FlyBase Gene Report: Dmel\RpS14b

General Information

Symbol

Dmel\RpS14b

Species

D. melanogaster

Name

Ribosomal protein S14b

Annotation Symbol

CG1527

Feature Type

protein_coding_gene

FlyBase ID

FBgn0004404

Gene Model Status

Current

Stock Availability

4 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Also Known As

S14

Key Links

Genomic Location

Cytogenetic map

7C8-7C8

Sequence location

X:7,934,898..7,935,792 [+]

Recombination map

1-21

RefSeq locus

NC_004354 REGION:7934898..7935792

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (7 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables structural constituent of ribosome

inferred from direct assay

(Anger et al., 2013)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables structural constituent of ribosome

traceable author statement

(Marygold et al., 2007)

inferred from electronic annotation with InterPro:IPR001971, InterPro:IPR036967

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000204884

(GO Reference Genome Project, 2011-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in cytoplasmic translation

inferred by curator from GO:0022626

(Anger et al., 2013)

traceable author statement

(Marygold et al., 2007)

involved_in ribosomal small subunit assembly

inferred from biological aspect of ancestor with PANTHER:PTN000204887

(GO Reference Genome Project, 2011-)

involved_in translation

inferred from electronic annotation with InterPro:IPR001971, InterPro:IPR036967

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000204884

(GO Reference Genome Project, 2011-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in cytosolic ribosome

inferred from direct assay

(Anger et al., 2013)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

part_of cytosolic small ribosomal subunit

traceable author statement

(Marygold et al., 2007)

inferred from biological aspect of ancestor with PANTHER:PTN000204886

(GO Reference Genome Project, 2011-)

located_in ribosome

inferred from electronic annotation with InterPro:IPR001971, InterPro:IPR036967

(InterPro Project Members, 2004-)

Gene Group (FlyBase)

CYTOPLASMIC SMALL RIBOSOMAL SUBUNIT

CYTOPLASMIC SMALL RIBOSOMAL SUBUNIT - TESTIS-SPECIFIC VARIANT

Protein Family (UniProt)

Belongs to the universal ribosomal protein uS11 family. (C0HKA1)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

CYTOPLASMIC SMALL RIBOSOMAL SUBUNIT -: Cytoplasmic ribosomes are found on the endoplasmic reticulum and in the cytosol. They translate all mRNAs produced from nuclear genes and perform the majority of cellular protein synthesis. Ribosomes are formed by two ribonucleoprotein subunits, large and small. The principle function of the small subunit is to bind mRNA. (Adapted from FBrf0205398.)
CYTOPLASMIC SMALL RIBOSOMAL SUBUNIT - TESTIS-SPECIFIC VARIANT -: Cytoplasmic ribosomes are found on the endoplasmic reticulum and in the cytosol. They translate all mRNAs produced from nuclear genes and perform the majority of cellular protein synthesis. Ribosomes are formed by two ribonucleoprotein subunits, large and small. The principle function of the small subunit is to bind mRNA. Tissue expression data from modENCODE has been used to infer the composition of the cytosolic small ribosomal subunit testis-specific variant. (Adapted from FBrf0205398.)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\RpS14b for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry C0HKA1)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.50

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.44

Gene model reviewed during 5.55

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

RpS14b-RA

FBtr0071096

NM_080427

594

151

RpS14b-RB

FBtr0345291

NM_001298066

562

151

Additional Transcript Data and Comments

Reported size (kB)

0.65 (northern blot)

(Andersson and Lambertsson, 1990)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

RpS14b-PA

FBpp0071052

16.3

151

11.05

FBpp0311458

16.3

151

11.05

C0HKA0

NP_001284995

AHN59466

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

151 aa isoforms: RpS14b-PA, RpS14b-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\RpS14b using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.34

Transcript Expression

Additional Descriptive Data

RpS14b transcripts accumulate to an extremely reduced level in two deficiency heterozygotes examined, rather than the expected level of 50% of wild type. The reason is unknown.

(Andersson and Lambertsson, 1990)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 5 of adulthood | male -- day 7 of adulthood | male

spermatozoon

(Wasbrough et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytosolic ribosome

inferred from direct assay

(Anger et al., 2013)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\RpS14b in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\RpS14b

View exonic expression by tissue for Dmel\RpS14b

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

47219/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0004404

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004404

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0004404

Flygut - An atlas of the Drosophila adult midgut

FBgn0004404

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 0 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of RpS14b

Transgenic constructs containing regulatory region of RpS14b

Aberrations (Deficiencies and Duplications) ( 6 )

Inferred from experimentation ( 6 )

Gene disrupted in

Df(1)hl-a

(Andersson and Lambertsson, 1990)

Df(1)hl-b

(Andersson and Lambertsson, 1990)

Df(1)hl-c

(Andersson and Lambertsson, 1990)

Df(1)hl-d

(Andersson and Lambertsson, 1990)

Dp(1;2)ct⁺90f

(Marygold et al., 2007, Stewart and Denell, 1993)

Gene not duplicated in

Dp(1;2)ct⁺90f

(Dorer et al., 1991)

Gene duplicated in

Dp(1;2)sn⁺72d

(Stewart and Denell, 1993)

Inferred from location ( 15 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (2)

Hsap\RPS14

12 of 14

Yes

Hsap\MRPS11

3 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (4)

Rnor\Rps14

12 of 14

Yes

Rnor\LOC120101650

7 of 14

Yes

Rnor\Mrps11

3 of 14

Rnor\LOC100911847

1 of 14

Mus musculus (laboratory mouse) (2)

Mmus\Rps14

12 of 14

Yes

Mmus\Mrps11

3 of 14

Xenopus tropicalis (Western clawed frog) (2)

Xtro\rps14

9 of 13

Yes

Xtro\mrps11

1 of 13

Danio rerio (Zebrafish) (2)

Drer\rps14

13 of 14

Yes

Drer\mrps11

2 of 14

Caenorhabditis elegans (Nematode, roundworm) (2)

Cele\rps-14

12 of 14

Yes

Cele\mrps-11

3 of 14

Anopheles gambiae (African malaria mosquito) (3)

Agam\RS14A_ANOGA

11 of 12

Yes

Agam\RS14B_ANOGA

11 of 12

Yes

Agam\AgaP_AGAP003644

2 of 12

Arabidopsis thaliana (thale-cress) (5)

Atha\AT2G36160

11 of 13

Yes

Atha\AT3G11510

11 of 13

Yes

Atha\AT3G52580

11 of 13

Yes

Atha\NFD3

2 of 13

Atha\rps11

2 of 13

Saccharomyces cerevisiae (Brewer's yeast) (3)

Scer\RPS14A

12 of 13

Yes

Scer\RPS14B

12 of 13

Yes

Scer\MRPS18

2 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (3)

Spom\rps1402

11 of 12

Yes

Spom\rps1401

3 of 12

Spom\mrps18

2 of 12

Yes

Escherichia coli (enterobacterium) (1)

Ecol\rpsK

7 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:RpS14b. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (2)

mRpS11

5 of 13

RpS14a

5 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

RPS14; ribosomal protein S14

model of chromosome 5q deletion syndrome

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

RPS14; ribosomal protein S14

12 of 14

130620

CHROMOSOME 5q DELETION SYNDROME

chromosome 5q deletion syndrome

MRPS11; mitochondrial ribosomal protein S11

3 of 14

611977

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

RpS14b - Rack1

cosedimentation, electron microscopy

(Anger et al., 2013)

RpS14b - RpL10

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpL10Ab

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpL11

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpL12

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpL13

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpL13A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpL14

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpL15

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpL17

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpL18

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpL18A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpL19

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpL21

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpL22

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpL23

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpL23A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpL24

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpL26

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpL27

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpL27A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpL28

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpL29

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpL3

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpL30

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpL31

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpL32

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpL34a

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpL35

cosedimentation, electron microscopy

(Anger et al., 2013)

RpS14b - RpL35A

cosedimentation, electron microscopy

(Anger et al., 2013)

RpS14b - RpL36

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpL36A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpL37-1

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpL37A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpL38

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpL39

cosedimentation, electron microscopy

(Anger et al., 2013)

RpS14b - RpL4

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpL40

cosedimentation, electron microscopy

(Anger et al., 2013)

RpS14b - RpL41

cosedimentation, electron microscopy

(Anger et al., 2013)

RpS14b - RpL5

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpL6

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpL7

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpL7A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpL8

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpL9

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpLP0

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpLP1

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpLP2

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpS10a

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpS11

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpS12

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpS13

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpS14a

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpS15

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpS15Aa

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpS16

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpS17

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpS18

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpS19a

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpS2

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpS20

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpS21

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpS23

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpS24

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpS25

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpS26

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpS27

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpS27A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpS28b

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpS29

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpS3

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpS30

cosedimentation, electron microscopy

(Anger et al., 2013)

RpS14b - RpS3A

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpS4

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpS5a

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpS6

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpS7

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpS8

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - RpS9

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - eEF2

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - sta

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RpS14b - vig2

cosedimentation, Identification by mass spectrometry, electron microscopy

(Anger et al., 2013)

RNA-protein

Physical Interaction

Assay

References

RpS14b - 18SrRNA

cosedimentation, electron microscopy

(Anger et al., 2013)

RpS14b - 28SrRNA

cosedimentation, electron microscopy

(Anger et al., 2013)

RpS14b - 2SrRNA

cosedimentation, electron microscopy

(Anger et al., 2013)

RpS14b - 5.8SrRNA

cosedimentation, electron microscopy

(Anger et al., 2013)

RpS14b - 5SrRNA

cosedimentation, electron microscopy

(Anger et al., 2013)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

70691

DroID - A comprehensive database of gene and protein interactions.

FBgn0004404

MIST (protein-protein) - An integrated Molecular Interaction Database

47219

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Ribosome

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-21

Cytogenetic map

7C8-7C8

Sequence location

X:7,934,898..7,935,792 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

7C8-7C8

Limits computationally determined from genome sequence between P{EP}CG10777^EP1347&P{EP}CG10777^EP1363 and P{EP}EP1243

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

7C5-7C9

(determined by in situ hybridisation)

(Brown et al., 1988)

Experimentally Determined Recombination Data

Location

1-21

(FlyBase, 2016)

1-22.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (4)

Aberrations including deletions of this gene Aberrations including duplications of this gene

FlyORF

F001481

M{UAS-RpS14b.ORF}ZH-86Fb

F001001

M{UAS-RpS14b.ORF.3xHA}ZH-86Fb

1527R-2

v109250

Genomic Clones (14)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (26)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE34379

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0004404

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0004404

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Not a Minute gene.

(Marygold et al., 2007)

RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R⁺ cells.

(Boutros et al., 2004)

Expression of transcript changes with adult age.

(Shikama and Brack, 1996)

A deficiency chromosome that removes RpS14A and RpS14B does not display the Minute phenotype associated with the M(1)7C locus: RpS14A and RpS14B do not correspond to the M(1)7C locus.

(Dorer et al., 1991)

RpS14a and RpS14b, a pair of nearly identical tandemly duplicated genes, have been cloned and sequenced, and their expression patterns have been analysed.

(Brown et al., 1988)

Relationship to Other Genes

Source for database merge of

Source for merge of: RpS14b CG1527

(Misra, 2000.4.14)

Additional comments

The genes RpS14b and RpS14a share >70% identity and close proximity, and so may have been derived from a DNA-based tandem duplication.

(Langille and Clark, 2007)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (14)

Reported As

Symbol Synonym

CG1527

(Kolkhof et al., 2017, Fukuoh et al., 2014, Schertel et al., 2013, Keleman et al., 2009.8.5, Marygold et al., 2007, Fulton et al., 2001)

RPS14B

(Brown et al., 1988)

RpS14

(Stewart and Denell, 1993)

RpS14B

RpS14b

(Adashev et al., 2022, Loganathan et al., 2022, Baumgartner et al., 2021, Jin et al., 2020, Wei et al., 2015, Bischof and FlyORF project members, 2014.6.20, Majzoub et al., 2014, Handler et al., 2013, Schertel et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Wasbrough et al., 2010, Langille and Clark, 2007, Marygold et al., 2007)

S11

(Anger et al., 2013)

S14

(Anger et al., 2013, Brogna et al., 2002, Maki et al., 1990)

S14b

(Carpenter et al., 2009)

anon-EST:Posey115

anon-EST:Posey131

anon-EST:Posey154

anon-EST:Posey77

rpS14B

Name Synonyms

Ribosomal protein S14b

Secondary FlyBase IDs

FBgn0002585
FBgn0025283
FBgn0025314
FBgn0025318
FBgn0025321
FBgn0029982

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 41 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

47219

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

C0HKA1

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

C0HKA1

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

X2JCX8

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

C0HKA1

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

47219/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0004404

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0004404

FlyMine - An integrated database for Drosophila genomics

FBgn0004404

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG1527

MARRVEL_MODEL - MARRVEL (model organism gene)

47219

Linkouts

BioGRID - A database of protein and genetic interactions.

70691

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0004404

DroID - A comprehensive database of gene and protein interactions.

FBgn0004404

DRSC - Results frm RNAi screens

FBgn0004404

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004404

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0004404

Flygut - An atlas of the Drosophila adult midgut

FBgn0004404

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0004404

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Ribosome

MIST (protein-protein) - An integrated Molecular Interaction Database

47219

References (50)

The following external sites may use different assemblies or annotations than FlyBase.

0.34

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