FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Xbp1
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General Information
Symbol
Dmel\Xbp1
Species
D. melanogaster
Name
X box binding protein-1
Annotation Symbol
CG9415
Feature Type
protein_coding_gene
FlyBase ID
FBgn0021872
Gene Model Status
Current
Stock Availability
21 publicly available
Gene Summary
X box binding protein-1 (Xbp1) encodes a transcription factor that mediates the unfolded protein response. Xbp1 mRNA undergoes splicing after being cleaved by the product of Ire1, inducing the expression of ER quality control transcripts. Xbp1 mutants fail to develop beyond the 2nd instar larval stage, indicative of a requirement to resolve inherent ER stress during normal development. [Date last reviewed: 2019-03-21] (FlyBase Gene Snapshot)
All Summaries
Also Known As

xbp-1, l(2)k13803

Key Links
Genomic Location
Cytogenetic map
57C3-57C4
Sequence location
Recombination map
2-93
RefSeq locus
NT_033778 REGION:21143545..21145750
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (15 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN000999262
(GO Reference Genome Project, 2011-)
enables DNA-binding transcription factor activity
inferred from electronic annotation with InterPro:IPR004827, InterPro:IPR046347
(InterPro Project Members, 2004-)
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN000999262
(GO Reference Genome Project, 2011-)
Biological Process (11 terms)
Terms Based on Experimental Evidence (10 terms)
CV Term
Evidence
References
involved_in endoplasmic reticulum unfolded protein response
inferred from direct assay
(Ryoo et al., 2007)
involved_in intestinal stem cell homeostasis
inferred from mutant phenotype
(Wang et al., 2014)
inferred from genetic interaction with FLYBASE:bsk; FB:FBgn0000229
(Wang et al., 2014)
inferred from genetic interaction with FLYBASE:N; FB:FBgn0004647
(Wang et al., 2014)
inferred from genetic interaction with FLYBASE:hep; FB:FBgn0010303
(Wang et al., 2014)
inferred from genetic interaction with FLYBASE:Keap1; FB:FBgn0038475
(Wang et al., 2014)
inferred from genetic interaction with FLYBASE:Prx2; FB:FBgn0040309
(Wang et al., 2014)
inferred from genetic interaction with FLYBASE:InR; FB:FBgn0283499
(Wang et al., 2014)
involved_in IRE1-mediated unfolded protein response
inferred from direct assay
(Ryoo et al., 2013, Plongthongkum et al., 2007)
inferred from genetic interaction with FLYBASE:Gp93; FB:FBgn0039562
(Xu et al., 2024)
involved_in negative regulation of organ growth
inferred from mutant phenotype
(Yang et al., 2022)
involved_in positive regulation of proteasomal protein catabolic process
inferred from direct assay
(Zhao et al., 2021)
involved_in positive regulation of transcription by RNA polymerase II
inferred from direct assay
(Plongthongkum et al., 2007)
involved_in regulation of axon regeneration
inferred from mutant phenotype
(Vargas et al., 2020)
involved_in regulation of translation in response to endoplasmic reticulum stress
inferred from mutant phenotype
(Wang et al., 2014)
involved_in response to endoplasmic reticulum stress
inferred from mutant phenotype
(Wang et al., 2014)
inferred from genetic interaction with FLYBASE:bsk; FB:FBgn0000229
(Wang et al., 2014)
inferred from genetic interaction with FLYBASE:Prx2; FB:FBgn0040309
(Wang et al., 2014)
inferred from high throughput mutant phenotype
(Chow et al., 2013)
inferred from direct assay
(Plongthongkum et al., 2007, Ryoo et al., 2007)
involved_in triglyceride mobilization
inferred from genetic interaction with FLYBASE:Ire1; FB:FBgn0261984
(Zhao et al., 2021)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in IRE1-mediated unfolded protein response
traceable author statement
(Yang et al., 2022)
involved_in regulation of DNA-templated transcription
inferred from electronic annotation with InterPro:IPR004827, InterPro:IPR046347
(InterPro Project Members, 2004-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000999262
(GO Reference Genome Project, 2011-)
located_in nucleus
inferred from sequence or structural similarity with UniProtKB:P17861
(Gene Ontology Curators, 2002-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
X box binding protein-1 (Xbp1) encodes a transcription factor that mediates the unfolded protein response. Xbp1 mRNA undergoes splicing after being cleaved by the product of Ire1, inducing the expression of ER quality control transcripts. Xbp1 mutants fail to develop beyond the 2nd instar larval stage, indicative of a requirement to resolve inherent ER stress during normal development. [Date last reviewed: 2019-03-21]
Gene Group (FlyBase)
BASIC LEUCINE ZIPPER TRANSCRIPTION FACTORS -
The basic leucine zipper (bZIP) transcription factors are sequence-specific DNA-binding proteins that regulate transcription. They are characterized by a 60-80 amino acid bZIP domain: a basic DNA binding domain followed by a leucine zipper dimerization domain. (Adapted from FBrf0152056).
Summary (Interactive Fly)

