FlyBase Gene Report: Dpse\Hsp83

Important message

Updated sequence information for this Drosophila species is no longer provided by FlyBase. Gene model annotations for this species are now updated and maintained at NCBI, using the gnomon automated annotation pipeline. See the NCBI page ‘Eukaryotic genomes annotated at NCBI’.

The FlyBase BLAST tool will continue to support queries against the reference genome of this species, but not queries against annotated transcripts or proteins. For the current release, there is no JBrowse or GBrowse view of the gene model annotations for this species.

The FlyBase archived release FB2017_05 includes the last NCBI annotation update for this species that was imported into FlyBase. That sequence data can be accessed from archived gene reports, via the archived GBrowse tool, and via archived bulk-data downloads.

General Information

Symbol

Dpse\Hsp83

Species

D. pseudoobscura pseudoobscura

Name

Annotation Symbol

Feature Type

protein_coding_gene

FlyBase ID

FBgn0012701

Gene Model Status

Withdrawn

Stock Availability

None publicly available

Gene Summary

Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Required for piRNA biogenesis by facilitating loading of piRNAs into PIWI proteins (By similarity). (UniProt, P04809)

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All Summaries

Also Known As

Hsp82, Hsp83

Summaries

Protein Function (UniProtKB)

(UniProt, P04809)

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 0 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 1 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Dpse\Hsp83

Transgenic constructs containing regulatory region of Dpse\Hsp83

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

Homodimer. Interacts with shu (By similarity).

(UniProt, P04809 )

Linkouts

Class of Gene

nuclear_gene

(Drosophila 12 Genomes Consortium, 2008)

protein_coding_gene

(Drosophila 12 Genomes Consortium, 2008)

Stocks and Reagents

Stocks (0)

Genomic Clones (0)

cDNA Clones (0)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

A dendrogram of protein sequence for representative members of the HSP90 family is generated.

(Konstantopoulou and Scouras, 1998)

The frequency distribution of "silent" DNA polymorphisms has been studied in a number of D.simulans and D.pseudoobscura.pseudoobscura genes.

(Akashi and Schaeffer, 1997)

Insertions of Tn\neoR^{22.Dpse\Hsp83} at euchromatic sites on the X chromosome of D.melanogaster are fully dosage compensated in both adults and larvae. Autosomal insertions and an insertion in a β-heterochromatic region of the X chromosome are not compensated at either stage. Heat induced activity of Tn\neoR^{22.Dpse\Hsp83} at insertion sites demonstrates an absence of position effect.

(Arkhipova et al., 1997)

The Dpse\Hsp83 promoter directs similar levels of reporter gene expression in D.melanogaster and L.cuprina embryos, indicating that this promoter can function efficiently in the non-drosophilid L.cuprina.

(Coates et al., 1996)

Chromosome homologies of Muller's element D (J chromosome in the Paleartic species and XR chromosome arm in Nearctic species) and of element E (O chromosome in the Paleartic species and 2 chromosome in Nearctic species) have been confirmed by single copy probes in the species of the obscura group and in D.melanogaster.

(Segarra et al., 1996)

Dpse\Hsp83 promoter is more active in a wider range of insect species than the more commonly used Hsp70A, Hsp70B or Act5C.

(Coates et al., 1994)

Transcribed larval mRNA was measured from the autosomal Adh gene and the X chromosomal Dpse\Hsp83 gene, both carried on the same P-element construct. Both genes are fully dosage compensated at transposon insertion sites in the euchromatic regions of the X chromosome but neither were compensated at an insertion site in the β-heterochromatin of the X chromosome. No compensation of the Dpse\Hsp83 gene was found at any of the autosomal insertion sites. The compensation behaviour of the transposed genes was determined by their new chromosomal environment.

(Sass and Meselson, 1991)

Sequence analysis of the Hsp83 gene in several species reveals a conserved 5' 34 base pair imperfect dyad made up of three overlapping copies of the consensus heat shock regulatory sequence. The region from -21 to -133 is repeated further upstream, possibly related to dosage compensation.

(Blackman and Meselson, 1986)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

Dpse\GA11622

Dpse\Hsp82

Dpse\Hsp83

(Drosophila 12 Genomes Consortium, 2008)

Dpse\hsp82

(Coates et al., 1994)

GA11622

Hsp82

(Hey and Nielsen, 2004, Machado et al., 2002, Ashburner et al., 1998, Wang, 1997.6.3, Wang, 1997.6.3, Wang, 1997.6.3, Wang, 1997.6.3, Wang, 1997.6.3, Wang, 1997.6.3, Wang, 1997.6.3, Wang, 1997.6.3, Wang, 1997.6.3, Wang, 1997.6.3, Wang, 1997.6.3, Wang et al., 1997, Blackman and Meselson, 1986)

Hsp83

(Drosophila 12 Genomes Consortium, 2008, Bartolome and Charlesworth, 2006)

dpse_GLEANR_12510

(Drosophila 12 Genomes Consortium, 2008)

hsp82

(Coates et al., 1996, Comeron, 1995, Eickbush et al., 1995, Sass, 1994, Moriyama and Gojobori, 1992)

hsp83

(Segarra et al., 1996)

Name Synonyms

Heat shock protein 83

Secondary FlyBase IDs

FBgn0012702

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 76 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

4813013

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P04809

Other crossreferences

FlyMine - An integrated database for Drosophila genomics

FBgn0012701

GNOMON -

Dpse_gnomon_102_gene.19743202

InterPro - A database of protein families, domains and functional sites

References (43)

Important message

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