FlyBase Gene Report: Dmel\Tsp2A

General Information

Symbol

Dmel\Tsp2A

Species

D. melanogaster

Name

Tetraspanin 2A

Annotation Symbol

CG11415

Feature Type

protein_coding_gene

FlyBase ID

FBgn0024361

Gene Model Status

Current

Stock Availability

4 publicly available

Gene Summary

Required for assembly of smooth septate junctions (sSJs), together with Ssk and mesh. Important for barrier function of the midgut epithelium. (UniProt, O46101)

Contribute a Gene Snapshot for this gene.

All Summaries

Also Known As

EG:8D8.7

Key Links

Genomic Location

Cytogenetic map

1F4-1F4

Sequence location

X:1,346,553..1,348,143 [+]

Recombination map

1-0.1

RefSeq locus

NC_004354 REGION:1346553..1348143

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables protein binding

inferred from physical interaction with UniProtKB:Q0KHY3, UniProtKB:Q9VW87

(Izumi et al., 2016)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in establishment of endothelial barrier

inferred from mutant phenotype

(Izumi et al., 2016)

involved_in glial cell migration

inferred from genetic interaction with FLYBASE:Pvr; FB:FBgn0032006

(Jeibmann et al., 2015)

involved_in smooth septate junction assembly

inferred from mutant phenotype

(Izumi et al., 2016)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in apicolateral plasma membrane

inferred from direct assay

(Izumi et al., 2016)

inferred from direct assay

(Izumi et al., 2021)

located_in smooth septate junction

inferred from direct assay

(Izumi et al., 2021, Izumi et al., 2016)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in membrane

inferred from sequence model

(Fradkin et al., 2002)

inferred from electronic annotation with InterPro:IPR000301, InterPro:IPR008952, InterPro:IPR018499

(InterPro Project Members, 2004-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN001060286

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

TETRASPANINS

Protein Family (UniProt)

Belongs to the tetraspanin (TM4SF) family. (O46101)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

TETRASPANINS -: Tetraspanins (TSP) have four transmembrane domains and two extracellular loops containing specific short motifs, including highly conserved cysteine residues. TSPs are thought to function as scaffolds that bring multiple proteins - including other TSPs, membrane-associated proteins, extracellular and cytosolic proteins - into single membrane region. These regions are called tetraspanin-enriched microdomains. (Adapted from FBrf0227776 and FBrf0152316).

Protein Function (UniProtKB)

Required for assembly of smooth septate junctions (sSJs), together with Ssk and mesh. Important for barrier function of the midgut epithelium.

(UniProt, O46101)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Tsp2A for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry O46101)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.43

Gene model reviewed during 5.45

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Tsp2A-RA

FBtr0070211

NM_080298

1002

244

Tsp2A-RB

FBtr0303284

NM_001201594

910

244

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Tsp2A-PA

FBpp0070204

26.9

244

4.35

FBpp0292376

26.9

244

4.35

O46101

NP_001188523

ADV37607

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

244 aa isoforms: Tsp2A-PA, Tsp2A-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Forms a complex with Ssk and mesh.

(UniProt, O46101)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

O46101

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tsp2A using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.35

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 7 -- 8

head mesoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

amnioserosa

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

yolk nucleus

(Fisher et al., 2012)

embryonic stage 11 -- 12

head mesoderm

(Fisher et al., 2012)

plasmatocyte primordium

Comment: reported as plasmatocytes anlage

(Fisher et al., 2012)

procrystal cell

(Fisher et al., 2012)

yolk nucleus

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic/larval crystal cell

(Fisher et al., 2012)

embryonic brain

(Fisher et al., 2012)

embryonic/larval fat body

(Fisher et al., 2012)

embryonic/larval garland cell

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

larval ventral midline glial cell

(Fisher et al., 2012)

embryonic/larval plasmatocyte

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

single cell RNA-seq

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

intestinal stem cell

(Xu et al., 2019)

adult midgut enterocyte

(Xu et al., 2019)

enteroblast

(Xu et al., 2019)

Additional Descriptive Data

Coepression analysis by singel cell RNA-seq shows that Tsp2A expression initiates in intestinal stem cells (ISCs) and increases during ISC-EC (enterocyte) transition. Under tissue homeostasis conditions, Tsp2A staining is mostly observed in ECs and rarely in ISCs/EBs (enteroblasts).

(Xu et al., 2019)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 16

embryonic/larval proventriculus

Comment: outer epithelial layer

(Izumi et al., 2016)

first instar larval stage

embryonic/larval midgut

(Izumi et al., 2016)

embryonic/larval Malpighian tubule

(Izumi et al., 2016)

embryonic/larval proventriculus

Comment: outer epithelial layer

(Izumi et al., 2016)

adult stage

enteroblast

(Xu et al., 2019)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Tsp2A protein is produced in enteroblasts in the adult midgut and is assembled at septate junctions during the intestinal stem cell to enterocyte differentiation.

(Xu et al., 2019)

Tsp2A localizes to the smooth septate junction in first instar larval midgut, Malpighian tubules, and the outer epithelial layer of the proventriculus.

