FlyBase Gene Report: Dmel\cpb

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Gene: Dmel\cpb

General Information

Symbol

Dmel\cpb

Species

D. melanogaster

Name

capping protein beta

Annotation Symbol

CG17158

Feature Type

protein_coding_gene

FlyBase ID

FBgn0011570

Gene Model Status

Stock Availability

20 publicly available

Gene Summary

capping protein beta (cpb) encodes an actin-binding protein that, together with cpa, binds to the fast growing ends of actin filaments, restricting the addition or loss of actin monomers. It restricts JNK signaling, modulates Hippo signaling, maintains epithelial integrity and neuronal homeostasis, controls proliferation/apoptosis in wing imaginal discs, and promotes oogenesis. [Date last reviewed: 2018-09-13] (FlyBase Gene Snapshot)

All Summaries

Also Known As

capping protein β, capping protein, burned, CapZ, Cap2

Key Links

Genomic Location

Cytogenetic map

Sequence location

2L:1,704,902..1,706,962 [+]

Recombination map

2-3

RefSeq locus

NT_033779 REGION:1704902..1706962

Sequence

Get Decorated FASTA

Genomic Maps

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (23 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables protein heterodimerization activity

inferred from physical interaction with FLYBASE:cpa; FB:FBgn0289712

(Amândio et al., 2014)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables actin binding

inferred from electronic annotation with InterPro:IPR019771

(InterPro Project Members, 2004-)

enables actin filament binding

inferred from biological aspect of ancestor with PANTHER:PTN000065509

(GO Reference Genome Project, 2011-)

Biological Process (14 terms)

Terms Based on Experimental Evidence (12 terms)

CV Term

Evidence

References

involved_in actin cytoskeleton organization

inferred from mutant phenotype

(Delalle et al., 2005)

involved_in actin filament organization

inferred from mutant phenotype

(Gates et al., 2009)

involved_in barbed-end actin filament capping

inferred from mutant phenotype

(Amândio et al., 2014)

inferred from direct assay

(Hopmann et al., 1996)

involved_in border follicle cell migration

inferred from mutant phenotype

(Lucas et al., 2013, Gates et al., 2009)

involved_in negative regulation of filopodium assembly

inferred from mutant phenotype

(Gonçalves-Pimentel et al., 2011)

involved_in negative regulation of JNK cascade

inferred from genetic interaction with FLYBASE:cpa; FB:FBgn0289712

(Fernández et al., 2014)

involved_in nuclear envelope budding

inferred from mutant phenotype

(Verboon et al., 2020)

involved_in ovarian nurse cell to oocyte transport

inferred from mutant phenotype

(Gates et al., 2009)

involved_in positive regulation of synaptic assembly at neuromuscular junction

inferred from mutant phenotype

(Loya et al., 2014)

involved_in regulation of actin filament length

inferred from mutant phenotype

(Rogers et al., 2003)

involved_in regulation of lamellipodium assembly

inferred from mutant phenotype

(Iwasa and Mullins, 2007)

involved_in wing disc development

inferred from mutant phenotype

(Janody and Treisman, 2006)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in actin cytoskeleton organization

inferred from electronic annotation with InterPro:IPR019771

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000065509

(GO Reference Genome Project, 2011-)

involved_in barbed-end actin filament capping

inferred from biological aspect of ancestor with PANTHER:PTN000065509

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR001698

(InterPro Project Members, 2004-)

involved_in cell morphogenesis

inferred from biological aspect of ancestor with PANTHER:PTN000065509

(GO Reference Genome Project, 2011-)

involved_in microtubule-based movement

inferred by curator from GO:0005869

(Eckley and Schroer, 2003)

Cellular Component (6 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

colocalizes_with adherens junction

inferred from direct assay

(Amândio et al., 2014)

part_of F-actin capping protein complex

inferred from direct assay

(Amândio et al., 2014)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

is_active_in cortical actin cytoskeleton

inferred from biological aspect of ancestor with PANTHER:PTN000065509

(GO Reference Genome Project, 2011-)

located_in cytoplasm

inferred from electronic annotation with InterPro:IPR019771

(InterPro Project Members, 2004-)

part_of dynactin complex

inferred from sequence or structural similarity with MGI:MGI:104652

(Eckley and Schroer, 2003)

part_of F-actin capping protein complex

inferred from biological aspect of ancestor with PANTHER:PTN000065509

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR001698, InterPro:IPR019771

(InterPro Project Members, 2004-)

part_of WASH complex

inferred from sequence or structural similarity with UniProtKB:P47756

(Derivery and Gautreau, 2010)

