FlyBase Allele Report: Dmel\Cisd[KO]

General Information

Symbol

Dmel\Cisd^KO

Species

D. melanogaster

Name

FlyBase ID

FBal0392875

Feature type

allele

Associated gene

Dmel\Cisd

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Ham et al., 2023)

Mutagen

CRISPR/Cas9

(Ham et al., 2023)

Progenitor genotype

Cytology

Description

Deletion of Cisd2.

(Ham et al., 2023)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease 2

modeled by park¹

(Ham et al., 2023)

ameliorates Parkinson's disease 6

modeled by Pink1^B9

(Ham et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

endoplasmic reticulum | larval stage

(Ham et al., 2023)

larval muscle cell | larval stage

(Ham et al., 2023)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Cisd^KO is a suppressor of visible | adult stage phenotype of Pink1^B9

(Ham et al., 2023)

Cisd^KO is a suppressor of increased cell death | adult stage phenotype of Pink1^B9

(Ham et al., 2023)

Cisd^KO is a suppressor of visible | adult stage phenotype of park¹

(Ham et al., 2023)

Cisd^KO is a suppressor of increased cell death | adult stage phenotype of park¹

(Ham et al., 2023)

Cisd^KO is a suppressor of decreased rate of adult locomotory behavior phenotype of park¹

(Ham et al., 2023)

Cisd^KO is a suppressor of decreased cell number | adult stage phenotype of park¹

(Ham et al., 2023)

Cisd^KO is a suppressor of decreased rate of adult locomotory behavior phenotype of Pink1^B9

(Ham et al., 2023)

Cisd^KO is a suppressor of decreased cell number | adult stage phenotype of Pink1^B9

(Ham et al., 2023)

Other

Statement

Reference

Cisd^KO, Cisd^UAS.Tag:HA, Pink1^B9, Scer\GAL4^hs.PB has visible | adult stage phenotype

(Ham et al., 2023)

Cisd^KO, Cisd^UAS.Tag:HA, Pink1^B9, Scer\GAL4^hs.PB has increased cell death | adult stage phenotype

(Ham et al., 2023)

Cisd^KO, Cisd^UAS.Tag:HA, Pink1^B9, Scer\GAL4^hs.PB has decreased cell number | adult stage phenotype

(Ham et al., 2023)

Cisd^KO, Cisd^UAS.Tag:HA, Pink1^B9, Scer\GAL4^hs.PB has decreased rate of adult locomotory behavior phenotype

(Ham et al., 2023)

Cisd^KO, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has visible | adult stage phenotype

(Ham et al., 2023)

Cisd^KO, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has visible | adult stage phenotype

(Ham et al., 2023)

Cisd^KO, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has increased cell death | adult stage phenotype

(Ham et al., 2023)

Cisd^KO, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has decreased cell number | adult stage phenotype

(Ham et al., 2023)

Cisd^KO, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has decreased rate of adult locomotory behavior phenotype

(Ham et al., 2023)

Cisd^KO, Itpr^UAS.cVa, Pink1^B9, Scer\GAL4^hs.PB has visible | adult stage phenotype

(Ham et al., 2023)

Cisd^KO, Itpr^UAS.cVa, Pink1^B9, Scer\GAL4^hs.PB has increased cell death | adult stage phenotype

(Ham et al., 2023)

Cisd^KO, Itpr^UAS.cVa, Pink1^B9, Scer\GAL4^hs.PB has decreased cell number | adult stage phenotype

(Ham et al., 2023)

Cisd^KO, Itpr^UAS.cVa, Pink1^B9, Scer\GAL4^hs.PB has decreased rate of adult locomotory behavior phenotype

(Ham et al., 2023)

Cisd^KO, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has increased cell death | adult stage phenotype

(Ham et al., 2023)

Cisd^KO, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has decreased cell number | adult stage phenotype

(Ham et al., 2023)

Cisd^KO, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has decreased rate of adult locomotory behavior phenotype

(Ham et al., 2023)

Phenotype Manifest In

Suppressor of

Statement

Reference

Cisd^KO is a suppressor of larval muscle cell | larval stage phenotype of Pink1^B9

(Ham et al., 2023)

Cisd^KO is a suppressor of endoplasmic reticulum | larval stage phenotype of park¹

(Ham et al., 2023)

