FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Lis-1
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General Information
Symbol
Dmel\Lis-1
Species
D. melanogaster
Name
Lissencephaly-1
Annotation Symbol
CG8440
Feature Type
protein_coding_gene
FlyBase ID
FBgn0015754
Gene Model Status
Current
Stock Availability
22 publicly available
Gene Summary
Lissencephaly-1 (Lis-1) encodes a regulator of the cytoplasmic dynein-1 motor complex, binding to Dynein heavy chain and regulating dynein force production, microtubule affinity and velocity. It is involved in the transport of many of dynein's cargoes, including mRNPs, mitochondria and nuclei. The Lis-1 product is also a non-catalytic subunit of platelet-activating factor acetylhydrolase. [Date last reviewed: 2018-09-20] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Lis1, DLis-1, DLis1, l(2)k13209, Paf-AHβ

Key Links
Genomic Location
Cytogenetic map
52F4-52F5
Sequence location
Recombination map
2-78
RefSeq locus
NT_033778 REGION:16178826..16185103
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (57 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables dynein complex binding
inferred from physical interaction with FLYBASE:Dhc64C; FB:FBgn0261797
(Siller et al., 2005)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables dynein complex binding
inferred from sequence or structural similarity with UniProtKB:P43034
(Sheffield et al., 2000)
Biological Process (42 terms)
Terms Based on Experimental Evidence (41 terms)
CV Term
Evidence
References
involved_in axo-dendritic transport
inferred from mutant phenotype
(Liu et al., 2000)
involved_in axonal transport
inferred from mutant phenotype
(Liu et al., 2000)
involved_in border follicle cell migration
inferred from mutant phenotype
(Yang et al., 2012)
involved_in centrosome localization
inferred from mutant phenotype
(Sitaram et al., 2012)
involved_in centrosome separation
inferred from mutant phenotype
(Siller et al., 2005)
involved_in chorion-containing eggshell pattern formation
inferred from mutant phenotype
(Lei and Warrior, 2000)
involved_in clathrin-dependent endocytosis involved in vitellogenesis
inferred from direct assay
(Liu et al., 2015)
involved_in dendrite development
inferred from mutant phenotype
(Liu et al., 2000)
involved_in dendrite morphogenesis
inferred from mutant phenotype
(Satoh et al., 2008, Liu et al., 2000)
involved_in female germ-line cyst formation
inferred from mutant phenotype
(Liu et al., 1999)
involved_in fusome organization
inferred from mutant phenotype
(Liu et al., 1999)
involved_in germarium-derived cystoblast division
inferred from mutant phenotype
(Liu et al., 1999)
involved_in germarium-derived oocyte differentiation
inferred from mutant phenotype
(Liu et al., 1999)
involved_in germarium-derived oocyte fate determination
inferred from mutant phenotype
(Swan et al., 1999)
involved_in intracellular mRNA localization
inferred from mutant phenotype
(Dix et al., 2013, Lei and Warrior, 2000)
involved_in intracellular protein localization
inferred from mutant phenotype
(Lei and Warrior, 2000, Swan et al., 1999)
inferred from genetic interaction with FLYBASE:Dhc64C; FB:FBgn0261797
(Swan et al., 1999)
involved_in intracellular protein transport
inferred from mutant phenotype
(Siller et al., 2005)
involved_in kinetochore organization
inferred from mutant phenotype
(Siller et al., 2005)
involved_in muscle cell cellular homeostasis
inferred from mutant phenotype
(Kucherenko et al., 2011)
inferred from genetic interaction with FLYBASE:Dys; FB:FBgn0260003
(Kucherenko et al., 2011)
involved_in mushroom body development
inferred from mutant phenotype
(Liu et al., 2000)
involved_in neuroblast proliferation
inferred from mutant phenotype
(Liu et al., 2000)
involved_in nuclear migration along microtubule
inferred from genetic interaction with FLYBASE:DCTN1-p150; FB:FBgn0001108
(Lei and Warrior, 2000)
inferred from genetic interaction with FLYBASE:Dhc64C; FB:FBgn0261797
(Lei and Warrior, 2000)
involved_in nuclear migration
inferred from mutant phenotype
(Swan et al., 1999)
involved_in nucleus localization
inferred from mutant phenotype
(Swan et al., 1999)
involved_in oocyte fate determination
inferred from genetic interaction with FLYBASE:BicD; FB:FBgn0000183
(Swan et al., 1999)
involved_in oocyte nucleus migration involved in oocyte dorsal/ventral axis specification
inferred from mutant phenotype
(Lei and Warrior, 2000)
involved_in oogenesis
inferred from mutant phenotype
(Liu et al., 1999, Swan et al., 1999)
involved_in ovarian fusome organization
inferred from mutant phenotype
(Liu et al., 1999)
involved_in ovarian nurse cell to oocyte transport
inferred from mutant phenotype
(Swan et al., 1999)
involved_in photoreceptor cell axon guidance
inferred from mutant phenotype
(Marrone et al., 2011)
involved_in positive regulation of axonogenesis
inferred from mutant phenotype
(Kudumala et al., 2017)
involved_in positive regulation of BMP signaling pathway
inferred from direct assay
(Chen et al., 2010)
involved_in positive regulation of mitotic metaphase/anaphase transition
inferred from mutant phenotype
(Siller et al., 2005)
inferred from genetic interaction with FLYBASE:rod; FB:FBgn0003268
(Siller et al., 2005)
involved_in protein localization to kinetochore
inferred from mutant phenotype
(Dzhindzhev et al., 2005)
involved_in regulation of dendrite morphogenesis
inferred from mutant phenotype
(Zheng et al., 2008)
involved_in retrograde axonal transport
inferred from mutant phenotype
(Kudumala et al., 2017, Yang et al., 2008)
involved_in rhabdomere development
inferred from mutant phenotype
(Marrone et al., 2011)
involved_in spermatogenesis
inferred from mutant phenotype
(Sitaram et al., 2012)
involved_in spindle assembly
inferred from mutant phenotype
(Siller et al., 2005)
involved_in stem cell population maintenance
inferred from direct assay
(Chen et al., 2010)
involved_in transport along microtubule
inferred from mutant phenotype
(Dix et al., 2013)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in maintenance of centrosome location
inferred from biological aspect of ancestor with PANTHER:PTN002891240
(GO Reference Genome Project, 2011-)
involved_in retrograde axonal transport
inferred from biological aspect of ancestor with PANTHER:PTN002891240
(GO Reference Genome Project, 2011-)
Cellular Component (14 terms)
Terms Based on Experimental Evidence (12 terms)
CV Term
Evidence
References
located_in axon
inferred from direct assay
(Liu et al., 2000)
located_in cell cortex
inferred from direct assay
(Swan et al., 1999)
located_in centrosome
inferred from direct assay
(Sitaram et al., 2012)
located_in dendrite
inferred from direct assay
(Liu et al., 2000)
part_of dynactin complex
inferred from direct assay
(Siller et al., 2005)
part_of dynein complex
inferred from direct assay
(Siller et al., 2005)
located_in growth cone
inferred from direct assay
(Beaven et al., 2015)
colocalizes_with kinetochore microtubule
inferred from direct assay
(Siller et al., 2005)
colocalizes_with kinetochore
inferred from direct assay
(Siller et al., 2005)
located_in kinetochore
inferred from direct assay
(Sitaram et al., 2012)
located_in neuronal cell body
inferred from direct assay
(Liu et al., 2000)
colocalizes_with spindle pole centrosome
inferred from direct assay
(Siller et al., 2005)
located_in spindle pole
inferred from direct assay
(Sitaram et al., 2012)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN008687761
(GO Reference Genome Project, 2011-)
is_active_in kinetochore
inferred from biological aspect of ancestor with PANTHER:PTN002336971
(GO Reference Genome Project, 2011-)
is_active_in microtubule cytoskeleton
inferred from biological aspect of ancestor with PANTHER:PTN002336971
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the WD repeat LIS1/nudF family. (Q7KNS3)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Lissencephaly-1 (Lis-1) encodes a regulator of the cytoplasmic dynein-1 motor complex, binding to Dynein heavy chain and regulating dynein force production, microtubule affinity and velocity. It is involved in the transport of many of dynein's cargoes, including mRNPs, mitochondria and nuclei. The Lis-1 product is also a non-catalytic subunit of platelet-activating factor acetylhydrolase. [Date last reviewed: 2018-09-20]
Pathway (FlyBase)
POSITIVE REGULATORS OF BMP SIGNALING PATHWAY -
Positive regulators of Bone Morphogenetic Protein (BMP) signaling up-regulate the pathway, ultimately resulting in the increased nuclear activity of the Mad/Med transcription factor complex.
Protein Function (UniProtKB)
Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as nuclear migration during cell division, mitotic spindle formation and the removal of mitotic checkpoint proteins from kinetochores at the metaphase to anaphase transition. Required for several aspects of neurogenesis including neuroblast proliferation, neuronal cell differentiation, dendritic growth, branching and maturation and axonal transport. Required for synchronized cell divisions in the germline, fusome integrity and oocyte differentiation. Acts together with BicD, Egl, dynein and microtubules to determine oocyte identity during oogenesis. Also required for nurse cell to oocyte transport during oocyte growth and for the positioning of the nucleus in the oocyte.
(UniProt, Q7KNS3)
Summary (Interactive Fly)

