Expression of Hsap\HTT^{152Q.Ex1.Scer\UAS.T:Avic\GFP-EGFP.T:Zzzz\nls1} in larval body wall sensory neurons under the control of Scer\GAL4^RluA1 has no apparent effect on larval da neuron viability.

Expression of Hsap\HTT^{152Q.Ex1.Scer\UAS.T:Avic\GFP-EGFP.T:Zzzz\nls1} in larval body wall sensory neurons under the control of Scer\GAL4^RluA1 results in the formation of nuclear aggregates in the axon and cell body, and in addition aggregates are seen throughout the extensive dendritic arbors of the da neurons. A small proportion of these cells also display cytosolic aggregates.

Expression of Hsap\HTT^{152Q.Ex1.Scer\UAS.T:Avic\GFP-EGFP.T:Zzzz\nls1} in larval body wall sensory neurons under the control of Scer\GAL4^RluA1 reduces the level of dendritic coverage of da neurons in the dorsal cluster. In particular, dendritic branches fail to reach the dorsal midline and segment boundaries.

The speed of locomotion is significantly lower in Hsap\HTT^{152Q.Ex1.Scer\UAS.T:Avic\GFP-EGFP.T:Zzzz\nls1} expressing larva (driven by Scer\GAL4^RluA1) compared to wild-type controls. The trajectory of larval locomotion is also affected. Mutant larvae crawl in tight circles, with many changes in direction, rather than predominantly straight ahead, as in wild-type controls.

Expression of Hsap\HTT^{152Q.Ex1.Scer\UAS.T:Avic\GFP-EGFP.T:Zzzz\nls1} in the da neurons from embryonic stage 15, under the control of Scer\GAL4^109(2)80 significantly reduces the speed of larval locomotion and increases the number of turns and head shakings.

Expression of Hsap\HTT^{152Q.Ex1.Scer\UAS.T:Avic\GFP-EGFP.T:Zzzz\nls1} in larval body wall sensory neurons under the control of Scer\GAL4^RluA1 affects segmental nerve bursting activity. In the anterior segment (A3) the duration of bursts is distributed to a smaller value in Hsap\HTT^{152Q.Ex1.Scer\UAS.T:Avic\GFP-EGFP.T:Zzzz\nls1} larvae compared to controls. The mean value of the duration is significantly smaller in Hsap\HTT^{152Q.Ex1.Scer\UAS.T:Avic\GFP-EGFP.T:Zzzz\nls1} larvae compared to controls. Inter-burst intervals are slightly longer in these larvae compared to controls. In the posterior (A7) segment the duration of bursts is slightly, but significantly longer in Hsap\HTT^{152Q.Ex1.Scer\UAS.T:Avic\GFP-EGFP.T:Zzzz\nls1} larvae compared to controls. The mean value of interburst intervals is significantly shorter in Hsap\HTT^{152Q.Ex1.Scer\UAS.T:Avic\GFP-EGFP.T:Zzzz\nls1} posterior (A7) segments compared to controls.

In approximately 58% of larvae expressing Hsap\HTT^{152Q.Ex1.Scer\UAS.T:Avic\GFP-EGFP.T:Zzzz\nls1} (in larval body wall sensory neurons under the control of Scer\GAL4^RluA1), an irregular pattern and different frequency of segmental nerve bursting activity is observed between anterior and posterior segments. There are always more bursts in A7 than A3 and hence there is a common failure to forward propagate the waves of contraction.

 :Expression of Hsap\HTT^{152Q.Ex1.Scer\UAS.T:Avic\GFP-EGFP.T:Zzzz\nls1} in the developing eye using the Scer\GAL4^GMR.PF driver generates a moderate loss of eye pigmentation.

Expression of Hsap\HTT^{152Q.Ex1.Scer\UAS.T:Avic\GFP-EGFP} and Hsap\HTT^{48Q.Ex1.Scer\UAS.T:Avic\GFP-EGFP.T:Zzzz\nls1} in the developing eye using the Scer\GAL4^GMR.PF driver produces a degenerative eye phenotype characterized by loss of pigment cells and an increased occurrence of dark necrotic spots on the external eye.