FlyBase Allele Report: Dmel\Maf1[RNAi.UAS]

General Information

Symbol

Dmel\Maf1^RNAi.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0269077

Feature type

allele

Associated gene

Dmel\Maf1

Associated Insertion(s)

Carried in Construct

P{UAS-Maf1.RNAi}

Key Links

Transgenic product class

RNAi_reagent

(Rideout et al., 2012)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Rideout et al., 2012)

Mutagen

in vitro construct

(Rideout et al., 2012)

Progenitor genotype

Carried in construct

P{UAS-Maf1.RNAi}

Cytology

Description

UAS regulatory sequences drive expression of a Maf1 RNAi construct.

(Rideout et al., 2012)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Maf1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate, with Scer\GAL4^Cg.PA

(Rideout et al., 2012)

abnormal developmental rate, with Scer\GAL4^da.PU

(Rideout et al., 2012)

abnormal developmental rate, with Scer\GAL4^ppl.PP

(Rideout et al., 2012)

increased body size | pupal stage, with Scer\GAL4^da.PU

(Rideout et al., 2012)

Phenotype Manifest In

Detailed Description

Statement

Reference

Larvae expressing Maf1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^da.G32 progress from egg laying to pupation approximately 24 hours sooner than control larvae. Pupae expressing Maf1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^da.G32 show a significant increase in volume compared to controls.

Larvae expressing Maf1^{dsRNA.Scer\UAS} under the control of either Scer\GAL4^Cg.PA or Scer\GAL4^ppl.PP progress from egg laying to pupation faster than control larvae.

Larvae expressing Maf1^{dsRNA.Scer\UAS} under the control of either Scer\GAL4^Mef2.PR or Scer\GAL4^elav.PU show a normal rate of development.

(Rideout et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Maf1^RNAi.UAS, Scer\GAL4^da.PU has increased body size | pupal stage phenotype, suppressible by InR[+]/InR^unspecified

(Rideout et al., 2012)

Maf1^RNAi.UAS, Scer\GAL4^da.PU has increased body size | pupal stage phenotype, suppressible by RpS3[+]/RpS3^unspecified

(Rideout et al., 2012)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

The increase in pupal volume caused by expression of Maf1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^da.G32 is suppressed by RpS3^unspecified/+ and by InR^unspecified/+.

(Rideout et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Maf1^RNAi.UAS

Maf1^{dsRNA.Scer\UAS}

Maf1^dsRNA.UAS

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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