FlyBase Allele Report: Hsap\S100A4[wt.UAS]

General Information

Symbol

Hsap\S100A4^wt.UAS

Species

H. sapiens

Name

FlyBase ID

FBal0342457

Feature type

allele

Associated gene

Hsap\S100A4

Associated Insertion(s)

Carried in Construct

P{UAS-hS100A4.wt}

Key Links

Transgenic product class

wild_type

(Ismail et al., 2017)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Ismail et al., 2017)

Mutagen

in vitro construct

(Ismail et al., 2017)

Progenitor genotype

Carried in construct

P{UAS-hS100A4.wt}

Cytology

Description

UAS regulates expression of a wild type Hsap\S100A4 ORF.

(Ismail et al., 2017)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Hsap\S100A4

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of cancer

CEA with Ras85D^V12.UAS

(Ismail et al., 2017)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 1 )

Ras85D^V12.UAS coexpressed with Hsap\S100A4^wt.UAS serves to model metastasis.

(Ismail et al., 2017)

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Whole eye-antennal disc clones expressing Hsap\S100A4^wt.UAS under the control of Scer\GAL4^Act5C.PI do not form tumors.

(Ismail et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Hsap\S100A4^wt.UAS, Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has neoplasia | somatic clone | larval stage phenotype, suppressible by bsk^DN.UAS, Scer\GAL4^Act5C.PI

(Ismail et al., 2017)

Enhancer of

Statement

Reference

Hsap\S100A4^wt.UAS, Scer\GAL4^Act5C.PI is an enhancer of neoplasia | larval stage | somatic clone phenotype of Ras85D^V12.UAS, Scer\GAL4^Act5C.PI

(Ismail et al., 2017)

Phenotype Manifest In

Suppressed by

Statement

Reference

Hsap\S100A4^wt.UAS, Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has eye-antennal disc | somatic clone phenotype, suppressible by bsk^DN.UAS, Scer\GAL4^Act5C.PI

(Ismail et al., 2017)

Hsap\S100A4^wt.UAS, Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has larval ventral nerve cord | somatic clone | larval stage phenotype, suppressible by bsk^DN.UAS, Scer\GAL4^Act5C.PI

(Ismail et al., 2017)

Enhancer of

Statement

Reference

Hsap\S100A4^wt.UAS, Scer\GAL4^Act5C.PI is an enhancer of eye-antennal disc | somatic clone phenotype of Ras85D^V12.UAS, Scer\GAL4^Act5C.PI

(Ismail et al., 2017)

Hsap\S100A4^wt.UAS, Scer\GAL4^Act5C.PI is an enhancer of larval ventral nerve cord | larval stage | somatic clone phenotype of Ras85D^V12.UAS, Scer\GAL4^Act5C.PI

(Ismail et al., 2017)

Other

Statement

Reference

Hsap\S100A4^wt.UAS, Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has embryonic/larval gut | somatic clone | larval stage phenotype

(Ismail et al., 2017)

Hsap\S100A4^wt.UAS, Ras85D^V12.UAS, Scer\GAL4^Act5C.PI has gonad | somatic clone | larval stage phenotype

(Ismail et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The tumorigenesis of whole eye-antennal disc clones expressing Hsap\S100A4^wt.UAS in addition to Ras85D^V12.UAS, under the control of Scer\GAL4^Act5C.PI, is much higher that upon the expression of Ras85D^V12.UAS alone, leading to extensive metastasis to the VNC and other organs, particularly to the gut and gonads.

(Ismail et al., 2017)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Hsap\S100A4^wt.UAS

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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