FlyBase Allele Report: Dmel\Rel[RNAi.UAS.cUa]

General Information

Symbol

Dmel\Rel^RNAi.UAS.cUa

Species

D. melanogaster

Name

FlyBase ID

FBal0407471

Feature type

allele

Associated gene

Dmel\Rel

Associated Insertion(s)

Carried in Construct

P{UAS-Rel.RNAi.U}

Also Known As

Relish RNAi, UAS-relishRNAi

Key Links

Transgenic product class

RNAi_reagent

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

(FlyBase Curators, 2025-)

Progenitor genotype

Carried in construct

P{UAS-Rel.RNAi.U}

Cytology

Description

UAS regulatory sequences drive expression of an RNAi construct targeting Rel.

(FlyBase Curators, 2025-)

FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

(FlyBase Curators, 2025-)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Rel

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates neurodegenerative disease

modeled by Zzzz\CAG^{127Q.UAS.Tag:HA}

(Dubey and Tapadia, 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response | adult stage, with Scer\GAL4^c564

(Kumar et al., 2016)

increased occurrence of cell division | adult stage, with Scer\GAL4^NP0001

(Wang et al., 2013)

increased occurrence of cell division | adult stage, with Scer\GAL4^NP5130

(Wang et al., 2013)

Phenotype Manifest In

intestinal stem cell, with Scer\GAL4^NP0001

(Wang et al., 2013)

intestinal stem cell, with Scer\GAL4^NP5130

(Wang et al., 2013)

Detailed Description

Statement

Reference

The expression of Rel^VDRC.cUa under the control of Scer\GAL4^c564 blocks the normal inflammatory response to Gram-negative (assessed by the expression levels of Diptericin) bacterial infection, but has no effect under basal, non-infected conditions, as compared to controls.

(Kumar et al., 2016)

Bacterial injection in the head leads to neurodegeneration in fly brains (compared to control sterile injections) and locomotion defects at 25 days old; these phenotypes are suppressed by expression of Rel^VDRC.cUa driven by Scer\GAL4^repo.PU or Scer\GAL4^elav.PU.

(Cao et al., 2013)

Expression of Scer\GAL4^esg-NP5130>Rel^{dsRNA.Scer\UAS.cUa} in progenitor cells results in increased intestinal stem cell proliferation. Scer\GAL4^{Myo31DF-NP0001}>Rel^{dsRNA.Scer\UAS.cUa} expression in enterocytes has similar effects.

(Wang et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

Rel^RNAi.UAS.cUa, Scer\GAL4^repo.PU is a non-suppressor of abnormal neuroanatomy | adult stage | progressive phenotype of Def^UAS.cUa, Scer\GAL4^repo.PU

(Cao et al., 2013)

Rel^RNAi.UAS.cUa, Scer\GAL4^repo.PU is a non-suppressor of abnormal neuroanatomy | adult stage | progressive phenotype of Drs^UAS.cUa, Scer\GAL4^repo.PU

(Cao et al., 2013)

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

Rel^RNAi.UAS.cUa, Scer\GAL4^repo.PU is a non-suppressor of adult brain | adult stage | progressive phenotype of Def^UAS.cUa, Scer\GAL4^repo.PU

(Cao et al., 2013)

Rel^RNAi.UAS.cUa, Scer\GAL4^repo.PU is a non-suppressor of adult brain | adult stage | progressive phenotype of Drs^UAS.cUa, Scer\GAL4^repo.PU

(Cao et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Rel^VDRC.cUa does not suppress age-dependent neurodegeneration in fly brains with Def^Scer\UAS.cUa or Drs^Scer\UAS.cUa driven by Scer\GAL4^repo.PU.

(Cao et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Rel^RNAi.UAS.cUa

Rel^TRiP.cUa

Rel^VDRC.cUa

Rel^{dsRNA.Scer\UAS.cUa}

Rel^{dsRNA.UAS.cUa}

Name Synonyms

Secondary FlyBase IDs

FBal0295799
FBal0370458
FBal0319751

References (8)

Report Sections

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