Gene Group (FlyBase)

DYNACTIN COMPLEX

F-ACTIN CAPPING PROTEIN COMPLEX

Protein Family (UniProt)

Belongs to the F-actin-capping protein beta subunit family. (P48603)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

capping protein beta (cpb) encodes an actin-binding protein that, together with cpa, binds to the fast growing ends of actin filaments, restricting the addition or loss of actin monomers. It restricts JNK signaling, modulates Hippo signaling, maintains epithelial integrity and neuronal homeostasis, controls proliferation/apoptosis in wing imaginal discs, and promotes oogenesis. [Date last reviewed: 2018-09-13]

Gene Group (FlyBase)

DYNACTIN COMPLEX -: Dynactin is a large 1.2 MDa multisubunit protein complex that associates with the cytoplasmic dynein complex to drive microtubule-based transport. (Adapted from PMID:15473859 and PMID:25751425).
F-ACTIN CAPPING PROTEIN COMPLEX -: The F-actin capping protein complex is a heterodimer which regulates actin polymerization. The complex binds to the plus (barbed) end of actin filaments and blocks the exchange of actin monomers. (Adapted from FBrf0213674 and FBrf0224864).

Protein Function (UniProtKB)

F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity).

(UniProt, P48603)

Summary (Interactive Fly)

regulates nonbundle actin filament assembly during bristle development - acts upstream of the Hippo pathway and functions as a tumor suppressor, antagonized by Enabled, maintains epithelial integrity and prevents JNK-mediated apoptosis, functions in oocyte determination

Interactive Fly

Gene Model and Products

Number of Transcripts

2

Number of Unique Polypeptides

1

Please see the JBrowse view of Dmel\cpb for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P48603)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.45

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0077881

1591

276

FBtr0331630

1713

276

Additional Transcript Data and Comments

Reported size (kB)

1.9, 1.8 (northern blot)

(Hopmann et al., 1996)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

FBpp0077549

31.4

276

5.08

FBpp0304020

31.4

276

5.08

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

276 aa isoforms: cpb-PA, cpb-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

276 (aa); 32 (kD observed)

(Hopmann et al., 1996)

Comments

External Data

Subunit Structure (UniProtKB)

Component of the F-actin capping complex, composed of a heterodimer of an alpha and a beta subunit (By similarity). Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3 (By similarity).

(UniProt, P48603)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\cpb using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.65

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

(Fisher et al., 2012)

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

(Fisher et al., 2012)

anterior midgut primordium

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

plasmatocyte primordium

Comment: reported as plasmatocytes anlage

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

procrystal cell

(Fisher et al., 2012)

embryonic stage 13 -- 16

(Fisher et al., 2012)

embryonic/larval crystal cell

(Fisher et al., 2012)

embryonic hindgut

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

larval muscle system

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic/larval plasmatocyte

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

(Hopmann et al., 1996)

Additional Descriptive Data

cpb transcripts are expressed at fairly constant levels in all developmental stages.

(Hopmann et al., 1996)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

(Hopmann et al., 1996)

indirect flight muscle cell

• Z disc

(Deng et al., 2021)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

• membrane

(Aradska et al., 2015)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

(Hopmann et al., 1996)

muscle cell of thorax

• Z disc

(Hopmann et al., 1996)

Additional Descriptive Data

cpb localizes to the Z disc in indirect flight muscle sarcomeres.

(Deng et al., 2021)

cpb protein is expressed in all developmental stages at relatively constant levels. In bristles, cbp protein localizes along the length of actin bundles and is found in the periphery of the bristle. In adult flies, cpb protein localizes to the Z discs of thoracic muscles.

(Hopmann et al., 1996)

Marker for

Subcellular Localization

CV Term

Evidence

References

colocalizes_with adherens junction

inferred from direct assay

(Amândio et al., 2014)

part_of F-actin capping protein complex

inferred from direct assay

(Amândio et al., 2014)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\cpb in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\cpb

View exonic expression by tissue for Dmel\cpb

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0011570

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33346/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0011570

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0011570

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0011570

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG17158

Flygut - An atlas of the Drosophila adult midgut

FBgn0011570

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\cpb

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 13 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 13 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of cpb

Transgenic constructs containing regulatory region of cpb

Aberrations (Deficiencies and Duplications) ( 10 )

Inferred from experimentation ( 10 )

Gene disrupted in

(Delalle et al., 2005, Hopmann et al., 1996)

(Christensen et al., 2008.4.15)

