Hoshino et al., 2006, Rujano et al., 2006, Lievens et al., 2005, Warrick et al., 2005, Kazantsev et al., 2002, Kazemi-Esfarjani and Benzer, 2002, Steffan et al., 2001)

Huntingtin

(Fernandez-Funez et al., 2001)

IT15

(HGNC Curators and FlyBase Curators, 2013-)

hHTT

(Ecovoiu et al., 2022, Billes et al., 2016, White et al., 2015)

hHtt

(Arribat et al., 2013, Mugat et al., 2008)

human Htt

(Schulte et al., 2011)

huntingtin

(Berger et al., 2006)

mHTT

(Jantrapirom et al., 2019, Lin et al., 2019)

mHtt

(Subhan and Siddique, 2021)

Name Synonyms

HUNTINGTIN

(McGurk et al., 2015)

Huntingtin

(Gohel et al., 2020, Chongtham and Agrawal, 2016, Sontag et al., 2012, Tamura et al., 2011, Wu et al., 2011, Lloyd and Taylor, 2010, Doumanis et al., 2009, Branco et al., 2008, Liévens et al., 2008, Mugat et al., 2008, Mclear et al., 2007, Iijima-Ando et al., 2005)

Huntington Disease

human HTT

(Al-Ramahi et al., 2017)

huntingtin (Huntington disease)

(HGNC Curators and FlyBase Curators, 2013-)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 7 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

3064

Other crossreferences

Ensembl_Homo_sapiens -

ENSG00000197386

HUGO Gene Nomenclature Committee -

HTT; huntingtin

MARRVEL - MARRVEL (human gene)

OMIM_GENE - Online Mendelian Inheritance in Man (Genes)

HUNTINGTIN; HTT

OMIM_PHENOTYPE - Online Mendelian Inheritance in Man (Phenotypes)

References (342)

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