unfolded protein response (UPR) - enhances the expression of genes encoding ER chaperones, enzymes, and the ER protein degradation machinery

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Xbp1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q8MLW7)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene with transcript subject to HAC1-type intron splice site recognition and cleavage, creating a frameshift; highly conserved phenomenon (FBrf0194899, FBrf0214754).

Gene model reviewed during 5.42

Multiphase exon postulated: exon reading frame differs in alternative transcripts; overlap >20aa. (FBrf0194899).

Gene model reviewed during 5.43

Gene model reviewed during 5.51

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Xbp1-RD
FBtr0310044
NM_079983
2138
307
Xbp1-RE
FBtr0310045
NM_166427
2119
498
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Xbp1-PD
FBpp0301745
33.7
307
9.80
Q5BI44
NP_524722
AAF46681
Xbp1-PE
FBpp0301746
53.1
498
4.41
Q8MLW7
NP_726032
AAM70855
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Xbp1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.66

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
embryonic/larval salivary gland
(Ryoo et al., 2013)
embryonic/larval gut
(Ryoo et al., 2013)
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
head mesoderm
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
amnioserosa
(Fisher et al., 2012)
amnioserosa primordium
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 10 -- 11
embryonic/larval tracheal section
(Chung et al., 2011)
embryonic stage 11 -- 12
amnioserosa
(Fisher et al., 2012)
dorsal epidermis primordium
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
plasmatocyte primordium

Comment: reported as plasmatocytes anlage

(Fisher et al., 2012)
salivary gland body primordium
(Fisher et al., 2012)
tracheal primordium
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
larval foregut atrium
(Fisher et al., 2012)
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic epipharynx
(Fisher et al., 2012)
embryonic esophagus
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic hypopharynx
(Fisher et al., 2012)
embryonic proventriculus
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
embryonic/larval salivary gland
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
embryonic/larval plasmatocyte
(Fisher et al., 2012)
embryonic stage 15
embryonic/larval salivary gland
(Ryoo et al., 2007)
embryonic/larval midgut
(Ryoo et al., 2007)
adult stage
antennal sense organ | subset
(Jafari et al., 2012)
adult olfactory receptor neuron Or92a | subset
(Jafari et al., 2012)
adult olfactory receptor neuron Or47b | subset
(Jafari et al., 2012)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
organism
(Song et al., 2015)
Additional Descriptive Data

Xbp1 transcript is expressed in a subset of olfactory sense organs in the antenna. These include some sensilla labelled by MmusCd8aOr47b.330.T:AvicGFP or MmusCd8aOr92a.AvicGFP.T:HsapMYC.