(Christensen et al., 2008.4.15)

(Hopmann et al., 1996)

(Whited et al., 2004)

(Ryder, 2004.4.26)

(Delalle et al., 2005, Welte, 2000.2.23)

Gene not disrupted in

(Delalle et al., 2005)

(Collier et al., 2005)

(Delalle et al., 2005, Welte, 2000.2.23)

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal (with cpb^bnd1)

lethal (with cpb^bnd2)

lethal (with cpb^bnd3)

lethal | recessive

lethal - all die before end of larval stage | recessive

partially lethal - majority die (with cpb^6.15)

cpb^F19

partially lethal - majority die (with cpb^F19)

cpb^6.15

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

cpb^GD9299

viable, with Scer\GAL4^tin.CΔ4

cpb^GD9299

Sterility

Allele

semi-sterile | dominant | female

Other Phenotypes

Allele

abnormal cell migration

cpb^M143

abnormal developmental rate (with cpb^6.15)

cpb^F19

abnormal developmental rate (with cpb^F19)

cpb^6.15

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^how-24B

cpb^GD9299

abnormal size | larval stage, with Scer\GAL4^ap.PU

cpb^GD9299

abnormal size | larval stage, with Scer\GAL4^hh.PU

cpb^GD9299

some die during larval stage | recessive

visible | recessive | somatic clone

cpb^unspecified

cpb^+t4.5

Phenotype manifest in

Allele

actin cytoskeleton & eye disc | somatic clone

cpb^bnd1

actin filament & dorsal mesothoracic disc & pupa | somatic clone

cpb^4.18

actin filament & egg chamber (with cpb^6.15)

cpb^F19

actin filament & egg chamber (with cpb^F19)

cpb^6.15

adult abdomen | somatic clone

cpb^unspecified

border follicle cell

cpb^M143

border follicle cell, with Scer\GAL4^slbo.2.6

cpb^UAS.cWa

chaeta | somatic clone

cpb^unspecified

egg | maternal effect (with cpb^6.15)

cpb^F19

egg | maternal effect (with cpb^F19)

cpb^6.15

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^how-24B

cpb^GD9299

eye | somatic clone

eye photoreceptor cell & nucleus | somatic clone

cpb^M143

eye photoreceptor cell | somatic clone

cpb^unspecified

filopodium | increased number

interommatidial bristle | somatic clone

cpb^unspecified

macrochaeta (with cpb^6.15)

cpb^F19

macrochaeta (with cpb^F19)

cpb^6.15

macrochaeta & head

macrochaeta & thorax

NMJ bouton | third instar larval stage, with Scer\GAL4^how-24B

cpb^GD9299

nurse cell (with cpb^6.15)

cpb^F19

nurse cell (with cpb^F19)

cpb^6.15

ommatidium | somatic clone

rhabdomere | somatic clone

cpb^M143

sternopleural bristle (with cpb^6.15)

cpb^F19

sternopleural bristle (with cpb^F19)

cpb^6.15

trichogen cell & actin filament & pupa (with cpb^6.15)

cpb^F19

trichogen cell & actin filament & pupa (with cpb^F19)

cpb^6.15

wing | somatic clone

cpb^unspecified

wing disc | somatic clone

cpb^M143

wing disc dorsal compartment, with Scer\GAL4^ap.PU

cpb^GD9299

wing disc posterior compartment, with Scer\GAL4^hh.PU

cpb^GD9299

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (1)

14 of 14

Yes

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (1)

14 of 14

Yes

Yes

Mus musculus (laboratory mouse) (1)

13 of 14

Yes

Yes

Xenopus tropicalis (Western clawed frog) (2)

7 of 13

Yes

Yes

1 of 13

No

Yes

Danio rerio (Zebrafish) (1)

13 of 14

Yes

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

14 of 14

Yes

Yes

Anopheles gambiae (African malaria mosquito) (1)

Agam\AgaP_AGAP007864

11 of 12

Yes

Yes

Arabidopsis thaliana (thale-cress) (1)

13 of 13

Yes

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

13 of 13

Yes

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

12 of 12

Yes

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:cpb. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

cancer, multiple, actin-remodeling regulators

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CAPZB; capping actin protein of muscle Z-line subunit beta

14 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-protein

Physical Interaction

Assay

References

anti bait coimmunoprecipitation, partial DNA sequence identification by hybridization, anti tag coimmunoprecipitation

