FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\org-1
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General Information
Symbol
Dmel\org-1
Species
D. melanogaster
Name
optomotor-blind-related-gene-1
Annotation Symbol
CG11202
Feature Type
protein_coding_gene
FlyBase ID
FBgn0021767
Gene Model Status
Current
Stock Availability
11 publicly available
Gene Summary
optomotor-blind-related-gene-1 (org-1) encodes a T-box transcription factor involved in the combinatorial activation of somatic muscle lineage-specific targets. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

org1

Key Links
Genomic Location
Cytogenetic map
7E9-7E10
Sequence location
Recombination map
1-23
RefSeq locus
NC_004354 REGION:8447691..8455069
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (11 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables DNA-binding transcription factor activity
inferred from direct assay
(Porsch et al., 2005)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN004251338
(GO Reference Genome Project, 2011-)
enables DNA-binding transcription factor activity
(InterPro Project Members, 2004-)
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN004251338
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR001699
(InterPro Project Members, 2004-)
Biological Process (6 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in positive regulation of transcription by RNA polymerase II
inferred from direct assay
(Gaziova and Bhat, 2009, Porsch et al., 2005)
involved_in somatic muscle development
inferred from mutant phenotype
(Schaub et al., 2012)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in cell fate specification
inferred from biological aspect of ancestor with PANTHER:PTN000137774
(GO Reference Genome Project, 2011-)
involved_in positive regulation of DNA-templated transcription
inferred from electronic annotation with InterPro:IPR046360
(InterPro Project Members, 2004-)
involved_in regulation of DNA-templated transcription
(InterPro Project Members, 2004-)
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN004251338
(GO Reference Genome Project, 2011-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in chromatin
inferred from biological aspect of ancestor with PANTHER:PTN004251338
(GO Reference Genome Project, 2011-)
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN004251338
(GO Reference Genome Project, 2011-)
located_in nucleus
inferred from electronic annotation with InterPro:IPR018186, InterPro:IPR036960
(InterPro Project Members, 2004-)
inferred by curator from GO:0045944
(Porsch et al., 2005)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
optomotor-blind-related-gene-1 (org-1) encodes a T-box transcription factor involved in the combinatorial activation of somatic muscle lineage-specific targets. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
T-BOX TRANSCRIPTION FACTORS -
The T-box transcription factors are sequence-specific DNA binding proteins that regulate transcription. They are characterized by a conserved DNA-binding immunoglobulin-fold domain of 180-200 amino acids, known as T-box, named after its founding member, the mouse T protein. (Adapted from FBrf0218841).
Summary (Interactive Fly)

T-box transcription factor - involved in the combinatorial activation of somatic muscle lineage-specific targets - visceral mesoderm - gain of function causes antenna-to-leg transformations and shortened leg

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\org-1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9W3F4)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.52

Gene model reviewed during 5.56

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
org-1-RA
FBtr0071244
NM_078530
3067
699
org-1-RB
FBtr0345983
NM_001298090
3417
699
Additional Transcript Data and Comments
Reported size (kB)

3.8 (northern blot)

(Porsch et al., 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
org-1-PA
FBpp0071187
75.7
699
7.51
Q9W3F4
NP_511085
AAF46373
org-1-PB
FBpp0311870
75.7
699
7.51
Q9W3F4
NP_001285019
AHN59490
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

699 aa isoforms: org-1-PA, org-1-PB
Additional Polypeptide Data and Comments
Reported size (kDa)

712 (aa)

(Porsch et al., 1998)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\org-1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.52

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 9 -- 10
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
trunk mesoderm
(Fisher et al., 2012)
trunk visceral muscle primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
larval somatic muscle cell
(Fisher et al., 2012)
larval visceral muscle cell
(Fisher et al., 2012)
Additional Descriptive Data

org-1 transcript is expressed through most of development, and expression is strongest between 6 and 21 hours of embryonic development.