component of Dynein complex, Beta-transducin family Trp-Asp repeats protein - required in the germline for synchronized cystocyte division and oocyte differentiation

Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Lis-1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q7KNS3)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.46

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Lis-1-RA
FBtr0087236
NM_057812
2862
411
Lis-1-RB
FBtr0087240
NM_176190
2775
411
Lis-1-RF
FBtr0087241
NM_206130
3292
411
Lis-1-RG
FBtr0304747
NM_001259432
1675
411
Additional Transcript Data and Comments
Reported size (kB)

3.0, 2.8, 2.0, 1.8, 1.756 (longest cDNA)

(Liu et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Lis-1-PA
FBpp0086375
46.5
411
7.61
Q7KNS3
NP_477160
AAF58050
Lis-1-PB
FBpp0086379
46.5
411
7.61
Q7KNS3
NP_788370
AAO41380
Lis-1-PF
FBpp0089100
46.5
411
7.61
Q7KNS3
NP_995852
AAS64845
Lis-1-PG
FBpp0293289
46.5
411
7.61
Q7KNS3
NP_001246361
AFH08114
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

411 aa isoforms: Lis-1-PA, Lis-1-PB, Lis-1-PF, Lis-1-PG
Additional Polypeptide Data and Comments
Reported size (kDa)

411 (aa); 45 (kD observed)

(Liu et al., 1999)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with dynein and dynactin. Does not interact with Paf-A-Halpha.

(UniProt, Q7KNS3)
Domain

Dimerization mediated by the LisH domain may be required to activate dynein.

(UniProt, Q7KNS3)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Lis-1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.31

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
ventral midline of embryo
(Wheeler et al., 2009)
pre-blastoderm stage
organism | ubiquitous
(Liu et al., 1999)
embryonic stage 1 -- 3
organism | ubiquitous | uniform
(Liu et al., 1999)
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 3 -- 4
organism | ubiquitous | uniform

Comment: maternally supplied

(Lei and Warrior, 2000)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
primordial germ cell
(Fisher et al., 2012)
embryonic stage 6 -- 8
organism | restricted
(Lei and Warrior, 2000)
embryonic stage 7 -- 8
organism | faint | ubiquitous
(Fisher et al., 2012)
primordial germ cell
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
central brain primordium
(Fisher et al., 2012)
midgut interstitial cell primordium
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic foregut
(Fisher et al., 2012)
embryonic proventriculus inner layer
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
embryonic/larval midgut interstitial cell
(Fisher et al., 2012)
larval nervous system
(Fisher et al., 2012)
ventral midline of embryo
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
embryonic stage 13 -- 17
larval central nervous system
(Lei and Warrior, 2000)
third instar larval stage
imaginal disc | faint | uniform
(Lei and Warrior, 2000)
larval brain | faint
(Lei and Warrior, 2000)
adult stage | female
germarium
(Liu et al., 1999)
female germline stem cell
(Liu et al., 1999)
follicle stem cell
(Liu et al., 1999)
adult stage | femaleoogenesis stage S4 -- S7
oocyte
(Liu et al., 1999)
adult stage | femaleoogenesis stage S1 -- S10
egg chamber
(Liu et al., 1999)
oogenesis stage S10 & adult stage | female
nurse cell
(Liu et al., 1999)
oogenesis
germarium region 1 | faint
(Lei and Warrior, 2000)
germarium region 2 | faint
(Lei and Warrior, 2000)
oogenesis stage S2 -- S4
egg chamber
(Lei and Warrior, 2000)
oogenesis stage S5 -- S7
oocyte
(Lei and Warrior, 2000)
oogenesis stage S8 -- S10
nurse cell
(Lei and Warrior, 2000)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
(Liu et al., 1999)
organism
(Lei and Warrior, 2000)
embryonic stage 1 -- 17
organism