(Laver et al., 2013)

protein-protein

Physical Interaction

Assay

References

experimental knowledge based

(Guruharsha et al., 2011)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

cpb - DCTN2-p50

experimental knowledge based

(Guruharsha et al., 2011)

cpb - DCTN4-p62

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

experimental knowledge based

(Guruharsha et al., 2011)

anti bait coimmunoprecipitation, western blot, peptide massfingerprinting

(Johnson et al., 2008)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Hurd et al., 2016)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Hopmann and Miller, 2003)

suppressible

(Gaspar et al., 2015)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Johnson et al., 2008)

enhanceable

(Rudrapatna et al., 2014)

enhanceable

(Kuzina et al., 2011)

suppressible

(Badmos et al., 2021)

suppressible

(Ferreira et al., 2014)

enhanceable

(Fernández et al., 2014)

suppressible

(Fernández et al., 2014)

suppressible

(Lucas et al., 2013)

suppressible

(Gaspar et al., 2015)

enhanceable

(Gaspar et al., 2015)

External Data

Subunit Structure (UniProtKB)

Component of the F-actin capping complex, composed of a heterodimer of an alpha and a beta subunit (By similarity). Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3 (By similarity).

(UniProt, P48603 )

Linkouts

BioGRID - A database of protein and genetic interactions.

59586

DroID - A comprehensive database of gene and protein interactions.

FBgn0011570

MIST (genetic) - An integrated Molecular Interaction Database

33346

MIST (protein-protein) - An integrated Molecular Interaction Database

33346

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

2L

Recombination map

2-3

Cytogenetic map

Sequence location

2L:1,704,902..1,706,962 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

22B1-22B1

Limits computationally determined from genome sequence between P{PZ}l(2)04111⁰⁴¹¹¹ and P{lacW}CG17646^k11021

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

22A1-22B

(Delalle et al., 2002)

22A4-22A4

(Hopmann, 1995.8.31)

22A4-22A4

(determined by in situ hybridisation)

(Hopmann et al., 1996, Hopmann, 1995, Hopmann et al., 1994)

22B1-22B1

(determined by in situ hybridisation)

(Hopmann et al., 1993)

Localised by meiotic and deletion mapping (details unspecified).

(Delalle et al., 2002)

Experimentally Determined Recombination Data

Location

2-3

(FlyBase, 2016)

2-3.0

(Comeron et al., 2012)

2-

(Hopmann, 1995.8.31)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (20)

Aberrations including deletions of this gene Aberrations including duplications of this gene

93759

w^*; cpb^KO/CyO

26298

y¹ v¹; P{TRiP.JF02068}attP2

50954

y¹ v¹; P{TRiP.HMJ21056}attP40

92526

y¹ v¹; P{U6.2-cpb.dgRNA}attP2

58727

y¹ w^*; M{UASp-mCherry.cpb}ZH-51D

58726

w^*; P{Ubi-mCherry.cpb}3/TM6B, Tb¹

8742

w^*; cpb^6.15/CyO, P{lacZ.w⁺}276

58728

w^*; M{UASp-mCherry.cpb}ZH-86Fb/TM3, Sb¹

16946

P{VT000850-lexA::GADfl}attP40

HMJ21056

y¹ v¹; P{TRiP.HMJ21056}attP40/CyO

v330050

P{VSH330050}attP40

v45668

w¹¹¹⁸; P{GD9299}v45668

More stocks available...

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (46)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

SD07714

Other clones

DPiM_SD07714

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0011570

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0011570

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Amândio et al., 2014, Hopmann et al., 1996)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R⁺ cells: increased or polarized (uneven) accumulation of F-actin.

(Kiger et al., 2003)

dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.

(Rogers et al., 2003)

Identification: in a screen for mutations that cause retinal degeneration in homozygous clones in the eye.

(Delalle et al., 2002)

Homozygous clones in the retina are darkly pigmented with no discernible ommatidial organisation. The degeneration has already occurred at eclosion and still occurs in flies reared in complete darkness.

(Delalle et al., 2002)

Molecular and genetic characterisation reveals cpb has an essential function during development. cpb is required to regulate actin assembly during the development of specialised structures that depend on actin for their morphology.

(Hopmann et al., 1996)

In mutants affecting Actn, an actin crosslinker, capping protein shows allele-specific alterations in its distribution but it is still seen in the Z discs.