(Jafari et al., 2012)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Xbp1 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 11 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 24 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Xbp1
Transgenic constructs containing regulatory region of Xbp1
Aberrations (Deficiencies and Duplications) ( 10 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal (with Df(2R)CC2)
lethal (with Df(2R)XE3030)
lethal | recessive
lethal - all die before end of first instar larval stage | recessive
lethal - all die before end of first instar larval stage | recessive | chemical conditional
lethal - all die before end of second instar larval stage | recessive
partially lethal - majority die, with Scer\GAL4ap-md544
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal cell number, with Scer\GAL4MESO.dome
abnormal cell number, with Scer\GAL4Tep4.PU
abnormal developmental rate | recessive
abnormal eye color, with Scer\GAL4GMR.PF
abnormal mitotic cell cycle | larval stage, with Scer\GAL4MESO.dome
abnormal neuroanatomy, with Scer\GAL4elav-C155
abnormal starvation stress response | adult stage, with Scer\GAL4Cg.PA
decreased cell growth rate | second instar larval stage | conditional
decreased cell growth rate | second instar larval stage | conditional, with Scer\GAL4ppk.PU
decreased cell growth rate | second instar larval stage | conditional (with Df(2R)BSC484)
decreased cell number | adult stage | somatic clone, with Scer\GAL4unspecified
decreased cell number | larval stage | somatic clone, with Scer\GAL4Act.PU
decreased cell size | larval stage | somatic clone, with Scer\GAL4Act.PU
decreased rate of movement | first instar larval stage | recessive
decreased size | adult stage, with Scer\GAL4Cg.PA
decreased size | larval stage | somatic clone, with Scer\GAL4Act.PU
increased cell death, with Scer\GAL4elav-C155
increased cell death, with Scer\GAL4GMR.PF
increased cell death, with Scer\GAL4ninaE.PT
increased cell death | larval stage | somatic clone, with Scer\GAL4Act.PU
increased cell growth rate | second instar larval stage | conditional, with Scer\GAL419-12, Scer\GAL80repo.PL
increased cell growth rate | second instar larval stage | conditional, with Scer\GAL4ppk.PU
increased cell number | adult stage, with Scer\GAL4esg.PU
increased cell number | adult stage | somatic clone
increased cell number | adult stage | somatic clone, with Scer\GAL4Act.PU
increased cell number | adult stage | somatic clone, with Scer\GAL4NP5130
increased cell number | adult stage | somatic clone, with Scer\GAL4unspecified
increased mortality | adult stage, with Scer\GAL4Cg.PA
increased occurrence of cell division | adult stage, with Scer\GAL4Su(H).GBE
long lived, with Scer\GAL4bun-GSG5961
long lived, with Scer\GAL4Switch1.106
some die during first instar larval stage | recessive
some die during second instar larval stage | recessive
visible, with Scer\GAL4pnr-MD237
visible | larval stage (with Df(2R)XE3030)
Phenotype manifest in
Allele
adult gut, with Scer\GAL4Su(H).GBE
autophagic vacuole & larval fat body | somatic clone | cell autonomous
autophagic vacuole & larval fat body | somatic clone | cell autonomous, with Scer\GAL4Act5C.PP
chaeta | increased number, with Scer\GAL4pnr-MD237
embryonic/larval cuticle | larval stage (with Df(2R)XE3030)
