FlyBase Allele Report: Dmel\upd3[UAS.cUa]

General Information

Symbol

Dmel\upd3^UAS.cUa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Unknown

FlyBase ID

FBal0316453

Feature type

allele

Associated gene

Dmel\upd3

Associated Insertion(s)

Carried in Construct

P{UAS-upd3.U}

Also Known As

UAS-upd3

Key Links

Transgenic product class

wild_type

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

(FlyBase Curators, 2025-)

Progenitor genotype

Carried in construct

P{UAS-upd3.U}

Cytology

Description

UAS regulatory sequences drive expression of upd3.

(FlyBase Curators, 2025-)

FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

(FlyBase Curators, 2025-)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

upd3

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of cancer

CEA with Ras85D^V12.UAS

(Wu et al., 2010)

CEA

(Ding et al., 2021)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of cancer

is exacerbated by Pvf1^UASp.cRb

(Ding et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | third instar larval stage, with Scer\GAL4^path-c135

(Ho et al., 2019)

increased cell number | adult stage, with Scer\GAL4^byn-Gal4

(Cohen et al., 2021)

increased size | adult stage, with Scer\GAL4^byn-Gal4

(Cohen et al., 2021)

increased size | adult stage, with Scer\GAL4^GMR13E02

(Cohen et al., 2021)

short lived, with Scer\GAL4^Hml.Δ

(Woodcock et al., 2015)

short lived | nutrition conditional, with Scer\GAL4^c564

(Woodcock et al., 2015)

Phenotype Manifest In

adult pylorus, with Scer\GAL4^byn-Gal4

(Cohen et al., 2021)

adult pylorus, with Scer\GAL4^GMR13E02

(Cohen et al., 2021)

eye disc | third instar larval stage, with Scer\GAL4^path-c135

(Ho et al., 2019)

nucleus | adult stage, with Scer\GAL4^GMR13E02

(Cohen et al., 2021)

Detailed Description

Statement

Reference

The expression of upd3^UAS.cUa under the control of Scer\GAL4^byn-Gal4 for 2h at the third instar larval wandering stage (using Gal80[ts] for the temporal control of expression) leads to an enlarged pylorus due to increased cell number.

Expression under the control of Scer\GAL4^GMR13E02 during adulthood (using Gal80[ts] for the temporal control of expression) leads to enlarged pylorus due to endocycles (i.e. no increase in cell number and increased nuclear size).

(Cohen et al., 2021)

Expression of upd3^UAS.cUa under the control of Scer\GAL4^path-c135 leads to generally larger imaginal eye discs while carpet glia cells form normally with anteriorly extending membrane in the eye disc of the third instar larvae when compared to controls.

(Ho et al., 2019)

Expression of upd3^Scer\UAS.cUa under the control of either Scer\GAL4^Hml.Δ or Scer\GAL4^c564 impairs the lifespan of adult flies on a standard diet but does not further decrease the lowered survival of flies fed lard-supplemented diet.

Expression of upd3^Scer\UAS.cUa under the control of Scer\GAL4^Hml.Δ in the upd3^Δ hemizygote background reduces the lifespan of upd3^Δ hemizygote males on a standard diet.

(Woodcock et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^Act.PU, upd3^UAS.cUa has neoplasia | somatic clone phenotype

(Wu et al., 2010)

Phenotype Manifest In

Other

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^Act.PU, upd3^UAS.cUa has eye disc | somatic clone phenotype

(Wu et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Eye-antennal disc clones that simultaneously express Ras85D^V12.Scer\UAS and upd3^Scer\UAS.cUa under the control of Scer\GAL4^Act.PU result in small non-invasive tumors.

(Wu et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

upd3^Scer\UAS.cUa

upd3^UAS.cUa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Unknown

Secondary FlyBase IDs

References (17)

Report Sections

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