(Izumi et al., 2016)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in apicolateral plasma membrane

inferred from direct assay

(Izumi et al., 2016)

inferred from direct assay

(Izumi et al., 2021)

located_in smooth septate junction

inferred from direct assay

(Izumi et al., 2021, Izumi et al., 2016)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Tsp2A in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Tsp2A

View exonic expression by tissue for Dmel\Tsp2A

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0024361

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31080/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0024361

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0024361

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0024361

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG11415

Flygut - An atlas of the Drosophila adult midgut

FBgn0024361

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Tsp2A

Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 3 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 11 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Tsp2A

Transgenic constructs containing regulatory region of Tsp2A

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(1)Exel6227

(Ryder, 2004.4.26)

Inferred from location ( 28 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die before end of first instar larval stage

lethal - all die during larval stage, with Scer\GAL4^48Y

Tsp2A^NIG.11415R

Other Phenotypes

Allele

abnormal cell adhesion | first instar larval stage

Tsp2A^1-2

abnormal cell adhesion | first instar larval stage, with Scer\GAL4^48Y

abnormal immune response | adult stage, with Scer\GAL4^esg.PU

Tsp2A^HMS02147

increased mortality | conditional, with Scer\GAL4^esg.PU

Tsp2A^HMS02147

Phenotype manifest in

Allele

adult midgut, with Scer\GAL4^esg.PU

Tsp2A^HMS02147

adult midgut epithelial cell, with Scer\GAL4^Su(H).GBE

Tsp2A^KK106844

embryonic/larval midgut | first instar larval stage

Tsp2A^1-2

embryonic/larval midgut | first instar larval stage, with Scer\GAL4^48Y

smooth septate junction | first instar larval stage

Tsp2A^1-2

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (33)

Hsap\CD81

4 of 14

Yes

Hsap\TSPAN2

4 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\UPK1B

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (30)

Rnor\Cd9

4 of 14

Yes

Rnor\Cd81

4 of 14

Yes

Rnor\Tspan2

4 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Upk1a

1 of 14

Yes

Mus musculus (laboratory mouse) (31)

Mmus\Cd9

4 of 14

Yes

Mmus\Cd81

4 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Upk1a

1 of 14

Mmus\Upk1b

1 of 14

Xenopus tropicalis (Western clawed frog) (20)

Xtro\cd9

2 of 13

Yes

Xtro\cd81

2 of 13

Yes

Xtro\LOC101730599

2 of 13

Yes

Xtro\tspan2

2 of 13

Yes

Xtro\tspan5

2 of 13

Yes

Xtro\tspan14

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (48)

Drer\cd9a

4 of 14

Yes

Drer\cd81a

4 of 14

Yes

Drer\cd81b

4 of 14

Yes

Drer\tspan2a

4 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (19)

Cele\tsp-9

4 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (17)

Agam\AgaP_AGAP010598

12 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (1)

Atha\TET10

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Tsp2A. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (36)

Tsp96F

4 of 13

CG30160

3 of 13

lbm

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

CD81; CD81 molecule

model of common variable immunodeficiency 6

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CD81; CD81 molecule

4 of 14

186845

IMMUNODEFICIENCY, COMMON VARIABLE, 6; CVID6

common variable immunodeficiency 6

TSPAN2; tetraspanin 2

4 of 14

613133

CD9; CD9 molecule

3 of 14

143030

TSPAN5; tetraspanin 5

3 of 14

613136

TSPAN14; tetraspanin 14

3 of 14

TSPAN15; tetraspanin 15

3 of 14

613140

TSPAN17; tetraspanin 17

3 of 14

620446

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Tsp2A - Rack1

anti tag coimmunoprecipitation, anti tag western blot

(Xu et al., 2019)

Tsp2A - Ssk

anti tag coimmunoprecipitation, western blot

(Izumi et al., 2016)

Tsp2A - aPKC

anti tag coimmunoprecipitation, anti tag western blot

(Xu et al., 2019)

Tsp2A - hoka

anti tag coimmunoprecipitation, western blot

(Izumi et al., 2021)

Tsp2A - mesh

anti tag coimmunoprecipitation, western blot

(Izumi et al., 2016)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

Forms a complex with Ssk and mesh.

(UniProt, O46101 )

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0024361

MIST (protein-protein) - An integrated Molecular Interaction Database

31080

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Neutrophil degranulation

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-0.1

Cytogenetic map

1F4-1F4

Sequence location

X:1,346,553..1,348,143 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

1F4-1F4

Limits computationally determined from genome sequence between P{EP}EP1542 and P{EP}futsch^EP1419

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-0.1

(FlyBase, 2016, Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (4)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

40899

y¹ sc^* v¹ sev²¹; P{TRiP.HMS02147}attP40

11415R-1

11415R-2

v101081

Genomic Clones (10)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (28)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE51204

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0024361

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0024361

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Jonusaite et al., 2020, Izumi et al., 2016)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Tsp2A EG:8D8.7

(Todres et al., 2000)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

CG11415

(Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Tomancak et al., 2007, Fradkin et al., 2002, Benos, 2000.12.13, Todres et al., 2000)

D8.7

(Seigneuret et al., 2001)

Dm.Tsp2A

(Todres et al., 2000)

EG:8D8.7

(Benos et al., 2001, Jasper et al., 2001)

Tsp2a

(Plygawko et al., 2025, Galenza et al., 2023)

tsp2A

(Jeibmann et al., 2015)

tsp2a

(Rouka et al., 2021)

Name Synonyms

Tetraspanin 2A

(Beyenbach et al., 2020, Jeibmann et al., 2015, Todres et al., 2000)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 38 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

31080

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

O46101

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

O46101

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

O46101

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0024361

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31080/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0024361

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0024361

FlyMine - An integrated database for Drosophila genomics

FBgn0024361

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG11415

MARRVEL_MODEL - MARRVEL (model organism gene)

31080

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0024361

DroID - A comprehensive database of gene and protein interactions.

FBgn0024361

DRSC - Results frm RNAi screens

FBgn0024361

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0024361

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0024361

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG11415

Flygut - An atlas of the Drosophila adult midgut

FBgn0024361

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0024361

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

MIST (protein-protein) - An integrated Molecular Interaction Database

31080

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Neutrophil degranulation

References (53)

The following external sites may use different assemblies or annotations than FlyBase.

-0.35

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