FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\dnkUAS.cLa
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General Information
Symbol
Dmel\dnkUAS.cLa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Legent
FlyBase ID
FBal0278150
Feature type
allele
Associated gene
Dmel\dnk
Associated Insertion(s)
Carried in Construct
P{UAS-dnk.L}
Key Links
Transgenic product class
cDNA
(Legent et al., 2006)
wild_type
(Legent et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Legent et al., 2006)
wild_type
(Legent et al., 2006)
Mutagen
in vitro construct
(Legent et al., 2006)
Progenitor genotype
Carried in construct
P{UAS-dnk.L}
Cytology
Description

UAS regulatory sequences drive expression of a dnk cDNA.

(Legent et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dnk
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Parkinson's disease
      modeled by Pink1B9
      (Tufi et al., 2014)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of dnkScer\UAS.cLa under the control of Scer\GAL4da.PU results in an increase in mtDNA synthesis and an increase in the mtDNA/rDNA ratio in adults. The flies show enhanced respiration compared to controls.

      Flies expressing dnkScer\UAS.cLa under the control of Scer\GAL4da.PU show an increase in locomotor activity compared to controls.

      (Tufi et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Scer\GAL4elav.PU/dnkUAS.cLa is a suppressor of abnormal neuroanatomy | adult stage phenotype of Pink1B9

      (Tufi et al., 2014)
      Phenotype Manifest In
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of TFAMKK108639 suppresses the increase in mtDNA/rDNA seen in flies expressing dnkScer\UAS.cLa under the control of Scer\GAL4da.PU.

      Expression of dnkScer\UAS.cLa under the control of Scer\GAL4da.PU suppresses the reduction in the mtDNA/nDNA ratio seen in Pink1B9 flies. Mitochondrial defects in the indirect flight muscles are rescued.

      Expression of dnkScer\UAS.cLa under the control of Scer\GAL4elav.PU suppresses the loss of dopaminergic neurons in the PPL1 cluster which is seen in Pink1B9 flies. The loss of mitochondrial mass and mitochondrial potential in the brain is also suppressed. The adult thorax defects are suppressed.

      (Tufi et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      dnkScer\UAS.cLa
      dnkUAS.cLa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Legent
      Secondary FlyBase IDs
        References (3)