FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\COX5A
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General Information
Symbol
Dmel\COX5A
Species
D. melanogaster
Name
Cytochrome c oxidase subunit 5A
Annotation Symbol
CG14724
Feature Type
protein_coding_gene
FlyBase ID
FBgn0019624
Gene Model Status
Current
Stock Availability
9 publicly available
Gene Summary
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. (UniProt, Q94514)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

CoVa, cytochrome c oxidase subunit Va, tend, tenured, cytochrome-c oxidase subunit Va

Key Links
Genomic Location
Cytogenetic map
86F9-86F9
Sequence location
Recombination map
3-51
RefSeq locus
NT_033777 REGION:11819359..11820299
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (5 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in positive regulation of cell cycle
inferred from mutant phenotype
(Mandal et al., 2005)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in mitochondrial electron transport, cytochrome c to oxygen
inferred from sequence or structural similarity with UniProtKB:P00427
(Gene Ontology Curators, 2002-)
inferred from biological aspect of ancestor with PANTHER:PTN000367750
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR003204, InterPro:IPR036545
(InterPro Project Members, 2004-)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
located_in mitochondrial inner membrane
inferred from direct assay
(Brischigliaro et al., 2022)
located_in mitochondrion
inferred from high throughput direct assay
(Tan et al., 2009, Alonso et al., 2005)
inferred from direct assay
(Ren et al., 2010)
part_of respiratory chain complex IV
inferred from direct assay
(Brischigliaro et al., 2022)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in mitochondrial inner membrane
inferred from electronic annotation with InterPro:IPR003204, InterPro:IPR036545
(InterPro Project Members, 2004-)
part_of respiratory chain complex IV
inferred from electronic annotation with InterPro:IPR036545
(InterPro Project Members, 2004-)
non-traceable author statement
(Porcelli et al., 2007)
inferred from biological aspect of ancestor with PANTHER:PTN000367750
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity with UniProtKB:P00427
(Gene Ontology Curators, 2002-)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the cytochrome c oxidase subunit 5A family. (Q94514)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
MITOCHONDRIAL COMPLEX IV - SUPERNUMERARY SUBUNITS -
Cytochrome c oxidase (COX) is the terminal complex (complex IV) of the electron transfer chain, embedded in the mitochondrial inner membrane. It catalyzes electron transfer from reduced cytochrome c to molecular oxygen in a process coupled to the transfer of protons across the inner membrane, thus contributing to the generation of the proton gradient that is used by ATP synthase to drive ATP synthesis. Eukaryotic COX is a multimeric enzyme formed by subunits of dual genetic origin. The three subunits forming the catalytic core of the enzyme (COX1, COX2 and COX3) are encoded by the mitochondrial DNA. The non-catalytic subunits are all encoded by the nuclear DNA. The functions of these 'supernumerary subunits' are largely unknown, though are assumed to regulate complex IV activity and to coordinate energy production with cellular needs. (Adapted from PMID:17091399 and PMID:28870773.)
MITOCHONDRIAL COMPLEX IV - TESTIS-SPECIFIC VARIANT -
Cytochrome c oxidase (COX) is the terminal complex (complex IV) of the electron transfer chain, embedded in the mitochondrial inner membrane. It catalyzes electron transfer from reduced cytochrome c to molecular oxygen in a process coupled to the transfer of protons across the inner membrane, thus contributing to the generation of the proton gradient that is used by ATP synthase to drive ATP synthesis. (Adapted from PMID:17091399 and PMID:28870773.)
MITOCHONDRIAL COMPLEX IV -
Cytochrome c oxidase (COX) is the terminal complex (complex IV) of the electron transfer chain, embedded in the mitochondrial inner membrane. It catalyzes electron transfer from reduced cytochrome c to molecular oxygen in a process coupled to the transfer of protons across the inner membrane, thus contributing to the generation of the proton gradient that is used by ATP synthase to drive ATP synthesis. (Adapted from PMID:17091399 and PMID:28870773.)
Pathway (FlyBase)
OXIDATIVE PHOSPHORYLATION -
Oxidative phosphorylation (OXPHOS) is the coordinated transfer of electrons and protons leading to the production of ATP. The OXPHOS system is composed of five mitochondrial inner membrane complexes, Complexes I-IV comprise the electron respiratory chain and Complex V the ATP synthase. Complexes I and II oxidize the electron donors NADH and FADH2, respectively, derived from the tricarboxylic acid (TCA) cycle, and the electrons are transferred to the electron carrier ubiquinone which shuttles them to Complex III. Cytochrome c transfers electrons between Complex III and the terminal complex in the respiratory chain, Complex IV. Complex IV catalyzes electron transfer from reduced cytochrome c to oxygen. Complex I, II and IV couple electron transfer to proton transport across the inner mitochondrial membrane into the inner membrane space. This generates a proton electrochemical gradient which is used to drive the synthesis of ATP from ADP and inorganic phosphate by ATP synthase (Complex V). (Adapted from PMID:23356252 and PMID:11331900.)
Protein Function (UniProtKB)
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
(UniProt, Q94514)
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\COX5A for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q94514)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.47

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 6.04

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
COX5A-RA
FBtr0082473
NM_057869
730
149
COX5A-RB
FBtr0082474
NM_169436
701
149
COX5A-RC
FBtr0334890
NM_001275559
635
149
COX5A-RD
FBtr0347553
NM_001316557
639
149
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
COX5A-PA
FBpp0081947
16.6
149
5.35
Q94514
NP_477217
AAF54706
COX5A-PB
FBpp0081948
16.6
149
5.35
Q94514
NP_731641
AAN13534
COX5A-PC
FBpp0306911
16.6
149
5.35
Q94514
NP_001262488
AGB95870
COX5A-PD
FBpp0312586
16.6
149
5.35
Q94514
NP_001303486
ALI30558
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

149 aa isoforms: COX5A-PA, COX5A-PB, COX5A-PC, COX5A-PD
Additional Polypeptide Data and Comments
Reported size (kDa)

149 (aa)

(Caggese et al., 1999)
Comments
External Data
Subunit Structure (UniProtKB)

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

(UniProt, Q94514)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\COX5A using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.72

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | ubiquitous
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 5 of adulthood | male -- day 7 of adulthood | male
spermatozoon
(Wasbrough et al., 2010, Dorus et al., 2006)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in mitochondrial inner membrane
inferred from direct assay
(Brischigliaro et al., 2022)
located_in mitochondrion
inferred from high throughput direct assay
(Tan et al., 2009, Alonso et al., 2005)
inferred from direct assay
(Ren et al., 2010)
part_of respiratory chain complex IV
inferred from direct assay
(Brischigliaro et al., 2022)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\COX5A in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 3 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of COX5A
Transgenic constructs containing regulatory region of COX5A
Aberrations (Deficiencies and Duplications) ( 3 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | recessive
lethal - all die before end of P-stage, with Scer\GAL4r4
lethal - all die during larval stage, with Scer\GAL4Mef2.PR
partially lethal - majority die, with Scer\GAL4pnr-MD237
partially lethal - majority die | RU486 conditional, with Scer\GAL4αTub84B.Switch.PK
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Ilp2.215-1
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal body color, with Scer\GAL4pnr-MD237
abnormal developmental rate, with Scer\GAL4r4
abnormal neuroanatomy | pupal stage, with Scer\GAL4wor.PA, Scer\GAL80ase.PN
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4109(2)80
abnormal size | larval stage
decreased cell death | larval stage
decreased occurrence of cell division | adult stage | somatic clone
decreased occurrence of cell division | larval stage
decreased occurrence of cell division | larval stage | somatic clone
increased cell number | third instar larval stage, with Scer\GAL4Antp-10
increased cell size | larval stage | somatic clone
some die during pupal stage, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4pnr-MD237
visible | adult stage, with Scer\GAL4eya.enh1+E+2
visible | recessive | somatic clone
Phenotype manifest in
Allele
abdominal dorsal multidendritic neuron ddaC | third instar larval stage, with Scer\GAL4109(2)80
cone cell | somatic clone
dendrite | third instar larval stage, with Scer\GAL4109(2)80
eye, with Scer\GAL4eya.enh1+E+2
eye | somatic clone
eye disc | somatic clone
eye disc posterior to the morphogenetic furrow | somatic clone
lamellocyte | third instar larval stage, with Scer\GAL4Antp-10
lens | somatic clone
mesonotum, with Scer\GAL4pnr-MD237
neuroblast | pupal stage, with Scer\GAL4wor.PA, Scer\GAL80ase.PN
ommatidial precursor cluster | somatic clone
ommatidium, with Scer\GAL4ey.PU
trichogen cell, with Scer\GAL4pnr-MD237
wing disc | larval stage
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (1)
Hsap\COX5A
14 of 14
Yes
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (1)
Rnor\Cox5a
14 of 14
Yes
Yes
Mus musculus (laboratory mouse) (1)
Mmus\Cox5a
13 of 14
Yes
Yes
Xenopus tropicalis (Western clawed frog) (2)
Xtro\cox5a
7 of 13
Yes
Yes
Xtro\ube2e2
1 of 13
No
No
Danio rerio (Zebrafish) (2)
Drer\cox5aa
14 of 14
Yes
Yes
Drer\cox5ab
12 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\cox-5A
13 of 14
Yes
Yes
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP011159
12 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\COX6
11 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\cox6
10 of 12
Yes
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:COX5A. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Allele
Disease
Evidence
References
COX5AGD5167
model of  cytochrome-c oxidase deficiency disease
CEA
(Kemppainen et al., 2014)
Potential Models Based on Orthology ( 1 )
Modifiers Based on Experimental Evidence ( 2 )
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
COX5A; cytochrome c oxidase subunit 5A
14 of 14
603773
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
Interaction Browsers
View in FlyBase Interactions Browser   View in MIST tool (external link)
Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
COX5A - ATPsynF
experimental knowledge based
(Guruharsha et al., 2011)
COX5A - CG32700
anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
(Rhee et al., 2014)
COX5A - CG5174
experimental knowledge based
(Guruharsha et al., 2011)
COX5A - COX4
cosedimentation, blue native page, peptide massfingerprinting
(Brischigliaro et al., 2022, Rahman et al., 2014)
COX5A - COX5B
cosedimentation, blue native page, peptide massfingerprinting
(Brischigliaro et al., 2022)
COX5A - COX6B
cosedimentation, blue native page, peptide massfingerprinting
(Brischigliaro et al., 2022, Rahman et al., 2014)
COX5A - COX7A
cosedimentation, blue native page, peptide massfingerprinting
(Brischigliaro et al., 2022)
COX5A - COX7AL2
cosedimentation, blue native page, peptide massfingerprinting
(Brischigliaro et al., 2022)
COX5A - COX7B
cosedimentation, blue native page, peptide massfingerprinting
(Brischigliaro et al., 2022)
COX5A - COX8
cosedimentation, blue native page, peptide massfingerprinting
(Brischigliaro et al., 2022)
COX5A - Cyt-c1
experimental knowledge based
(Guruharsha et al., 2011)
COX5A - GstS1
experimental knowledge based
(Guruharsha et al., 2011)
COX5A - ND-MLRQ
cosedimentation, blue native page, peptide massfingerprinting
(Brischigliaro et al., 2022)
COX5A - TpnC4
experimental knowledge based
(Guruharsha et al., 2011)
COX5A - cype
cosedimentation, blue native page, peptide massfingerprinting
(Brischigliaro et al., 2022, Rahman et al., 2014)
COX5A - fln
experimental knowledge based
(Guruharsha et al., 2011)
COX5A - levy
blue native page, peptide massfingerprinting, cosedimentation
(Brischigliaro et al., 2022, Rahman et al., 2014)
COX5A - mt:CoI
cosedimentation, blue native page, peptide massfingerprinting
(Brischigliaro et al., 2022, Rahman et al., 2014)
COX5A - mt:CoII
blue native page, peptide massfingerprinting, cosedimentation
(Brischigliaro et al., 2022, Rahman et al., 2014)
COX5A - mt:CoIII
cosedimentation, blue native page, peptide massfingerprinting
(Brischigliaro et al., 2022)
Summary of Genetic Interactions
Interaction Browsers
View in FlyBase Interactions Browser   View in MIST tool (external link)
Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
COX5A
suppressible
Cul1
(Mandal et al., 2010)
COX5A
suppressible
Cul3
(Mandal et al., 2010)
COX5A
suppressible
p53
(Mandal et al., 2010, Mandal et al., 2005)
COX5A
suppressible
PPP1R15
(Tsuyama et al., 2017)
COX5A
suppressible
Prosβ6
(Mandal et al., 2010)
COX5A
suppressible
SNF4Aγ
(Mandal et al., 2005)
COX5A
enhanceable
Wwox
(Choo et al., 2015)
COX5A
suppressible
Wwox
(Choo et al., 2015)
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Subunit Structure (UniProtKB)
Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
(UniProt, Q94514 )
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Metabolic Pathways
FlyBase
OXIDATIVE PHOSPHORYLATION
External Links
KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
External Data
Linkouts
KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
Class of Gene
Genomic Location and Detailed Mapping Data
Chromosome (arm)
3R
Recombination map
3-51
Cytogenetic map
86F9-86F9
Sequence location
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
86F9-86F9
Limits computationally determined from genome sequence between P{EP}Lk6EP886 and P{PZ}svp07842
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
86F1-87A10
(Caggese, 1996.10.24)
86F8-86F11
(determined by in situ hybridisation)
(Caggese et al., 1999)
Experimentally Determined Recombination Data
Location

3-51

(FlyBase, 2016)

3-48.8

(Comeron et al., 2012)

3-

(Caggese, 1996.10.24)
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (9)
Genomic Clones (19)
 

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (182)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Other clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi and Array Information
Linkouts
DRSC - Results frm RNAi screens
Antibody Information
Laboratory Generated Antibodies
 

polyclonal

(Ren et al., 2010)
Commercially Available Antibodies
 
Cell Line Information
Publicly Available Cell Lines
 
    Other Stable Cell Lines
     
      Other Comments

      FBti0009814 (P{lacW}gloS011046) previously thought to map to CoVa actually maps to glo transcription unit, outwith the region of overlap with CoVa.

      (Das, 2002.7.3)

      Area matching Drosophila cytochrome c oxidase subunit Va preprotein gene, Acc. No. Y09065. Probable intron.

      (Davies, 2001.3.15)

      FlyBase curator comment: Insertion FBti0009814, 'S011046', stated to map to CoVa since flanking sequence extends to CoVa transcription unit. Release 3 annotation places FBti0009814 insertion site 5' to CoVa and within glo.

      (Deak, 1999.12.22)

      Cytochrome C gene identified solely by homology of the coding sequence to genes from other organisms. FlyBase curator comment: Insertion FBti0009814, 'S011046', stated to map to CoVa, however release 3 annotation places FBti0009814 insertion site 5' to CoVa and within glo.

      (Deak et al., 1997)
      Relationship to Other Genes
      Source for database merge of
      Additional comments
      Nomenclature History
      Source for database identify of

      Source for identity of: COX5A CoVa

      (Porcelli and Marygold, 2014.9.16)
      Nomenclature comments
      Etymology
      Synonyms and Secondary IDs (37)
      Reported As
      Symbol Synonym
      CG14724
      (Curcio et al., 2024, Müller-Eigner et al., 2024, Choo et al., 2015, Foriel et al., 2015, Hosono et al., 2015, Fukuoh et al., 2014, Homem et al., 2014, Kemppainen et al., 2014, Cammarato et al., 2011, Müller et al., 2010, Ni et al., 2010.12.1, Tiefenböck et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009, Porcelli et al., 2007, Cermelli et al., 2006, Kalifa et al., 2006)
      COX
      (Walker and Benzer, 2004, Maier et al., 2001)
      COX-5A
      (Groen et al., 2022)
      COX5A
      (Meyer et al., 2024, Müller-Eigner et al., 2024, Salminen et al., 2024, Monteiro et al., 2023, Ren et al., 2023, Brischigliaro et al., 2022, O'Hanlon et al., 2022, Sen and Cox, 2022, Wang et al., 2015, Porcelli and Marygold, 2014.9.16)
      COX5a
      (Sorge et al., 2020)
      COXA
      (Caggese et al., 2006)
      COXA_DROME
      (Storm and Sonnhammer, 2003)
      CoVa
      (Curcio et al., 2024, Mo et al., 2023, Liu et al., 2019, Pletcher et al., 2019, Tsuyama et al., 2017, Zhang et al., 2016, Choo et al., 2015, Hill et al., 2014, Homem et al., 2014, Kemppainen et al., 2014, Van Vranken et al., 2014, Yan et al., 2014, Tixier et al., 2013, Tixier et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Wang et al., 2012, Friedman et al., 2011, Sinenko et al., 2011, Sinenko et al., 2011, Mandal et al., 2010, Müller et al., 2010, Porcelli et al., 2010, Tiefenböck et al., 2010, Wasbrough et al., 2010, Tan et al., 2009, Owusu-Ansah et al., 2008, Curtis et al., 2007, Mandal et al., 2007, Beller et al., 2006, Caggese et al., 2006, Cermelli et al., 2006, Dorus et al., 2006, Kalifa et al., 2006, Liao et al., 2006, McBride et al., 2006, Tripoli et al., 2005)
      Cox5A
      (González Morales et al., 2023)
      Cox5a
      (Chen et al., 2025, Feng et al., 2024, Barry and Thummel, 2016, Kemppainen et al., 2014)
      Q94514
      (Ebanks et al., 2021)
      Va
      (Ren et al., 2010, Szuplewski and Terracol, 2001)
      cova
      (Chowdhary et al., 2017, Gordon et al., 2013)
      cox5A
      (Wong et al., 2020)
      mito
      (Enomoto and Igaki, 2022)
      tend
      (Wang et al., 2015, Liao et al., 2006, Mandal et al., 2005)
      Name Synonyms
      CYTOCHROME C OXIDASE SUBUNIT Va
      (Alonso et al., 2005)
      Complex IV
      (Monteiro et al., 2023)
      Cytochrome c oxidase
      (Feng et al., 2015)
      Cytochrome c oxidase Polypeptide Va
      (Tripoli et al., 2005)
      Cytochrome c oxidase Va
      (Porcelli et al., 2007)
      Cytochrome c oxidase Va, mt precursor
      (Pedersen et al., 2010)
      Cytochrome c oxidase polypeptide Va
      (Caggese et al., 2006)
      Cytochrome c oxidase subunit 5A
      (Porcelli and Marygold, 2014.9.16)
      Cytochrome c oxidase subunit Va
      (Cammarato et al., 2011)
      Cytochrome oxidase Va
      (Mandal et al., 2007)
      Subunit Va
      (Ren et al., 2010)
      cytochrome C oxidase subunit Va
      (Mandal et al., 2010)
      cytochrome c oxidase
      (Hosamani et al., 2016)
      cytochrome c oxidase Va
      (Gordon et al., 2013)
      cytochrome c oxidase subunit Va
      (Hill et al., 2014, Cermelli et al., 2006, Liao et al., 2006, Caggese, 1996.10.24)
      cytochrome c oxidase subunit Va preprotein
      (Jaspers et al., 2012)
      cytochrome oxidase subunit Va
      (McBride et al., 2006)
      cytochrome-c oxidase subunit Va
      (Sinenko et al., 2011, Curtis et al., 2007)
      subunit 5A
      (Hosamani et al., 2016)
      subunit Va of complex IV
      (Tiefenböck et al., 2010)
      tenured
      (Liao et al., 2006, Mandal et al., 2005)
      Secondary FlyBase IDs
      • FBgn0023019
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      Study result (0)
      Result
      Result Type
      Title
      External Crossreferences and Linkouts ( 57 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
      EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
      FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
      FlyMine - An integrated database for Drosophila genomics
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      MARRVEL_MODEL - MARRVEL (model organism gene)
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
      KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
      References (136)