Comment: 0-20 hr AEL

(Sheffield et al., 2000)
late third instar larval stage
organism
(Sheffield et al., 2000)
prepupal stage
organism
(Sheffield et al., 2000)
pharate adult stage
organism | faint
(Sheffield et al., 2000)
adult stage
ovary
(Liu et al., 1999)
head
(Sheffield et al., 2000)
adult thorax | faint
(Sheffield et al., 2000)
adult abdomen | faint
(Sheffield et al., 2000)
adult stage | male
organism
(Sheffield et al., 2000)
adult stage | female
organism
(Sheffield et al., 2000)
ovary
(Sheffield et al., 2000)
adult stage & oogenesis
germarium | restricted
(Liu et al., 1999)
adult stageoogenesis stage S4 -- S7
oocyte
(Liu et al., 1999)
adult stage & oogenesis stage S10
nurse cell
(Liu et al., 1999)
Additional Descriptive Data

Four size classes of transcripts are detected in all developmental stages, with high levels in ovaries. In the ovary, Lis-1 transcripts are detected in all germline and soma cells in the germarium.

(Liu et al., 1999)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
(Liu et al., 1999)
adult stage
ovary
(Liu et al., 1999)
Additional Descriptive Data

A single band of 45 kD is detected in all developmental stages.

