FlyBase Allele Report: Dmel\InR[HMS03166]

General Information

Symbol

Dmel\InR^HMS03166

Species

D. melanogaster

Name

FlyBase ID

FBal0293553

Feature type

allele

Associated gene

Dmel\InR

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS03166}

Also Known As

InR RNAi, UAS-InR-RNAi, InR^RNAi, UAS-InR RNAi HMS03166, UAS-InR^RNAi, UAS-InR RNAi, UAS-InRRNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS03166}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS03166

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates lung adenocarcinoma

modeled by Hsap\KIF5B::Hsap\RET^UAS.cDa

(Das and Cagan, 2017)

ameliorates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Pragati and Sarkar, 2025, Pragati and Sarkar, 2024)

modeled by Hsap\MAPT^V337M.UAS

(Pragati and Sarkar, 2024)

modeled by Hsap\MAPT^R406W.UAS

(Pragati and Sarkar, 2024)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell adhesion | oogenesis, with Scer\GAL4^slbo.2.6

(Raza et al., 2019)

abnormal cell migration | oogenesis, with Scer\GAL4^slbo.2.6

(Raza et al., 2019)

abnormal developmental rate, with Scer\GAL4^phtm.PO

(Pan and O'Connor, 2021)

abnormal immune response | adult stage, with Scer\GAL4^NP0001

(Socha et al., 2023)

abnormal neuroanatomy | adult stage, with Scer\GAL4^pnr-MD237

(Urwyler et al., 2019)

abnormal size | adult stage, with Scer\GAL4^pnr-MD237

(Urwyler et al., 2019)

abnormal starvation stress response | adult stage, with Hsap\RELA^AD.nSyb, Scer\GAL4^DBD.AkhR

(Yu et al., 2016)

decreased cell number | oogenesis, with Scer\GAL4^{VP16.nanos.UTR}

(Amartuvshin et al., 2025)

decreased efficacy of long-term memory | adult stage, with Scer\GAL4^GMR54H02

(de Tredern et al., 2021)

increased rate of movement | adult stage | nutrition conditional, with Hsap\RELA^AD.nSyb, Scer\GAL4^DBD.AkhR

(Yu et al., 2016)

partially lethal, with Scer\GAL4^phtm.PO

(Pan and O'Connor, 2021)

Phenotype Manifest In

Detailed Description

Statement

Reference

The expression of InR^HMS03166 under the control of Scer\GAL4^slbo.2.6 leads to a prevalent border cell cluster disassociation phenotype, as well as border cell migration failure or delay in some egg chamber.

(Raza et al., 2019)

Posterior dorsocentral bristle neurons expressing InR^HMS03166 under the control of Scer\GAL4^pnr-MD237 show a significantly decreased terminal arbor territory and significantly fewer synapses (Syt1 puncta) on the contralateral collateral branch, as compared to controls.

(Urwyler et al., 2019)

Expression of InR^HMS03166 under the control of the split-GAL4 pair of Scer\GAL4^DBD.AkhR and Hsap\RELA^AD.nSyb in adult females results in acceleration of starvation-induced hyperactivity, compared to controls.

(Yu et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

InR^HMS03166, Scer\GAL4^ptc.PU is a suppressor | partially of increased mortality during development phenotype of Hsap\KIF5B::Hsap\RET^UAS.cDa, Scer\GAL4^ptc.PU

(Das and Cagan, 2017)

InR^HMS03166, Scer\GAL4^NP0001 is a suppressor of increased cell size phenotype of Atg9^HMS01246, Scer\GAL4^NP0001

(Wen et al., 2017)

Other

Statement

Reference

Acc^HMS01230, InR^HMS03166, Scer\GAL4^{VP16.nanos.UTR} has decreased cell number | oogenesis phenotype

(Amartuvshin et al., 2025)

InR^HMS03166, Scer\GAL4^GMR54H02, nebu^HMS01072 has decreased efficacy of long-term memory | adult stage phenotype

(Rabah et al., 2023)

Hsap\KIF5B::Hsap\RET^UAS.cDa, InR^HMS03166, Scer\GAL4^ptc.PU has partially lethal - majority die phenotype

(Das and Cagan, 2017)

Phenotype Manifest In

Suppressor of

Statement

Reference

InR^HMS03166, Scer\GAL4^{VP16.nanos.UTR} is a suppressor of female fusome phenotype of Acc^HMS01230, Scer\GAL4^{VP16.nanos.UTR}

(Amartuvshin et al., 2025)

InR^HMS03166, Scer\GAL4^{VP16.nanos.UTR} is a suppressor of female germline cyst phenotype of Acc^HMS01230, Scer\GAL4^{VP16.nanos.UTR}

(Amartuvshin et al., 2025)

InR^HMS03166, Scer\GAL4^NP0001 is a suppressor of adult midgut epithelium phenotype of Atg9^HMS01246, Scer\GAL4^NP0001

(Wen et al., 2017)

Other

Statement

Reference

Acc^HMS01230, InR^HMS03166, Scer\GAL4^{VP16.nanos.UTR} has female germline stem cell | decreased number phenotype

(Amartuvshin et al., 2025)

Additional Comments

Genetic Interactions

Statement

Reference

The co-expression of InR^HMS03166 suppresses the increased midgut cell size resulting from the expression of Atg9^HMS01246 under the control of Scer\GAL4^{Myo31DF-NP0001}.

(Wen et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

51518