embryonic/larval lymph gland, with Scer\GAL4MESO.dome
embryonic/larval lymph gland, with Scer\GAL4Tep4.PU
eye, with Scer\GAL4GMR.PF
eye-antennal disc | somatic clone, with Scer\GAL4Act.PU
eye photoreceptor cell, with Scer\GAL4ninaE.PT
imaginal disc (with Df(2R)F36)
intestinal stem cell | adult stage, with Scer\GAL4NP5130
intestinal stem cell of posterior adult midgut epithelium | increased number, with Scer\GAL4esg.PU
larval fat cell | somatic clone, with Scer\GAL4Act.PU
lipid droplet | adult stage, with Scer\GAL4Cg.PA
lipid droplet | larval stage | somatic clone, with Scer\GAL4Act.PU
lysosome & larval fat body | somatic clone | cell autonomous
lysosome & larval fat body | somatic clone | cell autonomous, with Scer\GAL4Act5C.PP
macrochaeta | increased number, with Scer\GAL4ap-md544
macrochaeta | increased number, with Scer\GAL4pnr-MD237
midgut | adult stage, with Scer\GAL4NP0001
midgut | adult stage, with Scer\GAL4NP5130
midgut | adult stage, with Scer\GAL4NP5130, Scer\GAL80Su(H).GBE
midgut | adult stage, with Scer\GAL4Su(H).GBE
midgut | adult stage | somatic clone
midgut | adult stage | somatic clone, with Scer\GAL4Act.PU
midgut | adult stage | somatic clone, with Scer\GAL4unspecified
mouthpart | larval stage (with Df(2R)XE3030)
photoreceptor neuron, with Scer\GAL4GMR.PF
retina, with Scer\GAL4GMR.PF
scutellar bristle, with Scer\GAL4pnr-MD237
scutum, with Scer\GAL4ap-md544
scutum, with Scer\GAL4pnr-MD237
secondary tracheal branch, with Scer\GAL4bs.Term
tormogen cell, with Scer\GAL4pnr-MD237
tracheal section, with Scer\GAL4bs.Term
wing, with Scer\GAL4ap-md544
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (9)
Hsap\XBP1
7 of 14
Yes
Yes
1  
Hsap\ATF2
1 of 14
No
No
Hsap\ATF4
1 of 14
No
No
Hsap\ATF6B
1 of 14
No
No
Hsap\ATF7
1 of 14
No
No
1  
Hsap\CREB3L3
1 of 14
No
No
2  
Hsap\CREB3L4
1 of 14
No
No
1  
Hsap\CREB5
1 of 14
No
No
Hsap\JUN
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (7)
Rnor\Xbp1
7 of 14
Yes
Yes
Rnor\Atf2
1 of 14
No
No
Rnor\Atf4
1 of 14
No
No
Rnor\Atf7
1 of 14
No
No
Rnor\Creb3l3
1 of 14
No
No
Rnor\Creb3l4
1 of 14
No
No
Rnor\Creb5
1 of 14
No
No
Mus musculus (laboratory mouse) (7)
Mmus\Xbp1
6 of 14
Yes
Yes
1  
Mmus\Atf2
1 of 14
No
No
Mmus\Atf4
1 of 14
No
No
Mmus\Atf7
1 of 14
No
No
Mmus\Creb3l3
1 of 14
No
No
Mmus\Creb3l4
1 of 14
No
No
Mmus\Creb5
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (3)
Xtro\xbp1
5 of 13
Yes
Yes
Xtro\atf1
1 of 13
No
No
Xtro\atf6b
1 of 13
No
No
Danio rerio (Zebrafish) (10)
Drer\xbp1
5 of 14
Yes
Yes
Drer\atf2
1 of 14
No
No
Drer\atf4a
1 of 14
No
No
Drer\atf6
1 of 14
No
No
Drer\atf7a
1 of 14
No
No
Drer\bach1a
1 of 14
No
Yes
Drer\creb3l3l
1 of 14
No
No
Drer\creb5a
1 of 14
No
No
Drer\creb5b
1 of 14
No
No
Drer\jun
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\xbp-1
3 of 14
Yes
Yes
Anopheles gambiae (African malaria mosquito) (2)
Agam\AgaP_AGAP010623
11 of 12
Yes
Yes
Agam\AgaP_AGAP001464
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (45)
Atha\HY5
2 of 13
Yes
Yes
Atha\HYH
2 of 13
Yes
Yes
Atha\ABF1
1 of 13
No
Yes
Atha\ABF2
1 of 13
No
Yes
Atha\ABF3
1 of 13
No
Yes
Atha\ABF4
1 of 13
No
Yes
Atha\ABI5
1 of 13
No
Yes
Atha\AT2G31370
1 of 13
No
Yes
Atha\AT2G40620
1 of 13
No
Yes
Atha\AT5G07160
1 of 13
No
Yes
Atha\AT5G42910
1 of 13
No
Yes
Atha\bZIP1
1 of 13
