FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Ets97D
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General Information
Symbol
Dmel\Ets97D
Species
D. melanogaster
Name
Ets at 97D
Annotation Symbol
CG6338
Feature Type
protein_coding_gene
FlyBase ID
FBgn0004510
Gene Model Status
Current
Stock Availability
10 publicly available
Gene Summary
May have a role in germline development. (UniProt, Q04688)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

Delg, D-elg, elg

Key Links
Genomic Location
Cytogenetic map
97D7-97D7
Sequence location
Recombination map
3-92
RefSeq locus
NT_033777 REGION:26910775..26912886
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (12 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN000218930
(GO Reference Genome Project, 2011-)
enables DNA-binding transcription factor activity
inferred from electronic annotation with InterPro:IPR000418, InterPro:IPR046328
(InterPro Project Members, 2004-)
enables sequence-specific DNA binding
inferred from electronic annotation with InterPro:IPR000418, InterPro:IPR003118
(InterPro Project Members, 2004-)
Biological Process (8 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in cellular response to starvation
inferred from mutant phenotype
(Baltzer et al., 2009)
involved_in positive regulation of oxidative phosphorylation
inferred from mutant phenotype
(Tiefenböck et al., 2010)
involved_in positive regulation of transcription by RNA polymerase II
inferred from mutant phenotype
(Tiefenböck et al., 2010)
involved_in regulation of L-glutamine biosynthetic process
inferred from mutant phenotype
(Baltzer et al., 2009)
involved_in regulation of mitochondrion organization
inferred from mutant phenotype
(Baltzer et al., 2009)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in cell differentiation
inferred from biological aspect of ancestor with PANTHER:PTN000218930
(GO Reference Genome Project, 2011-)
involved_in regulation of DNA-templated transcription
inferred from electronic annotation with InterPro:IPR000418
(InterPro Project Members, 2004-)
involved_in regulation of transcription by RNA polymerase II
inferred from electronic annotation with InterPro:IPR046328
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN000218930
(GO Reference Genome Project, 2011-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000218930
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the ETS family. (Q04688)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
ETS DOMAIN TRANSCRIPTION FACTORS -
The E26 transformation specific (ETS) domain transcription factors are sequence-specific DNA-binding proteins that regulate transcription. These factors are characterized by a conserved 85 amino acid DNA binding ETS domain that binds specifically to purine-rich DNA motif GGAA/T. (Adapted from PMID:11715049 and PMID:9570133).
Protein Function (UniProtKB)
May have a role in germline development.
(UniProt, Q04688)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
tne: tiny eggs
Female sterile. Very small eggs.
Summary (Interactive Fly)

Ets domain transcription factor - homolog of the alpha subunit of mammalian NRF-2/GABP - required for proper expression of most genes encoding mitochondrial proteins -regulator of mitochondrial number and mass - required for proper follicle cell migration, chorion formation, and nurse cell chromosome decondensation

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Ets97D for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q04688)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Stop-codon suppression (UGA) postulated; FBrf0216884.

Gene model reviewed during 5.44

Gene model reviewed during 5.48

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Ets97D-RA
FBtr0085088
NM_079799
1858
464
Ets97D-RB
FBtr0330167
NM_001276071
1858
484
Additional Transcript Data and Comments
Reported size (kB)

1.8 (northern blot)

(Chen et al., 1992)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Ets97D-PA
FBpp0084458
52.6
464
4.75
Q04688
NP_524523
AAF56638
Ets97D-PB
FBpp0303200
55.0
484
4.71
A0A0B4KHY6
NP_001263000
AGB96380
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)

135 (aa)

(Lautenberger et al., 1992)

464 (aa); 56 (kD)

(The et al., 1992)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ets97D using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.96

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism | ubiquitous
(Chen et al., 1992)
primordial germ cell
(Chen et al., 1992)
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 8 -- 11
primordial germ cell
(Chen et al., 1992)
posterior midgut primordium
(Chen et al., 1992)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | ubiquitous
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
organism
(Chen et al., 1992)
Additional Descriptive Data

Ets97D transcripts are expressed during most of development with relatively lower levels during larval stages. Transcripts are present throughout the embryo during germ band extension with slightly higher levels in the pole cells.