(Porsch et al., 1998)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 9 -- 10
somatic trunk mesoderm | striped
(Schaub et al., 2012)
embryonic stage 10
visceral trunk mesoderm
(Schaub et al., 2012)
embryonic stage 10 -- 11
trunk visceral muscle primordium
(Schaub et al., 2012)
embryonic stage 11
muscle cell of A1-7 lateral oblique muscle 1
(Schaub et al., 2012)
muscle cell of A2-7 ventral transverse muscle 1
(Schaub et al., 2012)
A1-7 segment border muscle cell
(Schaub et al., 2012)
visceral trunk mesoderm
(Reim et al., 2012)
embryonic stage 11 -- 12
embryonic somatic muscle cell
(Schaub et al., 2012)
embryonic stage 12 -- 14
embryonic/larval alary muscle cell
(Schaub et al., 2012)
abdominal lateral adult muscle precursor cell
(Schaub et al., 2012)
embryonic stage 14
muscle cell of lateral oblique muscle 1
(Schaub et al., 2012)
muscle cell of ventral transverse muscle 1
(Schaub et al., 2012)
segment border muscle cell
(Schaub et al., 2012)
Additional Descriptive Data

At stage 11, org-1 labels the founder cells of the circular trunk visceral mesoderm, where it colocalizes with ths mRNA.

(Reim et al., 2012)

org-1 is expressed in a dynamic pattern in the developing embryonic mesoderm. In early stage 9, org-1 protein expression begins in narrow segmental stripes within the somatic mesoderm. By stage 10, org-1 expression also appears in 11 segmental clusters of trunk visceral mesoderm precursors. During stages 10-11 expression in the visceral mesoderm becomes restricted to the visceral muscle progenitor and founder cells. Somatic mesodermal expression also refines during stage 11 and remains active in a few somatic muscle progenitors per hemisegment. During stage 12, these muscle progenitors divide into somatic muscle founder cells. After myoblast fusion, the abdominal expression of org-1 was assigned to somatic muscles M5/LO1 (lateral oblique muscle 1)) and M25/VT1 (ventral transverse muscle 1), which are derived from sibling founder cells, M8/SBM (segment border muscle) and two lateral adult muscle precursors (lAMPs), one of which is a sibling of the M8 founder. In addition, org-1 is expressed in alary muscle, formed from one of the founder cells located in dorsolateral mesodermal areas. During stage 14, org-1 mRNA and protein expression becomes extinct in lateral oblique muscle 1 and segment border muscle.