No
Yes
Atha\bZIP2
1 of 13
No
Yes
Atha\bZIP3
1 of 13
No
Yes
Atha\bZIP4
1 of 13
No
Yes
Atha\bZIP5
1 of 13
No
Yes
Atha\bZIP6
1 of 13
No
Yes
Atha\bZIP7
1 of 13
No
Yes
Atha\BZIP9
1 of 13
No
Yes
Atha\bZIP16
1 of 13
No
Yes
Atha\BZIP17
1 of 13
No
No
Atha\bZIP19
1 of 13
No
Yes
Atha\bZIP23
1 of 13
No
Yes
Atha\BZIP24
1 of 13
No
Yes
Atha\BZIP27
1 of 13
No
Yes
Atha\BZIP28
1 of 13
No
No
Atha\BZIP34
1 of 13
No
Yes
Atha\bZIP42
1 of 13
No
Yes
Atha\bZIP43
1 of 13
No
Yes
Atha\bZIP44
1 of 13
No
Yes
Atha\bZIP48
1 of 13
No
Yes
Atha\BZIP49
1 of 13
No
No
Atha\bZIP52
1 of 13
No
Yes
Atha\BZIP53
1 of 13
No
Yes
Atha\bZIP58
1 of 13
No
Yes
Atha\bZIP68
1 of 13
No
Yes
Atha\bZIP70
1 of 13
No
Yes
Atha\bZIP75
1 of 13
No
Yes
Atha\bZIP
1 of 13
No
Yes
Atha\FD
1 of 13
No
Yes
Atha\GBF1
1 of 13
No
Yes
Atha\GBF2
1 of 13
No
Yes
Atha\GBF3
1 of 13
No
Yes
Atha\GBF4
1 of 13
No
Yes
Atha\GBF6
1 of 13
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\HAC1
1 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Xbp1. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 8 )
    Allele
    Disease
    Interaction
    References
    Xbp1d08698
    ameliorates  Alzheimer's disease
    modeled by Hsap\APP2xAPP.SP.UAS
    (Casas-Tinto et al., 2011)
    ameliorates  Alzheimer's disease 1
    modeled by Hsap\APPAβ42.UAS.Tag:SS(rPENK)
    (Cheng and Chiang, 2018)
    Xbp1k13803
    exacerbates  retinitis pigmentosa
    modeled by ninaEG69D
    (Ryoo et al., 2007)
    ameliorates  Alzheimer's disease 1
    modeled by Hsap\APP3-42.E3Q.UAS.Tag:SS(rPENK)
    (Tsuda et al., 2017)
    exacerbates  cancer
    modeled by Ras85DV12.cUa.UAS, dlg1GD4689
    (Yang et al., 2022)
    Xbp1JF02012
    exacerbates  prion disease
    modeled by Hsap\PRNPV129.UAS.att
    (Myers et al., 2022)
    Xbp1GD4745
    exacerbates  Alzheimer's disease
    modeled by Hsap\APP2xAPP.SP.UAS
    (Casas-Tinto et al., 2011)
    ameliorates  carcinoma
    modeled by scrib1
    (Zheng et al., 2023)
    Xbp1UAS.LG.EGFP
    ameliorates  neurodegenerative disease
    modeled by sws1
    (Sunderhaus et al., 2019)
    Xbp1HMS03015
    ameliorates  focal segmental glomerulosclerosis
    modeled by Hsap\APOL1G1.UAS.Tag:HA
    (Gerstner et al., 2022)
    modeled by Hsap\APOL1G2.UAS.Tag:HA
    (Gerstner et al., 2022)
    ameliorates  hyperuricemia
    modeled by UroNIG.7171R
    (Hilsabeck et al., 2022)
    Xbp1KK102632
    exacerbates  prion disease
    modeled by Hsap\PRNPV129.UAS.att
    (Myers et al., 2022)
    exacerbates  Alzheimer's disease 1
    modeled by Hsap\APPArctic.UAS.Tag:SS(nec)
    (Catterson et al., 2023)
    Xbp1UAS.s.Tag:V5
    ameliorates  cancer
    modeled by Ras85DV12.cUa.UAS, l(2)gl4
    (Yang et al., 2022)
    modeled by Ras85DV12.cUa.UAS, scrib1
    (Yang et al., 2022)
    modeled by RafUAS.F179, scrib1
    (Yang et al., 2022)
    modeled by sav3
    (Yang et al., 2022)
    modeled by wtsx1
    (Yang et al., 2022)
    modeled by ykiUAS.cHa
    (Yang et al., 2022)
    modeled by wtsKK101055
    (Yang et al., 2022)
    modeled by scribGD11663
    (Yang et al., 2022)
    modeled by dlg1GD4689
    (Yang et al., 2022)
    ameliorates  carcinoma
    modeled by scrib1
    (Zheng et al., 2023)
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    XBP1; X-box binding protein 1
    7 of 14
    194355
       