Cisd^KO is a suppressor of adult thorax phenotype of park¹

(Ham et al., 2023)

Cisd^KO is a suppressor of wing phenotype of park¹

(Ham et al., 2023)

Cisd^KO is a suppressor of mitochondrion | adult stage phenotype of park¹

(Ham et al., 2023)

Cisd^KO is a suppressor of flight muscle cell phenotype of park¹

(Ham et al., 2023)

Cisd^KO is a suppressor of adult dopaminergic neuron | decreased number phenotype of park¹

(Ham et al., 2023)

Cisd^KO is a suppressor of larval muscle cell | larval stage phenotype of park¹

(Ham et al., 2023)

Cisd^KO is a suppressor of endoplasmic reticulum | larval stage phenotype of Pink1^B9

(Ham et al., 2023)

Cisd^KO is a suppressor of adult thorax phenotype of Pink1^B9

(Ham et al., 2023)

Cisd^KO is a suppressor of wing phenotype of Pink1^B9

(Ham et al., 2023)

Cisd^KO is a suppressor of mitochondrion | adult stage phenotype of Pink1^B9

(Ham et al., 2023)

Cisd^KO is a suppressor of flight muscle cell phenotype of Pink1^B9

(Ham et al., 2023)

Cisd^KO is a suppressor of adult dopaminergic neuron | decreased number phenotype of Pink1^B9

(Ham et al., 2023)

Other

Statement

Reference

Cisd^KO, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has wing phenotype

(Ham et al., 2023)

Cisd^KO, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has adult thorax phenotype

(Ham et al., 2023)

Cisd^KO, Cisd^UAS.Tag:HA, Pink1^B9, Scer\GAL4^hs.PB has adult thorax phenotype

(Ham et al., 2023)

Cisd^KO, Cisd^UAS.Tag:HA, Pink1^B9, Scer\GAL4^hs.PB has flight muscle cell phenotype

(Ham et al., 2023)

Cisd^KO, Cisd^UAS.Tag:HA, Pink1^B9, Scer\GAL4^hs.PB has mitochondrion | adult stage phenotype

(Ham et al., 2023)

Cisd^KO, Cisd^UAS.Tag:HA, Pink1^B9, Scer\GAL4^hs.PB has adult dopaminergic neuron | decreased number phenotype

(Ham et al., 2023)

Cisd^KO, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has wing phenotype

(Ham et al., 2023)

Cisd^KO, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has adult thorax phenotype

(Ham et al., 2023)

Cisd^KO, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has flight muscle cell phenotype

(Ham et al., 2023)

Cisd^KO, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has mitochondrion | adult stage phenotype

(Ham et al., 2023)

Cisd^KO, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has adult dopaminergic neuron | decreased number phenotype

(Ham et al., 2023)

Cisd^KO, Itpr^UAS.cVa, Pink1^B9, Scer\GAL4^hs.PB has wing phenotype

(Ham et al., 2023)

Cisd^KO, Itpr^UAS.cVa, Pink1^B9, Scer\GAL4^hs.PB has adult thorax phenotype

(Ham et al., 2023)

Cisd^KO, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has flight muscle cell phenotype

(Ham et al., 2023)

Cisd^KO, Itpr^UAS.cVa, Pink1^B9, Scer\GAL4^hs.PB has flight muscle cell phenotype

(Ham et al., 2023)

Cisd^KO, Itpr^UAS.cVa, Pink1^B9, Scer\GAL4^hs.PB has mitochondrion | adult stage phenotype

(Ham et al., 2023)

Cisd^KO, Itpr^UAS.cVa, Pink1^B9, Scer\GAL4^hs.PB has adult dopaminergic neuron | decreased number phenotype

(Ham et al., 2023)

Cisd^KO, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has mitochondrion | adult stage phenotype

(Ham et al., 2023)

Cisd^KO, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has adult dopaminergic neuron | decreased number phenotype

(Ham et al., 2023)

Cisd^KO, Cisd^UAS.Tag:HA, Pink1^B9, Scer\GAL4^hs.PB has wing phenotype

(Ham et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

CISD KO

(Ham et al., 2023)

Cisd2^KO

Cisd^KO

dCISD KO

(Ham et al., 2025)

dCISD^KO

(Ham et al., 2025)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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