FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\zipD1847K.UAS.GFP
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General Information
Symbol
Dmel\zipD1847K.UAS.GFP
Species
D. melanogaster
Name
FlyBase ID
FBal0278256
Feature type
allele
Associated gene
Dmel\zip
Associated Insertion(s)
Carried in Construct
P{UAS-zip.GFP.D1847K}
Key Links
Genomic Maps

Transgenic product class
missense_variant
(Franke et al., 2007)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Franke et al., 2007)
Mutagen
in vitro construct
(Franke et al., 2007)
Progenitor genotype
zipFL.UAS.GFP
(Franke et al., 2007)
Carried in construct
P{UAS-zip.GFP.D1847K}
Cytology
Description

The amino acid replacement D1847K has been introduced into the zip coding region. This mutation corresponds to the disease-associated mutation E1841K in the orthologous human MYH9 gene.

(Franke et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
zip
Tagged with
GFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:24,992,111..24,992,113 [-]
Nucleotide change:

GAC24992113AAG

Reported nucleotide change:

gac>aag

Amino acid change:

D1931K | zip-PA; D1886K | zip-PB; D1846K | zip-PC; D1891K | zip-PD; D1846K | zip-PE; D1854K | zip-PF; D1846K | zip-PG; D1854K | zip-PH; D1899K | zip-PI

Reported amino acid change:

D1847K

Comment:

Analogous E1841K mutation in human MYH-9 implicated in MYH-9 related disease; mutation carried on in vitro construct.

(Franke et al., 2007)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  MYH-9 related disease
      CEA
      (Li et al., 2016)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Franke et al., 2007)
      MYH9:p.Glu1841Lys
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      Associated human disease model(s)
      External database links
      ClinVar: MYH9_14073
      Comments concerning this variant
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies carrying clones expressing zipD1847K.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4Act.PU in the Johnston's organ display detached scolopidia phenotype.

      (Li et al., 2016)

      zipD1847K.Scer\UAS.T:Avic\GFP (expressed using Scer\GAL4sqh.PW) does not show dominant negative activity in a zip1/+ background: the animals complete development and eclose as adult flies simultaneously with their wild-type siblings.

      (Franke et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      Rho1E3.10/Rho1[+], Scer\GAL4en-e16E, zip2, zipD1847K.UAS.GFP has visible phenotype

      (Franke et al., 2007)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Some adults expressing zipD1847K.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4en-e16E in a zip2/+ ; Rho1E3.10/+ background show both leg and wing abnormalities (8.2%).

      (Franke et al., 2007)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      zipD1847K.UAS.GFP/Scer\GAL4sqh.PW partially rescues zip2/zip1

      (Franke et al., 2007)
      Comments

      Expression of zipD1847K.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4sqh.PW rescues the embryonic lethality of zip1/zip2 animals. 85 +/- 12% of the rescued animals survive to the pupal stage, but no animals survive to the adult stage.

      (Franke et al., 2007)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      zipD1847K.Scer\UAS.T:Avic\GFP
      zipD1847K.UAS.GFP
      Name Synonyms
      Secondary FlyBase IDs
        References (3)