(Schaub et al., 2012)
Marker for
 
embryonic/larval alary muscle cell
(Schaub et al., 2012)
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\org-1 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 11-12
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 3 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of org-1
Transgenic constructs containing regulatory region of org-1
Aberrations (Deficiencies and Duplications) ( 1 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL4Act5C.PP
lethal, with Scer\GAL4Tub.PU
lethal | male limited, with Scer\GAL4Bx-MS1096
lethal | male limited | cold sensitive, with Scer\GAL4Bx-MS1096
partially lethal - majority die, with Scer\GAL4pnr-MD237
Other Phenotypes
Allele
decreased size | adult stage, with Scer\GAL4org-1.HN39
increased sleep | female limited, with Scer\GAL4elav-C155
some die during pupal stage, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4pnr-MD237
visible | female limited, with Scer\GAL4Bx-MS1096
visible | female limited | cold sensitive, with Scer\GAL4Bx-MS1096
Phenotype manifest in
Allele
A1-7 segment border muscle cell
abdominal lateral adult muscle precursor cell
adult heart ventral longitudinal muscle cell, with Scer\GAL4org-1.HN39
antenna, with Scer\GAL4dpp.blk1
arista, with Scer\GAL4dpp.blk1
embryonic/larval alary muscle cell
embryonic/larval alary muscle cell | embryonic stage, with Scer\GAL4twi.2PE
embryonic/larval thoracic alary-related muscle cell | embryonic stage, with Scer\GAL4twi.2PE
eye, with Scer\GAL4dpp.blk1
eye, with Scer\GAL4GMR.PF
interommatidial bristle, with Scer\GAL4GMR.PF
larval somatic muscle cell, with Scer\GAL4how-24B, Scer\GAL4twi.2PE
macrochaeta | ectopic, with Scer\GAL4dpp.blk1
muscle cell of A1-7 lateral oblique muscle 1
muscle cell of A2-7 ventral transverse muscle 1
ommatidium | increased number, with Scer\GAL4dpp.blk1
tarsal segment, with Scer\GAL4dpp.blk1
third segment of antenna, with Scer\GAL4dpp.blk1
tormogen cell, with Scer\GAL4pnr-MD237
trichogen cell, with Scer\GAL4pnr-MD237
unguis | ectopic, with Scer\GAL4dpp.blk1
wing | female limited, with Scer\GAL4Bx-MS1096
wing | female limited | cold sensitive, with Scer\GAL4Bx-MS1096
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (17)
Hsap\TBX1
9 of 14
Yes
Yes
Hsap\TBX10
9 of 14
Yes
Yes
Hsap\TBX18
5 of 14
No
Yes
Hsap\MGA
4 of 14
No
Yes
Hsap\TBX4
4 of 14
No
Yes
Hsap\TBX5
4 of 14
No
Yes
1  
Hsap\EOMES
3 of 14
No
Yes
Hsap\TBR1
3 of 14
No
Yes
Hsap\TBX6
3 of 14
No
No
Hsap\TBX15
3 of 14
No
Yes
Hsap\TBX19
3 of 14
No
No
Hsap\TBX21
3 of 14
No
No
Hsap\TBX22
3 of 14
No
Yes
Hsap\TBXT
3 of 14
No
No
Hsap\TBX2
2 of 14
No
No
4  
Hsap\TBX3
2 of 14
No
No
5  
Hsap\TBX20
2 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (17)
Rnor\Tbx1
10 of 14
Yes
Yes
Rnor\Tbx10
9 of 14
No
Yes
Rnor\Mga
4 of 14
No
Yes
Rnor\Tbx18
4 of 14
No
Yes
Rnor\Tbx4
3 of 14
No
Yes
Rnor\Tbx5
3 of 14
No
Yes
Rnor\Tbx6
3 of 14
No
No
Rnor\Tbx15
3 of 14
No
No
Rnor\Tbx21
3 of 14
No
No
Rnor\Tbx22
3 of 14
No
No
Rnor\Tbxt
3 of 14
No
No
Rnor\Eomes
2 of 14
No
Yes
Rnor\Tbr1
2 of 14
No
Yes
Rnor\Tbx2
2 of 14
No
No
Rnor\Tbx3
2 of 14
No
No
Rnor\Tbx19
2 of 14
No
No
Rnor\Tbx20
2 of 14
No
No
Mus musculus (laboratory mouse) (17)
Mmus\Tbx1
10 of 14
Yes
Yes
Mmus\Tbx10
10 of 14
Yes
Yes
Mmus\Mga
4 of 14
No
Yes
Mmus\Tbx18
4 of 14
No
Yes
Mmus\Eomes
3 of 14
No
Yes
Mmus\Tbr1
3 of 14
No
Yes
Mmus\Tbx4
3 of 14
No
Yes
Mmus\Tbx5
3 of 14
No
Yes
Mmus\Tbx6
3 of 14
No
No
Mmus\Tbx15
3 of 14
No
No
Mmus\Tbx21
3 of 14
No
No
Mmus\Tbx22
3 of 14
No
No
Mmus\T
3 of 14
No
No
1  
Mmus\Tbx2
2 of 14
No
No
Mmus\Tbx3
2 of 14
No
No
Mmus\Tbx19
2 of 14
No
No
Mmus\Tbx20
2 of 14
No
No
Xenopus tropicalis (Western clawed frog) (19)
Xtro\tbx1
6 of 13
Yes
Yes
Xtro\mga
3 of 13
No
Yes
Xtro\tbr1
2 of 13
No
Yes
Xtro\tbx4
2 of 13
No
No
Xtro\tbx5
2 of 13
No
No
Xtro\tbx6
2 of 13
No
No
Xtro\tbx15
2 of 13
No
Yes
Xtro\tbx18
2 of 13
No
Yes
Xtro\tbx21
2 of 13
No
Yes
Xtro\tbx22
2 of 13
No
Yes
Xtro\vegt
2 of 13
No
No
Xtro\eomes
1 of 13
No
Yes
Xtro\nkrf
1 of 13
No
Yes
Xtro\plch1
1 of 13
No
No
Xtro\prnp
1 of 13
No
Yes
Xtro\tbx2
1 of 13
No
No
Xtro\tbx20
1 of 13
No
No
Xtro\tbxt.2
1 of 13
No
No
Xtro\tbxt
1 of 13
No
No
Danio rerio (Zebrafish) (25)
Drer\tbx1
9 of 14
Yes
Yes
Drer\tbx16l
5 of 14
No
Yes
Drer\tbx22
4 of 14
No
Yes
Drer\eomesa
3 of 14
No
Yes
Drer\mgaa
3 of 14
No
Yes
Drer\tbr1a
3 of 14
No
Yes
Drer\tbr1b
3 of 14
No
Yes
Drer\tbx4
3 of 14
No
Yes
Drer\tbx5a
3 of 14
No
Yes
Drer\tbx5b
3 of 14
No
Yes
Drer\tbx6
3 of 14
No
No
Drer\tbx16
3 of 14
No
No
Drer\tbx18
3 of 14
No
Yes
Drer\tbx19
3 of 14
No
No
Drer\tbx21
3 of 14
No
Yes
Drer\tbxtb
3 of 14
No
No
Drer\eomesb
2 of 14
No
Yes
Drer\tbx2a
2 of 14
No
No
Drer\tbx2b
2 of 14
No
No
Drer\tbx3a
2 of 14
No
No
Drer\tbx3b
2 of 14
No
No
Drer\tbx15
2 of 14
No
No
Drer\tbxta
2 of 14
No
No
Drer\LOC110439164
1 of 14
No
Yes
Drer\tbx20
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (23)
Cele\mls-1
7 of 14
Yes
Yes
Cele\sea-1
3 of 14
No
Yes
Cele\tbx-7
3 of 14
No
No
Cele\tbx-8
3 of 14
No
No
Cele\tbx-9
3 of 14
No
No
Cele\tbx-11
3 of 14
No
Yes
Cele\tbx-30
3 of 14
No
No
Cele\tbx-31
3 of 14
No
Yes
Cele\tbx-32
3 of 14
No
Yes
Cele\tbx-33
3 of 14
No
Yes
Cele\tbx-34
3 of 14
No
Yes
Cele\tbx-35
3 of 14
No
No
Cele\tbx-36
3 of 14
No
Yes
Cele\tbx-37
3 of 14
No
No
Cele\tbx-38
3 of 14
No
No
Cele\tbx-39
3 of 14
No
Yes
Cele\tbx-40
3 of 14
No
Yes
Cele\tbx-42
3 of 14
No
No
Cele\tbx-43
3 of 14
No
Yes
Cele\mab-9
2 of 14
No
No
Cele\tbx-2
2 of 14
No
No
Cele\tbx-41
2 of 14
No
Yes
Cele\ZK328.6
1 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (12)
Agam\AgaP_AGAP001344
8 of 12
Yes
Yes
Agam\AgaP_AGAP005895
3 of 12
No
No
Agam\AgaP_AGAP005896
3 of 12
No
No
Agam\AgaP_AGAP011927
3 of 12
No
No
Agam\AgaP_AGAP008563
2 of 12
No
No
Agam\AgaP_AGAP008567
2 of 12
No
No
Agam\AgaP_AGAP008569
2 of 12
No
No
Agam\AgaP_AGAP010686
2 of 12
No
No
Agam\AgaP_AGAP011711
2 of 12
No
No
Agam\AgaP_AGAP011712
2 of 12
No
No
Agam\AgaP_AGAP008564
1 of 12
No
Yes
Agam\AgaP_AGAP008565
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:org-1. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (8)
H15
5 of 13
mid
5 of 13
bi
4 of 13
byn
4 of 13
Doc1
4 of 13
Doc2
4 of 13
Doc3
4 of 13
ocm
3 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Evidence
    References
    org-1MB01466
    model of  autism spectrum disorder
    CEA with pashaLL03660
    (Grice et al., 2015)
    Potential Models Based on Orthology ( 9 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    TBX1; T-box transcription factor 1
    9 of 14
    602054
    TBX10; T-box transcription factor 10
    9 of 14
    604648
        TBX18; T-box transcription factor 18
        5 of 14
        604613
        MGA; MAX dimerization protein MGA
        4 of 14
        616061
          TBX4; T-box transcription factor 4
          4 of 14
          601719
          TBX5; T-box transcription factor 5
          4 of 14
          601620
           