(Liu et al., 1999)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in axon
inferred from direct assay
(Liu et al., 2000)
located_in cell cortex
inferred from direct assay
(Swan et al., 1999)
located_in centrosome
inferred from direct assay
(Sitaram et al., 2012)
located_in dendrite
inferred from direct assay
(Liu et al., 2000)
part_of dynactin complex
inferred from direct assay
(Siller et al., 2005)
part_of dynein complex
inferred from direct assay
(Siller et al., 2005)
located_in growth cone
inferred from direct assay
(Beaven et al., 2015)
colocalizes_with kinetochore microtubule
inferred from direct assay
(Siller et al., 2005)
colocalizes_with kinetochore
inferred from direct assay
(Siller et al., 2005)
located_in kinetochore
inferred from direct assay
(Sitaram et al., 2012)
located_in neuronal cell body
inferred from direct assay
(Liu et al., 2000)
colocalizes_with spindle pole centrosome
inferred from direct assay
(Siller et al., 2005)
located_in spindle pole
inferred from direct assay
(Sitaram et al., 2012)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Lis-1 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 19 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 28 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Lis-1
Transgenic constructs containing regulatory region of Lis-1
Aberrations (Deficiencies and Duplications) ( 3 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4insc-Mz1407
lethal | recessive
lethal - all die before end of larval stage | recessive
lethal - all die before end of pupal stage
lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female sterile, with Scer\GAL4VP16.nanos.UTR
female sterile (with Df(2R)Jp8)
female sterile | recessive
fertile
male sterile
sterile (with Lis-11.2.2)
sterile (with Lis-13.1.2)
sterile (with Lis-18.25.3)
sterile (with Lis-111.4.13)
sterile (with Lis-1k11702)
Other Phenotypes
Allele
abnormal heat stress response | third instar larval stage, with Scer\GAL4ppk.1.9
abnormal mitotic cell cycle (with Lis-1G10.14)
abnormal mitotic cell cycle (with Lis-1k13209)
abnormal neuroanatomy | adult stage, with Scer\GAL4GMR91H05
abnormal neuroanatomy | adult stage, with Scer\GAL4shot-OK307
abnormal neuroanatomy | adult stage (with Lis-1G10.14)
abnormal neuroanatomy | adult stage (with Lis-1k11702)
abnormal neuroanatomy | recessive | somatic clone | third instar larval stage
abnormal neuroanatomy | somatic clone
abnormal neuroanatomy | third instar larval stage
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4GMR.PU
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4ppk.1.9
abnormal neurophysiology | adult stage, with Scer\GAL4GMR91H05
abnormal neurophysiology | adult stage, with Scer\GAL4shot-OK307
abnormal neurophysiology | adult stage (with Lis-1G10.14)
abnormal neurophysiology | adult stage (with Lis-1k11702)
abnormal pain response | adult stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
abnormal size | adult stage, with Scer\GAL4GMR91H05
abnormal size | adult stage, with Scer\GAL4shot-OK307
abnormal size | adult stage (with Lis-1G10.14)
abnormal size | adult stage (with Lis-1k11702)
decreased cell number | larval stage | somatic clone
decreased cell number | oogenesis
decreased occurrence of cell division | larval stage | somatic clone
decreased occurrence of cell division | oogenesis
some die during larval stage | recessive
some die during pupal stage
some die during pupal stage, with Scer\GAL4pnr-MD237
wild-type
Phenotype manifest in
Allele
adult mushroom body | somatic clone
axon | adult stage
axon | adult stage, with Scer\GAL4dpr1-PGaw
axon | adult stage (with Lis-1E415)
axon | adult stage (with Lis-1k11702)
axon | third instar larval stage, with Scer\GAL4GMR.PU
border follicle cell, with Scer\GAL4upd1.PU
border follicle cell | somatic clone
border follicle cell | somatic clone, with Lis-1GD1480, Scer\GAL4Act.PU
border follicle cell | somatic clone, with Lis-1KK108813, Scer\GAL4Act.PU
border follicle cell | somatic clone, with Scer\GAL4Act.PU
centrosome
centrosome & spermatocyte
cystoblast | female
cystoblast | germline clone
cyst progenitor cell (with Lis-1k11702)
cyst progenitor cell (with Lis-1k13209)
dendrite & abdominal dorsal multidendritic neuron ddaC | somatic clone
dendrite | somatic clone
dendrite | third instar larval stage, with Scer\GAL4ppk.1.9
dendritic tree | larval stage
dorsal appendage (with Lis-11.2.2)
dorsal appendage (with Lis-13.1.2)
dorsal appendage (with Lis-18.25.3)
dorsal appendage (with Lis-111.4.13)
dorsal appendage (with Lis-1k11702)
dorsal appendage (with Lis-1k13209)
egg | germline clone
egg chamber, with Scer\GAL4VP16.mat.αTub67C
egg chamber (with Df(2R)Jp8)
egg chamber | germline clone
embryonic/larval mushroom body | somatic clone
eye | somatic clone
eye photoreceptor cell | somatic clone
germarium | germline clone
germ band
germline stem cell | germline clone
giant fiber neuron | adult stage, with Hsap\RELAAD.R17A04, Scer\GAL4DBD.R68A06
giant fiber neuron | adult stage, with Scer\GAL4GMR68A06
giant fiber neuron | adult stage, with Scer\GAL4GMR91H05
giant fiber neuron | adult stage, with Scer\GAL4shot-OK307
giant fiber neuron | adult stage (with Lis-1G10.14)
giant fiber neuron | adult stage (with Lis-1k11702)
indirect flight muscle cell, with Scer\GAL4Mhc.PU
investment cone
lamina plexus | third instar larval stage
lamina plexus | third instar larval stage, with Scer\GAL4GMR.PU
larval brain | larval stage, with Scer\GAL4insc-Mz1407
larval dorsal multidendritic neuron ddaC | third instar larval stage, with Scer\GAL4ppk.1.9