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      Summary of Genetic Interactions
      Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Xbp1
      suppressible
      bsk
      (Wang et al., 2015, Wang et al., 2014)
      scrib|Xbp1
      suppressible
      bsk
      (Zheng et al., 2023)
      Xbp1
      suppressible
      cnc
      (Wang et al., 2014)
      Xbp1
      suppressible
      foxo
      (Zhao et al., 2021)
      Xbp1
      suppressible
      Keap1
      (Wang et al., 2014)
      Xbp1
      suppressible
      upd3
      (Wang et al., 2015)
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      ap
      enhanceable
      Xbp1
      (Bronstein et al., 2010)
      bsk
      suppressible
      Xbp1
      (Wang et al., 2014)
      Bx
      enhanceable
      Xbp1
      (Bronstein et al., 2010)
      Chi
      suppressible
      Xbp1
      (Bronstein et al., 2010)
      Dref
      suppressible
      Xbp1
      (Ida et al., 2009)
      egr
      enhanceable
      Xbp1
      (Zheng et al., 2023)
      Ero1L
      suppressible
      Xbp1
      (Wang et al., 2015)
      foxo
      suppressible
      Xbp1
      (Zhao et al., 2021)
      hep
      suppressible
      Xbp1
      (Wang et al., 2014)
      InR
      suppressible
      Xbp1
      (Wang et al., 2014)
      Ire1
      enhanceable
      Xbp1
      (Yan et al., 2019)
      Ire1
      suppressible
      Xbp1
      (Zhao et al., 2021, Yan et al., 2019)
      N
      suppressible
      Xbp1
      (Wang et al., 2014)
      N
      enhanceable
      Xbp1
      (Wang et al., 2014)
      ninaE
      enhanceable
      Xbp1
      (Ryoo et al., 2007)
      pcx
      suppressible
      Xbp1
      (Yamakawa et al., 2012)
      Pex5
      suppressible
      Xbp1
      (Makdissi et al., 2025)
      Rtca
      suppressible
      Xbp1
      (Song et al., 2015)
      scrib
      suppressible
      Xbp1
      (Zheng et al., 2023)
      scrib
      enhanceable
      Xbp1
      (Zheng et al., 2023)
      Ssdp
      suppressible
      Xbp1
      (Bronstein et al., 2010)
      Tcs3
      suppressible
      Xbp1
      (Rojas-Benítez et al., 2017)
      External Data
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      FlyBase
      External Links
      External Data
      Linkouts
      KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
      Class of Gene
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      2R
      Recombination map
      2-93
      Cytogenetic map
      57C3-57C4
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      57C3-57C4
      Limits computationally determined from genome sequence between P{PZ}king-tubby02821&P{lacW}Xbp1k13803 and P{EP}CG4266EP2258
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      57C1-57C2
      (determined by in situ hybridisation)
      (Spradling et al., 1999)
      57C1-57C2
      (BDGP Project Members, 1994-1999)
      Experimentally Determined Recombination Data
      Location

