FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Atx2ΔC1.UAS
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General Information
Symbol
Dmel\Atx2ΔC1.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0280933
Feature type
allele
Associated gene
Dmel\Atx2
Associated Insertion(s)
Carried in Construct
P{UAS-Atx2.ΔC1}
Key Links
Transgenic product class
inframe_deletion
(Satterfield and Pallanck, 2006)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Satterfield and Pallanck, 2006)
Mutagen
in vitro construct
(Satterfield and Pallanck, 2006)
Progenitor genotype
Carried in construct
P{UAS-Atx2.ΔC1}
Cytology
Description

UASt regulatory sequences drive expression of Atx2 lacking the 15 residue PAM2 motif (residues 855-869).

(Satterfield and Pallanck, 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Atx2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Atx2ΔC1.Scer\UAS in the developing eye under the control of Scer\GAL4GMR.PF results in black patches on the surface of the eye and the underlying retina is disorganised although intact, showing no evidence of degeneration. Expression in differentiated photoreceptor neurons under the control of Scer\GAL4ninaE.PD also fails to result in any degeneration; even at 18 days the flies have a normal retinal structure with seven visible photoreceptors per ommatidium.

      (Lessing and Bonini, 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      Statement
      Reference

      Atx2ΔC1.UAS, Scer\GAL4GMR.PF has visible phenotype, non-enhanceable by Hsap\ATXN3tr.Q78.UAS.Tag:HA

      (Lessing and Bonini, 2008)
      NOT Enhancer of
      Phenotype Manifest In
      NOT Enhanced by
      NOT Enhancer of
      Statement
      Reference

      Atx2ΔC1.UAS, Scer\GAL4ninaE.PD is a non-enhancer of photoreceptor | conditional phenotype of Hsap\ATXN3tr.Q78.UAS.Tag:HA, Scer\GAL4ninaE.PD

      (Lessing and Bonini, 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Hsap\ATXN3tr.Q78.Scer\UAS.T:Ivir\HA1 has no effect on the eye phenotype seen when Atx2ΔC1.Scer\UAS is expressed in the developing eye under the control of Scer\GAL4GMR.PF. The phenotype seen is identical to that seen when Atx2ΔC1.Scer\UAS is expressed alone.

      Co-expression of Hsap\ATXN3tr.Q78.Scer\UAS.T:Ivir\HA1 and Atx2ΔC1.Scer\UAS in differentiated photoreceptor neurons under the control of Scer\GAL4ninaE.PD causes mild photoreceptor loss at six days (an average of 6.7 visible photoreceptors per ommatidium, compared to seven in controls). This is similar to the phenotype seen when Hsap\ATXN3tr.Q78.Scer\UAS.T:Ivir\HA1 is expressed alone.

      Expression of Atx2ΔC1.Scer\UAS does not enhance the rate of inclusion formation seen when Hsap\ATXN3tr.Q78.Scer\UAS.T:Ivir\HA1 is expressed in differentiated photoreceptor neurons under the control of Scer\GAL4ninaE.PD.

      (Lessing and Bonini, 2008)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Atx2ΔC1.Scer\UAS
      Atx2ΔC1.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)