larval multidendritic class IV neuron | somatic clone | third instar larval stage
larval neuroblast | larval stage
marginal nerve | adult stage
marginal nerve | adult stage, with Scer\GAL4dpr1-PGaw
marginal nerve | adult stage (with Lis-1E415)
marginal nerve | adult stage (with Lis-1k11702)
microtubule
microtubule organizing center (with Df(2R)Jp8)
mitochondrion | adult stage
mitochondrion | adult stage, with Scer\GAL4dpr1-PGaw
mitochondrion | adult stage (with Lis-1E415)
mitochondrion | adult stage (with Lis-1k11702)
Nebenkern (with Df(2R)Jp5)
nurse cell | increased number (with Df(2R)Jp8)
nurse cell fusome
oocyte
oocyte (with Df(2R)Jp8)
oocyte | germline clone
oocyte | somatic clone
oocyte nucleus
photoreceptor cell & nucleus
retina | somatic clone
rhabdomere | adult stage, with Scer\GAL4GMR.PU
rhabdomere of eye photoreceptor cell | somatic clone
spermatid
spermatid (with Df(2R)Jp5)
spermatocyte
spindle
spindle (with Lis-1G10.14)
spindle (with Lis-1k11702)
spindle (with Lis-1k13209)
spindle | germline clone
spindle pole centrosome (with Lis-1G10.14)
spindle pole centrosome (with Lis-1k13209)
transport vesicle | adult stage, with Hsap\RELAAD.R17A04, Scer\GAL4DBD.R68A06
transport vesicle | adult stage, with Scer\GAL4GMR68A06
vesicle | adult stage | female, with Scer\GAL4VP16.mat.αTub67C
yolk, with Scer\GAL4VP16.mat.αTub67C
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (48)
Hsap\PAFAH1B1
13 of 14
Yes
Yes
1  
Hsap\DAW1
2 of 14
No
No
Hsap\MLST8
2 of 14
No
No
Hsap\PLRG1
2 of 14
No
No
Hsap\POC1A
2 of 14
No
No
1  
Hsap\WDR5B
2 of 14
No
No
1  
Hsap\WDR5
2 of 14
No
No
11  
Hsap\WDR86
2 of 14
No
Yes
Hsap\AAMP
1 of 14
No
No
Hsap\BOP1
1 of 14
No
No
Hsap\BTRC
1 of 14
No
No
1  
Hsap\CDRT1
1 of 14
No
No
Hsap\CIAO1
1 of 14
No
No
Hsap\COPA
1 of 14
No
No
Hsap\COPB2
1 of 14
No
No
Hsap\EED
1 of 14
No
No
Hsap\ELP2
1 of 14
No
No
Hsap\FBXW7
1 of 14
No
No
Hsap\FBXW10
1 of 14
No
No
Hsap\FBXW11
1 of 14
No
No
1  
Hsap\KATNB1
1 of 14
No
No
Hsap\KIF21A
1 of 14
No
No
Hsap\LOC102724159
1 of 14
No
No
Hsap\NLE1
1 of 14
No
No
Hsap\PAK1IP1
1 of 14
No
No
Hsap\POC1B
1 of 14
No
No
1  
Hsap\PWP2
1 of 14
No
No
1  
Hsap\SEC13
1 of 14
No
No
Hsap\SEH1L
1 of 14
No
No
Hsap\SNRNP40
1 of 14
No
No
Hsap\SPAG16
1 of 14
No
Yes
Hsap\STRN3
1 of 14
No
No
Hsap\STRN4
1 of 14
No
No
Hsap\STRN
1 of 14
No
No
1  
Hsap\TAF5
1 of 14
No
No
Hsap\TAF5L
1 of 14
No
No
Hsap\TBC1D31
1 of 14
No
No
Hsap\TBL1X
1 of 14
No
No
1  
Hsap\TBL1XR1
1 of 14
No
No
Hsap\TBL1Y
1 of 14
No
No
1  
Hsap\TBL3
1 of 14
No
No
Hsap\TEP1
1 of 14
No
No
Hsap\TRAF7
1 of 14
No
No
Hsap\WDR33
1 of 14
No
No
Hsap\WDR37
1 of 14
No
No
4  
Hsap\WDR44
1 of 14
No
No
Hsap\WDR48
1 of 14
No
No
Hsap\WDR61
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (35)
Rnor\Pafah1b1
13 of 14
Yes
Yes
Rnor\Daw1
2 of 14
No
No
Rnor\Plrg1
2 of 14
No
No
Rnor\Poc1a
2 of 14
No
No
Rnor\Wdr5
2 of 14
No
No
Rnor\Wdr86
2 of 14
No
Yes
Rnor\Aamp
1 of 14
No
No
Rnor\Bop1
1 of 14
No
No
Rnor\Btrc
1 of 14
No
No
Rnor\Copa
1 of 14
No
No
Rnor\Copb2
1 of 14
No
No
Rnor\Eed
1 of 14
No
No
Rnor\Elp2
1 of 14
No
No
Rnor\Fbxw7
1 of 14
No
No
Rnor\Fbxw10
1 of 14
No
Yes
Rnor\Fbxw11
1 of 14
No
No
Rnor\Katnb1
1 of 14
No
No
Rnor\Mlst8
1 of 14
No
No
Rnor\Pak1ip1
1 of 14
No
No
Rnor\Poc1b
1 of 14
No
No
Rnor\Snrnp40
1 of 14
No
No
Rnor\Strn3
1 of 14
No
No
Rnor\Strn4
1 of 14
No
No
Rnor\Strn
1 of 14
No
No
Rnor\Taf5l
1 of 14
No
No
Rnor\Tbc1d31
1 of 14
No
No
Rnor\Tbl1xr1
1 of 14
No
No
Rnor\Tbl1x
1 of 14
No
No
Rnor\Tbl3
1 of 14
No
No
Rnor\Traf7
1 of 14
No
No
Rnor\Wdr5b
1 of 14
No
No
Rnor\Wdr37
1 of 14
No
No
Rnor\Wdr44
1 of 14
No
No
Rnor\Wdr48
1 of 14
No
No
Rnor\Wdr61
1 of 14
No
No
Mus musculus (laboratory mouse) (35)
Mmus\Pafah1b1
12 of 14
Yes
Yes
Mmus\Daw1
2 of 14
No
No
Mmus\Plrg1
2 of 14
No
No
Mmus\Poc1a
2 of 14
No
No
Mmus\Wdr5b
2 of 14
No
No
Mmus\Wdr5
2 of 14
No
No
Mmus\Wdr86
2 of 14
No
Yes
Mmus\Aamp
1 of 14
No
No
Mmus\Bop1
1 of 14
No
No
Mmus\Btrc
1 of 14
No
No
Mmus\Copa
1 of 14
No
No
Mmus\Copb2
1 of 14
No
No
Mmus\Eed
1 of 14
No
No
Mmus\Elp2
1 of 14
No
No
Mmus\Fbxw7
1 of 14
No
No
Mmus\Fbxw10
1 of 14
No
Yes
Mmus\Fbxw11
1 of 14
No
No
Mmus\Katnb1
1 of 14
No
No
Mmus\Mlst8
1 of 14
No
No
Mmus\Pak1ip1
1 of 14
No
No
Mmus\Snrnp40
1 of 14
No
No
Mmus\Spag16
1 of 14
No
Yes
Mmus\Strn3
1 of 14
No
No
Mmus\Strn4
1 of 14
No
No
Mmus\Strn
1 of 14
No
No
Mmus\Taf5l
1 of 14
No
No
Mmus\Tbc1d31
1 of 14
No
No
Mmus\Tbl1x
1 of 14
No
No
Mmus\Tbl1xr1
1 of 14
No
No
Mmus\Tbl3
1 of 14
No
No
Mmus\Traf7
1 of 14
No
No
Mmus\Wdr37
1 of 14
No
No
Mmus\Wdr44
1 of 14
No
No
Mmus\Wdr48
1 of 14
No
No
Mmus\Wdr61
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (30)
Xtro\pafah1b1
10 of 13
Yes
Yes
Xtro\daw1
2 of 13
No
No
Xtro\mlst8
2 of 13
No
No
Xtro\poc1a
2 of 13
No
No
Xtro\wdr5
2 of 13
No
No
Xtro\bop1
1 of 13
No
No
Xtro\cdrt1
1 of 13
No
Yes
Xtro\copa
1 of 13
No
No
Xtro\copb2
1 of 13
No
No
Xtro\depdc4
1 of 13
No
Yes
Xtro\eed
1 of 13
No
No
Xtro\elp2
1 of 13
No
No
Xtro\gnb5
1 of 13
No
No
Xtro\ift122
1 of 13
No
No
Xtro\katnb1
1 of 13
No
No
Xtro\lrwd1
1 of 13
No
No
Xtro\plrg1
1 of 13
No
No
Xtro\poc1b
1 of 13
No
No
Xtro\seh1l
1 of 13
No
No
Xtro\snrnp40
1 of 13
No
No
Xtro\spag16
1 of 13
No
Yes
Xtro\strn
1 of 13
No
No
Xtro\taf5l
1 of 13
No
No
Xtro\taf5
1 of 13
No
No
Xtro\tbl1xr1
1 of 13
No
No
Xtro\wdr37
1 of 13
No
No
Xtro\wdr47
1 of 13
No
No
Xtro\wdr48
1 of 13
No
No
Xtro\wdr61
1 of 13
No
No
Xtro\wdr86
1 of 13
No
No
Danio rerio (Zebrafish) (39)
Drer\pafah1b1b
14 of 14
Yes
Yes
Drer\pafah1b1a
13 of 14
No
Yes
Drer\daw1
2 of 14
No
No
Drer\plrg1
2 of 14
No
No
Drer\poc1a
2 of 14
No
No
Drer\poc1b
2 of 14
No
No
Drer\wdr5
2 of 14
No
No
Drer\aamp
1 of 14
No
No
Drer\bop1
1 of 14
No
No
Drer\cfap52
1 of 14
No
No