      2-93

      (FlyBase, 2016)

      2-100.3

      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (21)
      Genomic Clones (21)
      cDNA Clones (250)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      Antibody Information
      Laboratory Generated Antibodies
       

      polyclonal

      (Plongthongkum et al., 2007)
      Commercially Available Antibodies
       
      Cell Line Information
      Publicly Available Cell Lines
       
        Other Stable Cell Lines
         
          Other Comments

          The ability of Xbp1 overexpression and loss-of-function alleles to modify Hsap\APP neurotoxicity in the eye suggests that Xbp1 plays a key role in Hsap\APP pathobiology.

          (Casas-Tinto et al., 2011)

          In response to ER stress, the original processed transcript of this gene is subject to HAC1-type intron splice-site recognition and cleavage by the Ire1 gene product. A small intron of 23nt is enzymatically removed, creating a frameshift in the resulting transcript and production of an alternative protein isoform.

          (Ryoo et al., 2007)

          Changes in expression profiles associated with the unfolded protein response have been analyzed in S2 cells following treatment with dsRNA made from templates generated with primers directed against this gene.

          (Hollien and Weissman, 2006)

          Gene isolated in a screen of the second chromosome identifying mutants affecting disc morphology.

          (Roch et al., 1998)
          Relationship to Other Genes
          Source for database merge of

          Source for merge of: Xbp1 CG9415

          (Misra, 2000.8.9)

          Source for merge of: Xbp1 anon- EST:Liang-1.41

          (FlyBase, 1996-)
          Additional comments

          Source for merge of Xbp1 anon- EST:Liang-1.41 was sequence comparison ( date:030707 ).