(Chen et al., 1992)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Ets97D in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 8 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Ets97D
Transgenic constructs containing regulatory region of Ets97D
Aberrations (Deficiencies and Duplications) ( 7 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | recessive
lethal - all die before end of pupal stage (with Df(3R)ro80b)
partially lethal - majority die, with Scer\GAL4pnr-MD237
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female sterile
female sterile | recessive
Other Phenotypes
Allele
abnormal developmental rate
some die during pupal stage, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4pnr-MD237
wild-type
Phenotype manifest in
Allele
abdominal segment 2
abdominal segment 3
abdominal segment 4
abdominal segment 5
abdominal segment 6
abdominal segment 7
border follicle cell
dorsal appendage
egg
egg chamber | germline clone
egg chorion
fat body
fat body | third instar larval stage (with Df(3R)ro80b)
follicle cell
mitochondrial chromosome
mitochondrion
mitochondrion | somatic clone | third instar larval stage
mitochondrion | third instar larval stage (with Df(3R)ro80b)
nurse cell & nuclear chromosome
trichogen cell, with Scer\GAL4pnr-MD237
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (29)
Hsap\GABPA
13 of 14
Yes
Yes
Hsap\ETS1
3 of 14
No
No
2  
Hsap\ETV2
3 of 14
No
No
Hsap\ELK3
2 of 14
No
Yes
Hsap\ELK4
2 of 14
No
Yes
Hsap\ERF
2 of 14
No
Yes
Hsap\ERG
2 of 14
No
No
1  
Hsap\ETS2
2 of 14
No
No
Hsap\ETV1
2 of 14
No
No
1  
Hsap\ETV3
2 of 14
No
Yes
Hsap\ETV3L
2 of 14
No
Yes
Hsap\ETV4
2 of 14
No
No
Hsap\ETV5
2 of 14
No
No
Hsap\FEV
2 of 14
No
No
0  
Hsap\FLI1
2 of 14
No
No
1  
Hsap\EHF
1 of 14
No
No
Hsap\ELF1
1 of 14
No
No
1  
Hsap\ELF2
1 of 14
No
No
Hsap\ELF3
1 of 14
No
Yes
Hsap\ELF4
1 of 14
No
No
1  
Hsap\ELF5
1 of 14
No
No
Hsap\ELK1
1 of 14
No
No
2  
Hsap\ERFL
1 of 14
No
Yes
Hsap\ETV6
1 of 14
No
No
1  
Hsap\ETV7
1 of 14
No
No
1  
Hsap\SPDEF
1 of 14
No
No
Hsap\SPI1
1 of 14
No
No
Hsap\SPIB
1 of 14
No
No
Hsap\SPIC
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (27)
Rnor\Gabpa
12 of 14
Yes
Yes
Rnor\Ets1
3 of 14
No
No
Rnor\Ets2
3 of 14
No
No
Rnor\Etv2
3 of 14
No
No
Rnor\Elk1
2 of 14
No
No
Rnor\Elk3
2 of 14
No
Yes
Rnor\Erf
2 of 14
No
Yes
Rnor\Etv1
2 of 14
No
No
Rnor\Etv3l
2 of 14
No
Yes
Rnor\Etv3
2 of 14
No
Yes
Rnor\Etv4
2 of 14
No
No
Rnor\Etv5
2 of 14
No
No
Rnor\Fli1
2 of 14
No
No
Rnor\Ehf
1 of 14
No
No
Rnor\Elf1
1 of 14
No
No
Rnor\Elf2
1 of 14
No
No
Rnor\Elf3
1 of 14
No
No
Rnor\Elf4
1 of 14
No
No
Rnor\Elf5
1 of 14
No
No
Rnor\Elk4
1 of 14
No
No
Rnor\Erg
1 of 14
No
No
Rnor\Etv6
1 of 14
No
No
Rnor\Fev
1 of 14
No
No
Rnor\Spdef
1 of 14
No
No
Rnor\Spi1
1 of 14
No
No
Rnor\Spib
1 of 14
No
No
Rnor\Spic
1 of 14
No
No
Mus musculus (laboratory mouse) (28)
Mmus\Gabpa
13 of 14
Yes
Yes
Mmus\Ets1
3 of 14
No
No
Mmus\Ets2
3 of 14
No
No
Mmus\Elk1
2 of 14
No
No
Mmus\Elk3
2 of 14
No
Yes
Mmus\Erf
2 of 14
No
Yes
Mmus\Etv1
2 of 14
No
No
Mmus\Etv2
2 of 14
No
No
Mmus\Etv3
2 of 14
No
Yes
Mmus\Etv4
2 of 14
No
No
Mmus\Etv5
2 of 14
No
No
Mmus\Fev
2 of 14
No
Yes
Mmus\Fli1
2 of 14
No
No
Mmus\Ehf
1 of 14
No
No
Mmus\Elf1
1 of 14
No
No
Mmus\Elf2
1 of 14
No
No
Mmus\Elf3
1 of 14
No
No
Mmus\Elf4
1 of 14
No
No
Mmus\Elf5
1 of 14
No
No
Mmus\Elk4
1 of 14
No
Yes
Mmus\Erfl
1 of 14
No
Yes
Mmus\Erg
1 of 14
No
No
Mmus\Etv3l
1 of 14
No
Yes
Mmus\Etv6
1 of 14
No
No
Mmus\Spdef
1 of 14
No
No
Mmus\Spi1
1 of 14
No
No
Mmus\Spib
1 of 14
No
No
Mmus\Spic
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (18)
Xtro\gabpa
10 of 13
Yes
Yes
Xtro\ets1
2 of 13
No
No
Xtro\ets2
2 of 13
No
No
Xtro\ankfn1l
1 of 13
No
No
Xtro\ehf
1 of 13
No
Yes
Xtro\elf1
1 of 13
No
No
Xtro\elf2
1 of 13
No
No
Xtro\elf5
1 of 13
No
Yes
Xtro\elk4
1 of 13
No
Yes
Xtro\erg
1 of 13
No
No
Xtro\etv2
1 of 13
No
No
Xtro\etv3l
1 of 13
No
Yes
Xtro\etv3
1 of 13
No
Yes
Xtro\etv6
1 of 13
No
No
Xtro\fev
1 of 13
No
No
Xtro\fli1
1 of 13
No
No
Xtro\psme3ip1
1 of 13
No
No
Xtro\saxo2
1 of 13
No
No
Danio rerio (Zebrafish) (30)
Drer\gabpa
13 of 14
Yes
Yes
Drer\etsrp
3 of 14
No
No
Drer\elk1
2 of 14
No
No
Drer\elk3
2 of 14
No
Yes
Drer\elk4
2 of 14
No
Yes
Drer\erf
2 of 14
No
Yes
Drer\erfl3
2 of 14
No
Yes
Drer\erg
2 of 14
No
No
Drer\ets2
2 of 14
No
No
Drer\etv4
2 of 14
No
No
Drer\etv5a
2 of 14
No
No
Drer\fev
2 of 14
No
No
Drer\fli1
2 of 14
No
No
Drer\ehf
1 of 14
No
No
Drer\elf1
1 of 14
No
No
Drer\elf2a
1 of 14
No
No
Drer\elf2b
1 of 14
No
No
Drer\elf3
1 of 14
No
Yes
Drer\erfl1
1 of 14
No
Yes
Drer\ets1
1 of 14
No
No
Drer\etv1
1 of 14
No
No
Drer\etv5b
1 of 14
No
No
Drer\etv7
1 of 14
No
No
Drer\fli1rs
1 of 14
No
No
Drer\LOC100537796
1 of 14
No
Yes
Drer\spdef
1 of 14
No
No
Drer\spi1a
1 of 14
No
No
Drer\spi1b
1 of 14
No
No
Drer\spi2
1 of 14
No
No
Drer\spic
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (12)
Cele\ast-1
2 of 14
Yes
No
Cele\ets-7
2 of 14
Yes
Yes
Cele\ets-8
2 of 14
Yes
No
Cele\F19F10.1
2 of 14
Yes
Yes
Cele\C52B9.19
1 of 14
No
Yes
Cele\elf-1
1 of 14
No
No
Cele\elk-2
1 of 14
No
Yes
Cele\ets-4
1 of 14
No
No
Cele\ets-5
1 of 14
No
No
Cele\ets-9
1 of 14
No
Yes
Cele\lin-1
1 of 14
No
Yes
Cele\svh-5
1 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (7)
Agam\AgaP_AGAP004337
12 of 12
Yes
Yes
Agam\AgaP_AGAP004619
2 of 12
No
No
Agam\AgaP_AGAP009494
2 of 12
No
No
Agam\AgaP_AGAP009513
2 of 12
No
No
Agam\AgaP_AGAP005755
1 of 12
No
No
Agam\AgaP_AGAP007327
1 of 12
No
No
Agam\AgaP_AGAP009350
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Ets97D. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (9)
Ets96B
5 of 13
pnt
5 of 13
Ets21C
4 of 13
Eip74EF
3 of 13
Ets65A
3 of 13
Ets98B
3 of 13
aop
2 of 13
edl
1 of 13
Pbp49
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    GABPA; GA binding protein transcription factor subunit alpha
    13 of 14
    600609
        ETS1; ETS proto-oncogene 1, transcription factor
        3 of 14
        164720
             
