FlyBase Allele Report: Hsap\MECP2[Δ166.UAS]

General Information

Symbol

Hsap\MECP2^Δ166.UAS

Species

H. sapiens

Name

FlyBase ID

FBal0294768

Feature type

allele

Associated gene

Hsap\MECP2

Associated Insertion(s)

Carried in Construct

P{UAS-MeCP2.Δ166}

Key Links

Transgenic product class

inframe_deletion

(Cukier et al., 2008)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Cukier et al., 2008)

Mutagen

in vitro construct

(Cukier et al., 2008)

Progenitor genotype

Carried in construct

P{UAS-MeCP2.Δ166}

Cytology

Description

UASt regulates expression of the Hsap\MECP2 e2 isoform with the methyl-CpG-binding domain and N-terminal portion of the protein removed.

(Cukier et al., 2008)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Hsap\MECP2

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Rett syndrome

CEA

(Hess-Homeier et al., 2014)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PU

(Cukier et al., 2008)

interommatidial bristle, with Scer\GAL4^GMR.PU

(Cukier et al., 2008)

ommatidium, with Scer\GAL4^GMR.PU

(Cukier et al., 2008)

Detailed Description

Statement

Reference

Expression of Hsap\MECP2^{Δ166.Scer\UAS} in MN5 motoneurons (via Scer\GAL4^futsch-C380 and Scer\GAL80^Cha.3.3P) does not cause any obvious dendritic defects.

(Vonhoff et al., 2012)

Expression via Scer\GAL4^GMR.PU disrupts the external structure of the eye, resulting in a 'glassy' effect on the surface. Ommatidia are disorganized and interommatidial bristles are partially lost.

(Cukier et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by Sin3A[+]/Sin3A^dQ4

(Cukier et al., 2008)

Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by Asx[+]/Asx¹

(Cukier et al., 2008)

Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by Scm^UAS.Tag:HA, Scer\GAL4^GMR.PU

(Cukier et al., 2008)

Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by trx[+]/trx¹

(Cukier et al., 2008)

Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by trx[+]/trx^E2

(Cukier et al., 2008)

Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by trx^KG04195/trx[+]

(Cukier et al., 2008)

Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by osa^UAS.cCa, Scer\GAL4^GMR.PU

(Cukier et al., 2008)

Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by pbl^UAS.cPa, Scer\GAL4^GMR.PU

(Cukier et al., 2008)

NOT Enhanced by

Statement

Reference

Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by osa[+]/osa^EY09619

(Cukier et al., 2008)

Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by pbl[+]/pbl²

(Cukier et al., 2008)

Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by pbl[+]/pbl³

(Cukier et al., 2008)

Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by pbl[+]/pbl⁵

(Cukier et al., 2008)

Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by pbl[+]/pbl⁰⁹⁶⁴⁵

(Cukier et al., 2008)

Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by Scm^D1/Scm[+]

(Cukier et al., 2008)

Suppressed by

Statement

Reference

Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Asx[+]/Asx^EY07384

(Cukier et al., 2008)

Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Asx^XF23/Asx[+]

(Cukier et al., 2008)

Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by corto^07128b/corto[+]

(Cukier et al., 2008)

Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by corto[+]/corto^c03244

(Cukier et al., 2008)

Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by corto^e02822/corto[+]

(Cukier et al., 2008)

Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by osa⁰⁰⁰⁹⁰/osa[+]

(Cukier et al., 2008)

Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by osa[+]/osa³⁰⁸

(Cukier et al., 2008)

Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Scm^e01989/Scm[+]

(Cukier et al., 2008)

Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Scm^ET50/Scm[+]

(Cukier et al., 2008)

Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Scm[+]/Scm^M36

(Cukier et al., 2008)

Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Scm^M56/Scm[+]

(Cukier et al., 2008)

Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Scm⁴/Scm[+]

(Cukier et al., 2008)

Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by trc^UAS.cUa, Scer\GAL4^GMR.PU

(Cukier et al., 2008)

Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by crol^c04670/crol[+]

(Cukier et al., 2008)

Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by crol[+]/crol^e04017

(Cukier et al., 2008)

Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Smr^e04377/Smr[+]

(Cukier et al., 2008)

Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Smr^e04389/Smr[+]

(Cukier et al., 2008)

NOT suppressed by

Statement

Reference

Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by osa[+]/osa^EY09619

(Cukier et al., 2008)

Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by pbl[+]/pbl²

(Cukier et al., 2008)

Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by pbl[+]/pbl³

(Cukier et al., 2008)

Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by pbl[+]/pbl⁵

(Cukier et al., 2008)

Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by pbl[+]/pbl⁰⁹⁶⁴⁵

(Cukier et al., 2008)

Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by Scm^D1/Scm[+]

(Cukier et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Hsap\MECP2^{Δ166.Scer\UAS}

Hsap\MECP2^Δ166.UAS

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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