FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\DJ-1αUAS.cUa
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General Information
Symbol
Dmel\DJ-1αUAS.cUa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Unknown
FlyBase ID
FBal0319547
Feature type
allele
Associated gene
Dmel\DJ-1α
Associated Insertion(s)
Carried in Construct
P{UAS-DJ-1α.U}
Key Links
Transgenic product class
wild_type
(FlyBase Curators, 2025-)
Mutagen
    Nature of the Allele
    Transgenic product class
    wild_type
    (FlyBase Curators, 2025-)
    Mutagen
    Progenitor genotype
    Carried in construct
    P{UAS-DJ-1α.U}
    Cytology
    Description

    UAS regulatory sequences drive expression of DJ-1α.

    (FlyBase Curators, 2025-)

    FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

    (FlyBase Curators, 2025-)
    Allele components
    Component
    Use(s)
    Regulatory region(s)
    UAS
    Encoded product / tool
    DJ-1α
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 1 )
        Disease
        Interaction
        References
        ameliorates  Parkinson's disease
        modeled by Pink1B9
        (Hao et al., 2010)
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Expression of DJ-1αScer\UAS.cUa under the control of Scer\GAL4da.PU does not alter mitochondrial morphology in young (<3 days) adult male thoraces.

        (Hao et al., 2010)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressor of
        Statement
        Reference

        Scer\GAL4da.PU/DJ-1αUAS.cUa is a suppressor | partially of visible phenotype of Pink1B9

        (Hao et al., 2010)

        Scer\GAL4da.PU/DJ-1αUAS.cUa is a suppressor of increased cell death | adult stage phenotype of Pink1B9

        (Hao et al., 2010)
        NOT Suppressor of
        Statement
        Reference

        DJ-1αUAS.cUa/Scer\GAL4GMR.PU is a non-suppressor of visible phenotype of hidGMR.PG

        (Hao et al., 2010)

        DJ-1αUAS.cUa/Scer\GAL4how-24B is a non-suppressor of visible phenotype of park25

        (Hao et al., 2010)

        DJ-1αUAS.cUa/Scer\GAL4how-24B is a non-suppressor of increased cell death | adult stage phenotype of park25

        (Hao et al., 2010)
        Phenotype Manifest In
        Suppressor of
        NOT Suppressor of
        Statement
        Reference

        DJ-1αUAS.cUa/Scer\GAL4GMR.PU is a non-suppressor of eye phenotype of hidGMR.PG

        (Hao et al., 2010)

        DJ-1αUAS.cUa/Scer\GAL4how-24B is a non-suppressor of wing phenotype of park25

        (Hao et al., 2010)

        DJ-1αUAS.cUa/Scer\GAL4how-24B is a non-suppressor of adult somatic muscle cell of thorax phenotype of park25

        (Hao et al., 2010)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Expression of DJ-1αScer\UAS.cUa under the control of Scer\GAL4da.PU rescues the thoracic muscle defects and thoracic muscle apoptosis phenotype, and partially rescues the wing posture defect of Pink1B9/Pink1B9 mutants.

        Expression of DJ-1αScer\UAS.cUa under the control of Scer\GAL4how-24B is unable to rescue the thoracic muscle defects and apoptosis phenotype of park25/park25 mutants.

        Expression of DJ-1αScer\UAS.cUa under the control of Scer\GAL4GMR.PU is unable to rescue the eye phenotype of flies expressing hidGMR.PG.

        (Hao et al., 2010)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        DJ-1αScer\UAS.cUa
        DJ-1αUAS.cUa
        Name Synonyms
        Saccharomyces cerevisiae UAS construct a of Unknown
        Secondary FlyBase IDs
          References (2)