FlyBase Allele Report: Dmel\sns[HMC05745]

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Allele: Dmel\sns^HMC05745

General Information

Symbol

Dmel\sns^HMC05745

Species

D. melanogaster

Name

FlyBase ID

FBal0322014

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

P{TRiP.HMC05745}

Also Known As

UAS-sns-RNAi

Key Links

Genomic Maps

Transgenic product class

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.HMC05745}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

binary expression system - regulatory region

Encoded product / tool

Also carries

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

basement membrane, with Scer\GAL4^Ugt36A1.PK

(Wolff et al., 2025)

filamentous actin, with Scer\GAL4^Ugt36A1.PK

(Wolff et al., 2025)

nephrocyte, with Scer\GAL4^Ugt36A1.PK

(Wolff et al., 2025)

slit diaphragm, with Scer\GAL4^Ugt36A1.PK

(Wolff et al., 2025)

Detailed Description

Statement

Reference

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

sns^HMC05745, Scer\GAL4^Ugt36A1.PK is a suppressor of increased cell death phenotype of Hsap\NPHS1^UAS.cWb, Scer\GAL4^Ugt36A1.PK

(Wolff et al., 2025)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Scer\GAL4^Ugt36A1.PK, sns^HMC05745 has nephrocyte phenotype, non-suppressible by Hsap\NPHS1^UAS.cWb, Scer\GAL4^Ugt36A1.PK

(Wolff et al., 2025)

Scer\GAL4^Ugt36A1.PK, sns^HMC05745 has filamentous actin phenotype, non-suppressible by Hsap\NPHS1^UAS.cWb, Scer\GAL4^Ugt36A1.PK

(Wolff et al., 2025)

Other

Statement

Reference

Hsap\NPHS1^UAS.cWb, Scer\GAL4^Ugt36A1.PK, sns^HMC05745 has nephrocyte phenotype

(Wolff et al., 2025)

Hsap\NPHS1^UAS.cWb, Mmus\Kirrel^UAS.Tag:V5, Scer\GAL4^Ugt36A1.PK, sns^HMC05745 has nephrocyte phenotype

(Wolff et al., 2025)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

64872

y¹ sc^* v¹ sev²¹; P{TRiP.HMC05745}attP40

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

sns^HMC05745

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections