FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Hsap\CDKN1A
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General Information
Symbol
Hsap\CDKN1A
Species
H. sapiens
Name
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Annotation Symbol
Feature Type
engineered_foreign_gene
FlyBase ID
FBgn0016095
Gene Model Status
Not Applicable
Stock Availability
5 publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

p21, Hsap\p21

Key Links
Foreign Gene Data

Foreign sequence; species == Homo sapiens; gene == CDKN1A; HGNC:1784.

(FlyBase Curators, 1992-)
Summaries
Alleles, Insertions, Transgenic Constructs
Classical and Insertion Alleles ( 0 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Hsap\CDKN1A
Transgenic constructs containing regulatory region of Hsap\CDKN1A
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL432B
lethal, with Scer\GAL434B
lethal, with Scer\GAL4Act5C.PI
lethal, with Scer\GAL4ap-md544
lethal, with Scer\GAL4da.G32
lethal, with Scer\GAL4Dll-md23
lethal, with Scer\GAL4h-H10
lethal, with Scer\GAL4how-24B
lethal, with Scer\GAL4T80
lethal, with Scer\GAL4tey-5053A
lethal, with Scer\GAL4tsh-md621
lethal, with Scer\GAL4αTub84B.PL
Other Phenotypes
Allele
abnormal neuroanatomy, with Scer\GAL4sca-537.4
abnormal planar polarity, with Scer\GAL4en-e16E
abnormal size | adult stage
decreased cell number, with Scer\GAL4sca-537.4
decreased occurrence of cell division | larval stage
decreased occurrence of cell division | larval stage, with Scer\GAL41151
decreased occurrence of cell division | larval stage, with Scer\GAL4GMR.PF
increased cell death, with Scer\GAL4en-e16E
increased cell size | adult stage, with Scer\GAL4dpp.blk1
visible
visible, with Scer\GAL4dpp.blk1
visible, with Scer\GAL4en-e16E
visible, with Scer\GAL4ey.PH
visible, with Scer\GAL4GMR.PF
visible, with Scer\GAL4sca-T3
visible | adult stage
Phenotype manifest in
Allele
anterior crossvein, with Scer\GAL4dpp.blk1
embryonic/larval salivary gland, with Scer\GAL4ptc-559.1
embryonic precursor cell of adult muscle, with Scer\GAL41151
eye
eye, with Scer\GAL4ey.PH
eye, with Scer\GAL4GMR.PF
eye disc
eye disc, with Scer\GAL4ey.PH
eye disc, with Scer\GAL4GMR.PF
eye disc posterior compartment | larval stage, with Scer\GAL4GMR.PF
eye disc posterior to the morphogenetic furrow | larval stage
interommatidial bristle
macrochaeta, with Scer\GAL4sca-T3
muscle cell of mesothoracic dorsal oblique muscle 1, with Scer\GAL41151
muscle cell of mesothoracic dorsal oblique muscle 2, with Scer\GAL41151
muscle cell of mesothoracic dorsal oblique muscle 3, with Scer\GAL41151
neuron & embryonic thorax, with Scer\GAL4sca-537.4
ommatidium
pigment cell
thoracic neuroblast NB6-4, with Scer\GAL4sca-537.4
wing, with Scer\GAL4en-e16E
wing & cell, with Scer\GAL4en-e16E
wing & trichome, with Scer\GAL4en-e16E
wing cell, with Scer\GAL4dpp.blk1
wing cell, with Scer\GAL4en-e16E
wing vein L3, with Scer\GAL4dpp.blk1
Orthologs
Downloads
Download All DIOPT Orthologs
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Drosophila melanogaster (Fruit fly) (1)
dap
2 of 14
Yes
No
0  
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    Hsap\CDKN1AUAS.cHa
    ameliorates  carcinoma
    modeled by Ras85DV12.UAS
    (Karim and Rubin, 1998)
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Interaction Browsers
    Summary of Genetic Interactions
    Interaction Browsers
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    Class of Gene
    Stocks and Reagents
    Other Comments

    Cyclin-dependent kinase inhibitor.

    (Karim and Rubin, 1998)

    Expression of Hsap\CDKN1A has been used to block the second mitotic wave in the developing eye. Each cell type is still specified, hence cell fate determination is regulated independently of the division pattern of the precursor cells.

    (de Nooij and Hariharan, 1995)
    Relationship to Other Genes
    Source for database merge of
    Additional comments

    FlyBase curator comment: Name changed to reflect current HGNC name (19th Nov. 2012).

    (FlyBase Curators, 1992-)
    Nomenclature History
    Source for database identify of
    Nomenclature comments
    Etymology
    Synonyms and Secondary IDs (21)
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    Study result (0)
    Result
    Result Type
    Title
    External Crossreferences and Linkouts ( 5 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    Other crossreferences
    Ensembl_Homo_sapiens -
    HUGO Gene Nomenclature Committee -
    MARRVEL - MARRVEL (human gene)
    OMIM_GENE - Online Mendelian Inheritance in Man (Genes)
    References (45)