          EOMES; eomesodermin
          3 of 14
          604615
              TBR1; T-box brain transcription factor 1
              3 of 14
              604616
                TBX6; T-box transcription factor 6
                3 of 14
                602427
                TBX15; T-box transcription factor 15
                3 of 14
                604127
                  TBX19; T-box transcription factor 19
                  3 of 14
                  604614
                  TBX21; T-box transcription factor 21
                  3 of 14
                  604895
                  TBX22; T-box transcription factor 22
                  3 of 14
                  300307
                  TBXT; T-box transcription factor T
                  3 of 14
                  601397
                    Functional Complementation Data
                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                    Interactions
                    Summary of Physical Interactions
                    Summary of Genetic Interactions
                    Interaction Browsers
                    View in FlyBase Interactions Browser   View in MIST tool (external link)
                    Please look at the allele data for full details of the genetic interactions
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    Col4a1
                    suppressible
                    org-1
                    (Hollfelder et al., 2014)
                    LanB1
                    suppressible
                    org-1
                    (Hollfelder et al., 2014)
                    External Data
                    Linkouts
                    BioGRID - A database of protein and genetic interactions.
                    DroID - A comprehensive database of gene and protein interactions.
                    Pathways
                    Signaling Pathways (FlyBase)
                    Metabolic Pathways
                    FlyBase
                    External Links
                    External Data
                    Linkouts
                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                    Class of Gene
                    Genomic Location and Detailed Mapping Data
                    Chromosome (arm)
                    X
                    Recombination map
                    1-23
                    Cytogenetic map
                    7E9-7E10
                    Sequence location
                    FlyBase Computed Cytological Location
                    Cytogenetic map
                    Evidence for location
                    7E9-7E10
                    Limits computationally determined from genome sequence between P{EP}CG1632EP1583 and P{EP}MoeEP1652
                    Experimentally Determined Cytological Location
                    Cytogenetic map
                    Notes
                    References
                    7E3-7F2
                    (Pflugfelder, 1998.3.17)
                    7F-8A
                    (determined by in situ hybridisation)
                    (Porsch et al., 1998)
                    Experimentally Determined Recombination Data
                    Location