Drer\copa
1 of 14
No
No
Drer\copb2
1 of 14
No
No
Drer\eed
1 of 14
No
No
Drer\elp2
1 of 14
No
No
Drer\fbxw7
1 of 14
No
No
Drer\fbxw10
1 of 14
No
No
Drer\fbxw11a
1 of 14
No
No
Drer\fbxw11b
1 of 14
No
No
Drer\LOC100534785
1 of 14
No
No
Drer\lrwd1
1 of 14
No
Yes
Drer\mlst8
1 of 14
No
No
Drer\pak1ip1
1 of 14
No
No
Drer\smu1a
1 of 14
No
No
Drer\snrnp40
1 of 14
No
No
Drer\strn3
1 of 14
No
No
Drer\strn4
1 of 14
No
No
Drer\strn
1 of 14
No
No
Drer\taf5
1 of 14
No
No
Drer\tbc1d31
1 of 14
No
No
Drer\tbl1x
1 of 14
No
No
Drer\tbl1xr1a
1 of 14
No
No
Drer\tbl1xr1b
1 of 14
No
No
Drer\tbl3
1 of 14
No
No
Drer\traf7
1 of 14
No
No
Drer\wdr37
1 of 14
No
No
Drer\wdr44
1 of 14
No
No
Drer\wdr48a
1 of 14
No
No
Drer\wdr48b
1 of 14
No
No
Drer\wdr61
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (25)
Cele\lis-1
13 of 14
Yes
Yes
Cele\wdr-5.1
2 of 14
No
No
Cele\Y41C4A.32
2 of 14
No
No
Cele\cash-1
1 of 14
No
No
Cele\copa-1
1 of 14
No
No
Cele\copb-2
1 of 14
No
No
Cele\E03H4.8
1 of 14
No
No
Cele\elpc-2
1 of 14
No
No
Cele\F55F8.3
1 of 14
No
No
Cele\lin-23
1 of 14
No
No
Cele\mes-6
1 of 14
No
No
Cele\mlst-8
1 of 14
No
No
Cele\npp-18
1 of 14
No
No
Cele\npp-20
1 of 14
No
No
Cele\pfs-2
1 of 14
No
No
Cele\plrg-1
1 of 14
No
No
Cele\prp-19
1 of 14
No
No
Cele\sel-10
1 of 14
No
No
Cele\taf-5
1 of 14
No
No
Cele\unc-78
1 of 14
No
No
Cele\wdr-5.2
1 of 14
No
No
Cele\wdr-37
1 of 14
No
No
Cele\wdr-48
1 of 14
No
No
Cele\Y48B6A.1
1 of 14
No
No
Cele\Y111B2A.12
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (34)
Agam\AgaP_AGAP011849
12 of 12
Yes
Yes
Agam\AgaP_AGAP012731
3 of 12
No
No
Agam\AgaP_AGAP002019
2 of 12
No
No
Agam\AgaP_AGAP005631
2 of 12
No
No
Agam\AgaP_AGAP007626
2 of 12
No
No
Agam\AgaP_AGAP012029
2 of 12
No
No
Agam\AgaP_AGAP001036
1 of 12
No
No
Agam\AgaP_AGAP001149
1 of 12
No
No
Agam\AgaP_AGAP001361
1 of 12
No
No
Agam\AgaP_AGAP001362
1 of 12
No
No
Agam\AgaP_AGAP001944
1 of 12
No
No
Agam\AgaP_AGAP002221
1 of 12
No
No
Agam\AgaP_AGAP002509
1 of 12
No
No
Agam\AgaP_AGAP003183
1 of 12
No
No
Agam\AgaP_AGAP003524
1 of 12
No
No
Agam\AgaP_AGAP004374
1 of 12
No
No
Agam\AgaP_AGAP004798
1 of 12
No
No
Agam\AgaP_AGAP005174
1 of 12
No
No
Agam\AgaP_AGAP005320
1 of 12
No
No
Agam\AgaP_AGAP005359
1 of 12
No
No
Agam\AgaP_AGAP006113
1 of 12
No
No
Agam\AgaP_AGAP006889
1 of 12
No
No
Agam\AgaP_AGAP007739
1 of 12
No
No
Agam\AgaP_AGAP008550
1 of 12
No
No
Agam\AgaP_AGAP008755
1 of 12
No
No
Agam\AgaP_AGAP008925
1 of 12
No
No
Agam\AgaP_AGAP009506
1 of 12
No
No
Agam\AgaP_AGAP009574
1 of 12
No
No
Agam\AgaP_AGAP010251
1 of 12
No
No
Agam\AgaP_AGAP010693
1 of 12
No
No
Agam\AgaP_AGAP011387
1 of 12
No
No
Agam\AgaP_AGAP011678
1 of 12
No
No
Agam\BOP1_ANOGA
1 of 12
No
No
Agam\CIAO1_ANOGA
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (30)
Atha\AT1G71840
2 of 13
Yes
No
Atha\AT3G16650
2 of 13
Yes
No
Atha\HOS15
2 of 13
Yes
No
Atha\PRL1
2 of 13
Yes
No
Atha\WDR5a
2 of 13
Yes
No
Atha\WDR5b
2 of 13
Yes
No
Atha\AT1G52360
1 of 13
No
No
Atha\AT1G62020
1 of 13
No
No
Atha\AT1G65030
1 of 13
No
No
Atha\AT1G79990
1 of 13
No
No
Atha\AT2G21390
1 of 13
No
No
Atha\AT2G30050
1 of 13
No
No
Atha\AT2G40360
1 of 13
No
No
Atha\AT2G43770
1 of 13
No
No
Atha\AT2G46290
1 of 13
No
No
Atha\AT3G01340
1 of 13
No
No
Atha\AT3G15980
1 of 13
No
No
Atha\AT4G32990
1 of 13
No
No
Atha\AT5G52820
1 of 13
No
No
Atha\DWA3
1 of 13
No
No
Atha\ELP2
1 of 13
No
No
Atha\FIE
1 of 13
No
No
Atha\LRS1
1 of 13
No
No
Atha\LST8-1
1 of 13
No
No
Atha\LST8-2
1 of 13
No
No
Atha\PWP2
1 of 13
No
No
Atha\SEH1H
1 of 13
No
No
Atha\TAF5
1 of 13
No
No
Atha\TEX1
1 of 13
No
No
Atha\VIP3
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (16)
Scer\PAC1
8 of 13
Yes
Yes
Scer\SWD3
2 of 13
No
No
Scer\COP1
1 of 13
No
No
Scer\ELP2
1 of 13
No
No
Scer\ERB1
1 of 13
No
No
Scer\LST8
1 of 13
No
No
Scer\MAK11
1 of 13
No
No
Scer\PRP46
1 of 13
No
No
Scer\PWP2
1 of 13
No
No
Scer\SEC13
1 of 13
No
No
Scer\SEC27
1 of 13
No
No
Scer\SEH1
1 of 13
No
No
Scer\SIF2
1 of 13
No
No
Scer\SQT1
1 of 13
No
No
Scer\TAF5
1 of 13
No
No
Scer\TIF34
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (18)
Spom\bun107
1 of 12
Yes
No
Spom\caf4
1 of 12
Yes
Yes
Spom\elp2
1 of 12
Yes
No
Spom\hif2
1 of 12
Yes
No
Spom\pof1
1 of 12
Yes
No
Spom\pof11
1 of 12
Yes
No
Spom\pop1
1 of 12
Yes
No
Spom\pop2
1 of 12
Yes
No
Spom\pop3
1 of 12
Yes
No
Spom\prp5
1 of 12
Yes
No
Spom\rec14
1 of 12
Yes
No
Spom\sec27
1 of 12
Yes
No
Spom\skb15
1 of 12
Yes
No
Spom\SPAC25H1.08c
1 of 12
Yes
No
Spom\SPBC4F6.13c
1 of 12
Yes
No
Spom\SPBC1773.01
1 of 12
Yes
No
Spom\SPBPJ4664.04
1 of 12
Yes
No
Spom\utp13
1 of 12
Yes
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Lis-1. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (31)
CG10931
4 of 13
wds
4 of 13
CG12608
2 of 13
Poc1
2 of 13
ago
1 of 13
αCOP
1 of 13
β'COP
1 of 13
can
1 of 13
CG3436
1 of 13
CG5033
1 of 13
CG7568
1 of 13
CG7611
1 of 13
CG9123
1 of 13
CG12325
1 of 13
Cka
1 of 13
Elp2
1 of 13
esc
1 of 13
escl
1 of 13
Nup44A
1 of 13
Rbcn-3B
1 of 13
Sec13
1 of 13
Ski8
1 of 13
slmb
1 of 13
Taf5
1 of 13
Tango4
1 of 13
Uaf1
1 of 13
wda
1 of 13
Wdr33
1 of 13
Wdr37
1 of 13
Wdr62
1 of 13
Wdr81
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Modifiers Based on Experimental Evidence ( 2 )
    Allele
    Disease
    Interaction
    References
    Lis-1k11702
    exacerbates  muscular dystrophy
    modeled by DgO86
    (Kucherenko et al., 2011)
    Lis-1k13209
    exacerbates  muscular dystrophy
    modeled by DgO86
    (Kucherenko et al., 2011, Marrone et al., 2011)
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    PAFAH1B1; platelet activating factor acetylhydrolase 1b regulatory subunit 1
    13 of 14
    601545
     