(Hopmann et al., 1995)

Relationship to Other Genes

Source for database merge of

Source for merge of: cpb burned

(Delalle et al., 2005)

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (33)

Reported As

Symbol Synonym

CAPB_DROME

(Storm and Sonnhammer, 2003)

CG17158

(National Institute of Genetics Fly Stocks, 2022-, Trivedi et al., 2020, Kolkhof et al., 2017, Meadows, 2017.1.11, Hurd et al., 2016, Balakrishnan et al., 2015, Ni et al., 2010.12.1, Perkins et al., 2009.3.31, Eckley and Schroer, 2003, Rogers et al., 2003, Goldstein and Gunawardena, 2000)

CP

(Wear and Cooper, 2004)

CP-β

(Rogat and Miller, 2002)

CPB

(Gates et al., 2007)

Cap2

(Kollmar, 2015.9.21, Hammesfahr and Kollmar, 2012)

CapZ

(Hurst et al., 2019, Jacinto and Baum, 2003)

CapZβ

(Derivery and Gautreau, 2010)

CpB

(Verboon et al., 2020)

Cpb

(Schmidt et al., 2021, Richardson and Portela, 2017, Rebelo and Janody, 2007)

Cpβ

(Gou et al., 2020)

J

(Welte, 2000.2.23)

bnd

(Delalle et al., 2005)

cpb

(Aziz et al., 2024, Li et al., 2024, Badmos et al., 2021, Deng et al., 2021, Napoletano et al., 2021, Skouloudaki et al., 2020, Yuan et al., 2019, Gene Disruption Project members, 2018-, Butzlaff et al., 2015, Dent et al., 2015, Gaspar et al., 2015, Amândio et al., 2014, Fernández et al., 2014, Huelsmann, 2014.12.18, Huelsmann, 2014.12.18, Li et al., 2014, Loya et al., 2014, Rudrapatna et al., 2014, Beckett et al., 2013, Kwon et al., 2013, Lucas et al., 2013, Ogienko et al., 2013, Fernández et al., 2011, Friedman et al., 2011, Gonçalves-Pimentel et al., 2011, Guan et al., 2011, Kuzina et al., 2011, Rohn et al., 2011, Foley et al., 2010, Gates et al., 2009, Christensen et al., 2008.4.15, Christensen et al., 2008.4.15, Johnson et al., 2008, Pham et al., 2008, Bakal et al., 2007, Frank et al., 2006, Janody and Treisman, 2006)

cpβ

(Álvarez-Fernández et al., 2015)

Name Synonyms

Ancpβ

CP β subunit

(Hopmann et al., 1996)

Capping Protein

(Nowotarski et al., 2008)

Capping protein

(Rogers et al., 2003)

Capping protein beta

(Gates et al., 2007, Rebelo and Janody, 2007)

Capping protein β

(Iwasa and Mullins, 2007, Janody and Treisman, 2006)

Capping proteins β

(Lucas et al., 2013)

Capping-protein-β

F-actin capping protein

(Lucas et al., 2013)

actin capping protein

(Gou et al., 2020)

actin capping protein β

(Kuzina et al., 2011)

actin-capping protein

(van Soldt and Cardoso, 2020)

burned

(Delalle et al., 2002)

capping protein

(Hopmann and Miller, 2002, Petit et al., 2002, Rogat and Miller, 2002, Hopmann and Miller, 2001)

capping protein beta

(Sen and Cox, 2016, Ferreira et al., 2014, Rudrapatna et al., 2014, Laver et al., 2013, Ogienko et al., 2013, Johnson et al., 2008, Pham et al., 2008, Hopmann et al., 1996, Hopmann, 1995.8.31)

capping protein Β

(D'Ambrosio and Vale, 2010)

capping protein β

(Amândio et al., 2014, Guan et al., 2011, Sánchez-Soriano et al., 2010, Frank et al., 2006, Rogers et al., 2003)

capping proteinβ

(Gates et al., 2009)

Secondary FlyBase IDs

FBgn0015012
FBgn0061517

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 52 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

33346

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P48603

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P48603

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

M9PBN7

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P48603

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0011570

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33346/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0011570

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0011570

FlyMine - An integrated database for Drosophila genomics

FBgn0011570

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG17158

MARRVEL_MODEL - MARRVEL (model organism gene)

33346

Linkouts

BioGRID - A database of protein and genetic interactions.

59586

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0011570

DroID - A comprehensive database of gene and protein interactions.

FBgn0011570

DRSC - Results frm RNAi screens

FBgn0011570

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0011570

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0011570

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG17158

Flygut - An atlas of the Drosophila adult midgut

FBgn0011570

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0011570

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC030614

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (genetic) - An integrated Molecular Interaction Database

33346

MIST (protein-protein) - An integrated Molecular Interaction Database

33346

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (147)