                    1-23

                    (FlyBase, 2016)

                    1-23.4

                    (Comeron et al., 2012)
                    Left of (cM)
                    Right of (cM)
                    Notes
                    Stocks and Reagents
                    Stocks (11)
                    Genomic Clones (8)
                     

                    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                    cDNA Clones (10)
                     

                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                    cDNA clones, fully sequenced
                    BDGP DGC clones
                      Other clones
                        Drosophila Genomics Resource Center cDNA clones

                        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                        cDNA Clones, End Sequenced (ESTs)
                        BDGP DGC clones
                          Other clones
                            RNAi and Array Information
                            Linkouts
                            DRSC - Results frm RNAi screens
                            Antibody Information
                            Laboratory Generated Antibodies
                             

                            polyclonal

                            (Mendoza-García et al., 2017, Schaub et al., 2012)
                            Commercially Available Antibodies
                             
                            Cell Line Information
                            Publicly Available Cell Lines
                             
                              Other Stable Cell Lines
                               
                                Other Comments

                                Identification: Low stringency hybridisation to a bi probe.

                                (Grimm et al., 1997)
                                Relationship to Other Genes
                                Source for database merge of
                                Additional comments
                                Nomenclature History
                                Source for database identify of
                                Nomenclature comments
                                Etymology
                                Synonyms and Secondary IDs (11)
                                Datasets (0)
                                Study focus (0)
                                Experimental Role
                                Project
                                Project Type
                                Title
                                Study result (0)
                                Result
                                Result Type
                                Title
                                External Crossreferences and Linkouts ( 37 )
                                Sequence Crossreferences
                                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                Other crossreferences
                                AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                FlyMine - An integrated database for Drosophila genomics
                                InterPro - A database of protein families, domains and functional sites
                                KEGG Genes - Molecular building blocks of life in the genomic space.
                                MARRVEL_MODEL - MARRVEL (model organism gene)
                                Linkouts
                                BioGRID - A database of protein and genetic interactions.
                                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                DroID - A comprehensive database of gene and protein interactions.
                                DRSC - Results frm RNAi screens
                                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                Flygut - An atlas of the Drosophila adult midgut
                                FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                References (76)