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Lis-1
    enhanceable
    DCTN1-p150
    (Lei and Warrior, 2000)
    Lis-1
    suppressible
    Dhc64C
    (Swan et al., 1999)
    Lis-1
    enhanceable
    Egfr
    (Lei and Warrior, 2000)
    Lis-1
    enhanceable
    grk
    (Lei and Warrior, 2000)
    Lis-1
    suppressible
    shg
    (Chen et al., 2010)
    Lis-1
    suppressible
    tkv
    (Chen et al., 2010)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    BicD
    enhanceable
    Lis-1
    (Swan et al., 1999)
    BicD
    suppressible
    Lis-1|stau
    (Navarro et al., 2004)
    DCTN1-p150
    enhanceable
    Lis-1
    (Lei and Warrior, 2000)
    Dys
    suppressible
    Lis-1
    (Kucherenko et al., 2008)
    grk
    enhanceable
    Lis-1
    (Lei and Warrior, 2000)
    msn
    enhanceable
    Lis-1
    (Houalla et al., 2005)
    nudE
    suppressible
    Lis-1
    (Arthur et al., 2015)
    stau|BicD
    suppressible
    Lis-1
    (Navarro et al., 2004)
    tkv
    suppressible
    Lis-1
    (Chen et al., 2010)
    External Data
    Subunit Structure (UniProtKB)
    Interacts with dynein and dynactin. Does not interact with Paf-A-Halpha.
    (UniProt, Q7KNS3 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyBase
    External Links
    KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
    External Data
    Linkouts
    KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2R
    Recombination map
    2-78
    Cytogenetic map
    52F4-52F5
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    52F4-52F5
    Limits computationally determined from genome sequence between P{EP}spinEP645&P{lacW}spink09905 and P{lacW}Lis-1k11702&P{EP}CG8443EP969
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    52F-52F
    (Swan, 1999.1.3)
    52F5-52F9
    (Liu, 1999.5.18)
    52F5-52F7
    (determined by in situ hybridisation) 52F3--5 (determined by in situ hybridisation)
    (Spradling et al., 1999)
    52F-53A
    (determined by in situ hybridisation)
    (Liu et al., 1999)
    52F5-52F7
    (BDGP Project Members, 1994-1999)
    Experimentally Determined Recombination Data
    Location