            ETV2; ETS variant transcription factor 2
            3 of 14
            609358
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Interactions
                Summary of Physical Interactions
                Summary of Genetic Interactions
                Interaction Browsers
                View in FlyBase Interactions Browser   View in MIST tool (external link)
                Please look at the allele data for full details of the genetic interactions
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Ets97D
                enhanceable
                capu
                (Gajewski and Schulz, 1995)
                Ets97D
                enhanceable
                srl
                (Tiefenböck et al., 2010)
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                CycD|Cdk4
                suppressible
                Ets97D
                (Baltzer et al., 2009)
                Myc
                suppressible
                Ets97D
                (Baltzer et al., 2009)
                Rbf
                suppressible
                Ets97D
                (Sainz de la Maza et al., 2022)
                Rbf
                suppressible
                Ets97D|srl
                (Sainz de la Maza et al., 2022)
                srl
                enhanceable
                Ets97D
                (Tiefenböck et al., 2010)
                External Data
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                DroID - A comprehensive database of gene and protein interactions.
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Pathways
                Signaling Pathways (FlyBase)
                Metabolic Pathways
                FlyBase
                External Links
                External Data
                Linkouts
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                Class of Gene
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                3R
                Recombination map
                3-92
                Cytogenetic map
                97D7-97D7
                Sequence location
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                97D7-97D7
                Limits computationally determined from genome sequence between P{lacW}His2AvL1602 and P{PZ}sda03884
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                97D-97D
                (Watson, 1992.8.27)
                97D-97D
                (determined by in situ hybridisation)
                (Chen et al., 1992, Pribyl et al., 1991)
                Experimentally Determined Recombination Data
                Location