          (FlyBase, 1996-)
          Nomenclature History
          Source for database identify of
          Nomenclature comments
          Etymology
          Synonyms and Secondary IDs (24)
          Reported As
          Symbol Synonym
          138/3
          (Roch et al., 1998)
          CG 9415
          (Ryoo et al., 2007)
          CG9415
          (Minervini et al., 2022, Koya and Meller, 2015, Park et al., 2014, Reinke et al., 2013, Casso et al., 2012, Ni et al., 2011.7.19, Bronstein et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009.1.15, Hollien and Weissman, 2006, Fassler et al., 2002)
          DM18
          (Reinke et al., 2013)
          Dxbp-1
          (Souid et al., 2007)
          XBP-1
          (Hollien and Weissman, 2006)
          XBP1
          (Medina et al., 2023, Myers et al., 2022, Kumar and Maity, 2021, Yu and Hyun, 2021, Zarini-Gakiye et al., 2021, Demirev et al., 2019, Hunt et al., 2019, Sunderhaus et al., 2019, Yan et al., 2019, Gregory et al., 2017, Kang et al., 2017, Marcora et al., 2017, Sepúlveda-Salinas and Ramos-Castañeda, 2017, Tsuda et al., 2017, Park et al., 2014, Malzer et al., 2013, Ryoo et al., 2013, Rincon-Limas et al., 2012, Casas-Tinto et al., 2011, Plongthongkum et al., 2007)
          Xbp-1
          (Hao and Collins, 2017, Ida et al., 2009)
          Xbp1
          (Santos et al., 2025, Cho et al., 2024, Dutta et al., 2024, Guo et al., 2024, Hersperger et al., 2024, Li et al., 2024, Li et al., 2024, Liu et al., 2024, Xu et al., 2024, Candia et al., 2023, Fedorova et al., 2023, Fisher et al., 2023, Glashauser et al., 2023, Yamada et al., 2023, Zheng et al., 2023, Zhu and Liu, 2023, Aggarwal et al., 2022, Cairrão et al., 2022, Ding et al., 2022, Gerstner et al., 2022, Huang et al., 2022, Yang et al., 2022, Cabasso et al., 2021, Cattenoz et al., 2021, Joy et al., 2021, Kamemura et al., 2021, Loganathan et al., 2021, Mesquita et al., 2021, Zhao et al., 2021, Braunstein et al., 2020, Cho et al., 2020, Funk et al., 2020, Gupta and Stocker, 2020, Jeon et al., 2020, Johnson et al., 2020, Martínez et al., 2020, Palu et al., 2020, Parkhitko et al., 2020, Vargas et al., 2020, Xu et al., 2020, Grandon et al., 2019, Guo et al., 2019, Katsube et al., 2019, Mitra and Ryoo, 2019, Napoli et al., 2019, Şentürk et al., 2019, Shokri et al., 2019, Suisse and Treisman, 2019, Villanueva-Cañas et al., 2019, Yan et al., 2019, Bardai et al., 2018, Bischof et al., 2018, Cheng and Chiang, 2018, Guida et al., 2018, Moehlman et al., 2018, Owings et al., 2018, Palu and Chow, 2018, Pandey et al., 2018, Sakakibara et al., 2018, Troha et al., 2018, Huang et al., 2017, Ríos-Barrera et al., 2017, Sekiya et al., 2017, Sarov et al., 2016, Xu et al., 2016, Bhandari et al., 2015, Chow et al., 2015, Kavi et al., 2015, Koya and Meller, 2015, Satoh et al., 2015, Schertel et al., 2015, Song et al., 2015, Ugrankar et al., 2015, Wang et al., 2015, Wang et al., 2015, Coelho et al., 2014, Debattisti et al., 2014, Katz et al., 2014, Wang et al., 2014, Chow et al., 2013, Coelho et al., 2013, Groth et al., 2013, Maor et al., 2013, Moore et al., 2013, Nagy et al., 2013, Velentzas et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Yamakawa et al., 2012, Baranov et al., 2011, Chung et al., 2011, Rumpf et al., 2011, Loewen and Feany, 2010, Arsham and Neufeld, 2009, Carbone et al., 2009, Deng et al., 2009, Ida et al., 2009, Liu et al., 2009, Christensen et al., 2008.4.15, Farkas et al., 2008, FlyBase Curators, 2008-, Fox et al., 2008, Buszczak et al., 2007, Farkas et al., 2007, FlyBase Genome Annotators, 2007, Johansson et al., 2007, Ryoo et al., 2007, Greene et al., 2005, Girardot et al., 2004)
          Xbp1s
          (Fehr et al., 2025)
          XbpI
          (Casso et al., 2012)
          anon-EST:Liang-1.41
          clone 1.41
          (Liang and Biggin, 1998)
          dXbp-1
          (Garrey et al., 2010)
          dmXBP1
          (Poothong et al., 2017)
          l(2)k13803
          (BDGP Project Members, 1994-1999)
          sXbp1
          (Cabasso et al., 2019)
          xbp-1
          (Haddadi et al., 2024, Kang and Ryoo, 2009, Haecker et al., 2008)
          xbp1
          (Fangninou et al., 2023, Lee et al., 2022, Zhang et al., 2019, Guida et al., 2018, Brace and DiAntonio, 2017, Kawasaki et al., 2017, Helmfors et al., 2016, Zhang et al., 2016, Kang et al., 2015, Kim et al., 2015, Ryoo, 2015, Liang et al., 2014, Martin et al., 2013, Ryoo et al., 2013, Sekine et al., 2013, Sone et al., 2013, Suzuki et al., 2013, Casso et al., 2012, Garcia et al., 2012, Jafari et al., 2012, Kang et al., 2012, Kumita et al., 2012, Pimenta de Castro et al., 2012, Chang et al., 2011, Bronstein et al., 2010, Griciuc et al., 2010, Arsham and Neufeld, 2009, Carbone et al., 2009, Mendes et al., 2009, Kang and Ryoo, 2008, Kang and Ryoo, 2007, Ryoo and Steller, 2007, Ryoo et al., 2007, Ryoo et al., 2006, Souid et al., 2003)
          Name Synonyms
          X box binding protein 1
          (Ida et al., 2009)
          X box binding protein-1
          (Harrop et al., 2014, Manh et al., 2005, Spradling et al., 1999)
          X-box binding protein
          (Plongthongkum et al., 2007)
          X-box protein 1
          (Hao and Collins, 2017)
          X-box-binding protein 1
          (Hollien and Weissman, 2006)
          Secondary FlyBase IDs
          • FBgn0025990
          • FBgn0034593
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          Study result (0)
          Result
          Result Type
          Title
          External Crossreferences and Linkouts ( 43 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          FlyMine - An integrated database for Drosophila genomics
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
          KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
          MIST (protein-protein) - An integrated Molecular Interaction Database
          References (258)