    2-78

    (FlyBase, 2016)

    2-81.1

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (22)
    Genomic Clones (22)
    cDNA Clones (179)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    Antibody Information
    Laboratory Generated Antibodies
     

    polyclonal

    (Dix et al., 2013, Liu et al., 1999)
    Commercially Available Antibodies
     
    Cell Line Information
    Publicly Available Cell Lines
     
      Other Stable Cell Lines
       
        Other Comments

        Lis-1 acts as a negative regulator of mitochondrial transport along the axons in aging adult neurons.

        (Vagnoni et al., 2016)

        Lis-1 protein is recruited to RNA localisation signals and is required for net minus end-directed transport of apically localised RNAs. Lis-1 promotes the recruitment of dynein and dynactin to RNA localisation complexes. In addition, Lis-1 protein levels appear to regulate the overall association of dynein with dynactin.

        (Dix et al., 2013)

        Lis-1 controls germline stem cell self-renewal by maintaining BMP signaling in germline stem cells and shg accumulation in the stem cell-niche interface.

        (Chen et al., 2010)

        One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders.

        (Inlow and Restifo, 2004)

        Lis-1 is involved in microtubule based nuclear motility.

        (Lei and Warrior, 2000)

        Lis-1 is required in the female germline for synchronised germline cell division, fusome integrity and oocyte differentiation.

        (Liu et al., 1999)
        Relationship to Other Genes
        Source for database merge of

        Source for merge of: Lis1 Paf-AHβ

        (FlyBase, 1996-)
        Additional comments

        Source for merge of Lis1 Paf-AHβ was sequence comparison ( date:000219 ).

        (FlyBase, 1996-)
        Nomenclature History
        Source for database identify of
        Nomenclature comments
        Etymology
        Synonyms and Secondary IDs (24)
        Reported As
        Symbol Synonym
        CG8440
        (National Institute of Genetics Fly Stocks, 2022-, Ibaraki et al., 2021, Neuert et al., 2017, Çiçek et al., 2016, Honjo et al., 2016, Hosono et al., 2015, Bilousov et al., 2014, Howell et al., 2012, Cammarato et al., 2011, Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Perkins et al., 2009, Goldstein and Gunawardena, 2000)
        D-Lis1
        (Yang and Steward, 1997)
        DLIS-1
        (Liu and Steward, 1998, Cooperstock and Lipshitz, 1997, Lei and Warrior, 1997, Liu and Steward, 1997)
        DLIS1
        (Liu and Steward, 1999)
        DLis-1
        (Houalla et al., 2005, Januschke et al., 2002, Sardet et al., 2002, Wodarz, 2002, Johnstone and Lasko, 2001, Fischer, 2000, Duncan et al., 1999, Swan et al., 1999, Lei et al., 1998)
        DLis1
        (Duncan et al., 2001, Schindelholz et al., 2001, Wynshaw-Boris and Gambello, 2001, Duncan et al., 2000, Lei and Warrior, 2000)
        Dlis-1
        (Liu and Steward, 1996)
        Dlis1
        (Gervais and Casanova, 2010)
        DmLIS1
        (Sheffield et al., 2000)
        LIS-1
        (Lu and Johnston, 2013, Kai et al., 2005, Tromans, 2000)
        Lis
        (Yuan et al., 2019)
        Lis 1
        (Jan and Jan, 2003)
        Lis-1
        (Guo et al., 2025, Katzenberger et al., 2023, Sebastian et al., 2022, Du et al., 2021, Ibaraki et al., 2021, Ricolo et al., 2021, Aboukilila et al., 2020, Robinson et al., 2020, Neuert et al., 2017, Transgenic RNAi Project members, 2017-, Honjo et al., 2016, Noble et al., 2016, Sarov et al., 2016, Beaven et al., 2015, Copf, 2015, Huang et al., 2015, Chen et al., 2013, Fabian and Brill, 2012, Schottenfeld-Roames and Ghabrial, 2012, Sitaram et al., 2012, Yang et al., 2012, Harris and Ashe, 2011, Kucherenko et al., 2011, Neumüller et al., 2011, Van De Bor et al., 2011, Ségalen et al., 2010, Johnston et al., 2009, Wheeler et al., 2009, Gandre-Babbe and van der Bliek, 2008, Kucherenko et al., 2008, Toda et al., 2008, Yang et al., 2008, Kaplow et al., 2007, Luo, 2007.3.23, Navarro et al., 2004, Cohen, 2002, FlyBase, 1992-)
        Lis1
        (Lu et al., 2023, Lu et al., 2022, Moutaoufik and Tanguay, 2021, Puñal et al., 2021, Dubey et al., 2020, Penserga et al., 2019, Vagnoni et al., 2016, Arthur et al., 2015, Bajaj et al., 2015, Del Castillo et al., 2015, Port et al., 2015, Yalgin et al., 2015, Copf, 2014, Dix et al., 2013, Puram and Bonni, 2013, Raftery and Umulis, 2012, Yang et al., 2012, Zhao et al., 2012, Marrone et al., 2011, Chen et al., 2010, Williams, 2009, Siller and Doe, 2008, Yang et al., 2008, Zheng et al., 2008, Griffis et al., 2007, Solecki et al., 2006, Dzhindzhev et al., 2005, Javier et al., 2005, Siller et al., 2005, Starr and Fischer, 2005, Huynh and St. Johnston, 2004, Siller et al., 2004, Driscoll and Gerstbrein, 2003, Gao and Bogert, 2003, Giot et al., 2003, Morris, 2003, Tekotte and Davis, 2002, Lee and Luo, 2001, Goldstein and Gunawardena, 2000, Liu et al., 2000, Morris, 2000, Reiner, 2000, Steward, 2000.8.14, Liu et al., 1999)
        dLis1
        (Bakal et al., 2007)
        l(2)k13209
        (BDGP Project Members, 1994-1999)
        l(2R)W8
        (Liu et al., 1999)
        lis-1
        (Amartuvshin et al., 2025, Kucherenko et al., 2011, Satoh et al., 2007)
        lis1
        (Yoong et al., 2020, Kudumala et al., 2017, Liu et al., 2015, Schulman et al., 2014, Dix et al., 2013, Cheng et al., 2011, Wainman et al., 2009, Satoh et al., 2008, Cabernard et al., 2007, Matova and Cooley, 2001)
        n(2)k11702
        (Spradling, 1999.12.9)
        Name Synonyms
        Lissencephaly-1
        (Howell et al., 2012, Cammarato et al., 2011, Harris and Ashe, 2011, Kucherenko et al., 2011, Marrone et al., 2011, Chen et al., 2010, McGraw et al., 2008, Kaplow et al., 2007)
        Paf-AHβ
        (Spradling et al., 1999)
        lissencephaly-1
        (Williams, 2009)
        platelet-activating factor acetylhydrolase Ib β-subunit homolog
        (Sheffield et al., 2000)
        Secondary FlyBase IDs
        • FBgn0021892
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        Study result (0)
        Result
        Result Type
        Title
        External Crossreferences and Linkouts ( 76 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
        FlyMine - An integrated database for Drosophila genomics
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL - MARRVEL (model organism gene)
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
        KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
        KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        SignaLink - A signaling pathway resource with multi-layered regulatory networks.
        References (178)