                3-92

                (FlyBase, 2016)

                3-89.3

                (Comeron et al., 2012)

                3-91

                (Tearle and Nusslein-Volhard, 1987)
                Left of (cM)
                Right of (cM)
                Notes
                Stocks and Reagents
                Stocks (10)
                Genomic Clones (11)
                 

                Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                cDNA Clones (124)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequenced
                BDGP DGC clones
                Other clones
                Drosophila Genomics Resource Center cDNA clones

                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                cDNA Clones, End Sequenced (ESTs)
                BDGP DGC clones
                Other clones
                RNAi and Array Information
                Linkouts
                DRSC - Results frm RNAi screens
                Antibody Information
                Laboratory Generated Antibodies
                 
                Commercially Available Antibodies
                 
                Cell Line Information
                Publicly Available Cell Lines
                 
                  Other Stable Cell Lines
                   
                    Other Comments

                    Identification: in a germline clone screen for mutants that are defective in localisation of an Avic\GFP-stau marker in living oocytes. 1 allele of Ets97D has been identified in the screen.

                    (Martin et al., 2003)

                    Ets97D function is required for the correct localisation of the posterior determinants in the oocyte. It is also required for dorsoventral polarity in the follicle cells.

                    (Gajewski and Schulz, 1995)

                    Complementation analysis and sequence analysis of the female sterile mutant tiny eggs demonstrates that tiny eggs is an allele of Ets97D. Mutations of Ets97D demonstrate that the Ets97D gene product is required for proper follicle cell migration, chorion formation and nurse cell chromosome decondensation during oogenesis.

                    (Schulz et al., 1993)

                    Ets97D has been cloned, sequenced and its RNA expression pattern characterised.

                    (Chen et al., 1992)

                    Pattern and mode of coding gene divergence in the ets gene family examined. Results suggest that gene evolution recapitulates species divergence, though at different rates imposed by apparent selective constraints on 3 domains, and that there have been a minimum of 5 ets-primordial gene duplication events: one during X.laevis speciation, one near the time of vertebrate emergence and three prior to the divergence of vertebrates from the Echinodermata and Arthropoda.

                    (Lautenberger et al., 1992)

                    Isolated from a pupal cDNA library using pnt and viral ets gene fragments as probes, under low stringency conditions.

                    (Pribyl et al., 1991)

                    An Ets97D cDNA has been cloned and sequenced, and Ets97D mRNA expression has been analysed.

                    (Pribyl et al., 1991)
                    Relationship to Other Genes
                    Source for database merge of
                    Additional comments
                    Nomenclature History
                    Source for database identify of
                    Nomenclature comments
                    Etymology
                    Synonyms and Secondary IDs (17)
                    Reported As
                    Symbol Synonym
                    CG6338
                    (Hosono et al., 2015, Fukuoh et al., 2014, Ni et al., 2011.7.19, Baltzer et al., 2009, Keleman et al., 2009.8.5, Perkins et al., 2009.1.15)
                    D-Elg
                    (Chen et al., 1992)
                    D-elg
                    (Martin et al., 2003, Hsu and Schulz, 2000, Gajewski and Schulz, 1995, Gajewski and Schulz, 1995, Strutt and White, 1994, Chen, 1993.1.9, Schulz et al., 1993, The et al., 1992, Pribyl et al., 1991)
                    DELG
                    (Wasylyk et al., 1993)
                    Delg
                    (Hunter-Manseau et al., 2025, Li et al., 2025, Hunter-Manseau et al., 2024, Sainz de la Maza et al., 2022, Lubojemska et al., 2021, Sênos Demarco et al., 2019, Tain et al., 2017, Banerjee et al., 2013, Tiefenböck et al., 2010, Baltzer et al., 2009, V.Mirouse and St Johnston, 2007)
                    Elg
                    Ets
                    (Guruharsha et al., 2004)
                    Ets97D
                    (Taylor et al., 2024, Liu et al., 2023, Zhu and Liu, 2023, Port et al., 2020, Sigalova et al., 2020, Bischof et al., 2018, Schertel et al., 2015, Ugrankar et al., 2015, Chen et al., 2012, Spokony and White, 2012.5.22, Jungreis et al., 2011, Weake et al., 2011, Xing et al., 2007, Zhang et al., 2007, Pickeral et al., 2000)
                    d-elg
                    (Baltzer et al., 2007)
                    delg
                    (Gupta et al., 2022, Singh and Agrawal, 2022, Edenharter et al., 2018, Constantinou et al., 2016, Chartier et al., 2015, Tiefenböck et al., 2010, Baltzer et al., 2009)
                    elg
                    (Price and Lai, 1999, Watson, 1992.8.27)
                    tne
                    tny
                    (Tearle and Nusslein-Volhard, 1987)
                    Name Synonyms
                    Ets at 97D
                    (Xing et al., 2007)
                    Ets like gene
                    (Baltzer et al., 2009)
                    tiny
                    (Tearle and Nusslein-Volhard, 1987)
                    tiny eggs
                    Secondary FlyBase IDs
                    • FBgn0003727
                    Datasets (0)
                    Study focus (0)
                    Experimental Role
                    Project
                    Project Type
                    Title
                    Study result (0)
                    Result
                    Result Type
                    Title
                    External Crossreferences and Linkouts ( 49 )
                    Sequence Crossreferences
                    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                    UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                    Other crossreferences
                    AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                    DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                    EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                    FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                    FlyMine - An integrated database for Drosophila genomics
                    InterPro - A database of protein families, domains and functional sites
                    KEGG Genes - Molecular building blocks of life in the genomic space.
                    MARRVEL_MODEL - MARRVEL (model organism gene)
                    Linkouts
                    BioGRID - A database of protein and genetic interactions.
                    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                    DroID - A comprehensive database of gene and protein interactions.
                    DRSC - Results frm RNAi screens
                    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                    Flygut - An atlas of the Drosophila adult midgut
                    FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                    MIST (protein-protein) - An integrated Molecular Interaction Database
                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                    References (86)