FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Snx16Δ2
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General Information
Symbol
Dmel\Snx16Δ2
Species
D. melanogaster
Name
FlyBase ID
FBal0260799
Feature type
allele
Associated gene
Dmel\Snx16
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Rodal et al., 2011)
Mutagen
Delta2-3 transposase
(Rodal et al., 2011)
Progenitor genotype
P{EPgy2}EY10175
(Rodal et al., 2011)
Caused by aberration
Df(2R)Snx16Δ2
Cytology
Description

Imprecise excision of the progenitor insertion, resulting in a 2298bp deletion that removes the entire Snx16 coding region and part of the CG10933 gene.

(Rodal et al., 2011)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Huntington's disease
      modeled by Hsap\HTTQ138.UAS.mRFP1
      (Akbergenova and Littleton, 2017)
      Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
       

      Snx16Δ2 used in trans to Snx16Δ1 ameliorates the phenotype of Hsap\HTTQ138.UAS.mRFP1.

      (Akbergenova and Littleton, 2017)
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      7 days old Snx16Δ2 homozygotes show a significant increase in the number of mitotic cells per midgut (phospho-H3 staining), as compared to heterozygous and wild-type controls.

      (Zhang et al., 2019)

      Homozygous mushroom body gamma neuron clones show normal axon pruning.

      (Issman-Zecharya and Schuldiner, 2014)

      Average bouton number and average satellite bouton number at the neuromuscular junction is not significantly different from wild type in Snx16e01600/Snx16Δ2 and Snx16Δ2/Df(2R)Exel7150 animals.

      (Rodal et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Snx16e01600/Snx16Δ2 is a suppressor of abnormal neuroanatomy | larval stage phenotype of nwk2

      (Rodal et al., 2011)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Snx16e01600/Snx16Δ2 is a suppressor of NMJ bouton | increased number | larval stage phenotype of nwk2

      (Rodal et al., 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The increase in average bouton number and satellite bouton number at the neuromuscular junction which is seen in nwk2 larvae is suppressed if they are also carrying Snx16Δ2/Snx16e01600.

      (Rodal et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Snx16Δ2
      (Akbergenova and Littleton, 2017, Issman-Zecharya and Schuldiner, 2014, Rodal et al., 2011)
      snx16Δ2
      (Zhang et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)